Ontology type: schema:ScholarlyArticle
2006-05-09
AUTHORSShantanu Karkare, Deepak Bhatnagar
ABSTRACTNucleic acid analogs and mimics are commonly the modifications of native nucleic acids at the nucleobase, the sugar ring, or the phosphodiester backbone. Many forms of promising nucleic acid analogs and mimics are available, such as locked nucleic acids (LNAs), peptide nucleic acids (PNAs), and morpholinos. LNAs, PNAs, and morpholinos can form both duplexes and triplexes and have improved biostability. They have become a general and versatile tool for DNA and RNA recognition. LNA is a general and versatile tool for specific, high-affinity recognition of single-stranded DNA (ssDNA) and single-stranded RNA (ssRNA). LNA can be used for designing LNA oligoes for hybridization studies or as real time polymerase chain reaction probes in the form of Taqman probes. LNA also has therapeutic and diagnostic applications. PNA is another type of DNA analog with neutral charge. The extreme stability of PNA makes it an ideal candidate for the antisense and antigene application. PNA is used as probe for gene cloning, mutation detection, and in homologous recombination studies. It was also used to design transcription factor decoy molecules for target gene induction. Morpholino, another structural type, was devised to circumvent cost problems associated with DNA analogs. It has become the premier knockdown tool in developmental biology due to its cytosolic delivery in the embryos by microinjection. Thus, the nucleic acid analogs provide an advantage to design and implementation, therapies, and research assays, which were not implemented due to limitations associated with standard nucleic acids chemistry. More... »
PAGES575-586
http://scigraph.springernature.com/pub.10.1007/s00253-006-0434-2
DOIhttp://dx.doi.org/10.1007/s00253-006-0434-2
DIMENSIONShttps://app.dimensions.ai/details/publication/pub.1007412287
PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/16683135
JSON-LD is the canonical representation for SciGraph data.
TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT
[
{
"@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json",
"about": [
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Biological Sciences",
"type": "DefinedTerm"
},
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0604",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Genetics",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Biotechnology",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Molecular Mimicry",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Morpholines",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Nucleic Acids",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Oligonucleotides",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Oligonucleotides, Antisense",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Peptide Nucleic Acids",
"type": "DefinedTerm"
}
],
"author": [
{
"affiliation": {
"alternateName": "Apticraft Systems (P) Ltd. 142, Electronics Complex, 452010, Indore, India",
"id": "http://www.grid.ac/institutes/None",
"name": [
"Apticraft Systems (P) Ltd. 142, Electronics Complex, 452010, Indore, India"
],
"type": "Organization"
},
"familyName": "Karkare",
"givenName": "Shantanu",
"id": "sg:person.01310256130.18",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01310256130.18"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "School of Biochemistry, Devi Ahilya University, Khandwa Road, 452017, Indore, India",
"id": "http://www.grid.ac/institutes/grid.412015.3",
"name": [
"School of Biochemistry, Devi Ahilya University, Khandwa Road, 452017, Indore, India"
],
"type": "Organization"
},
"familyName": "Bhatnagar",
"givenName": "Deepak",
"id": "sg:person.0655447022.75",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0655447022.75"
],
"type": "Person"
}
],
"citation": [
{
"id": "sg:pub.10.1038/73745",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1007730981",
"https://doi.org/10.1038/73745"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nsb0596-410",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1018987799",
"https://doi.org/10.1038/nsb0596-410"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/365566a0",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1004328835",
"https://doi.org/10.1038/365566a0"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nbt0596-615",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1037714549",
"https://doi.org/10.1038/nbt0596-615"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/978-1-4615-5177-5",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1004014317",
"https://doi.org/10.1007/978-1-4615-5177-5"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/sj.cr.7290209",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1029302551",
"https://doi.org/10.1038/sj.cr.7290209"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nbt0998-857",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1052207106",
"https://doi.org/10.1038/nbt0998-857"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nsb0297-98",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1048564534",
