Development and biodistribution of 188Re-SSS lipiodol following injection into the hepatic artery of healthy pigs View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2003-12-23

AUTHORS

E. Garin, N. Noiret, C. Malbert, N. Lepareur, A. Roucoux, S. Caulet-Maugendre, A. Moisan, J. Lecloirec, J. Y. Herry, P. Bourguet

ABSTRACT

Although intra-arterial radiotherapy with 131I-labelled lipiodol is a useful therapeutic approach in the treatment of hepatocellular carcinomas, various disadvantages limit its use. Here we describe the development of 188Re-SSS lipiodol, as well as its biodistribution in the healthy pig after injection into the hepatic artery. The 188Re-SSS lipiodol was obtained after dissolving a chelating agent, previously labelled with 188Re, in cold lipiodol. The radiochemical purity (RCP) of the labelling was checked immediately and at 24 and 48 h. The 188Re-SSS lipiodol was injected into the hepatic artery of six healthy pigs. They were killed 1, 24 and 48 h post injection, for ex vivo counting. An autoradiographic study was performed in three cases. 188Re-SSS lipiodol was obtained with a yield of 87%±9.1%. The immediate RCP was 93%±3.4%. This radiolabelling was reproducible and stable at 48 h in plasma: 90.6%±1.5% of the activity remained in the lipiodol with an RCP of 91%±4%. Ex vivo counting confirmed the predominantly hepatic uptake and revealed weak lung and intestinal uptake. There was very weak urinary elimination (2.3%±0.5% at 48 h) and a slightly higher level of intestinal elimination (4.8%±1.9% at 48 h). The autoradiographic studies showed 188Re-SSS lipiodol to be located mainly in sinusoids, like 131I-lipiodol. By using the method described here, 188Re-SSS lipiodol can be obtained with a very high yield and a satisfactory RCP. Its biodistribution in the healthy pig is in agreement with data published elsewhere concerning other types of radiolabelling used for lipiodol, except for the very weak urinary and intestinal elimination, which probably indicates better stability of 188Re-SSS labelling. More... »

