Cytosolic NADPH balancing in Penicillium chrysogenum cultivated on mixtures of glucose and ethanol View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2011-01

AUTHORS

Zheng Zhao, Karel Kuijvenhoven, Walter M. van Gulik, Joseph J. Heijnen, Wouter A. van Winden, Peter J. T. Verheijen

ABSTRACT

The in vivo flux through the oxidative branch of the pentose phosphate pathway (oxPPP) in Penicillium chrysogenum was determined during growth in glucose/ethanol carbon-limited chemostat cultures, at the same growth rate. Non-stationary (13)C flux analysis was used to measure the oxPPP flux. A nearly constant oxPPP flux was found for all glucose/ethanol ratios studied. This indicates that the cytosolic NADPH supply is independent of the amount of assimilated ethanol. The cofactor assignment in the model of van Gulik et al. (Biotechnol Bioeng 68(6):602-618, 2000) was supported using the published genome annotation of P. chrysogenum. Metabolic flux analysis showed that NADPH requirements in the cytosol remain nearly the same in these experiments due to constant biomass growth. Based on the cytosolic NADPH balance, it is known that the cytosolic aldehyde dehydrogenase in P. chrysogenum is NAD(+) dependent. Metabolic modeling shows that changing the NAD(+)-aldehyde dehydrogenase to NADP(+)-aldehyde dehydrogenase can increase the penicillin yield on substrate. More... »

