PEGylated human catalase elicits potent therapeutic effects on H1N1 influenza-induced pneumonia in mice View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2013-12

AUTHORS

Xunlong Shi, Zhihui Shi, Hai Huang, Hongguang Zhu, Haiyan Zhu, Dianwen Ju, Pei Zhou

ABSTRACT

Therapeutic recombinant human catalase (rhCAT) can quench infection-induced reactive oxygen species (ROS), thereby alleviating the associated tissue damage. Although the intranasal route is efficient to deliver native rhCAT to the lung, the therapeutic effect is limited by rapid elimination from the blood. In this study, we modified rhCAT with the active polymer, polyethylene glycol monomethyl ether (PEG)-5000, and analyzed the pharmacokinetics of PEGylated rhCAT in mice. The high tetra-PEGylation ratio was about 60%, and PEGylation prolonged the half-life of rhCAT in serum (75 vs. 13.5 min for native rhCAT). The protective effects of PEG-rhCAT were investigated in a mouse model of influenza virus A (H1N1)-associated pneumonia. PEG-rhCAT was more effectively delivered than native rhCAT and was associated with higher survival ratio, less extensive lung injuries, reduced ROS levels, and lower viral replication. Collectively, these findings indicate that PEGylation can enhance the therapeutic efficacy of native rhCAT and suggest that PEGylated rhCAT may represent a novel complement therapy for H1N1 influenza-induced pneumonia. More... »