PAGES

542-546

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00259-003-1402-z

DOI

http://dx.doi.org/10.1007/s00259-003-1402-z

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1002756691

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/14691613


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Carcinoma, Hepatocellular", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Drug Combinations", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Feasibility Studies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Hepatic Artery", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Injections, Spinal", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Iodized Oil", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Isotope Labeling", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Liver", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Liver Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Metabolic Clearance Rate", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Organ Specificity", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Organometallic Compounds", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Radionuclide Imaging", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Radiopharmaceuticals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Swine", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Tissue Distribution", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Service de M\u00e9decine Nucl\u00e9aire, Centre Eug\u00e8ne Marquis, Rue de la bataille Flandes-Dunkerque, CS 44229, 35042, Rennes cedex, France", 
          "id": "http://www.grid.ac/institutes/grid.417988.b", 
          "name": [
            "Service de M\u00e9decine Nucl\u00e9aire, Centre Eug\u00e8ne Marquis, Rue de la bataille Flandes-Dunkerque, CS 44229, 35042, Rennes cedex, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Garin", 
        "givenName": "E.", 
        "id": "sg:person.0620512077.06", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0620512077.06"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "ENSCR UMR CNRS 6052, Rennes-Beaulieu, France", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "ENSCR UMR CNRS 6052, Rennes-Beaulieu, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Noiret", 
        "givenName": "N.", 
        "id": "sg:person.0672626707.15", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0672626707.15"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "INRA UMR VP, St Gilles, France", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "INRA UMR VP, St Gilles, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Malbert", 
        "givenName": "C.", 
        "id": "sg:person.0711610525.30", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0711610525.30"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "ENSCR UMR CNRS 6052, Rennes-Beaulieu, France", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "ENSCR UMR CNRS 6052, Rennes-Beaulieu, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lepareur", 
        "givenName": "N.", 
        "id": "sg:person.01276035557.58", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01276035557.58"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "ENSCR UMR CNRS 6052, Rennes-Beaulieu, France", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "ENSCR UMR CNRS 6052, Rennes-Beaulieu, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Roucoux", 
        "givenName": "A.", 
        "id": "sg:person.01100711031.07", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01100711031.07"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Service d\u2019Anatomopathologie, CHU Pontchaillou, Rennes, France", 
          "id": "http://www.grid.ac/institutes/grid.414271.5", 
          "name": [
            "Service d\u2019Anatomopathologie, CHU Pontchaillou, Rennes, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Caulet-Maugendre", 
        "givenName": "S.", 
        "id": "sg:person.01166337436.73", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01166337436.73"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Service de M\u00e9decine Nucl\u00e9aire, Centre Eug\u00e8ne Marquis, Rue de la bataille Flandes-Dunkerque, CS 44229, 35042, Rennes cedex, France", 
          "id": "http://www.grid.ac/institutes/grid.417988.b", 
          "name": [
            "Service de M\u00e9decine Nucl\u00e9aire, Centre Eug\u00e8ne Marquis, Rue de la bataille Flandes-Dunkerque, CS 44229, 35042, Rennes cedex, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Moisan", 
        "givenName": "A.", 
        "id": "sg:person.01245323203.45", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01245323203.45"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Service de M\u00e9decine Nucl\u00e9aire, Centre Eug\u00e8ne Marquis, Rue de la bataille Flandes-Dunkerque, CS 44229, 35042, Rennes cedex, France", 
          "id": "http://www.grid.ac/institutes/grid.417988.b", 
          "name": [
            "Service de M\u00e9decine Nucl\u00e9aire, Centre Eug\u00e8ne Marquis, Rue de la bataille Flandes-Dunkerque, CS 44229, 35042, Rennes cedex, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lecloirec", 
        "givenName": "J.", 
        "id": "sg:person.01313436403.09", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01313436403.09"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Service de M\u00e9decine Nucl\u00e9aire, Centre Eug\u00e8ne Marquis, Rue de la bataille Flandes-Dunkerque, CS 44229, 35042, Rennes cedex, France", 
          "id": "http://www.grid.ac/institutes/grid.417988.b", 
          "name": [
