Gorham–Stout disease: the experience of the Rizzoli Institute and review of the literature View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2010-10-25

AUTHORS

Pietro Ruggieri, Maurizio Montalti, Andrea Angelini, Marco Alberghini, Mario Mercuri

ABSTRACT

Gorham–Stout disease (also known as “disappearing bone disease”) was first described by Jackson in 1838, but was properly defined by Gorham and Stout in a series of 24 patients in 1954–1955. It is a rare disease of unknown etiology (about 200 cases reported in the literature) characterized by spontaneous progressive resorption of bone without malignant proliferation of vascular structures. The diagnosis is one of exclusion and it is based on combined histological, radiological, and clinical features. Benign vascular proliferation with fatty bone marrow and thinning of bony trabeculae is a typical histological feature. Standard radiographs of disappearing bone disease show progressive bony resorption with adjacent soft tissue involvement. Most cases of Gorham–Stout disease resolve spontaneously, but prognosis remains unpredictable. This study reports 13 cases of Gorham–Stout disease treated in our institution from 1968 to 2008. The aim of the work was to review our series and the literature on this rare disease, as well as to evaluate whether or not an optimal treatment can be identified and recommended. More... »

PAGES

1391-1397

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00256-010-1051-9

DOI

http://dx.doi.org/10.1007/s00256-010-1051-9

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1045340695

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/20972870


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