Human radiation dosimetry of [11C]MeAIB, a new tracer for imaging of system A amino acid transport View Full Text


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Article Info

DATE

2006-05-24

AUTHORS

Tuula Tolvanen, Kjell Någren, Meixiang Yu, Eija Sutinen, Katja Havu-Aurén, Sirkku Jyrkkiö, Markku Asola, Eira Kotoneva, Pirjo Nuutila, Heikki Minn

ABSTRACT

Purpose[N-methyl-11C]α-methylaminoisobutyric acid ([11C]MeAIB) is a promising positron emission tomography (PET) tracer for imaging hormonally regulated system A amino acid transport. Uptake of [11C]MeAIB is totally specific for amino acid transport since [11C]MeAIB is metabolically stable both extra- and intracellularly. The aim of this study was to measure cumulated radioactivity in different organs and estimate the absorbed radiation doses to humans with the Medical Internal Radiation Dosimetry (MIRD) method.MethodsRadiation absorbed doses were calculated from PET images for 25 volunteers. Dynamic acquisition data were obtained for the thoracic, abdominal, femoral and head and neck regions. The median dose of intravenously injected [11C]MeAIB was 422±35 MBq, with a range of 295–493 MBq. After PET imaging the radioactivity in voided urine was measured. Experimental human data were used for residence time estimates. Radiation doses were calculated with commonly used software.ResultsThe effective dose for a 70-kg adult was 0.004 mSv/MBq, corresponding to a 1.72 mSv effective dose from the PET study with injection of 430 MBq [11C]MeAIB. The highest absorbed doses were in the pancreas (0.018 mGy/MBq), kidneys (0.017 mGy/MBq), intestine (0.014 mGy/MBq), liver (0.008 mGy/MBq) and stomach (0.005 mGy/MBq). Only 0.57% of injected activity was excreted to urine within 1 h after injection.ConclusionBiodistribution of [11C]MeAIB in the abdominal region reflected the high activity of the transportation of amino acids via system A and these organs also had the highest radiation doses. An effective dose of 0.004 mSv/MBq is fully justified when [11C]MeAIB PET is performed to study system A activity in vivo. More... »

PAGES

1178-1184

References to SciGraph publications

  • 2002-08-30. Amino acid uptake in the skeletal muscle measured using [11C]methylaminoisobutyrate (MEAIB) and PET in EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
  • 2001-06-01. Biodistribution of [11C]methylaminoisobutyric acid, a tracer for PET studies on system A amino acid transport in vivo in EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
  • 1998-06. Estimation of internal absorbed dose of l-[methyl-11C]methionine using whole-body positron emission tomography in EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
  • 2002-10-26. Uptake of [N-methyl-11C]α-methylaminoisobutyric acid in untreated head and neck cancer studied by PET in EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
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    URI

    http://scigraph.springernature.com/pub.10.1007/s00259-006-0096-4

    DOI

    http://dx.doi.org/10.1007/s00259-006-0096-4

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1015748178

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/16721566


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