Ontology type: schema:ScholarlyArticle
2002-12
AUTHORSKlaus F. Kofoed, Jens D. Hove, Jacob Freiberg, Ulla Høst, Søren Holm, Henning Kelbæk
ABSTRACTThe aim of this study was to assess regional and global variability of insulin-stimulated myocardial glucose uptake in healthy elderly subjects and to evaluate potentially responsible factors. Twenty men with a mean age of 64 years, no history of cardiovascular disease, and normal blood pressure, bicycle exercise test, electrocardiogram and echocardiography were studied [ P(coronary artery disease) <5%]. Whole-body insulin sensitivity and insulin-stimulated myocardial glucose uptake were measured during hyperinsulinaemic euglycaemic glucose clamp with fluorine-18 fluorodeoxyglucose, and myocardial rest and hyperaemic blood flow during dipyridamole infusion were measured with nitrogen-13 ammonia and positron emission tomography in 16 left ventricular myocardial segments. Intra-individual and inter-individual variability of insulin-stimulated myocardial glucose uptake [relative dispersion = (standard deviation/mean)] was 13% and 29% respectively. Although inter-individual variability of glucose uptake and blood flow at rest was of the same magnitude, no correlation was found between these measures. Regional and global insulin-stimulated myocardial glucose uptake correlated linearly with whole-body insulin sensitivity ( r=0.51, P<0.05 and r=0.56, P<0.01). The strongest independent association by multivariate linear regression analysis was found between myocardial glucose uptake and hyperaemic blood flow ( r=0.63, P<0.005). We conclude that in healthy elderly subjects, insulin-stimulated myocardial glucose uptake is homogeneous throughout the left ventricle, but has moderate inter-individual variability. Inter-individual variability of insulin-stimulated myocardial glucose uptake is primarily explained by variability in coronary vascular reactivity and tissue insulin sensitivity. More... »
PAGES1600-1607
http://scigraph.springernature.com/pub.10.1007/s00259-002-0972-5
DOIhttp://dx.doi.org/10.1007/s00259-002-0972-5
DIMENSIONShttps://app.dimensions.ai/details/publication/pub.1029483586
PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/12458394
JSON-LD is the canonical representation for SciGraph data.
TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT
[
{
"@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json",
"about": [
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1102",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Cardiorespiratory Medicine and Haematology",
"type": "DefinedTerm"
},
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Medical and Health Sciences",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Ammonia",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Blood Glucose",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Dipyridamole",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Fluorodeoxyglucose F18",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Glucose",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Glucose Clamp Technique",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Heart Ventricles",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Humans",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Hyperemia",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Hyperinsulinism",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Insulin",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Male",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Middle Aged",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Nitrogen Radioisotopes",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Radiopharmaceuticals",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Reproducibility of Results",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Sensitivity and Specificity",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Tissue Distribution",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Tomography, Emission-Computed",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Ventricular Function, Left",
"type": "DefinedTerm"
}
],
"author": [
{
"affiliation": {
"name": [
"Cardiovascular PET Research Unit, Section 9201, Medical Department B, The Heart Center, Rigshospitalet, University of Copenhagen, Juliane Mariesvej 24, 2100 Copenhagen, Denmark"
],
"type": "Organization"
},
"familyName": "Kofoed",
"givenName": "Klaus F.",
"id": "sg:person.016452166277.03",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016452166277.03"
],
"type": "Person"
},
{
"affiliation": {
"name": [
"Cardiovascular PET Research Unit, Section 9201, Medical Department B, The Heart Center, Rigshospitalet, University of Copenhagen, Juliane Mariesvej 24, 2100 Copenhagen, Denmark"
],
"type": "Organization"
},
"familyName": "Hove",
"givenName": "Jens D.",
"id": "sg:person.01136733117.88",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01136733117.88"
],
"type": "Person"
},
{
"affiliation": {
"name": [
"Cardiovascular PET Research Unit, Section 9201, Medical Department B, The Heart Center, Rigshospitalet, University of Copenhagen, Juliane Mariesvej 24, 2100 Copenhagen, Denmark"
],
"type": "Organization"
},
"familyName": "Freiberg",
"givenName": "Jacob",
"id": "sg:person.01253161517.23",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01253161517.23"
],
"type": "Person"
},
{
"affiliation": {
"name": [
"Cardiovascular PET Research Unit, Section 9201, Medical Department B, The Heart Center, Rigshospitalet, University of Copenhagen, Juliane Mariesvej 24, 2100 Copenhagen, Denmark"
],
"type": "Organization"
},
"familyName": "H\u00f8st",
"givenName": "Ulla",
"id": "sg:person.01064602103.14",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01064602103.14"
],
"type": "Person"
},
{
"affiliation": {
"name": [
"The Cyclotron and PET Unit, Department of Clinical Physiology and Nuclear Medicine, Rigshospitalet, University of Copenhagen, Denmark"
],
"type": "Organization"
},
"familyName": "Holm",
"givenName": "S\u00f8ren",
"id": "sg:person.0740340304.66",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0740340304.66"
],
"type": "Person"
},
{
"affiliation": {
"name": [
"Cardiovascular PET Research Unit, Section 9201, Medical Department B, The Heart Center, Rigshospitalet, University of Copenhagen, Juliane Mariesvej 24, 2100 Copenhagen, Denmark"
],
"type": "Organization"
},
"familyName": "Kelb\u00e6k",
"givenName": "Henning",
"id": "sg:person.0771034557.12",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0771034557.12"
],
"type": "Person"
}
],
"citation": [
{
"id": "sg:pub.10.1007/s00259-002-0827-0",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1003538953",
"https://doi.org/10.1007/s00259-002-0827-0"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1161/01.cir.86.3.1004",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1003553864"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1172/jci115780",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1004516243"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.2337/diabetes.50.2.241",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1005932425"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1006/jmcc.1993.1082",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1008122218"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1161/01.cir.87.5.1513",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1012224670"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1161/01.cir.99.4.578",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1018047152"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1038/jcbfm.1983.1",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1018753419"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1038/jcbfm.1983.1",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1018753419"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1056/nejm197906143002402",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1019126751"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1016/s1071-3581(97)90061-1",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1023219716",