PAGES

63-72

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00253-010-2851-5

DOI

http://dx.doi.org/10.1007/s00253-010-2851-5

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1048284600

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/20809073


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cytosol", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Ethanol", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Fungal Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Glucose", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "NADP", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Penicillium chrysogenum", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Pentose Phosphate Pathway", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Delft University of Technology", 
          "id": "https://www.grid.ac/institutes/grid.5292.c", 
          "name": [
            "Department of Biotechnology, Kluyver Centre for Genomics of Industrial Fermentation, Delft University of Technology, Julianalaan 67, 2628BC, Delft, The Netherlands"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Zhao", 
        "givenName": "Zheng", 
        "id": "sg:person.01322703027.80", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01322703027.80"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Delft University of Technology", 
          "id": "https://www.grid.ac/institutes/grid.5292.c", 
          "name": [
            "Department of Biotechnology, Kluyver Centre for Genomics of Industrial Fermentation, Delft University of Technology, Julianalaan 67, 2628BC, Delft, The Netherlands"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kuijvenhoven", 
        "givenName": "Karel", 
        "id": "sg:person.01242102435.12", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01242102435.12"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Delft University of Technology", 
          "id": "https://www.grid.ac/institutes/grid.5292.c", 
          "name": [
            "Department of Biotechnology, Kluyver Centre for Genomics of Industrial Fermentation, Delft University of Technology, Julianalaan 67, 2628BC, Delft, The Netherlands"
          ], 
          "type": "Organization"
        }, 
        "familyName": "van Gulik", 
        "givenName": "Walter M.", 
        "id": "sg:person.0615715153.53", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0615715153.53"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Delft University of Technology", 
          "id": "https://www.grid.ac/institutes/grid.5292.c", 
          "name": [
            "Department of Biotechnology, Kluyver Centre for Genomics of Industrial Fermentation, Delft University of Technology, Julianalaan 67, 2628BC, Delft, The Netherlands"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Heijnen", 
        "givenName": "Joseph J.", 
        "id": "sg:person.01026476151.36", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01026476151.36"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "DSM Anti-Infectives, A. Fleminglaan 1, 2613AX, Delft, The Netherlands"
          ], 
          "type": "Organization"
        }, 
        "familyName": "van Winden", 
        "givenName": "Wouter A.", 
        "id": "sg:person.01216753414.39", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01216753414.39"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Delft University of Technology", 
          "id": "https://www.grid.ac/institutes/grid.5292.c", 
          "name": [
            "Department of Biotechnology, Kluyver Centre for Genomics of Industrial Fermentation, Delft University of Technology, Julianalaan 67, 2628BC, Delft, The Netherlands"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Verheijen", 
        "givenName": "Peter J. T.", 
        "id": "sg:person.011222163543.61", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011222163543.61"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1074/jbc.m509461200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001858690"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m509461200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001858690"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/aem.68.12.5843-5859.2002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003807814"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m210076200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004847265"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0168-1656(95)00164-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005652033"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ymben.2005.09.004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005803201"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m706494200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006305178"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s004380000364", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007127768", 
          "https://doi.org/10.1007/s004380000364"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s004380000364", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007127768", 
          "https://doi.org/10.1007/s004380000364"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00726-005-0247-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008339978", 
          "https://doi.org/10.1007/s00726-005-0247-0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00726-005-0247-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008339978", 
          "https://doi.org/10.1007/s00726-005-0247-0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00726-005-0247-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008339978", 
          "https://doi.org/10.1007/s00726-005-0247-0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0014-5793(79)80642-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010104169"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.exer.2006.04.010", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010406515"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1529/biophysj.106.093138", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010780863"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/gb-2006-7-11-r108", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012626351", 
          "https://doi.org/10.1186/gb-2006-7-11-r108"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00253-008-1444-z", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015564480", 
          "https://doi.org/10.1007/s00253-008-1444-z"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00253-008-1444-z", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015564480", 
          "https://doi.org/10.1007/s00253-008-1444-z"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0006-291x(90)92397-i", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016482064"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/bit.10899", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018037495"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0005-2728(68)90185-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018870650"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0005-2728(68)90185-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018870650"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/aem.02955-05", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019494531"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1096-7176(03)00003-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020154850"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1096-7176(03)00003-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020154850"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ymben.2005.05.001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020941143"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/(sici)1097-0290(20000620)68:6<602::aid-bit3>3.0.co;2-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021204311"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ymben.2006.08.004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021686722"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00230397", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022698682", 
