Recombinant Escherichia coli K5 strain with the deletion of waaR gene decreases the molecular weight of the heparosan capsular polysaccharide View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2016-04-14

AUTHORS

Haichan Huang, Xiaobo Liu, Shencong Lv, Weihong Zhong, Fuming Zhang, Robert J. Linhardt

ABSTRACT

Heparosan, the capsular polysaccharide of Escherichia coli K5 having a carbohydrate backbone similar to that of heparin, has become a potential precursor for bioengineering heparin. In the heparosan biosynthesis pathway, the gene waaR encoding α-1-, 2-glycosyltransferasecatalyzes the third glucosyl residues linking to the oligosaccharide chain. In the present study, a waaR deletion mutant of E. coli K5 was constructed. The mutant showed improvement of capsule polysaccharide yield. It is interesting that the heparosan molecular weight of the mutant is reduced and may become more suitable as a precursor for the production of low molecular weight heparin derived from the wild-type K5 capsular polysaccharide. More... »

PAGES

7877-7885

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00253-016-7511-y

DOI

http://dx.doi.org/10.1007/s00253-016-7511-y

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1001560504

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/27079575


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