"https://doi.org/10.1016/s1071-3581(97)90061-1"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.2337/diabetes.49.5.768",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1024412321"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s0735-1097(10)80225-6",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1025962873"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1023/a:1011981526366",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1026381728",
"https://doi.org/10.1023/a:1011981526366"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1161/01.cir.102.8.908",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1030035429"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1172/jci119015",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1033275394"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/bf00169806",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1041367317",
"https://doi.org/10.1007/bf00169806"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/bf00169806",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1041367317",
"https://doi.org/10.1007/bf00169806"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1161/hc4401.098293",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1045393683"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s0008-6363(01)00202-4",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1054577668"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s0008-6363(99)00278-3",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1054580581"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1161/01.cir.91.9.2435",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1063336249"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1161/01.cir.93.4.737",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1063336988"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1161/01.cir.93.9.1658",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1063337111"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1161/01.cir.94.4.651",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1063337384"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1161/01.cir.95.3.600",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1063337789"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1210/jcem.86.11.7979",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1064323952"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1093/oxfordjournals.eurheartj.a059401",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1079089438"
],
"type": "CreativeWork"
}
],
"datePublished": "2002-12",
"datePublishedReg": "2002-12-01",
"description": "The aim of this study was to assess regional and global variability of insulin-stimulated myocardial glucose uptake in healthy elderly subjects and to evaluate potentially responsible factors. Twenty men with a mean age of 64 years, no history of cardiovascular disease, and normal blood pressure, bicycle exercise test, electrocardiogram and echocardiography were studied [ P(coronary artery disease) <5%]. Whole-body insulin sensitivity and insulin-stimulated myocardial glucose uptake were measured during hyperinsulinaemic euglycaemic glucose clamp with fluorine-18 fluorodeoxyglucose, and myocardial rest and hyperaemic blood flow during dipyridamole infusion were measured with nitrogen-13 ammonia and positron emission tomography in 16 left ventricular myocardial segments. Intra-individual and inter-individual variability of insulin-stimulated myocardial glucose uptake [relative dispersion = (standard deviation/mean)] was 13% and 29% respectively. Although inter-individual variability of glucose uptake and blood flow at rest was of the same magnitude, no correlation was found between these measures. Regional and global insulin-stimulated myocardial glucose uptake correlated linearly with whole-body insulin sensitivity ( r=0.51, P<0.05 and r=0.56, P<0.01). The strongest independent association by multivariate linear regression analysis was found between myocardial glucose uptake and hyperaemic blood flow ( r=0.63, P<0.005). We conclude that in healthy elderly subjects, insulin-stimulated myocardial glucose uptake is homogeneous throughout the left ventricle, but has moderate inter-individual variability. Inter-individual variability of insulin-stimulated myocardial glucose uptake is primarily explained by variability in coronary vascular reactivity and tissue insulin sensitivity.",
"genre": "research_article",
"id": "sg:pub.10.1007/s00259-002-0972-5",
"inLanguage": [
"en"
],
"isAccessibleForFree": false,
"isPartOf": [
{
"id": "sg:journal.1297401",
"issn": [
"1619-7070",
"1619-7089"
],
"name": "European Journal of Nuclear Medicine and Molecular Imaging",
"type": "Periodical"
},
{
"issueNumber": "12",
"type": "PublicationIssue"
},
{
"type": "PublicationVolume",
"volumeNumber": "29"
}
],
"name": "Variability of insulin-stimulated myocardial glucose uptake in healthy elderly subjects",
"pagination": "1600-1607",
"productId": [
{
"name": "readcube_id",
"type": "PropertyValue",
"value": [
"8c746f48bb5d7f06574e4661834954298c4e6bc8f5673f3890daea989cfdac3f"
]
},
{
"name": "pubmed_id",
"type": "PropertyValue",
"value": [
"12458394"
]
},
{
"name": "nlm_unique_id",
"type": "PropertyValue",
"value": [
"101140988"
]
},
{
"name": "doi",
"type": "PropertyValue",
"value": [
"10.1007/s00259-002-0972-5"
]
},
{
"name": "dimensions_id",
"type": "PropertyValue",
"value": [
"pub.1029483586"
]
}
],
"sameAs": [
"https://doi.org/10.1007/s00259-002-0972-5",
"https://app.dimensions.ai/details/publication/pub.1029483586"
],
"sdDataset": "articles",
"sdDatePublished": "2019-04-10T21:37",
"sdLicense": "https://scigraph.springernature.com/explorer/license/",
"sdPublisher": {
"name": "Springer Nature - SN SciGraph project",
"type": "Organization"
},
"sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8687_00000513.jsonl",
"type": "ScholarlyArticle",
"url": "http://link.springer.com/10.1007%2Fs00259-002-0972-5"
}
]
Download the RDF metadata as: json-ld nt turtle xml License info
JSON-LD is a popular format for linked data which is fully compatible with JSON.
curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s00259-002-0972-5'
N-Triples is a line-based linked data format ideal for batch operations.
curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s00259-002-0972-5'
Turtle is a human-readable linked data format.
curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s00259-002-0972-5'
RDF/XML is a standard XML format for linked data.
curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s00259-002-0972-5'
This table displays all metadata directly associated to this object as RDF triples.
275 TRIPLES
21 PREDICATES
75 URIs
41 LITERALS
29 BLANK NODES