          "https://doi.org/10.1007/bf00230397"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00230397", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022698682", 
          "https://doi.org/10.1007/bf00230397"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s004380050847", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023448968", 
          "https://doi.org/10.1007/s004380050847"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s004380050847", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023448968", 
          "https://doi.org/10.1007/s004380050847"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nbt.1498", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024762109", 
          "https://doi.org/10.1038/nbt.1498"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/bit.21813", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024911140"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/bit.260430103", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025145521"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1146/annurev.bi.52.070183.002541", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027219330"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1039/a801345d", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033474004"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10142-009-0110-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038876783", 
          "https://doi.org/10.1007/s10142-009-0110-6"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0014-5793(88)81036-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038888706"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1475-2859-6-36", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039489056", 
          "https://doi.org/10.1186/1475-2859-6-36"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/aem.70.1.229-239.2004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040687530"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00253-003-1306-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041292024", 
          "https://doi.org/10.1007/s00253-003-1306-7"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1432-1033.1972.tb01840.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043811951"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ymben.2008.04.003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045801372"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0304-4165(71)90129-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045898719"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0304-4165(71)90129-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045898719"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/b99259", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048145480", 
          "https://doi.org/10.1007/b99259"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.femsyr.2004.10.007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049244914"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s002530051509", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050399354", 
          "https://doi.org/10.1007/s002530051509"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ymben.2007.07.001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050569337"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0003-9861(71)90247-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051253760"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00253-006-0804-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053240153", 
          "https://doi.org/10.1007/s00253-006-0804-9"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00253-006-0804-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053240153", 
          "https://doi.org/10.1007/s00253-006-0804-9"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/bi00664a010", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055184519"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1099/00221287-129-4-965", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060364839"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1099/00221287-143-1-253", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060369230"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1099/00221287-67-1-85", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060374327"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1099/mic.0.2007/010017-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060396185"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/jb.169.12.5364-5372.1987", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062715615"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1075090071", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1076750128", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1080290641", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1080308658", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1080308825", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082617958", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1083268370", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2011-01", 
    "datePublishedReg": "2011-01-01", 
    "description": "The in vivo flux through the oxidative branch of the pentose phosphate pathway (oxPPP) in Penicillium chrysogenum was determined during growth in glucose/ethanol carbon-limited chemostat cultures, at the same growth rate. Non-stationary (13)C flux analysis was used to measure the oxPPP flux. A nearly constant oxPPP flux was found for all glucose/ethanol ratios studied. This indicates that the cytosolic NADPH supply is independent of the amount of assimilated ethanol. The cofactor assignment in the model of van Gulik et al. (Biotechnol Bioeng 68(6):602-618, 2000) was supported using the published genome annotation of P. chrysogenum. Metabolic flux analysis showed that NADPH requirements in the cytosol remain nearly the same in these experiments due to constant biomass growth. Based on the cytosolic NADPH balance, it is known that the cytosolic aldehyde dehydrogenase in P. chrysogenum is NAD(+) dependent. Metabolic modeling shows that changing the NAD(+)-aldehyde dehydrogenase to NADP(+)-aldehyde dehydrogenase can increase the penicillin yield on substrate.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/s00253-010-2851-5", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1083533", 
        "issn": [
          "0175-7598", 
          "1432-0614"
        ], 
        "name": "Applied Microbiology and Biotechnology", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "89"
      }
    ], 
    "name": "Cytosolic NADPH balancing in Penicillium chrysogenum cultivated on mixtures of glucose and ethanol", 
    "pagination": "63-72", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "e6058639b61292e53698806869203b8ba63595dd4b10fbce7ee12f1c5289ae73"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "20809073"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "8406612"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s00253-010-2851-5"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1048284600"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s00253-010-2851-5", 
      "https://app.dimensions.ai/details/publication/pub.1048284600"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T10:48", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000350_0000000350/records_77548_00000000.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1007%2Fs00253-010-2851-5"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s00253-010-2851-5'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s00253-010-2851-5'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s00253-010-2851-5'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s00253-010-2851-5'


