Non-specific binding of [18F]FDG to calcifications in atherosclerotic plaques: experimental study of mouse and human arteries View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2006-07-15

AUTHORS

Iina Laitinen, Päivi Marjamäki, Merja Haaparanta, Nina Savisto, V. Jukka O. Laine, Sanna L. Soini, Ian Wilson, Pia Leppänen, Seppo Ylä-Herttuala, Anne Roivainen, Juhani Knuuti

ABSTRACT

Purpose[18F]FDG has been used as an inflammation marker and shown to accumulate in inflammatory atherosclerotic plaques. The aim of this study was to investigate the uptake and location of [18F]FDG in atherosclerotic plaque compartments.MethodsThe biodistribution of intravenously administered [18F]FDG was analysed in atherosclerotic LDLR/ApoB48 mice (n=11) and control mice (n=9). Digital autoradiography was used to detect the ex vivo distribution in frozen aortic sections. In vitro binding of [18F]FDG in human atherosclerotic arteries was also examined.ResultsThe uptake of [18F]FDG was significantly higher in the aorta of atherosclerotic mice as compared with the control mice. Autoradiography of excised arteries showed higher [18F]FDG uptake in the plaques than in the healthy vessel wall (mean ratio ±SD 2.7±1.1). The uptake of [18F]FDG in the necrotic, calcified sites of the advanced atherosclerotic lesions was 6.2±3.2 times higher than that in the healthy vessel wall. The in vitro studies of human arterial sections showed marked binding of [18F]FDG to the calcifications but not to other structures of the artery wall.ConclusionIn agreement with previous studies, we observed [18F]FDG uptake in atherosclerotic plaques. However, prominent non-specific binding to calcified structures was found. This finding warrants further studies to clarify the significance of this non-specific binding in human plaques in vivo. More... »

PAGES

1461-1467

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00259-006-0159-6

DOI

http://dx.doi.org/10.1007/s00259-006-0159-6

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1022162075

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/16845513


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