Differential uptake of fumarate by Candida utilis and Schizosaccharomyces pombe View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2000-12

AUTHORS

M. Saayman, H. J. J. van Vuuren, W. H. van Zyl, M. Viljoen-Bloom

ABSTRACT

The dicarboxylic acid fumarate is an important intermediate in cellular processes and also serves as a precursor for the commercial production of fine chemicals such as L-malate. Yeast species differ remarkably in their ability to degrade extracellular dicarboxylic acids and to utilise them as their only source of carbon. In this study we have shown that the yeast Candida utilis effectively degraded extracellular fumarate and L-malate, but glucose or other assimilable carbon sources repressed the transport and degradation of these dicarboxylic acids. The transport of both dicarboxylic acids was shown to be strongly inducible by either fumarate or L-malate while kinetic studies suggest that the two dicarboxylic acids are transported by the same transporter protein. In contrast, Schizosaccharomyces pombe effectively degraded extracellular L-malate, but not fumarate, in the presence of glucose or other assimilable carbon sources. The Sch. pombe malate transporter was unable to transport fumarate, although fumarate inhibited the uptake of L-malate. More... »

PAGES

792-798

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s002530000469

DOI

http://dx.doi.org/10.1007/s002530000469

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1043315162

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/11152071


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