 

This table displays all metadata directly associated to this object as RDF triples.

305 TRIPLES      21 PREDICATES      91 URIs      28 LITERALS      16 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s00253-010-2851-5 schema:about N522598607de1420db1dfb123d2bf1a3d
2 N54232a8ce6ff45e0b9b444371ca3cd38
3 N5b171d65ae9a49d79fd2c68bac5030c0
4 N65ae6b12a2a747e1a457ce72f6a2054c
5 Nca30cc428cd24754a1c30aa9ef084ddd
6 Ncd7f991a4ce744e7be4d1fc4afc1f8bc
7 Necf70808cea340ed93206ec578198d5d
8 anzsrc-for:11
9 anzsrc-for:1103
10 schema:author N0c01f51692284a24b77328388d12211e
11 schema:citation sg:pub.10.1007/b99259
12 sg:pub.10.1007/bf00230397
13 sg:pub.10.1007/s00253-003-1306-7
14 sg:pub.10.1007/s00253-006-0804-9
15 sg:pub.10.1007/s00253-008-1444-z
16 sg:pub.10.1007/s002530051509
17 sg:pub.10.1007/s004380000364
18 sg:pub.10.1007/s004380050847
19 sg:pub.10.1007/s00726-005-0247-0
20 sg:pub.10.1007/s10142-009-0110-6
21 sg:pub.10.1038/nbt.1498
22 sg:pub.10.1186/1475-2859-6-36
23 sg:pub.10.1186/gb-2006-7-11-r108
24 https://app.dimensions.ai/details/publication/pub.1075090071
25 https://app.dimensions.ai/details/publication/pub.1076750128
26 https://app.dimensions.ai/details/publication/pub.1080290641
27 https://app.dimensions.ai/details/publication/pub.1080308658
28 https://app.dimensions.ai/details/publication/pub.1080308825
29 https://app.dimensions.ai/details/publication/pub.1082617958
30 https://app.dimensions.ai/details/publication/pub.1083268370
31 https://doi.org/10.1002/(sici)1097-0290(20000620)68:6<602::aid-bit3>3.0.co;2-2
32 https://doi.org/10.1002/bit.10899
33 https://doi.org/10.1002/bit.21813
34 https://doi.org/10.1002/bit.260430103
35 https://doi.org/10.1016/0003-9861(71)90247-5
36 https://doi.org/10.1016/0005-2728(68)90185-0
37 https://doi.org/10.1016/0006-291x(90)92397-i
38 https://doi.org/10.1016/0014-5793(79)80642-0
39 https://doi.org/10.1016/0014-5793(88)81036-6
40 https://doi.org/10.1016/0168-1656(95)00164-6
41 https://doi.org/10.1016/0304-4165(71)90129-2
42 https://doi.org/10.1016/j.exer.2006.04.010
43 https://doi.org/10.1016/j.femsyr.2004.10.007
44 https://doi.org/10.1016/j.ymben.2005.05.001
45 https://doi.org/10.1016/j.ymben.2005.09.004
46 https://doi.org/10.1016/j.ymben.2006.08.004
47 https://doi.org/10.1016/j.ymben.2007.07.001
48 https://doi.org/10.1016/j.ymben.2008.04.003
49 https://doi.org/10.1016/s1096-7176(03)00003-x
50 https://doi.org/10.1021/bi00664a010
51 https://doi.org/10.1039/a801345d
52 https://doi.org/10.1074/jbc.m210076200
53 https://doi.org/10.1074/jbc.m509461200
54 https://doi.org/10.1074/jbc.m706494200
55 https://doi.org/10.1099/00221287-129-4-965
56 https://doi.org/10.1099/00221287-143-1-253
57 https://doi.org/10.1099/00221287-67-1-85
58 https://doi.org/10.1099/mic.0.2007/010017-0
59 https://doi.org/10.1111/j.1432-1033.1972.tb01840.x
60 https://doi.org/10.1128/aem.02955-05
61 https://doi.org/10.1128/aem.68.12.5843-5859.2002
62 https://doi.org/10.1128/aem.70.1.229-239.2004
63 https://doi.org/10.1128/jb.169.12.5364-5372.1987
64 https://doi.org/10.1146/annurev.bi.52.070183.002541
65 https://doi.org/10.1529/biophysj.106.093138
66 schema:datePublished 2011-01
67 schema:datePublishedReg 2011-01-01
68 schema:description The in vivo flux through the oxidative branch of the pentose phosphate pathway (oxPPP) in Penicillium chrysogenum was determined during growth in glucose/ethanol carbon-limited chemostat cultures, at the same growth rate. Non-stationary (13)C flux analysis was used to measure the oxPPP flux. A nearly constant oxPPP flux was found for all glucose/ethanol ratios studied. This indicates that the cytosolic NADPH supply is independent of the amount of assimilated ethanol. The cofactor assignment in the model of van Gulik et al. (Biotechnol Bioeng 68(6):602-618, 2000) was supported using the published genome annotation of P. chrysogenum. Metabolic flux analysis showed that NADPH requirements in the cytosol remain nearly the same in these experiments due to constant biomass growth. Based on the cytosolic NADPH balance, it is known that the cytosolic aldehyde dehydrogenase in P. chrysogenum is NAD(+) dependent. Metabolic modeling shows that changing the NAD(+)-aldehyde dehydrogenase to NADP(+)-aldehyde dehydrogenase can increase the penicillin yield on substrate.
69 schema:genre research_article
70 schema:inLanguage en
71 schema:isAccessibleForFree true
72 schema:isPartOf Nd846a5b1cfe746daa7606433c7a92a59
73 Nec70ca09eaec4a3094a0ac0f7bf88e72
74 sg:journal.1083533
75 schema:name Cytosolic NADPH balancing in Penicillium chrysogenum cultivated on mixtures of glucose and ethanol