            "Service de M\u00e9decine Nucl\u00e9aire, Centre Eug\u00e8ne Marquis, Rue de la bataille Flandes-Dunkerque, CS 44229, 35042, Rennes cedex, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Herry", 
        "givenName": "J. Y.", 
        "id": "sg:person.012116171367.06", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012116171367.06"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Service de M\u00e9decine Nucl\u00e9aire, Centre Eug\u00e8ne Marquis, Rue de la bataille Flandes-Dunkerque, CS 44229, 35042, Rennes cedex, France", 
          "id": "http://www.grid.ac/institutes/grid.417988.b", 
          "name": [
            "Service de M\u00e9decine Nucl\u00e9aire, Centre Eug\u00e8ne Marquis, Rue de la bataille Flandes-Dunkerque, CS 44229, 35042, Rennes cedex, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bourguet", 
        "givenName": "P.", 
        "id": "sg:person.0620506232.31", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0620506232.31"
        ], 
        "type": "Person"
      }
    ], 
    "datePublished": "2003-12-23", 
    "datePublishedReg": "2003-12-23", 
    "description": "Although intra-arterial radiotherapy with 131I-labelled lipiodol is a useful therapeutic approach in the treatment of hepatocellular carcinomas, various disadvantages limit its use. Here we describe the development of 188Re-SSS lipiodol, as well as its biodistribution in the healthy pig after injection into the hepatic artery. The 188Re-SSS lipiodol was obtained after dissolving a chelating agent, previously labelled with 188Re, in cold lipiodol. The radiochemical purity (RCP) of the labelling was checked immediately and at 24 and 48\u00a0h. The 188Re-SSS lipiodol was injected into the hepatic artery of six healthy pigs. They were killed 1, 24 and 48\u00a0h post injection, for ex vivo counting. An autoradiographic study was performed in three cases. 188Re-SSS lipiodol was obtained with a yield of 87%\u00b19.1%. The immediate RCP was 93%\u00b13.4%. This radiolabelling was reproducible and stable at 48\u00a0h in plasma: 90.6%\u00b11.5% of the activity remained in the lipiodol with an RCP of 91%\u00b14%. Ex vivo counting confirmed the predominantly hepatic uptake and revealed weak lung and intestinal uptake. There was very weak urinary elimination (2.3%\u00b10.5% at 48\u00a0h) and a slightly higher level of intestinal elimination (4.8%\u00b11.9% at 48\u00a0h). The autoradiographic studies showed 188Re-SSS lipiodol to be located mainly in sinusoids, like 131I-lipiodol. By using the method described here, 188Re-SSS lipiodol can be obtained with a very high yield and a satisfactory RCP. Its biodistribution in the healthy pig is in agreement with data published elsewhere concerning other types of radiolabelling used for lipiodol, except for the very weak urinary and intestinal elimination, which probably indicates better stability of 188Re-SSS labelling.", 
    "genre": "article", 
    "id": "sg:pub.10.1007/s00259-003-1402-z", 
    "inLanguage": "en", 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1297401", 
        "issn": [
          "1619-7070", 
          "1619-7089"
        ], 
        "name": "European Journal of Nuclear Medicine and Molecular Imaging", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "4", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "31"
      }
    ], 
    "keywords": [
      "hepatic artery", 
      "healthy pigs", 
      "intestinal elimination", 
      "autoradiographic study", 
      "useful therapeutic approach", 
      "satisfactory radiochemical purity", 
      "intra-arterial radiotherapy", 
      "radiochemical purity", 
      "cold lipiodol", 
      "urinary elimination", 
      "therapeutic approaches", 
      "hepatocellular carcinoma", 
      "Lipiodol", 
      "hepatic uptake", 
      "post injection", 
      "artery", 
      "intestinal uptake", 
      "injection", 
      "pigs", 
      "biodistribution", 
      "high levels", 
      "radiotherapy", 
      "carcinoma", 
      "lung", 
      "elimination", 
      "uptake", 
      "treatment", 
      "study", 
      "labeling", 
      "vivo", 
      "radiolabelling", 
      "Ex", 
      "agents", 
      "sinusoids", 
      "plasma", 
      "development", 
      "levels", 
      "activity", 
      "cases", 
      "use", 
      "data", 
      "types", 
      "counting", 
      "disadvantages", 
      "method", 
      "approach", 
      "agreement", 
      "purity", 
      "stability", 
      "good stability", 
      "yield", 
      "high yield", 
      "immediate RCP", 
      "weak lung", 
      "weak urinary elimination", 
      "types of radiolabelling"
    ], 
    "name": "Development and biodistribution of 188Re-SSS lipiodol following injection into the hepatic artery of healthy pigs", 
    "pagination": "542-546", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1002756691"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s00259-003-1402-z"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "14691613"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s00259-003-1402-z", 
      "https://app.dimensions.ai/details/publication/pub.1002756691"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-01-01T18:12", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20220101/entities/gbq_results/article/article_376.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1007/s00259-003-1402-z"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s00259-003-1402-z'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s00259-003-1402-z'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s00259-003-1402-z'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s00259-003-1402-z'