PAGES

10025-10033

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00253-013-4775-3

DOI

http://dx.doi.org/10.1007/s00253-013-4775-3

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1039256333

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/23525936


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1199", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Other Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Catalase", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Disease Models, Animal", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Influenza A Virus, H1N1 Subtype", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Influenza, Human", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice, Inbred ICR", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Pneumonia", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Polyethylene Glycols", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Reactive Oxygen Species", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Fudan University", 
          "id": "https://www.grid.ac/institutes/grid.8547.e", 
          "name": [
            "Department of Drug Biosynthesis, School of Pharmacy, Fudan University, 826 Zhangheng Road, 201203, Shanghai, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Shi", 
        "givenName": "Xunlong", 
        "id": "sg:person.0755555513.92", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0755555513.92"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Fudan University", 
          "id": "https://www.grid.ac/institutes/grid.8547.e", 
          "name": [
            "Department of Drug Biosynthesis, School of Pharmacy, Fudan University, 826 Zhangheng Road, 201203, Shanghai, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Shi", 
        "givenName": "Zhihui", 
        "id": "sg:person.0773364441.63", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0773364441.63"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Fudan University", 
          "id": "https://www.grid.ac/institutes/grid.8547.e", 
          "name": [
            "Department of Drug Biosynthesis, School of Pharmacy, Fudan University, 826 Zhangheng Road, 201203, Shanghai, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Huang", 
        "givenName": "Hai", 
        "id": "sg:person.0764004225.42", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0764004225.42"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Fudan University", 
          "id": "https://www.grid.ac/institutes/grid.8547.e", 
          "name": [
            "Department of Drug Biosynthesis, School of Pharmacy, Fudan University, 826 Zhangheng Road, 201203, Shanghai, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Zhu", 
        "givenName": "Hongguang", 
        "id": "sg:person.0713312762.67", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0713312762.67"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Fudan University", 
          "id": "https://www.grid.ac/institutes/grid.8547.e", 
          "name": [
            "Department of Drug Biosynthesis, School of Pharmacy, Fudan University, 826 Zhangheng Road, 201203, Shanghai, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Zhu", 
        "givenName": "Haiyan", 
        "id": "sg:person.0657736344.58", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0657736344.58"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Fudan University", 
          "id": "https://www.grid.ac/institutes/grid.8547.e", 
          "name": [
            "Department of Drug Biosynthesis, School of Pharmacy, Fudan University, 826 Zhangheng Road, 201203, Shanghai, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ju", 
        "givenName": "Dianwen", 
        "id": "sg:person.01361572035.39", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01361572035.39"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Fudan University", 
          "id": "https://www.grid.ac/institutes/grid.8547.e", 
          "name": [
            "Department of Drug Biosynthesis, School of Pharmacy, Fudan University, 826 Zhangheng Road, 201203, Shanghai, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Zhou", 
        "givenName": "Pei", 
        "id": "sg:person.0636165735.21", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0636165735.21"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1016/s0531-5565(00)00079-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001976636"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.addr.2009.01.001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002055908"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.freeradbiomed.2010.11.025", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010216640"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/eji.200635977", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010851833"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jcv.2009.06.004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011346196"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.pep.2007.02.008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013240916"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1440-1843.2008.01404.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013769297"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jconrel.2008.12.012", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014689627"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1081/bio-100106919", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020054814"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.95.23.13847", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021206361"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cell.2008.02.043", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021589789"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.freeradbiomed.2006.01.023", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024477546"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(10)61459-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027372974"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-2362.1991.tb01350.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028017081"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.phymed.2010.03.016", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028493832"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0165-2478(02)00033-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028698866"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood-2003-09-3184", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029116051"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jviromet.2008.06.022", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035419308"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0076-6879(90)86093-b", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035732633"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.atherosclerosis.2006.08.018", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036864272"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1146/annurev.pa.36.040196.000503", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038214532"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10753-009-9170-y", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039009849", 
          "https://doi.org/10.1007/s10753-009-9170-y"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10753-009-9170-y", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039009849", 
          "https://doi.org/10.1007/s10753-009-9170-y"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.freeradbiomed.2009.03.018", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039126609"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.virol.2011.01.036", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043428358"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.antiviral.2003.11.008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044140584"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.yjmcc.2010.08.013", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046261862"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.bcp.2008.09.029", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046536532"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1078-0432.ccr-04-1020", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046723036"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ecoenv.2008.01.009", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050696702"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.clim.2008.05.008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051063170"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2471/blt.07.048769", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1070837040"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074362791", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2013-12", 
    "datePublishedReg": "2013-12-01", 
    "description": "Therapeutic recombinant human catalase (rhCAT) can quench infection-induced reactive oxygen species (ROS), thereby alleviating the associated tissue damage. Although the intranasal route is efficient to deliver native rhCAT to the lung, the therapeutic effect is limited by rapid elimination from the blood. In this study, we modified rhCAT with the active polymer, polyethylene glycol monomethyl ether (PEG)-5000, and analyzed the pharmacokinetics of PEGylated rhCAT in mice. The high tetra-PEGylation ratio was about 60%, and PEGylation prolonged the half-life of rhCAT in serum (75 vs. 13.5 min for native rhCAT). The protective effects of PEG-rhCAT were investigated in a mouse model of influenza virus A (H1N1)-associated pneumonia. PEG-rhCAT was more effectively delivered than native rhCAT and was associated with higher survival ratio, less extensive lung injuries, reduced ROS levels, and lower viral replication. Collectively, these findings indicate that PEGylation can enhance the therapeutic efficacy of native rhCAT and suggest that PEGylated rhCAT may represent a novel complement therapy for H1N1 influenza-induced pneumonia.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/s00253-013-4775-3", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1083533", 
        "issn": [
          "0175-7598", 
          "1432-0614"
        ], 
        "name": "Applied Microbiology and Biotechnology", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "23", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "97"
      }
    ], 
    "name": "PEGylated human catalase elicits potent therapeutic effects on H1N1 influenza-induced pneumonia in mice", 
    "pagination": "10025-10033", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "bafef4469d1d0523ad052cb24088a91759c8ec22682a0b575eb8bb15cc392597"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "23525936"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "8406612"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s00253-013-4775-3"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1039256333"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s00253-013-4775-3", 
      "https://app.dimensions.ai/details/publication/pub.1039256333"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T17:32", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8672_00000514.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1007%2Fs00253-013-4775-3"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s00253-013-4775-3'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s00253-013-4775-3'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s00253-013-4775-3'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s00253-013-4775-3'


 

This table displays all metadata directly associated to this object as RDF triples.