76 schema:pagination 63-72
77 schema:productId N113c1d4928764ebcaa724a7023a81944
78 N36fdbbae9b5a42a18929091336648958
79 Nb2e64ea1f62e4ec6a0886d9af773a984
80 Nb3903bf24481427e806852c50335ed1f
81 Nb9053f4c6b084c9db89bc40fe7c5fac3
82 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048284600
83 https://doi.org/10.1007/s00253-010-2851-5
84 schema:sdDatePublished 2019-04-11T10:48
85 schema:sdLicense https://scigraph.springernature.com/explorer/license/
86 schema:sdPublisher N106386c2bcf74cbd85f0ea4fcc377395
87 schema:url http://link.springer.com/10.1007%2Fs00253-010-2851-5
88 sgo:license sg:explorer/license/
89 sgo:sdDataset articles
90 rdf:type schema:ScholarlyArticle
91 N0c01f51692284a24b77328388d12211e rdf:first sg:person.01322703027.80
92 rdf:rest N285bccf14746471ab201391f0937c4bc
93 N106386c2bcf74cbd85f0ea4fcc377395 schema:name Springer Nature - SN SciGraph project
94 rdf:type schema:Organization
95 N113c1d4928764ebcaa724a7023a81944 schema:name doi
96 schema:value 10.1007/s00253-010-2851-5
97 rdf:type schema:PropertyValue
98 N1d37391b42e14dd299e4bd8c1d33468d rdf:first sg:person.011222163543.61
99 rdf:rest rdf:nil
100 N285bccf14746471ab201391f0937c4bc rdf:first sg:person.01242102435.12
101 rdf:rest N82b4992caae74887ab051e6863fae3b5
102 N36fdbbae9b5a42a18929091336648958 schema:name pubmed_id
103 schema:value 20809073
104 rdf:type schema:PropertyValue
105 N522598607de1420db1dfb123d2bf1a3d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
106 schema:name NADP
107 rdf:type schema:DefinedTerm
108 N54232a8ce6ff45e0b9b444371ca3cd38 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
109 schema:name Pentose Phosphate Pathway
110 rdf:type schema:DefinedTerm
111 N57003f11152c4d79a221b1ae7df71157 rdf:first sg:person.01026476151.36
112 rdf:rest N821e32b017ce472f9acb9064e6574707
113 N5b171d65ae9a49d79fd2c68bac5030c0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
114 schema:name Cytosol
115 rdf:type schema:DefinedTerm
116 N65ae6b12a2a747e1a457ce72f6a2054c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
117 schema:name Glucose
118 rdf:type schema:DefinedTerm
119 N821e32b017ce472f9acb9064e6574707 rdf:first sg:person.01216753414.39
120 rdf:rest N1d37391b42e14dd299e4bd8c1d33468d
121 N82b4992caae74887ab051e6863fae3b5 rdf:first sg:person.0615715153.53
122 rdf:rest N57003f11152c4d79a221b1ae7df71157
123 Nb0382c80e640484d83cb39fcd17e6376 schema:name DSM Anti-Infectives, A. Fleminglaan 1, 2613AX, Delft, The Netherlands
124 rdf:type schema:Organization
125 Nb2e64ea1f62e4ec6a0886d9af773a984 schema:name dimensions_id
126 schema:value pub.1048284600
127 rdf:type schema:PropertyValue
128 Nb3903bf24481427e806852c50335ed1f schema:name readcube_id
129 schema:value e6058639b61292e53698806869203b8ba63595dd4b10fbce7ee12f1c5289ae73
130 rdf:type schema:PropertyValue
131 Nb9053f4c6b084c9db89bc40fe7c5fac3 schema:name nlm_unique_id
132 schema:value 8406612
133 rdf:type schema:PropertyValue
134 Nca30cc428cd24754a1c30aa9ef084ddd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
135 schema:name Fungal Proteins
136 rdf:type schema:DefinedTerm
137 Ncd7f991a4ce744e7be4d1fc4afc1f8bc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
138 schema:name Ethanol
139 rdf:type schema:DefinedTerm
140 Nd846a5b1cfe746daa7606433c7a92a59 schema:issueNumber 1
141 rdf:type schema:PublicationIssue
142 Nec70ca09eaec4a3094a0ac0f7bf88e72 schema:volumeNumber 89
143 rdf:type schema:PublicationVolume
144 Necf70808cea340ed93206ec578198d5d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
145 schema:name Penicillium chrysogenum
146 rdf:type schema:DefinedTerm
147 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
148 schema:name Medical and Health Sciences
149 rdf:type schema:DefinedTerm
150 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
151 schema:name Clinical Sciences
152 rdf:type schema:DefinedTerm
153 sg:journal.1083533 schema:issn 0175-7598
154 1432-0614
155 schema:name Applied Microbiology and Biotechnology
156 rdf:type schema:Periodical
157 sg:person.01026476151.36 schema:affiliation https://www.grid.ac/institutes/grid.5292.c
158 schema:familyName Heijnen
159 schema:givenName Joseph J.
160 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01026476151.36
161 rdf:type schema:Person
162 sg:person.011222163543.61 schema:affiliation https://www.grid.ac/institutes/grid.5292.c
163 schema:familyName Verheijen
164 schema:givenName Peter J. T.
165 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011222163543.61
166 rdf:type schema:Person
167 sg:person.01216753414.39 schema:affiliation Nb0382c80e640484d83cb39fcd17e6376
