Combined effect of five single nucleotide polymorphisms related to IL23/Th17 pathway in the risk of psoriasis View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2014-01-14

AUTHORS

Xianyong Yin, Hui Cheng, Ran Zhang, Xing Fan, Fusheng Zhou, Long Jiang, Xianfa Tang, Gang Chen, Xianbo Zuo, Xiaodong Zheng, Sen Yang, Xuejun Zhang

ABSTRACT

Psoriasis is a common immune-mediated inflammatory skin disease with strong genetic components, in which the IL23/Th17 pathway has been implicated. To explore the effective role in psoriasis, we genotyped five single nucleotide polymorphisms in genes related to IL23/Th17 pathway in 14,929 Han Chinese samples. A Bonferroni-corrected significant single-variant association was identified between rs1512970 within IL21 (odds ratio (OR) = 1.07, 95 % confidence interval (CI) = 1.02–1.13, P = 4.94 × 10−03). We failed to validate rs744166 (OR = 1.06, 95 % CI = 1.01–1.11, P = 1.52 × 10−02) and other three SNPs (P = 2.48 × 10−01 ∼ 1.27 × 10−02) to meet the single-variant association significance threshold. However, we found that their combined effect substantially contributed to the risk of psoriasis in our sample (P = 3.91 × 10−07) and the highest score group conferred the largest risk effect size (OR = 1.22, 95 % CI = 1.11–1.34, P = 1.85 × 10−05). Our results implicate the ethnic heterogeneity in the susceptibility of psoriasis and suggest common variants with weak effect in IL23/Th17 pathway, which do not show significance in conventional single-variant association study, may contribute to the risk of psoriasis. This study sheds light on the important role of IL23/Th17 pathway in the susceptibility of psoriasis. More... »

PAGES

215-218

Journal

TITLE

Immunogenetics

ISSUE

3

VOLUME

66

Related Patents

  • Compositions Comprising Bacterial Strains
  • Compositions Comprising Bacterial Strains
  • Compositions Comprising Bacterial Strains
  • Pirin Polypeptide And Immune Modulation
  • Compositions Comprising Bacterial Strains
  • Compositions Comprising Bacterial Strains
  • Compositions Comprising Bacterial Strains
  • Compositions Comprising Bacterial Strains
  • Compositions Comprising Bacterial Strains
  • Compositions Comprising Bacterial Strains
  • Compositions Comprising Bacterial Strains
  • Composition Comprising Bacterial Strains
  • Compositions Comprising Bacterial Strains
  • Compositions Comprising Bacterial Strains
  • Compositions Comprising Bacterial Strains
  • Compositions Comprising Bacterial Strains
  • Compositions Comprising Bacterial Strains
  • Polypeptide And Immune Modulation
  • Bacterium For Use As A Probiotic For Nutritional And Medical Applications
  • Compositions Comprising Bacterial Strains
  • Compositions Comprising Bacterial Strains
  • Compositions Comprising Bacterial Strains
  • Compositions Comprising Bacterial Strains
  • Compositions Comprising Bacterial Strains
  • Pirin Polypeptide And Immune Modulation
  • Compositions Comprising Bacterial Strains
  • Compositions Comprising Bacterial Strains
  • Compositions Comprising Bacterial Strains
  • Compositions Comprising Bacterial Strains
  • Compositions Comprising Bacterial Strains
  • Compositions Comprising Bacterial Strains
  • Composition Of Bacteroides Thetaiotaomicron For Immune Modulation
  • Compositions Comprising Bacterial Strains
  • Compositions Comprising Bacterial Strains
  • Compositions Comprising Bacterial Strains
  • Compositions Comprising Bacterial Strains
  • Compositions Comprising Bacterial Strains
  • Compositions Comprising A Bacterial Strain Of The Genus Megasphera And Uses Thereof
  • Compositions Comprising Bacterial Strains
  • Compositions Comprising Bacterial Strains
  • Compositions Comprising Bacterial Strains
  • Polypeptide And Immune Modulation
  • Compositions Comprising Bacterial Strains
  • Compositions Comprising Bacterial Strains
  • Lactic Acid Bacterial Strains
  • Compositions Comprising Bacterial Strains
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s00251-013-0756-z

