Mechanisms of bactericidal action and resistance of polymyxins for Gram-positive bacteria View Full Text


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Article Info

DATE

2020-03-10

AUTHORS

Jianhua Yin, Qiu Meng, Dan Cheng, Jianv Fu, Qixia Luo, Yanqiu Liu, Zhiliang Yu

ABSTRACT

Polymyxins are cationic antimicrobial peptides used as the last-line therapy to treat multidrug-resistant Gram-negative bacterial infections. The bactericidal activity of polymyxins against Gram-negative bacteria relies on the electrostatic interaction between the positively charged polymyxins and the negatively charged lipid A of lipopolysaccharide (LPS). Given that Gram-positive bacteria lack an LPS-containing outer membrane, it is generally acknowledged that polymyxins are less active against Gram-positive bacteria. However, Gram-positive bacteria produce negatively charged teichoic acids, which may act as the target of polymyxins. More and more studies suggest that polymyxins have potential as a treatment for Gram-positive bacterial infection. This mini-review discusses recent advances in the mechanism of the antibacterial activity and resistance of polymyxins in Gram-positive bacteria.Key Points• Teichoic acids play a key role in the action of polymyxins on Gram-positive bacteria.• Polymyxin kills Gram-positive bacteria by disrupting cell surface and oxidative damage.• Modification of teichoic acids and phospholipids contributes to polymyxin resistance in Gram-positive bacteria.• Polymyxins have potential as a treatment for Gram-positive bacterial infection. More... »

PAGES

3771-3780

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00253-020-10525-y

DOI

http://dx.doi.org/10.1007/s00253-020-10525-y

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1125549452

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/32157424


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