Ontology type: schema:ScholarlyArticle Open Access: True
2000-04
AUTHORSL. H. De Beuckeleer, A. M. De Schepper, J. E. Vandevenne, J. L. Bloem, A. M. Davies, M. Oudkerk, E. Hauben, E. Van Marck, J. Somville, D. Vanel, L. S. Steinbach, J. M. Guinebretière, P. C. W. Hogendoorn, W. J. Mooi, K. Verstraete, C. Zaloudek, H. Jones
ABSTRACTOBJECTIVE: To evaluate MR imaging and pathology findings in order to define the characteristic features of clear cell sarcoma of the soft tissues (malignant melanoma of the soft parts). DESIGN AND PATIENTS: MR examinations of 21 patients with histologically proven clear cell sarcoma of the musculoskeletal system were retrospectively reviewed and assessed for shape, homogeneity, delineation, signal intensities on T1- and T2-weighted images, contrast enhancement, relationship with adjacent fascia or tendon, secondary bone involvement, and intratumoral necrosis. In 19 cases the pathology findings were available for review and for a comparative MR-pathology study. RESULTS: On T1-weighted images, lesions were isointense (n=3), hypointense (n=7) or slightly hyperintense to muscle (n=11). Immunohistochemical examination was performed in 17 patients. All 17 specimens showed positivity for HMB-45 antibody. In nine of 11 lesions with slightly increased signal intensity on T1-weighted images, a correlative MR imaging-pathology study was possible. All nine were positive to HMB-45 antibody. CONCLUSIONS: Clear cell sarcoma of the musculoskeletal system often has a benign-looking appearance on MR images. In up to 52% of patients, this lesion with melanocytic differentiation has slightly increased signal intensity on T1-weighted images compared with muscle. As the presence of this relative higher signal intensity on T1-weighted images is rather specific for tumors displaying melanocytic differentiation, radiologists should familiarize themselves with this rare entity and include it in their differential diagnosis when confronted with a well-defined, homogeneous, strongly enhancing mass with slightly higher signal intensity compared with muscle on native T1-weighted images. More... »
PAGES187-195
http://scigraph.springernature.com/pub.10.1007/s002560050592
DOIhttp://dx.doi.org/10.1007/s002560050592
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PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/10855466
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