168 schema:familyName van Winden
169 schema:givenName Wouter A.
170 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01216753414.39
171 rdf:type schema:Person
172 sg:person.01242102435.12 schema:affiliation https://www.grid.ac/institutes/grid.5292.c
173 schema:familyName Kuijvenhoven
174 schema:givenName Karel
175 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01242102435.12
176 rdf:type schema:Person
177 sg:person.01322703027.80 schema:affiliation https://www.grid.ac/institutes/grid.5292.c
178 schema:familyName Zhao
179 schema:givenName Zheng
180 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01322703027.80
181 rdf:type schema:Person
182 sg:person.0615715153.53 schema:affiliation https://www.grid.ac/institutes/grid.5292.c
183 schema:familyName van Gulik
184 schema:givenName Walter M.
185 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0615715153.53
186 rdf:type schema:Person
187 sg:pub.10.1007/b99259 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048145480
188 https://doi.org/10.1007/b99259
189 rdf:type schema:CreativeWork
190 sg:pub.10.1007/bf00230397 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022698682
191 https://doi.org/10.1007/bf00230397
192 rdf:type schema:CreativeWork
193 sg:pub.10.1007/s00253-003-1306-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041292024
194 https://doi.org/10.1007/s00253-003-1306-7
195 rdf:type schema:CreativeWork
196 sg:pub.10.1007/s00253-006-0804-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053240153
197 https://doi.org/10.1007/s00253-006-0804-9
198 rdf:type schema:CreativeWork
199 sg:pub.10.1007/s00253-008-1444-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1015564480
200 https://doi.org/10.1007/s00253-008-1444-z
201 rdf:type schema:CreativeWork
202 sg:pub.10.1007/s002530051509 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050399354
203 https://doi.org/10.1007/s002530051509
204 rdf:type schema:CreativeWork
205 sg:pub.10.1007/s004380000364 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007127768
206 https://doi.org/10.1007/s004380000364
207 rdf:type schema:CreativeWork
208 sg:pub.10.1007/s004380050847 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023448968
209 https://doi.org/10.1007/s004380050847
210 rdf:type schema:CreativeWork
211 sg:pub.10.1007/s00726-005-0247-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008339978
212 https://doi.org/10.1007/s00726-005-0247-0
213 rdf:type schema:CreativeWork
214 sg:pub.10.1007/s10142-009-0110-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038876783
215 https://doi.org/10.1007/s10142-009-0110-6
216 rdf:type schema:CreativeWork
217 sg:pub.10.1038/nbt.1498 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024762109
218 https://doi.org/10.1038/nbt.1498
219 rdf:type schema:CreativeWork
220 sg:pub.10.1186/1475-2859-6-36 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039489056
221 https://doi.org/10.1186/1475-2859-6-36
222 rdf:type schema:CreativeWork
223 sg:pub.10.1186/gb-2006-7-11-r108 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012626351
224 https://doi.org/10.1186/gb-2006-7-11-r108
225 rdf:type schema:CreativeWork
226 https://app.dimensions.ai/details/publication/pub.1075090071 schema:CreativeWork
227 https://app.dimensions.ai/details/publication/pub.1076750128 schema:CreativeWork
228 https://app.dimensions.ai/details/publication/pub.1080290641 schema:CreativeWork
229 https://app.dimensions.ai/details/publication/pub.1080308658 schema:CreativeWork
230 https://app.dimensions.ai/details/publication/pub.1080308825 schema:CreativeWork
231 https://app.dimensions.ai/details/publication/pub.1082617958 schema:CreativeWork
232 https://app.dimensions.ai/details/publication/pub.1083268370 schema:CreativeWork
233 https://doi.org/10.1002/(sici)1097-0290(20000620)68:6<602::aid-bit3>3.0.co;2-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021204311
234 rdf:type schema:CreativeWork
235 https://doi.org/10.1002/bit.10899 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018037495
236 rdf:type schema:CreativeWork
237 https://doi.org/10.1002/bit.21813 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024911140
238 rdf:type schema:CreativeWork
239 https://doi.org/10.1002/bit.260430103 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025145521
240 rdf:type schema:CreativeWork
241 https://doi.org/10.1016/0003-9861(71)90247-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051253760
242 rdf:type schema:CreativeWork
243 https://doi.org/10.1016/0005-2728(68)90185-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018870650
