Occurrence, function, and biosynthesis of mycofactocin View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2019-02-18

AUTHORS

Richard Ayikpoe, Vishnu Govindarajan, John A. Latham

ABSTRACT

Mycofactocin is a member of the rapidly growing class of ribosomally synthesized and post-translationally modified peptide (RiPP) natural products. Although the mycofactocin biosynthetic pathway is widely distributed among Mycobacterial species, the structure, function, and biosynthesis of the pathway product remain unknown. This mini-review will discuss the current state of knowledge regarding the mycofactocin biosynthetic pathway. In particular, we focus on the architecture and distribution of the mycofactocin biosynthetic cluster, mftABCDEF, among the Actinobacteria phylum. We discuss the potential molecular and physiological role of mycofactocin. We review known biosynthetic steps involving MftA, MftB, MftC, and MftE and relate them to pyrroloquinoline quinone biosynthesis. Lastly, we propose the function of the remaining putative biosynthetic enzymes, MftD and MftF. More... »

PAGES

2903-2912

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00253-019-09684-4

DOI

http://dx.doi.org/10.1007/s00253-019-09684-4

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1112216745

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30778644


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