"https://doi.org/10.1038/nsb0297-98"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/379214a0",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1007959929",
"https://doi.org/10.1038/379214a0"
],
"type": "CreativeWork"
}
],
"datePublished": "2006-05-09",
"datePublishedReg": "2006-05-09",
"description": "Nucleic acid analogs and mimics are commonly the modifications of native nucleic acids at the nucleobase, the sugar ring, or the phosphodiester backbone. Many forms of promising nucleic acid analogs and mimics are available, such as locked nucleic acids (LNAs), peptide nucleic acids (PNAs), and morpholinos. LNAs, PNAs, and morpholinos can form both duplexes and triplexes and have improved biostability. They have become a general and versatile tool for DNA and RNA recognition. LNA is a general and versatile tool for specific, high-affinity recognition of single-stranded DNA (ssDNA) and single-stranded RNA (ssRNA). LNA can be used for designing LNA oligoes for hybridization studies or as real time polymerase chain reaction probes in the form of Taqman probes. LNA also has therapeutic and diagnostic applications. PNA is another type of DNA analog with neutral charge. The extreme stability of PNA makes it an ideal candidate for the antisense and antigene application. PNA is used as probe for gene cloning, mutation detection, and in homologous recombination studies. It was also used to design transcription factor decoy molecules for target gene induction. Morpholino, another structural type, was devised to circumvent cost problems associated with DNA analogs. It has become the premier knockdown tool in developmental biology due to its cytosolic delivery in the embryos by microinjection. Thus, the nucleic acid analogs provide an advantage to design and implementation, therapies, and research assays, which were not implemented due to limitations associated with standard nucleic acids chemistry.",
"genre": "article",
"id": "sg:pub.10.1007/s00253-006-0434-2",
"isAccessibleForFree": false,
"isPartOf": [
{
"id": "sg:journal.1083533",
"issn": [
"0175-7598",
"1432-0614"
],
"name": "Applied Microbiology and Biotechnology",
"publisher": "Springer Nature",
"type": "Periodical"
},
{
"issueNumber": "5",
"type": "PublicationIssue"
},
{
"type": "PublicationVolume",
"volumeNumber": "71"
}
],
"keywords": [
"nucleic acid analogues",
"DNA analogues",
"application of PNA",
"nucleic acids",
"nucleic acid chemistry",
"acid analogues",
"native nucleic acids",
"versatile tool",
"acid chemistry",
"sugar ring",
"neutral charge",
"antigene applications",
"reaction probes",
"high-affinity recognition",
"structural types",
"phosphodiester backbone",
"cytosolic delivery",
"extreme stability",
"diagnostic applications",
"PNA",
"analogues",
"acid",
"ideal candidate",
"probe",
"chemistry",
"nucleobase",
"mimics",
"backbone",
"molecules",
"biostability",
"ring",
"triplexes",
"charge",
"applications",
"stability",
"duplex",
"RNA recognition",
"modification",
"DNA",
"candidates",
"detection",
"characteristic features",
"form",
"delivery",
"recombination studies",
"assays",
"morpholino",
"types",
"LNA",
"advantages",
"study",
"research assays",
"polymerase chain reaction probes",
"tool",
"biology",
"recognition",
"antisense",
"design",
"mutation detection",
"limitations",
"features",
"TaqMan probes",
"RNA",
"gene cloning",
"factors",
"cost problem",
"hybridization studies",
"problem",
"therapy",
"induction",
"implementation",
"cloning",
"transcription factors",
"developmental biology",
"target gene induction",
"embryos",
"microinjection",
"gene induction"
],
"name": "Promising nucleic acid analogs and mimics: characteristic features and applications of PNA, LNA, and morpholino",
"pagination": "575-586",
"productId": [
{
"name": "dimensions_id",
"type": "PropertyValue",
"value": [
"pub.1007412287"
]
},
{
"name": "doi",
"type": "PropertyValue",
"value": [
"10.1007/s00253-006-0434-2"
]
},
{
"name": "pubmed_id",
"type": "PropertyValue",
"value": [
"16683135"
]
}
],
"sameAs": [
"https://doi.org/10.1007/s00253-006-0434-2",
"https://app.dimensions.ai/details/publication/pub.1007412287"
],
"sdDataset": "articles",
"sdDatePublished": "2022-08-04T16:55",
"sdLicense": "https://scigraph.springernature.com/explorer/license/",
"sdPublisher": {
"name": "Springer Nature - SN SciGraph project",
"type": "Organization"
},
"sdSource": "s3://com-springernature-scigraph/baseset/20220804/entities/gbq_results/article/article_424.jsonl",
"type": "ScholarlyArticle",
"url": "https://doi.org/10.1007/s00253-006-0434-2"
}
]Download the RDF metadata as: json-ld nt turtle xml License info
JSON-LD is a popular format for linked data which is fully compatible with JSON.
curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s00253-006-0434-2'
N-Triples is a line-based linked data format ideal for batch operations.
curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s00253-006-0434-2'
Turtle is a human-readable linked data format.
curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s00253-006-0434-2'
RDF/XML is a standard XML format for linked data.
curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s00253-006-0434-2'
This table displays all metadata directly associated to this object as RDF triples.
213 TRIPLES
21 PREDICATES
119 URIs
102 LITERALS
14 BLANK NODES