259 TRIPLES      21 PREDICATES      74 URIs      34 LITERALS      22 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s00253-013-4775-3 schema:about N36164f19516f4bc898a1b3e55c648f5b
2 N3907449265e94472ae4e940595a64a1e
3 N3a79492cc16f4dc5895960cf069f64f1
4 N42b8327134f6466d9d3ae807938518f5
5 N4a1148d515e5417eb804e21256081c6c
6 N4cdff3ee183f4f5b8f9aff8c91e9ae4d
7 N657bbe6d8e0c45d5a5bdfbb400e84934
8 N700c6a3f322142788887e1febe619f4d
9 N74419fcc40ce418b832628200c67d08d
10 N8f986cab253848939492ba4820f8b1c9
11 N9d1146a3839a4c50a12768a212caaa79
12 Nebf5d5cc93634d61b9f2781685ffd3b8
13 Nf1d262df37ae41ca851f1fced6430a48
14 anzsrc-for:11
15 anzsrc-for:1199
16 schema:author N09f3fa5dbd6c4c8c907bd20edf66f509
17 schema:citation sg:pub.10.1007/s10753-009-9170-y
18 https://app.dimensions.ai/details/publication/pub.1074362791
19 https://doi.org/10.1002/eji.200635977
20 https://doi.org/10.1016/0076-6879(90)86093-b
21 https://doi.org/10.1016/j.addr.2009.01.001
22 https://doi.org/10.1016/j.antiviral.2003.11.008
23 https://doi.org/10.1016/j.atherosclerosis.2006.08.018
24 https://doi.org/10.1016/j.bcp.2008.09.029
25 https://doi.org/10.1016/j.cell.2008.02.043
26 https://doi.org/10.1016/j.clim.2008.05.008
27 https://doi.org/10.1016/j.ecoenv.2008.01.009
28 https://doi.org/10.1016/j.freeradbiomed.2006.01.023
29 https://doi.org/10.1016/j.freeradbiomed.2009.03.018
30 https://doi.org/10.1016/j.freeradbiomed.2010.11.025
31 https://doi.org/10.1016/j.jconrel.2008.12.012
32 https://doi.org/10.1016/j.jcv.2009.06.004
33 https://doi.org/10.1016/j.jviromet.2008.06.022
34 https://doi.org/10.1016/j.pep.2007.02.008
35 https://doi.org/10.1016/j.phymed.2010.03.016
36 https://doi.org/10.1016/j.virol.2011.01.036
37 https://doi.org/10.1016/j.yjmcc.2010.08.013
38 https://doi.org/10.1016/s0140-6736(10)61459-6
39 https://doi.org/10.1016/s0165-2478(02)00033-0
40 https://doi.org/10.1016/s0531-5565(00)00079-6
41 https://doi.org/10.1073/pnas.95.23.13847
42 https://doi.org/10.1081/bio-100106919
43 https://doi.org/10.1111/j.1365-2362.1991.tb01350.x
44 https://doi.org/10.1111/j.1440-1843.2008.01404.x
45 https://doi.org/10.1146/annurev.pa.36.040196.000503
46 https://doi.org/10.1158/1078-0432.ccr-04-1020
47 https://doi.org/10.1182/blood-2003-09-3184
48 https://doi.org/10.2471/blt.07.048769
49 schema:datePublished 2013-12
50 schema:datePublishedReg 2013-12-01
51 schema:description Therapeutic recombinant human catalase (rhCAT) can quench infection-induced reactive oxygen species (ROS), thereby alleviating the associated tissue damage. Although the intranasal route is efficient to deliver native rhCAT to the lung, the therapeutic effect is limited by rapid elimination from the blood. In this study, we modified rhCAT with the active polymer, polyethylene glycol monomethyl ether (PEG)-5000, and analyzed the pharmacokinetics of PEGylated rhCAT in mice. The high tetra-PEGylation ratio was about 60%, and PEGylation prolonged the half-life of rhCAT in serum (75 vs. 13.5 min for native rhCAT). The protective effects of PEG-rhCAT were investigated in a mouse model of influenza virus A (H1N1)-associated pneumonia. PEG-rhCAT was more effectively delivered than native rhCAT and was associated with higher survival ratio, less extensive lung injuries, reduced ROS levels, and lower viral replication. Collectively, these findings indicate that PEGylation can enhance the therapeutic efficacy of native rhCAT and suggest that PEGylated rhCAT may represent a novel complement therapy for H1N1 influenza-induced pneumonia.
52 schema:genre research_article
53 schema:inLanguage en
54 schema:isAccessibleForFree false
55 schema:isPartOf N919f13f9cf1f43e2a4e6510ea841fba7
56 Ndeb9bead871b4101ba91da007bacf4d9
57 sg:journal.1083533
58 schema:name PEGylated human catalase elicits potent therapeutic effects on H1N1 influenza-induced pneumonia in mice
