Origination, change, and modulation of geriatric disease-related gut microbiota during life View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2018-07-31

AUTHORS

Muhammad Shahid Riaz Rajoka, Haobin Zhao, Na Li, Yao Lu, Ziyang Lian, Dongyan Shao, Mingliang Jin, Qi Li, Liqing Zhao, Junling Shi

ABSTRACT

The age-related changes in the diversity and composition of the gut microbiota are well described in recent studies. These changes have been suggested to be influenced by age-associated weakening of the immune system and low-grade chronic inflammation, resulting in numerous age-associated pathological conditions. Gut microbiota homeostasis is important throughout the life of the host by providing vital functions to regulate various immunological functions and homeostasis. Based on published results, we summarize the relationship between the gut microbiota and aging-related diseases, especially Parkinson’s disease, immunosenescence, rheumatoid arthritis, bone loss, and metabolic syndrome. The change in composition of the gut microbiota and gut ecosystem during life and its influence on the host immunologic and metabolic phenotype are also analyzed to determine factors that affect aging-related diseases. Approaches to maintain host health and prevent or cure geriatric diseases are also discussed. More... »

PAGES

8275-8289

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s00253-018-9264-2

    DOI

    http://dx.doi.org/10.1007/s00253-018-9264-2

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1105916682

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/30066188


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