 

This table displays all metadata directly associated to this object as RDF triples.

257 TRIPLES      21 PREDICATES      99 URIs      91 LITERALS      24 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s00259-003-1402-z schema:about N1c521ecfb6524469ab07db155215adb4
2 N3102bb2952c7458086d3ad0b2a1d1367
3 N3ec21484905e4db5920a3f07046e58ea
4 N4a31d882f35f46e4a43fad0b801c3bf9
5 N4a4ff2be076f46b8838ff3ee3185d204
6 N4dd67cb9c38846b7a2ff4aa55c6eb713
7 N4ed914956c7c4e4a8e999b83c5b3180a
8 N56d6a46a56854b9abdbbdf63184da1c3
9 N6faacdeb0bc5456b805a2644141afbb4
10 N914211e2fb894237b08450fb2a617845
11 Naf7ef0f828ac4b519b07296799bb2a5a
12 Nba37d61ceea141168dc2de1fd9fbfd3a
13 Nde1d5eb13b5b4a27a9726540566b1264
14 Ne7d3ead5911f4a66924f8161778fc613
15 Nee756f3054394ba08d670ce954f6a8a0
16 Nf594d67ebc284e09900e8f688a367ece
17 Nf7b208bee10846b0b962e167a1e92c2e
18 anzsrc-for:11
19 anzsrc-for:1103
20 schema:author Nc6319cd8e5584002bb8926a8da40d6aa
21 schema:datePublished 2003-12-23
22 schema:datePublishedReg 2003-12-23
23 schema:description Although intra-arterial radiotherapy with 131I-labelled lipiodol is a useful therapeutic approach in the treatment of hepatocellular carcinomas, various disadvantages limit its use. Here we describe the development of 188Re-SSS lipiodol, as well as its biodistribution in the healthy pig after injection into the hepatic artery. The 188Re-SSS lipiodol was obtained after dissolving a chelating agent, previously labelled with 188Re, in cold lipiodol. The radiochemical purity (RCP) of the labelling was checked immediately and at 24 and 48 h. The 188Re-SSS lipiodol was injected into the hepatic artery of six healthy pigs. They were killed 1, 24 and 48 h post injection, for ex vivo counting. An autoradiographic study was performed in three cases. 188Re-SSS lipiodol was obtained with a yield of 87%±9.1%. The immediate RCP was 93%±3.4%. This radiolabelling was reproducible and stable at 48 h in plasma: 90.6%±1.5% of the activity remained in the lipiodol with an RCP of 91%±4%. Ex vivo counting confirmed the predominantly hepatic uptake and revealed weak lung and intestinal uptake. There was very weak urinary elimination (2.3%±0.5% at 48 h) and a slightly higher level of intestinal elimination (4.8%±1.9% at 48 h). The autoradiographic studies showed 188Re-SSS lipiodol to be located mainly in sinusoids, like 131I-lipiodol. By using the method described here, 188Re-SSS lipiodol can be obtained with a very high yield and a satisfactory RCP. Its biodistribution in the healthy pig is in agreement with data published elsewhere concerning other types of radiolabelling used for lipiodol, except for the very weak urinary and intestinal elimination, which probably indicates better stability of 188Re-SSS labelling.
24 schema:genre article
25 schema:inLanguage en
26 schema:isAccessibleForFree false
27 schema:isPartOf N043f15891e2042c9aea1866722130a13
28 N6aa113eb16c440b19d96e31f764f7d9b
29 sg:journal.1297401
30 schema:keywords Ex
31 Lipiodol
32 activity
33 agents
34 agreement
35 approach
36 artery
37 autoradiographic study
38 biodistribution
39 carcinoma
40 cases
41 cold lipiodol
42 counting
43 data
44 development
45 disadvantages
46 elimination
47 good stability
48 healthy pigs
49 hepatic artery
50 hepatic uptake
51 hepatocellular carcinoma
52 high levels
53 high yield
54 immediate RCP
55 injection
56 intestinal elimination
57 intestinal uptake
58 intra-arterial radiotherapy
59 labeling
60 levels
61 lung
62 method
63 pigs
64 plasma
65 post injection
66 purity
67 radiochemical purity
68 radiolabelling
69 radiotherapy
70 satisfactory radiochemical purity
71 sinusoids
72 stability
73 study
74 therapeutic approaches
75 treatment
76 types
77 types of radiolabelling
78 uptake
79 urinary elimination
80 use
81 useful therapeutic approach
82 vivo
83 weak lung
84 weak urinary elimination
85 yield
86 schema:name Development and biodistribution of 188Re-SSS lipiodol following injection into the hepatic artery of healthy pigs
87 schema:pagination 542-546
88 schema:productId N1b8b9f08bae74e2a98219058784591d1
89 N2275049d799947918e9c651174f3a40d
90 N7ad40ed881354d639b3e7872c24ca70f
91 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002756691
92 https://doi.org/10.1007/s00259-003-1402-z