59 schema:pagination 10025-10033
60 schema:productId Nd81bf03f4d58447e8db4ff58ce8fdc24
61 Ndf1f96782dc84ae3ae5b7753fcdb9bb6
62 Ne4cff83bf87f4493bceafecd08513b1e
63 Neab7ac2111d14d63ac6699740bf0e0a4
64 Nfd24810fc84442a481b8cf86bf05ba1f
65 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039256333
66 https://doi.org/10.1007/s00253-013-4775-3
67 schema:sdDatePublished 2019-04-10T17:32
68 schema:sdLicense https://scigraph.springernature.com/explorer/license/
69 schema:sdPublisher Naba975067c8a4275af9eb4eeaba22a65
70 schema:url http://link.springer.com/10.1007%2Fs00253-013-4775-3
71 sgo:license sg:explorer/license/
72 sgo:sdDataset articles
73 rdf:type schema:ScholarlyArticle
74 N09f3fa5dbd6c4c8c907bd20edf66f509 rdf:first sg:person.0755555513.92
75 rdf:rest N727c21ddd6134e55ac1d307a7b5fa41e
76 N0b6c9387e2dd43d1b63e9ee73db8c420 rdf:first sg:person.0657736344.58
77 rdf:rest Ne949d1b4670b437cab51af490bbe41c6
78 N36164f19516f4bc898a1b3e55c648f5b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
79 schema:name Reactive Oxygen Species
80 rdf:type schema:DefinedTerm
81 N3907449265e94472ae4e940595a64a1e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
82 schema:name Polyethylene Glycols
83 rdf:type schema:DefinedTerm
84 N3a79492cc16f4dc5895960cf069f64f1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
85 schema:name Female
86 rdf:type schema:DefinedTerm
87 N42b8327134f6466d9d3ae807938518f5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
88 schema:name Disease Models, Animal
89 rdf:type schema:DefinedTerm
90 N4a1148d515e5417eb804e21256081c6c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
91 schema:name Mice, Inbred ICR
92 rdf:type schema:DefinedTerm
93 N4cdff3ee183f4f5b8f9aff8c91e9ae4d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
94 schema:name Mice
95 rdf:type schema:DefinedTerm
96 N5b0d78b859bd4679ac0a1d0675937f54 rdf:first sg:person.0764004225.42
97 rdf:rest N5f4b68a8b84b44d99e2b36c709c18df6
98 N5f4b68a8b84b44d99e2b36c709c18df6 rdf:first sg:person.0713312762.67
99 rdf:rest N0b6c9387e2dd43d1b63e9ee73db8c420
100 N657bbe6d8e0c45d5a5bdfbb400e84934 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
101 schema:name Male
102 rdf:type schema:DefinedTerm
103 N700c6a3f322142788887e1febe619f4d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
104 schema:name Catalase
105 rdf:type schema:DefinedTerm
106 N727c21ddd6134e55ac1d307a7b5fa41e rdf:first sg:person.0773364441.63
107 rdf:rest N5b0d78b859bd4679ac0a1d0675937f54
108 N74419fcc40ce418b832628200c67d08d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
109 schema:name Humans
110 rdf:type schema:DefinedTerm
111 N8f986cab253848939492ba4820f8b1c9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
112 schema:name Pneumonia
113 rdf:type schema:DefinedTerm
114 N919f13f9cf1f43e2a4e6510ea841fba7 schema:volumeNumber 97
115 rdf:type schema:PublicationVolume
116 N9d1146a3839a4c50a12768a212caaa79 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
117 schema:name Animals
118 rdf:type schema:DefinedTerm
119 Naba975067c8a4275af9eb4eeaba22a65 schema:name Springer Nature - SN SciGraph project
120 rdf:type schema:Organization
121 Nd3465fbdc7e74127857a6d593a18d3b2 rdf:first sg:person.0636165735.21
122 rdf:rest rdf:nil
123 Nd81bf03f4d58447e8db4ff58ce8fdc24 schema:name pubmed_id
124 schema:value 23525936
125 rdf:type schema:PropertyValue
126 Ndeb9bead871b4101ba91da007bacf4d9 schema:issueNumber 23
127 rdf:type schema:PublicationIssue
128 Ndf1f96782dc84ae3ae5b7753fcdb9bb6 schema:name nlm_unique_id
129 schema:value 8406612
130 rdf:type schema:PropertyValue
131 Ne4cff83bf87f4493bceafecd08513b1e schema:name dimensions_id
132 schema:value pub.1039256333
133 rdf:type schema:PropertyValue
134 Ne949d1b4670b437cab51af490bbe41c6 rdf:first sg:person.01361572035.39
135 rdf:rest Nd3465fbdc7e74127857a6d593a18d3b2