    DOI

    http://dx.doi.org/10.1007/s00251-013-0756-z

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1007431074

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/24419661


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical and Health Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1107", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Immunology", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Alleles", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Case-Control Studies", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Female", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Genetic Predisposition to Disease", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Humans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Interleukin-23", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Male", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Odds Ratio", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Polymorphism, Single Nucleotide", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Psoriasis", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Risk", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Signal Transduction", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Th17 Cells", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Collaborative Innovation Center for Complex and Severe Dermatosis, Anhui Medical University, 230032, Hefei, Anhui, China", 
              "id": "http://www.grid.ac/institutes/grid.186775.a", 
              "name": [
                "Institute of Dermatology, Department of Dermatology, The First Affiliated Hospital, Anhui Medical University, 230032, Hefei, Anhui, China", 
                "Key Laboratory of Dermatology, Ministry of Education, Anhui Medical University and State Key Laboratory of Dermatology Incubation, 230032, Hefei, Anhui, China", 
                "Key Lab of Gene Resource Utilization for Complex Diseases, 230032, Hefei, Anhui, China", 
                "Collaborative Innovation Center for Complex and Severe Dermatosis, Anhui Medical University, 230032, Hefei, Anhui, China"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Yin", 
            "givenName": "Xianyong", 
            "id": "sg:person.0741205072.53", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0741205072.53"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Collaborative Innovation Center for Complex and Severe Dermatosis, Anhui Medical University, 230032, Hefei, Anhui, China", 
              "id": "http://www.grid.ac/institutes/grid.186775.a", 
              "name": [
                "Institute of Dermatology, Department of Dermatology, The First Affiliated Hospital, Anhui Medical University, 230032, Hefei, Anhui, China", 
                "Key Laboratory of Dermatology, Ministry of Education, Anhui Medical University and State Key Laboratory of Dermatology Incubation, 230032, Hefei, Anhui, China", 
                "Key Lab of Gene Resource Utilization for Complex Diseases, 230032, Hefei, Anhui, China", 
                "Collaborative Innovation Center for Complex and Severe Dermatosis, Anhui Medical University, 230032, Hefei, Anhui, China"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Cheng", 
            "givenName": "Hui", 
            "id": "sg:person.01007320272.22", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01007320272.22"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Collaborative Innovation Center for Complex and Severe Dermatosis, Anhui Medical University, 230032, Hefei, Anhui, China", 
              "id": "http://www.grid.ac/institutes/grid.186775.a", 
              "name": [
                "Institute of Dermatology, Department of Dermatology, The First Affiliated Hospital, Anhui Medical University, 230032, Hefei, Anhui, China", 
                "Key Laboratory of Dermatology, Ministry of Education, Anhui Medical University and State Key Laboratory of Dermatology Incubation, 230032, Hefei, Anhui, China", 
                "Key Lab of Gene Resource Utilization for Complex Diseases, 230032, Hefei, Anhui, China", 
                "Collaborative Innovation Center for Complex and Severe Dermatosis, Anhui Medical University, 230032, Hefei, Anhui, China"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Zhang", 
            "givenName": "Ran", 
            "id": "sg:person.01145613271.41", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01145613271.41"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Collaborative Innovation Center for Complex and Severe Dermatosis, Anhui Medical University, 230032, Hefei, Anhui, China", 
              "id": "http://www.grid.ac/institutes/grid.186775.a", 
              "name": [
                "Institute of Dermatology, Department of Dermatology, The First Affiliated Hospital, Anhui Medical University, 230032, Hefei, Anhui, China", 
                "Key Laboratory of Dermatology, Ministry of Education, Anhui Medical University and State Key Laboratory of Dermatology Incubation, 230032, Hefei, Anhui, China", 
                "Key Lab of Gene Resource Utilization for Complex Diseases, 230032, Hefei, Anhui, China", 