93 schema:sdDatePublished 2022-01-01T18:12
94 schema:sdLicense https://scigraph.springernature.com/explorer/license/
95 schema:sdPublisher N39d5822ff21640ffa302130f798b8847
96 schema:url https://doi.org/10.1007/s00259-003-1402-z
97 sgo:license sg:explorer/license/
98 sgo:sdDataset articles
99 rdf:type schema:ScholarlyArticle
100 N043f15891e2042c9aea1866722130a13 schema:volumeNumber 31
101 rdf:type schema:PublicationVolume
102 N0b64f8973048469a8a78283f69a6c1b6 rdf:first sg:person.0711610525.30
103 rdf:rest Nfa0deca14f124cd99bede7eece93fab8
104 N1b8b9f08bae74e2a98219058784591d1 schema:name doi
105 schema:value 10.1007/s00259-003-1402-z
106 rdf:type schema:PropertyValue
107 N1c521ecfb6524469ab07db155215adb4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
108 schema:name Carcinoma, Hepatocellular
109 rdf:type schema:DefinedTerm
110 N2275049d799947918e9c651174f3a40d schema:name dimensions_id
111 schema:value pub.1002756691
112 rdf:type schema:PropertyValue
113 N3102bb2952c7458086d3ad0b2a1d1367 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
114 schema:name Feasibility Studies
115 rdf:type schema:DefinedTerm
116 N39d5822ff21640ffa302130f798b8847 schema:name Springer Nature - SN SciGraph project
117 rdf:type schema:Organization
118 N3ec21484905e4db5920a3f07046e58ea schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
119 schema:name Radionuclide Imaging
120 rdf:type schema:DefinedTerm
121 N4132b7db1af041b383d44a468a17214b rdf:first sg:person.0672626707.15
122 rdf:rest N0b64f8973048469a8a78283f69a6c1b6
123 N427be1b7d3e340d39489ac22a96aa312 rdf:first sg:person.01100711031.07
124 rdf:rest Ndce5cabad1ae4d88ab4a0daa8f0be433
125 N4a31d882f35f46e4a43fad0b801c3bf9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
126 schema:name Metabolic Clearance Rate
127 rdf:type schema:DefinedTerm
128 N4a4ff2be076f46b8838ff3ee3185d204 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
129 schema:name Liver Neoplasms
130 rdf:type schema:DefinedTerm
131 N4dd67cb9c38846b7a2ff4aa55c6eb713 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
132 schema:name Radiopharmaceuticals
133 rdf:type schema:DefinedTerm
134 N4ed914956c7c4e4a8e999b83c5b3180a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
135 schema:name Animals
136 rdf:type schema:DefinedTerm
137 N56d6a46a56854b9abdbbdf63184da1c3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
138 schema:name Hepatic Artery
139 rdf:type schema:DefinedTerm
140 N5772125de02c4f6ca12f55f652b87c88 rdf:first sg:person.01245323203.45
141 rdf:rest Nf8aee0d0aa11488a8fb27d004eaa500b
142 N6aa113eb16c440b19d96e31f764f7d9b schema:issueNumber 4
143 rdf:type schema:PublicationIssue
144 N6faacdeb0bc5456b805a2644141afbb4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
145 schema:name Drug Combinations
146 rdf:type schema:DefinedTerm
147 N7ad40ed881354d639b3e7872c24ca70f schema:name pubmed_id
148 schema:value 14691613
149 rdf:type schema:PropertyValue
150 N914211e2fb894237b08450fb2a617845 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
151 schema:name Iodized Oil
152 rdf:type schema:DefinedTerm
153 Naf7ef0f828ac4b519b07296799bb2a5a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
154 schema:name Organ Specificity
155 rdf:type schema:DefinedTerm
156 Nba37d61ceea141168dc2de1fd9fbfd3a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
157 schema:name Liver
158 rdf:type schema:DefinedTerm
159 Nbf28e3b1cafc456d888bec71274c9735 rdf:first sg:person.012116171367.06
160 rdf:rest Nc67cf2db7be149ef9638cabd3ded17fd
161 Nc6319cd8e5584002bb8926a8da40d6aa rdf:first sg:person.0620512077.06
162 rdf:rest N4132b7db1af041b383d44a468a17214b
163 Nc67cf2db7be149ef9638cabd3ded17fd rdf:first sg:person.0620506232.31
164 rdf:rest rdf:nil
165 Ndce5cabad1ae4d88ab4a0daa8f0be433 rdf:first sg:person.01166337436.73
166 rdf:rest N5772125de02c4f6ca12f55f652b87c88
167 Nde1d5eb13b5b4a27a9726540566b1264 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
168 schema:name Organometallic Compounds
169 rdf:type schema:DefinedTerm
170 Ne7d3ead5911f4a66924f8161778fc613 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
171 schema:name Swine
172 rdf:type schema:DefinedTerm
173 Nee756f3054394ba08d670ce954f6a8a0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
