Cytosolic NADPH balancing in Penicillium chrysogenum cultivated on mixtures of glucose and ethanol View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2011-01

AUTHORS

Zheng Zhao, Karel Kuijvenhoven, Walter M. van Gulik, Joseph J. Heijnen, Wouter A. van Winden, Peter J. T. Verheijen

ABSTRACT

The in vivo flux through the oxidative branch of the pentose phosphate pathway (oxPPP) in Penicillium chrysogenum was determined during growth in glucose/ethanol carbon-limited chemostat cultures, at the same growth rate. Non-stationary (13)C flux analysis was used to measure the oxPPP flux. A nearly constant oxPPP flux was found for all glucose/ethanol ratios studied. This indicates that the cytosolic NADPH supply is independent of the amount of assimilated ethanol. The cofactor assignment in the model of van Gulik et al. (Biotechnol Bioeng 68(6):602-618, 2000) was supported using the published genome annotation of P. chrysogenum. Metabolic flux analysis showed that NADPH requirements in the cytosol remain nearly the same in these experiments due to constant biomass growth. Based on the cytosolic NADPH balance, it is known that the cytosolic aldehyde dehydrogenase in P. chrysogenum is NAD(+) dependent. Metabolic modeling shows that changing the NAD(+)-aldehyde dehydrogenase to NADP(+)-aldehyde dehydrogenase can increase the penicillin yield on substrate. More... »

PAGES

63-72

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s00253-010-2851-5

    DOI

    http://dx.doi.org/10.1007/s00253-010-2851-5

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1048284600

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/20809073


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