                "Collaborative Innovation Center for Complex and Severe Dermatosis, Anhui Medical University, 230032, Hefei, Anhui, China"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Fan", 
            "givenName": "Xing", 
            "id": "sg:person.01335351245.33", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01335351245.33"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Collaborative Innovation Center for Complex and Severe Dermatosis, Anhui Medical University, 230032, Hefei, Anhui, China", 
              "id": "http://www.grid.ac/institutes/grid.186775.a", 
              "name": [
                "Institute of Dermatology, Department of Dermatology, The First Affiliated Hospital, Anhui Medical University, 230032, Hefei, Anhui, China", 
                "Key Laboratory of Dermatology, Ministry of Education, Anhui Medical University and State Key Laboratory of Dermatology Incubation, 230032, Hefei, Anhui, China", 
                "Key Lab of Gene Resource Utilization for Complex Diseases, 230032, Hefei, Anhui, China", 
                "Collaborative Innovation Center for Complex and Severe Dermatosis, Anhui Medical University, 230032, Hefei, Anhui, China"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Zhou", 
            "givenName": "Fusheng", 
            "id": "sg:person.01171662072.71", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01171662072.71"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Collaborative Innovation Center for Complex and Severe Dermatosis, Anhui Medical University, 230032, Hefei, Anhui, China", 
              "id": "http://www.grid.ac/institutes/grid.186775.a", 
              "name": [
                "Institute of Dermatology, Department of Dermatology, The First Affiliated Hospital, Anhui Medical University, 230032, Hefei, Anhui, China", 
                "Key Laboratory of Dermatology, Ministry of Education, Anhui Medical University and State Key Laboratory of Dermatology Incubation, 230032, Hefei, Anhui, China", 
                "Key Lab of Gene Resource Utilization for Complex Diseases, 230032, Hefei, Anhui, China", 
                "Collaborative Innovation Center for Complex and Severe Dermatosis, Anhui Medical University, 230032, Hefei, Anhui, China"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Jiang", 
            "givenName": "Long", 
            "id": "sg:person.01237775272.31", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01237775272.31"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Collaborative Innovation Center for Complex and Severe Dermatosis, Anhui Medical University, 230032, Hefei, Anhui, China", 
              "id": "http://www.grid.ac/institutes/grid.186775.a", 
              "name": [
                "Institute of Dermatology, Department of Dermatology, The First Affiliated Hospital, Anhui Medical University, 230032, Hefei, Anhui, China", 
                "Key Laboratory of Dermatology, Ministry of Education, Anhui Medical University and State Key Laboratory of Dermatology Incubation, 230032, Hefei, Anhui, China", 
                "Key Lab of Gene Resource Utilization for Complex Diseases, 230032, Hefei, Anhui, China", 
                "Collaborative Innovation Center for Complex and Severe Dermatosis, Anhui Medical University, 230032, Hefei, Anhui, China"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Tang", 
            "givenName": "Xianfa", 
            "id": "sg:person.01306110472.61", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01306110472.61"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Collaborative Innovation Center for Complex and Severe Dermatosis, Anhui Medical University, 230032, Hefei, Anhui, China", 
              "id": "http://www.grid.ac/institutes/grid.186775.a", 
              "name": [
                "Institute of Dermatology, Department of Dermatology, The First Affiliated Hospital, Anhui Medical University, 230032, Hefei, Anhui, China", 
                "Key Laboratory of Dermatology, Ministry of Education, Anhui Medical University and State Key Laboratory of Dermatology Incubation, 230032, Hefei, Anhui, China", 
                "Key Lab of Gene Resource Utilization for Complex Diseases, 230032, Hefei, Anhui, China", 
                "Collaborative Innovation Center for Complex and Severe Dermatosis, Anhui Medical University, 230032, Hefei, Anhui, China"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Chen", 
            "givenName": "Gang", 
            "id": "sg:person.012240006035.07", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012240006035.07"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Collaborative Innovation Center for Complex and Severe Dermatosis, Anhui Medical University, 230032, Hefei, Anhui, China", 
              "id": "http://www.grid.ac/institutes/grid.186775.a", 
              "name": [
                "Institute of Dermatology, Department of Dermatology, The First Affiliated Hospital, Anhui Medical University, 230032, Hefei, Anhui, China", 
