Organization of the genes encoding the human proteasome activators PA28α and β View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1999-04

AUTHORS

Derek McCusker, Michael Wilson, J. Trowsdale

ABSTRACT

Two proteasome activators PA28alpha and beta, which have been implicated in antigen processing for loading class I MHC molecules, are synthesized in response to Ifn-gamma. The human genes encoding these activators (PSME1 and PSME2, respectively) were analyzed by sequencing. Each gene comprised 11 exons, consistent with gene duplication during vertebrate evolution. The intron/exon organization of both genes was highly conserved, the major difference being the absence of the exon encoding the lysine and glutamic acid-rich 'KEKE' motif in PA28beta. Two other genes of relevance to the immune system were located close to those for PA28 at 14q11.2 including ISGF3G, a protein involved in transcription after IFNalpha signalling. These sequences were also characterized. More... »

PAGES

438-445

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s002510050517

DOI

http://dx.doi.org/10.1007/s002510050517

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1043022048

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/10199920


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