Morphological, transcriptional, and metabolic analyses of osmotic-adapted mechanisms of the halophilic Aspergillus montevidensis ZYD4 under hypersaline conditions View Full Text


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Article Info

DATE

2019-03-11

AUTHORS

Xiaowei Ding, Kaihui Liu, Yuxin Lu, Guoli Gong

ABSTRACT

Halophilic fungi in hypersaline habitats require multiple cellular responses for high-salinity adaptation. However, the exact mechanisms behind these adaptation processes remain to be slightly known. The current study is aimed at elucidating the morphological, transcriptomic, and metabolomic changes of the halophilic fungus Aspergillus montevidensis ZYD4 under hypersaline conditions. Under these conditions, the fungus promoted conidia formation and suppressed cleistothecium development. Furthermore, the fungus differentially expressed genes (P < 0.0001) that controlled ion transport, amino acid transport and metabolism, soluble sugar accumulation, fatty acid β-oxidation, saturated fatty acid synthesis, electron transfer, and oxidative stress tolerance. Additionally, the hypersalinized mycelia widely accumulated metabolites, including amino acids, soluble sugars, saturated fatty acids, and other carbon- and nitrogen-containing compounds. The addition of metabolites-such as neohesperidin, biuret, aspartic acid, alanine, proline, and ornithine-significantly promoted the growth (P ≤ 0.05) and the morphological adaptations of A. montevidensis ZYD4 grown in hypersaline environments. Our study demonstrated that morphological shifts, ion equilibrium, carbon and nitrogen metabolism for solute accumulation, and energy production are vital to halophilic fungi so that they can build tolerance to high-salinity environments. More... »

PAGES

1-18

References to SciGraph publications

  • 2018-01. Deep sequencing analysis of transcriptomes in Aspergillus oryzae in response to salinity stress in APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
  • 2017-12. Differential Control of Asexual Development and Sterigmatocystin Biosynthesis by a Novel Regulator in Aspergillus nidulans in SCIENTIFIC REPORTS
  • 2013-12. Genome and transcriptome sequencing of the halophilic fungus Wallemia ichthyophaga: haloadaptations present and absent in BMC GENOMICS
  • 2014-12. Genomic adaptations of the halophilic Dead Sea filamentous fungus Eurotium rubrum in NATURE COMMUNICATIONS
  • 2017-05. Effect of salinity stress on growth, lipid productivity, fatty acid composition, and biodiesel properties in Acutodesmus obliquus and Chlorella vulgaris in ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
  • 2017-03. De novo transcriptome sequencing of marine-derived Aspergillus glaucus and comparative analysis of metabolic and developmental variations in response to salt stress in GENES & GENOMICS
  • 2010-05. Transcript assembly and quantification by RNA-Seq reveals unannotated transcripts and isoform switching during cell differentiation in NATURE BIOTECHNOLOGY
  • 2013-05. Aspartate protects Lactobacillus casei against acid stress in APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
  • 2013-03. Amino acid signalling upstream of mTOR in NATURE REVIEWS MOLECULAR CELL BIOLOGY
  • 2016. Transport Systems in Halophilic Fungi in YEAST MEMBRANE TRANSPORT
  • 2006-04. Comparative analysis of transcriptional responses to saline stress in the laboratory and brewing strains of Saccharomyces cerevisiae with DNA microarray in APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
  • 2014-06. Reflections on univariate and multivariate analysis of metabolomics data in METABOLOMICS
  • 2015-06. Is there a common water-activity limit for the three domains of life? in THE ISME JOURNAL
  • 2017-12. Osmotic stress in colony and planktonic cells of Pseudomonas putida mt-2 revealed significant differences in adaptive response mechanisms in AMB EXPRESS
  • 2014-12. Aspergillus: Sex and Recombination in MYCOPATHOLOGIA
  • 2011-07. Procedures for large-scale metabolic profiling of serum and plasma using gas chromatography and liquid chromatography coupled to mass spectrometry in NATURE PROTOCOLS
  • 2014-10. Ectopic expression of CaRLK1 enhances hypoxia tolerance with increasing alanine production in Nicotiana spp. in PLANT MOLECULAR BIOLOGY
  • 2011-07. Full-length transcriptome assembly from RNA-Seq data without a reference genome in NATURE BIOTECHNOLOGY
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s00253-019-09705-2

    DOI

    http://dx.doi.org/10.1007/s00253-019-09705-2

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1112683151

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/30859256


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