                "Key Laboratory of Dermatology, Ministry of Education, Anhui Medical University and State Key Laboratory of Dermatology Incubation, 230032, Hefei, Anhui, China", 
                "Key Lab of Gene Resource Utilization for Complex Diseases, 230032, Hefei, Anhui, China", 
                "Collaborative Innovation Center for Complex and Severe Dermatosis, Anhui Medical University, 230032, Hefei, Anhui, China"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Zuo", 
            "givenName": "Xianbo", 
            "id": "sg:person.01120521532.18", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01120521532.18"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Collaborative Innovation Center for Complex and Severe Dermatosis, Anhui Medical University, 230032, Hefei, Anhui, China", 
              "id": "http://www.grid.ac/institutes/grid.186775.a", 
              "name": [
                "Institute of Dermatology, Department of Dermatology, The First Affiliated Hospital, Anhui Medical University, 230032, Hefei, Anhui, China", 
                "Key Laboratory of Dermatology, Ministry of Education, Anhui Medical University and State Key Laboratory of Dermatology Incubation, 230032, Hefei, Anhui, China", 
                "Key Lab of Gene Resource Utilization for Complex Diseases, 230032, Hefei, Anhui, China", 
                "Collaborative Innovation Center for Complex and Severe Dermatosis, Anhui Medical University, 230032, Hefei, Anhui, China"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Zheng", 
            "givenName": "Xiaodong", 
            "id": "sg:person.0676732772.96", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0676732772.96"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Collaborative Innovation Center for Complex and Severe Dermatosis, Anhui Medical University, 230032, Hefei, Anhui, China", 
              "id": "http://www.grid.ac/institutes/grid.186775.a", 
              "name": [
                "Institute of Dermatology, Department of Dermatology, The First Affiliated Hospital, Anhui Medical University, 230032, Hefei, Anhui, China", 
                "Key Laboratory of Dermatology, Ministry of Education, Anhui Medical University and State Key Laboratory of Dermatology Incubation, 230032, Hefei, Anhui, China", 
                "Key Lab of Gene Resource Utilization for Complex Diseases, 230032, Hefei, Anhui, China", 
                "Collaborative Innovation Center for Complex and Severe Dermatosis, Anhui Medical University, 230032, Hefei, Anhui, China"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Yang", 
            "givenName": "Sen", 
            "id": "sg:person.0745046172.70", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0745046172.70"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Collaborative Innovation Center for Complex and Severe Dermatosis, Anhui Medical University, 230032, Hefei, Anhui, China", 
              "id": "http://www.grid.ac/institutes/grid.186775.a", 
              "name": [
                "Institute of Dermatology, Department of Dermatology, The First Affiliated Hospital, Anhui Medical University, 230032, Hefei, Anhui, China", 
                "Key Laboratory of Dermatology, Ministry of Education, Anhui Medical University and State Key Laboratory of Dermatology Incubation, 230032, Hefei, Anhui, China", 
                "Key Lab of Gene Resource Utilization for Complex Diseases, 230032, Hefei, Anhui, China", 
                "Collaborative Innovation Center for Complex and Severe Dermatosis, Anhui Medical University, 230032, Hefei, Anhui, China"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Zhang", 
            "givenName": "Xuejun", 
            "id": "sg:person.01013161372.10", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01013161372.10"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "sg:pub.10.1038/ng.694", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023718631", 
              "https://doi.org/10.1038/ng.694"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature09534", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010608717", 
              "https://doi.org/10.1038/nature09534"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng.311", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032264135", 
              "https://doi.org/10.1038/ng.311"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng.689", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017620469", 
              "https://doi.org/10.1038/ng.689"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng.2467", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030050039", 
              "https://doi.org/10.1038/ng.2467"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng.690", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035342457", 
              "https://doi.org/10.1038/ng.690"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature08494", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005147626", 
              "https://doi.org/10.1038/nature08494"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng.2579", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020935195", 
