CASPASE-12 and rheumatoid arthritis in African-Americans View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2014-04

AUTHORS

Laura Marshall, Mohammad Obaidullah, Trista Fuchs, Naomi S. Fineberg, Garland Brinkley, Ted R. Mikuls, S. Louis Bridges, Evan Hermel

ABSTRACT

CASPASE-12 (CASP12) has a downregulatory function during infection and thus may protect against inflammatory disease. We investigated the distribution of CASP12 alleles (#rs497116) in African-Americans (AA) with rheumatoid arthritis (RA). CASP12 alleles were genotyped in 953 RA patients and 342 controls. Statistical analyses comparing genotype groups were performed using Kruskal-Wallis non-parametric ANOVA with Mann-Whitney U tests and chi-square tests. There was no significant difference in the overall distribution of CASP12 genotypes within AA with RA, but CASP12 homozygous patients had lower baseline joint-narrowing scores. CASP12 homozygosity appears to be a subtle protective factor for some aspects of RA in AA patients. More... »

PAGES

281-285

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00251-014-0762-9

DOI

http://dx.doi.org/10.1007/s00251-014-0762-9

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1005277895

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/24515649


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