Promoter engineering strategies for the overproduction of valuable metabolites in microbes View Full Text


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Article Info

DATE

2019-10-19

AUTHORS

Li-Qun Jin, Wei-Rong Jin, Zhang-Chi Ma, Qi Shen, Xue Cai, Zhi-Qiang Liu, Yu-Guo Zheng

ABSTRACT

Promoter engineering is an enabling technology in metabolic engineering and synthetic biology. As an indispensable part of synthetic biology, the promoter is a key factor in regulating genetic circuits and in coordinating multi-gene biosynthetic pathways. In this review, we summarized the recent progresses in promoter engineering in microbes. Specifically, the endogenous promoters are firstly discussed, followed by the statement of the influence of nucleotides exchange on the strength of promoters explored by site-selective mutagenesis. We then introduced the promoter libraries with a wide range of strength, which are constructed focusing on core promoter regions and upstream activating sequences by rational designs. Finally, the application of promoter libraries in the optimization of multi-gene metabolic pathways for high-yield production of metabolites was illustrated with a couple of recent examples. More... »

PAGES

8725-8736

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    DOI

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    DIMENSIONS

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    PUBMED

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