              "https://doi.org/10.1038/ng.2579"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2014-01-14", 
        "datePublishedReg": "2014-01-14", 
        "description": "Psoriasis is a common immune-mediated inflammatory skin disease with strong genetic components, in which the IL23/Th17 pathway has been implicated. To explore the effective role in psoriasis, we genotyped five single nucleotide polymorphisms in genes related to IL23/Th17 pathway in 14,929 Han Chinese samples. A Bonferroni-corrected significant single-variant association was identified between rs1512970 within IL21 (odds ratio (OR)\u2009=\u20091.07, 95\u00a0% confidence interval (CI)\u2009=\u20091.02\u20131.13, P\u2009=\u20094.94\u2009\u00d7\u200910\u221203). We failed to validate rs744166 (OR\u2009=\u20091.06, 95\u00a0% CI\u2009=\u20091.01\u20131.11, P\u2009=\u20091.52\u2009\u00d7\u200910\u221202) and other three SNPs (P\u2009=\u20092.48\u2009\u00d7\u200910\u221201\u2009\u223c\u20091.27\u2009\u00d7\u200910\u221202) to meet the single-variant association significance threshold. However, we found that their combined effect substantially contributed to the risk of psoriasis in our sample (P\u2009=\u20093.91\u2009\u00d7\u200910\u221207) and the highest score group conferred the largest risk effect size (OR\u2009=\u20091.22, 95\u00a0% CI\u2009=\u20091.11\u20131.34, P\u2009=\u20091.85\u2009\u00d7\u200910\u221205). Our results implicate the ethnic heterogeneity in the susceptibility of psoriasis and suggest common variants with weak effect in IL23/Th17 pathway, which do not show significance in conventional single-variant association study, may contribute to the risk of psoriasis. This study sheds light on the important role of IL23/Th17 pathway in the susceptibility of psoriasis.", 
        "genre": "article", 
        "id": "sg:pub.10.1007/s00251-013-0756-z", 
        "isAccessibleForFree": false, 
        "isFundedItemOf": [
          {
            "id": "sg:grant.7191022", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.7178239", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.8331612", 
            "type": "MonetaryGrant"
          }
        ], 
        "isPartOf": [
          {
            "id": "sg:journal.1019755", 
            "issn": [
              "0093-7711", 
              "1432-1211"
            ], 
            "name": "Immunogenetics", 
            "publisher": "Springer Nature", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "3", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "66"
          }
        ], 
        "keywords": [
          "risk of psoriasis", 
          "susceptibility of psoriasis", 
          "immune-mediated inflammatory skin disease", 
          "common immune-mediated inflammatory skin disease", 
          "inflammatory skin disease", 
          "single nucleotide polymorphisms", 
          "high score group", 
          "risk effect size", 
          "nucleotide polymorphisms", 
          "psoriasis", 
          "IL23", 
          "score group", 
          "skin diseases", 
          "single-variant associations", 
          "strong genetic component", 
          "common variants", 
          "effect size", 
          "risk", 
          "Han Chinese samples", 
          "pathway", 
          "significance threshold", 
          "genetic component", 
          "association studies", 
          "polymorphism", 
          "IL21", 
          "susceptibility", 
          "disease", 
          "rs744166", 
          "important role", 
          "effect", 
          "study", 
          "association", 
          "role", 
          "weak effect", 
          "combined effect", 
          "Chinese sample", 
          "group", 
          "effective role", 
          "samples", 
          "significance", 
          "variants", 
          "genes", 
          "ethnic heterogeneity", 
          "SNPs", 
          "heterogeneity", 
          "threshold", 
          "results", 
          "components", 
          "size", 
          "light"
        ], 
        "name": "Combined effect of five single nucleotide polymorphisms related to IL23/Th17 pathway in the risk of psoriasis", 
        "pagination": "215-218", 
        "productId": [
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1007431074"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1007/s00251-013-0756-z"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "24419661"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1007/s00251-013-0756-z", 
          "https://app.dimensions.ai/details/publication/pub.1007431074"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2022-11-24T20:57", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-springernature-scigraph/baseset/20221124/entities/gbq_results/article/article_634.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://doi.org/10.1007/s00251-013-0756-z"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s00251-013-0756-z'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s00251-013-0756-z'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s00251-013-0756-z'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s00251-013-0756-z'