136 Neab7ac2111d14d63ac6699740bf0e0a4 schema:name doi
137 schema:value 10.1007/s00253-013-4775-3
138 rdf:type schema:PropertyValue
139 Nebf5d5cc93634d61b9f2781685ffd3b8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
140 schema:name Influenza, Human
141 rdf:type schema:DefinedTerm
142 Nf1d262df37ae41ca851f1fced6430a48 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
143 schema:name Influenza A Virus, H1N1 Subtype
144 rdf:type schema:DefinedTerm
145 Nfd24810fc84442a481b8cf86bf05ba1f schema:name readcube_id
146 schema:value bafef4469d1d0523ad052cb24088a91759c8ec22682a0b575eb8bb15cc392597
147 rdf:type schema:PropertyValue
148 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
149 schema:name Medical and Health Sciences
150 rdf:type schema:DefinedTerm
151 anzsrc-for:1199 schema:inDefinedTermSet anzsrc-for:
152 schema:name Other Medical and Health Sciences
153 rdf:type schema:DefinedTerm
154 sg:journal.1083533 schema:issn 0175-7598
155 1432-0614
156 schema:name Applied Microbiology and Biotechnology
157 rdf:type schema:Periodical
158 sg:person.01361572035.39 schema:affiliation https://www.grid.ac/institutes/grid.8547.e
159 schema:familyName Ju
160 schema:givenName Dianwen
161 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01361572035.39
162 rdf:type schema:Person
163 sg:person.0636165735.21 schema:affiliation https://www.grid.ac/institutes/grid.8547.e
164 schema:familyName Zhou
165 schema:givenName Pei
166 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0636165735.21
167 rdf:type schema:Person
168 sg:person.0657736344.58 schema:affiliation https://www.grid.ac/institutes/grid.8547.e
169 schema:familyName Zhu
170 schema:givenName Haiyan
171 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0657736344.58
172 rdf:type schema:Person
173 sg:person.0713312762.67 schema:affiliation https://www.grid.ac/institutes/grid.8547.e
174 schema:familyName Zhu
175 schema:givenName Hongguang
176 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0713312762.67
177 rdf:type schema:Person
178 sg:person.0755555513.92 schema:affiliation https://www.grid.ac/institutes/grid.8547.e
179 schema:familyName Shi
180 schema:givenName Xunlong
181 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0755555513.92
182 rdf:type schema:Person
183 sg:person.0764004225.42 schema:affiliation https://www.grid.ac/institutes/grid.8547.e
184 schema:familyName Huang
185 schema:givenName Hai
186 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0764004225.42
187 rdf:type schema:Person
188 sg:person.0773364441.63 schema:affiliation https://www.grid.ac/institutes/grid.8547.e
189 schema:familyName Shi
190 schema:givenName Zhihui
191 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0773364441.63
192 rdf:type schema:Person
193 sg:pub.10.1007/s10753-009-9170-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1039009849
194 https://doi.org/10.1007/s10753-009-9170-y
195 rdf:type schema:CreativeWork
196 https://app.dimensions.ai/details/publication/pub.1074362791 schema:CreativeWork
197 https://doi.org/10.1002/eji.200635977 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010851833
198 rdf:type schema:CreativeWork
199 https://doi.org/10.1016/0076-6879(90)86093-b schema:sameAs https://app.dimensions.ai/details/publication/pub.1035732633
200 rdf:type schema:CreativeWork
201 https://doi.org/10.1016/j.addr.2009.01.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002055908
202 rdf:type schema:CreativeWork
203 https://doi.org/10.1016/j.antiviral.2003.11.008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044140584
204 rdf:type schema:CreativeWork
205 https://doi.org/10.1016/j.atherosclerosis.2006.08.018 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036864272
206 rdf:type schema:CreativeWork
207 https://doi.org/10.1016/j.bcp.2008.09.029 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046536532
