Yeast cells as microcapsules. Analytical tools and process variables in the encapsulation of hydrophobes in S. cerevisiae View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2012-09

AUTHORS

Federica Ciamponi, Craig Duckham, Nicola Tirelli

ABSTRACT

Yeast cells can be used as biocompatible and biodegradable containers for the microencapsulation of a variety of actives. Despite the wide application of this process, e.g. in the food industry, mechanism and controlling factors are yet poorly known. In this study we have studied kinetics and mechanistic aspects of the spontaneous internalization of terpenes (as model hydrophobic compounds) in Saccharomyces cerevisiae, quantifying their encapsulation through HPLC analysis and fluorescent staining of lipidic bodies with Nile Red, while in parallel monitoring cell viability. Our results showed that this encapsulation process is essentially a phenomenon of passive diffusion with negligible relevance of active transport. Further, our evidence shows that the major determinant of the encapsulation kinetics is the solubility of the hydrophobe in the cell wall, which is inversely related to partition coefficient (log P). More... »

PAGES

1445-1456

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00253-012-4127-8

DOI

http://dx.doi.org/10.1007/s00253-012-4127-8

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1039875999

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/22581037


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