Mapping of a candidate region for susceptibility to inclusion body myositis in the human major histocompatibility complex View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1999-05

AUTHORS

Chee Choy Kok, Emma J. Croager, Campbell S. Witt, Lynette Kiers, Frank L. Mastaglia, Lawrence J. Abraham, M. J. Garlepp

ABSTRACT

Inclusion body myositis (IBM) is a form of idiopathic inflammatory myopathy of unknown aetiology. A strong association with HLA class II (HLA-DR3) suggested a role for genes in the human major histocompatibility complex (MHC) in the predisposition to this disease. In this study, we have taken advantage of the ancestral haplotype (AH) concept and historical recombinations to map for a possible susceptibility gene(s) in the MHC. We performed detailed typing of three MHC-related HSP70 genes and defined allelic combinations in the context of MHC AH. We also modified existing methods to give a simple and accurate method for typing two TNF microsatellites. Using the HSP70 and TNF markers and HLA-DR, -B, and C4 typing of our patients with IBM, we defined a potential site for the MHC-associated susceptibility gene(s) in the region between HLA-DR and C4. More... »

PAGES

508-516

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s002510050528

DOI

http://dx.doi.org/10.1007/s002510050528

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1031085334

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/10380695


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