     

    This table displays all metadata directly associated to this object as RDF triples.

    281 TRIPLES      21 PREDICATES      96 URIs      80 LITERALS      20 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1007/s00251-013-0756-z schema:about N04154a1e993840adac66fd337fee1e55
    2 N122be8dea8324b32a39d250cfc079f10
    3 N219f8cac9d1d4496acc00d6ba19324b0
    4 N23447c36ec7842bc896173cba5e5c266
    5 N29841c5939b24e4bbd5ac97ceff46bec
    6 N2d949539bcdc402bb08b883bbd7f9c5b
    7 N326e85f269a54f6d9a5db8a8919413f6
    8 N5b405c48b0b040e8b06f9d16d75899ed
    9 N976b54496ad9439e9998a5f184c78994
    10 Nd1c3120eb6b24807a63583678f0de622
    11 Necea8514eeea4b31af9a25f738b66759
    12 Nefea86e1f1fe4749931c1ef7c5e97849
    13 Nf70776ab1c7d497f9b2ea16208864c03
    14 anzsrc-for:11
    15 anzsrc-for:1107
    16 schema:author Ncb4a336c409f42198f66a2f6ae93db41
    17 schema:citation sg:pub.10.1038/nature08494
    18 sg:pub.10.1038/nature09534
    19 sg:pub.10.1038/ng.2467
    20 sg:pub.10.1038/ng.2579
    21 sg:pub.10.1038/ng.311
    22 sg:pub.10.1038/ng.689
    23 sg:pub.10.1038/ng.690
    24 sg:pub.10.1038/ng.694
    25 schema:datePublished 2014-01-14
    26 schema:datePublishedReg 2014-01-14
    27 schema:description Psoriasis is a common immune-mediated inflammatory skin disease with strong genetic components, in which the IL23/Th17 pathway has been implicated. To explore the effective role in psoriasis, we genotyped five single nucleotide polymorphisms in genes related to IL23/Th17 pathway in 14,929 Han Chinese samples. A Bonferroni-corrected significant single-variant association was identified between rs1512970 within IL21 (odds ratio (OR) = 1.07, 95 % confidence interval (CI) = 1.02–1.13, P = 4.94 × 10−03). We failed to validate rs744166 (OR = 1.06, 95 % CI = 1.01–1.11, P = 1.52 × 10−02) and other three SNPs (P = 2.48 × 10−01 ∼ 1.27 × 10−02) to meet the single-variant association significance threshold. However, we found that their combined effect substantially contributed to the risk of psoriasis in our sample (P = 3.91 × 10−07) and the highest score group conferred the largest risk effect size (OR = 1.22, 95 % CI = 1.11–1.34, P = 1.85 × 10−05). Our results implicate the ethnic heterogeneity in the susceptibility of psoriasis and suggest common variants with weak effect in IL23/Th17 pathway, which do not show significance in conventional single-variant association study, may contribute to the risk of psoriasis. This study sheds light on the important role of IL23/Th17 pathway in the susceptibility of psoriasis.
    28 schema:genre article
    29 schema:isAccessibleForFree false
    30 schema:isPartOf Naec48e5097814d03bc6046a3d9592e74
    31 Nde0b2bb504b746839863dfb93df3f768
    32 sg:journal.1019755
    33 schema:keywords Chinese sample
    34 Han Chinese samples
    35 IL21
    36 IL23
    37 SNPs
    38 association
    39 association studies
    40 combined effect
    41 common immune-mediated inflammatory skin disease
    42 common variants
    43 components
    44 disease
    45 effect
    46 effect size
    47 effective role
    48 ethnic heterogeneity
    49 genes
    50 genetic component
    51 group
    52 heterogeneity
    53 high score group
    54 immune-mediated inflammatory skin disease
    55 important role
    56 inflammatory skin disease
    57 light
    58 nucleotide polymorphisms
    59 pathway
    60 polymorphism
    61 psoriasis
    62 results
    63 risk
    64 risk effect size
    65 risk of psoriasis
    66 role
    67 rs744166
    68 samples
    69 score group
    70 significance
    71 significance threshold
    72 single nucleotide polymorphisms
    73 single-variant associations
    74 size
    75 skin diseases
    76 strong genetic component
    77 study
    78 susceptibility
    79 susceptibility of psoriasis
    80 threshold
    81 variants
    82 weak effect
