Tolerance to furfural-induced stress is associated with pentose phosphate pathway genes ZWF1, GND1, RPE1, and TKL1 in Saccharomyces cerevisiae View Full Text


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Article Info

DATE

2005-10-13

AUTHORS

S. W. Gorsich, B. S. Dien, N. N. Nichols, P. J. Slininger, Z. L. Liu, C. D. Skory

ABSTRACT

Engineering yeast to be more tolerant to fermentation inhibitors, furfural and 5-hydroxymethylfurfural (HMF), will lead to more efficient lignocellulose to ethanol bioconversion. To identify target genes involved in furfural tolerance, a Saccharomyces cerevisiae gene disruption library was screened for mutants with growth deficiencies in the presence of furfural. It was hypothesized that overexpression of these genes would provide a growth benefit in the presence of furfural. Sixty two mutants were identified whose corresponding genes function in a wide spectrum of physiological pathways, suggesting that furfural tolerance is a complex process. We focused on four mutants, zwf1, gnd1, rpe1, and tkl1, which represent genes encoding pentose phosphate pathway (PPP) enzymes. At various concentrations of furfural and HMF, a clear association with higher sensitivity to these inhibitors was demonstrated in these mutants. PPP mutants were inefficient at reducing furfural to the less toxic furfuryl alcohol, which we propose is a result of an overall decreased abundance of reducing equivalents or to NADPH's role in stress tolerance. Overexpression of ZWF1 in S. cerevisiae allowed growth at furfural concentrations that are normally toxic. These results demonstrate a strong relationship between PPP genes and furfural tolerance and provide additional putative target genes involved in furfural tolerance. More... »

PAGES

339-349

References to SciGraph publications

  • 2002-01. Fermentation performance and intracellular metabolite patterns in laboratory and industrial xylose-fermenting Saccharomyces cerevisiae in APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
  • 2001-07. Fuel ethanol production from lignocellulose: a challenge for metabolic engineering and process integration in APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
  • 2003-04-16. Hemicellulose bioconversion in JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY
  • 1995-04. Mutants of Saccharomyces cerevisiae sensitive to oxidative and osmotic stress in CURRENT GENETICS
  • 1996-09. Mutants that show increased sensitivity to hydrogen peroxide reveal an important role for the pentose phosphate pathway in protection of yeast against oxidative stress in MOLECULAR GENETICS AND GENOMICS
  • 1981-12. Inhibition of glycolysis by furfural in Saccharomyces cerevisiae in APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
  • 1997-12. Two genes of the putative mitochondrial fatty acid synthase in the genome of Saccharomyces cerevisiae in CURRENT GENETICS
  • 2000-06. Physiological effects of 5-hydroxymethylfurfural on Saccharomyces cerevisiae in APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
  • 2004-07-29. Adaptive response of yeasts to furfural and 5-hydroxymethylfurfural and new chemical evidence for HMF conversion to 2,5-bis-hydroxymethylfuran in JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY
  • 2005-03. Enhanced biotransformation of furfural and hydroxymethylfurfural by newly developed ethanologenic yeast strains in APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY
  • Journal

    TITLE

    Applied Microbiology and Biotechnology

    ISSUE

    3

    VOLUME

    71

    Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s00253-005-0142-3

    DOI

    http://dx.doi.org/10.1007/s00253-005-0142-3

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1051222224

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/16222531


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