174 schema:name Tissue Distribution
175 rdf:type schema:DefinedTerm
176 Nf594d67ebc284e09900e8f688a367ece schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
177 schema:name Injections, Spinal
178 rdf:type schema:DefinedTerm
179 Nf7b208bee10846b0b962e167a1e92c2e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
180 schema:name Isotope Labeling
181 rdf:type schema:DefinedTerm
182 Nf8aee0d0aa11488a8fb27d004eaa500b rdf:first sg:person.01313436403.09
183 rdf:rest Nbf28e3b1cafc456d888bec71274c9735
184 Nfa0deca14f124cd99bede7eece93fab8 rdf:first sg:person.01276035557.58
185 rdf:rest N427be1b7d3e340d39489ac22a96aa312
186 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
187 schema:name Medical and Health Sciences
188 rdf:type schema:DefinedTerm
189 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
190 schema:name Clinical Sciences
191 rdf:type schema:DefinedTerm
192 sg:journal.1297401 schema:issn 1619-7070
193 1619-7089
194 schema:name European Journal of Nuclear Medicine and Molecular Imaging
195 schema:publisher Springer Nature
196 rdf:type schema:Periodical
197 sg:person.01100711031.07 schema:affiliation grid-institutes:None
198 schema:familyName Roucoux
199 schema:givenName A.
200 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01100711031.07
201 rdf:type schema:Person
202 sg:person.01166337436.73 schema:affiliation grid-institutes:grid.414271.5
203 schema:familyName Caulet-Maugendre
204 schema:givenName S.
205 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01166337436.73
206 rdf:type schema:Person
207 sg:person.012116171367.06 schema:affiliation grid-institutes:grid.417988.b
208 schema:familyName Herry
209 schema:givenName J. Y.
210 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012116171367.06
211 rdf:type schema:Person
212 sg:person.01245323203.45 schema:affiliation grid-institutes:grid.417988.b
213 schema:familyName Moisan
214 schema:givenName A.
215 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01245323203.45
216 rdf:type schema:Person
217 sg:person.01276035557.58 schema:affiliation grid-institutes:None
218 schema:familyName Lepareur
219 schema:givenName N.
220 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01276035557.58
221 rdf:type schema:Person
222 sg:person.01313436403.09 schema:affiliation grid-institutes:grid.417988.b
223 schema:familyName Lecloirec
224 schema:givenName J.
225 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01313436403.09
226 rdf:type schema:Person
227 sg:person.0620506232.31 schema:affiliation grid-institutes:grid.417988.b
228 schema:familyName Bourguet
229 schema:givenName P.
230 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0620506232.31
231 rdf:type schema:Person
232 sg:person.0620512077.06 schema:affiliation grid-institutes:grid.417988.b
233 schema:familyName Garin
234 schema:givenName E.
235 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0620512077.06
236 rdf:type schema:Person
237 sg:person.0672626707.15 schema:affiliation grid-institutes:None
238 schema:familyName Noiret
239 schema:givenName N.
240 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0672626707.15
241 rdf:type schema:Person
242 sg:person.0711610525.30 schema:affiliation grid-institutes:None
243 schema:familyName Malbert
244 schema:givenName C.
245 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0711610525.30
246 rdf:type schema:Person
247 grid-institutes:None schema:alternateName ENSCR UMR CNRS 6052, Rennes-Beaulieu, France
248 INRA UMR VP, St Gilles, France
249 schema:name ENSCR UMR CNRS 6052, Rennes-Beaulieu, France
250 INRA UMR VP, St Gilles, France
251 rdf:type schema:Organization
252 grid-institutes:grid.414271.5 schema:alternateName Service d’Anatomopathologie, CHU Pontchaillou, Rennes, France
253 schema:name Service d’Anatomopathologie, CHU Pontchaillou, Rennes, France
254 rdf:type schema:Organization
255 grid-institutes:grid.417988.b schema:alternateName Service de Médecine Nucléaire, Centre Eugène Marquis, Rue de la bataille Flandes-Dunkerque, CS 44229, 35042, Rennes cedex, France
256 schema:name Service de Médecine Nucléaire, Centre Eugène Marquis, Rue de la bataille Flandes-Dunkerque, CS 44229, 35042, Rennes cedex, France
257 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...