Potentials and limitations of miniaturized calorimeters for bioprocess monitoring View Full Text


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Article Info

DATE

2011-10

AUTHORS

Thomas Maskow, Torsten Schubert, Antje Wolf, Friederike Buchholz, Lars Regestein, Jochen Buechs, Florian Mertens, Hauke Harms, Johannes Lerchner

ABSTRACT

In theory, heat production rates are very well suited for analysing and controlling bioprocesses on different scales from a few nanolitres up to many cubic metres. Any bioconversion is accompanied by a production (exothermic) or consumption (endothermic) of heat. The heat is tightly connected with the stoichiometry of the bioprocess via the law of Hess, and its rate is connected to the kinetics of the process. Heat signals provide real-time information of bioprocesses. The combination of heat measurements with respirometry is theoretically suited for the quantification of the coupling between catabolic and anabolic reactions. Heat measurements have also practical advantages. Unlike most other biochemical sensors, thermal transducers can be mounted in a protected way that prevents fouling, thereby minimizing response drifts. Finally, calorimetry works in optically opaque solutions and does not require labelling or reactants. It is surprising to see that despite all these advantages, calorimetry has rarely been applied to monitor and control bioprocesses with intact cells in the laboratory, industrial bioreactors or ecosystems. This review article analyses the reasons for this omission, discusses the additional information calorimetry can provide in comparison with respirometry and presents miniaturization as a potential way to overcome some inherent weaknesses of conventional calorimetry. It will be discussed for which sample types and scientific question miniaturized calorimeter can be advantageously applied. A few examples from different fields of microbiological and biotechnological research will illustrate the potentials and limitations of chip calorimetry. Finally, the future of chip calorimetry is addressed in an outlook. More... »

PAGES

55

References to SciGraph publications

  • 2010-08. Batch kinetic studies on growth of salt tolerant Pseudomonas aeruginosa secreting protease in a biocalorimeter in BIOTECHNOLOGY AND BIOPROCESS ENGINEERING
  • 2011-04. Photosynthetic energy conversion in the diatom Phaeodactylum tricornutum in JOURNAL OF THERMAL ANALYSIS AND CALORIMETRY
  • 2005-12. Biofilm reactors for industrial bioconversion processes: employing potential of enhanced reaction rates in MICROBIAL CELL FACTORIES
  • 2011-03-09. Closed Ampoule Isothermal Microcalorimetry for Continuous Real-Time Detection and Evaluation of Cultured Mammalian Cell Activity and Responses in MAMMALIAN CELL VIABILITY
  • 2004-09. High-throughput biochemistry heats up in NATURE BIOTECHNOLOGY
  • 1988-03. The use of microcalorimetry in studies of mammalian cells in JOURNAL OF THERMAL ANALYSIS AND CALORIMETRY
  • 2008-08. Dual thermopile integrated microfluidic calorimeter for biochemical thermodynamics in MICROFLUIDICS AND NANOFLUIDICS
  • 1987-01. The relationship between elemental composition and heat of combustion of microbial biomass in APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
  • 2004-06. Biomagnetic separation of Escherichia coli by use of anion-exchange beads: measurement and modeling of the kinetics of cell–bead interactions in ANALYTICAL AND BIOANALYTICAL CHEMISTRY
  • 2001-10. Identification of Micro-scale Calorimetric Devices. I. Establishing the experimental rules for accurate measurements in JOURNAL OF THERMAL ANALYSIS AND CALORIMETRY
  • 1994-03. Thiosulfate and tetrathionate degradation as well as biofilm generation by Thiobacillus intermedius and Thiobacillus versutus studied by microcalorimetry, HPLC, and ion-pair chromatography in ARCHIVES OF MICROBIOLOGY
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s00253-011-3497-7

    DOI

    http://dx.doi.org/10.1007/s00253-011-3497-7

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1015397399

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/21808971


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