Fumaric acid production by fermentation View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2008-03

AUTHORS

Carol A. Roa Engel, Adrie J. J. Straathof, Tiemen W. Zijlmans, Walter M. van Gulik, Luuk A. M. van der Wielen

ABSTRACT

The potential of fumaric acid as a raw material in the polymer industry and the increment of cost of petroleum-based fumaric acid raises interest in fermentation processes for production of this compound from renewable resources. Although the chemical process yields 112% w/w fumaric acid from maleic anhydride and the fermentation process yields only 85% w/w from glucose, the latter raw material is three times cheaper. Besides, the fermentation fixes CO2. Production of fumaric acid by Rhizopus species and the involved metabolic pathways are reviewed. Submerged fermentation systems coupled with product recovery techniques seem to have achieved economically attractive yields and productivities. Future prospects for improvement of fumaric acid production include metabolic engineering approaches to achieve low pH fermentations. More... »

PAGES

379-389

References to SciGraph publications

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  • 2000-07. Direct ammonium fumarate production by Rhizopus arrhizus under phosphorous limitation in BIOTECHNOLOGY LETTERS
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  • Journal

    TITLE

    Applied Microbiology and Biotechnology

    ISSUE

    3

    VOLUME

    78

    Author Affiliations

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s00253-007-1341-x

    DOI

    http://dx.doi.org/10.1007/s00253-007-1341-x

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1012233424

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/18214471


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