Two different primate species express an identical functional MHC class I allele View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1998-01

AUTHORS

David T. Evans, Marian S. Piekarczyk, Luis Cadavid, Virginia S. Hinshaw, D. I. Watkins

ABSTRACT

The products of the highly polymorphic and variable major histocompatibility complex (MHC) class I loci play a crucial role in host defenses against infectious disease. While similar alleles have been found in closely related species, sharing of a functional MHC class I allele between two species has never been reported. Here we show that an identical functional MHC class I molecule is present in two different primate species with an approximate divergence time of 0.7 million years. Lymphocytes from the red-crested tamarin (Saguinus geoffroyi) expressed an MHC class I allele (Sage-G*01) that was identical in coding sequence to an MHC class I allele (Saoe-G*08) found in the cotton-top tamarin (Saguinus oedipus). Furthermore, influenza virus-specific cytotoxic T lymphocytes (CTLs) generated in the cotton-top tamarin killed lymphocytes expressing the influenza virus nucleoprotein (NP) from the red-crested tamarin. Since the influenza virus NP epitope is bound by Saoe-G*08 in the cotton-top tamarin, it is likely that this molecule is functional in both species. These data provide the first evidence that functional MHC class I molecules can be maintained entirely intact in two separate species. More... »

PAGES

206-211

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s002510050349

DOI

http://dx.doi.org/10.1007/s002510050349

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1014794435

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/9435338


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