208 rdf:type schema:CreativeWork
209 https://doi.org/10.1016/j.cell.2008.02.043 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021589789
210 rdf:type schema:CreativeWork
211 https://doi.org/10.1016/j.clim.2008.05.008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051063170
212 rdf:type schema:CreativeWork
213 https://doi.org/10.1016/j.ecoenv.2008.01.009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050696702
214 rdf:type schema:CreativeWork
215 https://doi.org/10.1016/j.freeradbiomed.2006.01.023 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024477546
216 rdf:type schema:CreativeWork
217 https://doi.org/10.1016/j.freeradbiomed.2009.03.018 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039126609
218 rdf:type schema:CreativeWork
219 https://doi.org/10.1016/j.freeradbiomed.2010.11.025 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010216640
220 rdf:type schema:CreativeWork
221 https://doi.org/10.1016/j.jconrel.2008.12.012 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014689627
222 rdf:type schema:CreativeWork
223 https://doi.org/10.1016/j.jcv.2009.06.004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011346196
224 rdf:type schema:CreativeWork
225 https://doi.org/10.1016/j.jviromet.2008.06.022 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035419308
226 rdf:type schema:CreativeWork
227 https://doi.org/10.1016/j.pep.2007.02.008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013240916
228 rdf:type schema:CreativeWork
229 https://doi.org/10.1016/j.phymed.2010.03.016 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028493832
230 rdf:type schema:CreativeWork
231 https://doi.org/10.1016/j.virol.2011.01.036 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043428358
232 rdf:type schema:CreativeWork
233 https://doi.org/10.1016/j.yjmcc.2010.08.013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046261862
234 rdf:type schema:CreativeWork
235 https://doi.org/10.1016/s0140-6736(10)61459-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027372974
236 rdf:type schema:CreativeWork
237 https://doi.org/10.1016/s0165-2478(02)00033-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028698866
238 rdf:type schema:CreativeWork
239 https://doi.org/10.1016/s0531-5565(00)00079-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001976636
240 rdf:type schema:CreativeWork
241 https://doi.org/10.1073/pnas.95.23.13847 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021206361
242 rdf:type schema:CreativeWork
243 https://doi.org/10.1081/bio-100106919 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020054814
244 rdf:type schema:CreativeWork
245 https://doi.org/10.1111/j.1365-2362.1991.tb01350.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1028017081
246 rdf:type schema:CreativeWork
247 https://doi.org/10.1111/j.1440-1843.2008.01404.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1013769297
248 rdf:type schema:CreativeWork
249 https://doi.org/10.1146/annurev.pa.36.040196.000503 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038214532
250 rdf:type schema:CreativeWork
251 https://doi.org/10.1158/1078-0432.ccr-04-1020 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046723036
252 rdf:type schema:CreativeWork
253 https://doi.org/10.1182/blood-2003-09-3184 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029116051
254 rdf:type schema:CreativeWork
255 https://doi.org/10.2471/blt.07.048769 schema:sameAs https://app.dimensions.ai/details/publication/pub.1070837040
256 rdf:type schema:CreativeWork
257 https://www.grid.ac/institutes/grid.8547.e schema:alternateName Fudan University
258 schema:name Department of Drug Biosynthesis, School of Pharmacy, Fudan University, 826 Zhangheng Road, 201203, Shanghai, China
259 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...