    83 schema:name Combined effect of five single nucleotide polymorphisms related to IL23/Th17 pathway in the risk of psoriasis
    84 schema:pagination 215-218
    85 schema:productId N13a7557c8e21476e9a182d199ebfa717
    86 N39fdfeafe4984a16a56ce576096021ad
    87 Naf871090de794f4d9ca0288cbb127c2c
    88 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007431074
    89 https://doi.org/10.1007/s00251-013-0756-z
    90 schema:sdDatePublished 2022-11-24T20:57
    91 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    92 schema:sdPublisher Na24412969b6c4546bb32e6c4b7c8cca8
    93 schema:url https://doi.org/10.1007/s00251-013-0756-z
    94 sgo:license sg:explorer/license/
    95 sgo:sdDataset articles
    96 rdf:type schema:ScholarlyArticle
    97 N04154a1e993840adac66fd337fee1e55 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    98 schema:name Odds Ratio
    99 rdf:type schema:DefinedTerm
    100 N122be8dea8324b32a39d250cfc079f10 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    101 schema:name Humans
    102 rdf:type schema:DefinedTerm
    103 N13a7557c8e21476e9a182d199ebfa717 schema:name pubmed_id
    104 schema:value 24419661
    105 rdf:type schema:PropertyValue
    106 N1627684c5e034de885663c986d22fcde rdf:first sg:person.01120521532.18
    107 rdf:rest N4acf1e2189734c19b31146a516424398
    108 N219f8cac9d1d4496acc00d6ba19324b0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    109 schema:name Risk
    110 rdf:type schema:DefinedTerm
    111 N23447c36ec7842bc896173cba5e5c266 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    112 schema:name Genetic Predisposition to Disease
    113 rdf:type schema:DefinedTerm
    114 N29841c5939b24e4bbd5ac97ceff46bec schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    115 schema:name Signal Transduction
    116 rdf:type schema:DefinedTerm
    117 N2d949539bcdc402bb08b883bbd7f9c5b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    118 schema:name Interleukin-23
    119 rdf:type schema:DefinedTerm
    120 N326e85f269a54f6d9a5db8a8919413f6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    121 schema:name Th17 Cells
    122 rdf:type schema:DefinedTerm
    123 N39fdfeafe4984a16a56ce576096021ad schema:name doi
    124 schema:value 10.1007/s00251-013-0756-z
    125 rdf:type schema:PropertyValue
    126 N4acf1e2189734c19b31146a516424398 rdf:first sg:person.0676732772.96
    127 rdf:rest N4ccfbc79df9540f6a11857b0f2116b0d
    128 N4ccfbc79df9540f6a11857b0f2116b0d rdf:first sg:person.0745046172.70
    129 rdf:rest N52f0dcb5202b45d0a2c5f27c9f4ce445
    130 N52f0dcb5202b45d0a2c5f27c9f4ce445 rdf:first sg:person.01013161372.10
    131 rdf:rest rdf:nil
    132 N5b405c48b0b040e8b06f9d16d75899ed schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    133 schema:name Polymorphism, Single Nucleotide
    134 rdf:type schema:DefinedTerm
    135 N699d953648844948a1908046db4d0c33 rdf:first sg:person.01237775272.31
    136 rdf:rest Nd067aba4db4e4869bb21f53715d1e8bf
    137 N7e7de691f98843668411ae00a2630415 rdf:first sg:person.01145613271.41
    138 rdf:rest Nd9b0a6f5e6914c2d98c400b546e9d1ca
    139 N81088223901f45bd882d7e7ecd1b79c4 rdf:first sg:person.012240006035.07
    140 rdf:rest N1627684c5e034de885663c986d22fcde
    141 N82859e9c9f17420384d888c728436906 rdf:first sg:person.01171662072.71
    142 rdf:rest N699d953648844948a1908046db4d0c33
    143 N88434eff817444d595181e8508320528 rdf:first sg:person.01007320272.22
    144 rdf:rest N7e7de691f98843668411ae00a2630415
    145 N976b54496ad9439e9998a5f184c78994 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    146 schema:name Case-Control Studies
    147 rdf:type schema:DefinedTerm
    148 Na24412969b6c4546bb32e6c4b7c8cca8 schema:name Springer Nature - SN SciGraph project
    149 rdf:type schema:Organization
    150 Naec48e5097814d03bc6046a3d9592e74 schema:volumeNumber 66
    151 rdf:type schema:PublicationVolume
