Evidence for adaptation of porcine Toll-like receptors View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2016-03

AUTHORS

Kwame A. Darfour-Oduro, Hendrik-Jan Megens, Alfred Roca, Martien A. M. Groenen, Lawrence B. Schook

ABSTRACT

Naturally endemic infectious diseases provide selective pressures for pig populations. Toll-like receptors (TLRs) represent the first line of immune defense against pathogens and are likely to play a crucial adaptive role for pig populations. This study was done to determine whether wild and domestic pig populations representing diverse global environments demonstrate local TLR adaptation. The genomic sequence encoding the ectodomain, responsible for interacting with pathogen ligands of bacterial (TLR1, TLR2 and TLR6) and viral (TLR3, TLR7 and TLR8) receptors, was obtained. Mitochondrial D-loop region sequences were obtained and a phylogenetic analysis using these sequences revealed a clear separation of animals into Asian (n = 27) and European (n = 40) clades. The TLR sequences were then analyzed for population-specific positive selection signatures within wild boars and domesticated pig populations derived from Asian and European clades. Using within-population and between-population tests for positive selection, a TLR2-derived variant 376A (126Thr), estimated to have arisen in 163,000 years ago with a frequency of 83.33% within European wild boars, 98.00% within domestic pig breeds of European origin, 40.00% within Asian wild boars, and 11.36% within Asian domestic pigs, was identified to be under positive selection in pigs of European origin. The variant is located within the N terminal domain of the TLR2 protein 3D crystal structure and could affect ligand binding. This study suggests the TLR2 gene contributing to responses to bacterial pathogens has been crucial in adaptation of pigs to pathogens. More... »

PAGES

179-189

References to SciGraph publications

  • 2001-04. Genetic evidence for Near-Eastern origins of European cattle in NATURE
  • 2008-12. Molecular evolution of bovine Toll-like receptor 2 suggests substitutions of functional relevance in BMC EVOLUTIONARY BIOLOGY
  • 2008-03. Toll-like receptors — taking an evolutionary approach in NATURE REVIEWS GENETICS
  • 2006-05. Biased distribution of single nucleotide polymorphisms (SNPs) in porcine Toll-like receptor 1 (TLR1), TLR2, TLR4, TLR5, and TLR6 genes in IMMUNOGENETICS
  • 2012-11. Analyses of pig genomes provide insight into porcine demography and evolution in NATURE
  • 2013-10. How immunogenetically different are domestic pigs from wild boars: a perspective from single-nucleotide polymorphisms of 19 immunity-related candidate genes in IMMUNOGENETICS
  • 2014-12. Whole-genome sequence analysis reveals differences in population management and selection of European low-input pig breeds in BMC GENOMICS
  • 2011-12. SNiPlay: a web-based tool for detection, management and analysis of SNPs. Application to grapevine diversity projects in BMC BIOINFORMATICS
  • 2012-12. A high density recombination map of the pig reveals a correlation between sex-specific recombination and GC content in BMC GENOMICS
  • 2011-12. Polymorphisms in pattern recognition receptors and their relationship to infectious disease susceptibility in pigs in BMC PROCEEDINGS
  • 2015-10. Evidence of long-term gene flow and selection during domestication from analyses of Eurasian wild and domestic pig genomes in NATURE GENETICS
  • 2013-09. Genome sequencing reveals fine scale diversification and reticulation history during speciation in Sus in GENOME BIOLOGY
  • 2008-01. Biodiversity of pig breeds from China and Europe estimated from pooled DNA samples: differences in microsatellite variation between two areas of domestication in GENETICS SELECTION EVOLUTION
  • 2009-07. Predicting the effects of coding non-synonymous variants on protein function using the SIFT algorithm in NATURE PROTOCOLS
  • 2012-01. Positive selection of Toll-like receptor 2 polymorphisms in two closely related old world monkey species, rhesus and Japanese macaques in IMMUNOGENETICS
  • 2010-01. European wild boars and domestic pigs display different polymorphic patterns in the Toll-like receptor (TLR) 1, TLR2, and TLR6 genes in IMMUNOGENETICS
  • 2009-11. Spatial patterns of variation due to natural selection in humans in NATURE REVIEWS GENETICS
  • 2013-11. MuPIT interactive: webserver for mapping variant positions to annotated, interactive 3D structures in HUMAN GENETICS
  • 2009-12. Comparative genomics of Toll-like receptor signalling in five species in BMC GENOMICS
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s00251-015-0892-8

    DOI

    http://dx.doi.org/10.1007/s00251-015-0892-8

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1000577725

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/26701185


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