Ontology type: schema:ScholarlyArticle
2000-04
AUTHORSM. Stammers, L. Rowen, D. Rhodes, J. Trowsdale, S. Beck
ABSTRACTComparison of human and mouse genomic sequence at the border of the major histocompatibility complex (MHC) class II and class III regions revealed a locus encoding six exons with homology to the butyrophilin gene family and the location of a previously described gene, testis-specific basic protein (TSBP). We named the new locus BTL-II, for butyrophilin-like MHC class II associated. The six discernable exons of the BTL-II locus encode a small hydrophobic amino acid sequence (which may be a signal peptide), two immunoglobulin domains, a small 7-amino acid, heptad repeat-like exon, and a further two immunoglobulin domains. In mouse, an additional butyrophilin-like gene (NG10) is situated adjacent to BTL-II. Expression studies of the BTL-II locus in mouse showed that it is expressed in a range of gut tissues. We demonstrate that like many other genes from the MHC, BTL-II is polymorphic in a selection of diverse HLA haplotypes. In the light of the newly discovered locus, we revisit and discuss the possible origin of the butyrophilin gene family. More... »
PAGES373-382
http://scigraph.springernature.com/pub.10.1007/s002510050633
DOIhttp://dx.doi.org/10.1007/s002510050633
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PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/10803852
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