244 rdf:type schema:CreativeWork
245 https://doi.org/10.1016/0006-291x(90)92397-i schema:sameAs https://app.dimensions.ai/details/publication/pub.1016482064
246 rdf:type schema:CreativeWork
247 https://doi.org/10.1016/0014-5793(79)80642-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010104169
248 rdf:type schema:CreativeWork
249 https://doi.org/10.1016/0014-5793(88)81036-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038888706
250 rdf:type schema:CreativeWork
251 https://doi.org/10.1016/0168-1656(95)00164-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005652033
252 rdf:type schema:CreativeWork
253 https://doi.org/10.1016/0304-4165(71)90129-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045898719
254 rdf:type schema:CreativeWork
255 https://doi.org/10.1016/j.exer.2006.04.010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010406515
256 rdf:type schema:CreativeWork
257 https://doi.org/10.1016/j.femsyr.2004.10.007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049244914
258 rdf:type schema:CreativeWork
259 https://doi.org/10.1016/j.ymben.2005.05.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020941143
260 rdf:type schema:CreativeWork
261 https://doi.org/10.1016/j.ymben.2005.09.004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005803201
262 rdf:type schema:CreativeWork
263 https://doi.org/10.1016/j.ymben.2006.08.004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021686722
264 rdf:type schema:CreativeWork
265 https://doi.org/10.1016/j.ymben.2007.07.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050569337
266 rdf:type schema:CreativeWork
267 https://doi.org/10.1016/j.ymben.2008.04.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045801372
268 rdf:type schema:CreativeWork
269 https://doi.org/10.1016/s1096-7176(03)00003-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1020154850
270 rdf:type schema:CreativeWork
271 https://doi.org/10.1021/bi00664a010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1055184519
272 rdf:type schema:CreativeWork
273 https://doi.org/10.1039/a801345d schema:sameAs https://app.dimensions.ai/details/publication/pub.1033474004
274 rdf:type schema:CreativeWork
275 https://doi.org/10.1074/jbc.m210076200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004847265
276 rdf:type schema:CreativeWork
277 https://doi.org/10.1074/jbc.m509461200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001858690
278 rdf:type schema:CreativeWork
279 https://doi.org/10.1074/jbc.m706494200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006305178
280 rdf:type schema:CreativeWork
281 https://doi.org/10.1099/00221287-129-4-965 schema:sameAs https://app.dimensions.ai/details/publication/pub.1060364839
282 rdf:type schema:CreativeWork
283 https://doi.org/10.1099/00221287-143-1-253 schema:sameAs https://app.dimensions.ai/details/publication/pub.1060369230
284 rdf:type schema:CreativeWork
285 https://doi.org/10.1099/00221287-67-1-85 schema:sameAs https://app.dimensions.ai/details/publication/pub.1060374327
286 rdf:type schema:CreativeWork
287 https://doi.org/10.1099/mic.0.2007/010017-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1060396185
288 rdf:type schema:CreativeWork
289 https://doi.org/10.1111/j.1432-1033.1972.tb01840.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1043811951
290 rdf:type schema:CreativeWork
291 https://doi.org/10.1128/aem.02955-05 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019494531
292 rdf:type schema:CreativeWork
293 https://doi.org/10.1128/aem.68.12.5843-5859.2002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003807814
294 rdf:type schema:CreativeWork
295 https://doi.org/10.1128/aem.70.1.229-239.2004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040687530
296 rdf:type schema:CreativeWork
297 https://doi.org/10.1128/jb.169.12.5364-5372.1987 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062715615
298 rdf:type schema:CreativeWork
299 https://doi.org/10.1146/annurev.bi.52.070183.002541 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027219330
300 rdf:type schema:CreativeWork
301 https://doi.org/10.1529/biophysj.106.093138 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010780863
302 rdf:type schema:CreativeWork
303 https://www.grid.ac/institutes/grid.5292.c schema:alternateName Delft University of Technology
304 schema:name Department of Biotechnology, Kluyver Centre for Genomics of Industrial Fermentation, Delft University of Technology, Julianalaan 67, 2628BC, Delft, The Netherlands
305 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...