Oxetane-containing metabolites: origin, structures, and biological activities View Full Text


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Article Info

DATE

2019-03

AUTHORS

Vera Vil, Alexander O. Terent’ev, Abed Al Aziz Al Quntar, Tatyana A. Gloriozova, Nick Savidov, Valery M. Dembitsky

ABSTRACT

Cyclobutanes containing one oxygen atom in a molecule are called oxetane-containing compounds (OCC). More than 600 different OCC are found in nature; they are produced by microorganisms, and also found in marine invertebrates and algae. The greatest number of them is found in plants belonging to the genus Taxus. Oxetanes are high-energy oxygen-containing non-aromatic heterocycles that are of great interest as new potential pharmacophores with a significant spectrum of biological activities. The biological activity of OCC that is produced by bacteria and Actinomycetes demonstrates antineoplastic, antiviral (arbovirus), and antifungal activity with confidence an angiogenesis stimulator, respiratory analeptic, and antiallergic activity dominate with confidence from 81 to 99%. More... »

PAGES

2449-2467

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s00253-018-09576-z

    DOI

    http://dx.doi.org/10.1007/s00253-018-09576-z

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1111099584

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/30610285


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