    152 Naf871090de794f4d9ca0288cbb127c2c schema:name dimensions_id
    153 schema:value pub.1007431074
    154 rdf:type schema:PropertyValue
    155 Ncb4a336c409f42198f66a2f6ae93db41 rdf:first sg:person.0741205072.53
    156 rdf:rest N88434eff817444d595181e8508320528
    157 Nd067aba4db4e4869bb21f53715d1e8bf rdf:first sg:person.01306110472.61
    158 rdf:rest N81088223901f45bd882d7e7ecd1b79c4
    159 Nd1c3120eb6b24807a63583678f0de622 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    160 schema:name Male
    161 rdf:type schema:DefinedTerm
    162 Nd9b0a6f5e6914c2d98c400b546e9d1ca rdf:first sg:person.01335351245.33
    163 rdf:rest N82859e9c9f17420384d888c728436906
    164 Nde0b2bb504b746839863dfb93df3f768 schema:issueNumber 3
    165 rdf:type schema:PublicationIssue
    166 Necea8514eeea4b31af9a25f738b66759 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    167 schema:name Female
    168 rdf:type schema:DefinedTerm
    169 Nefea86e1f1fe4749931c1ef7c5e97849 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    170 schema:name Psoriasis
    171 rdf:type schema:DefinedTerm
    172 Nf70776ab1c7d497f9b2ea16208864c03 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    173 schema:name Alleles
    174 rdf:type schema:DefinedTerm
    175 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
    176 schema:name Medical and Health Sciences
    177 rdf:type schema:DefinedTerm
    178 anzsrc-for:1107 schema:inDefinedTermSet anzsrc-for:
    179 schema:name Immunology
    180 rdf:type schema:DefinedTerm
    181 sg:grant.7178239 http://pending.schema.org/fundedItem sg:pub.10.1007/s00251-013-0756-z
    182 rdf:type schema:MonetaryGrant
    183 sg:grant.7191022 http://pending.schema.org/fundedItem sg:pub.10.1007/s00251-013-0756-z
    184 rdf:type schema:MonetaryGrant
    185 sg:grant.8331612 http://pending.schema.org/fundedItem sg:pub.10.1007/s00251-013-0756-z
    186 rdf:type schema:MonetaryGrant
    187 sg:journal.1019755 schema:issn 0093-7711
    188 1432-1211
    189 schema:name Immunogenetics
    190 schema:publisher Springer Nature
    191 rdf:type schema:Periodical
    192 sg:person.01007320272.22 schema:affiliation grid-institutes:grid.186775.a
    193 schema:familyName Cheng
    194 schema:givenName Hui
    195 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01007320272.22
    196 rdf:type schema:Person
    197 sg:person.01013161372.10 schema:affiliation grid-institutes:grid.186775.a
    198 schema:familyName Zhang
    199 schema:givenName Xuejun
    200 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01013161372.10
    201 rdf:type schema:Person
    202 sg:person.01120521532.18 schema:affiliation grid-institutes:grid.186775.a
    203 schema:familyName Zuo
    204 schema:givenName Xianbo
    205 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01120521532.18
    206 rdf:type schema:Person
    207 sg:person.01145613271.41 schema:affiliation grid-institutes:grid.186775.a
    208 schema:familyName Zhang
    209 schema:givenName Ran
    210 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01145613271.41
    211 rdf:type schema:Person
    212 sg:person.01171662072.71 schema:affiliation grid-institutes:grid.186775.a
    213 schema:familyName Zhou
    214 schema:givenName Fusheng
    215 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01171662072.71
    216 rdf:type schema:Person
    217 sg:person.012240006035.07 schema:affiliation grid-institutes:grid.186775.a
    218 schema:familyName Chen
    219 schema:givenName Gang
    220 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012240006035.07
    221 rdf:type schema:Person
    222 sg:person.01237775272.31 schema:affiliation grid-institutes:grid.186775.a
    223 schema:familyName Jiang
    224 schema:givenName Long
    225 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01237775272.31
    226 rdf:type schema:Person
    227 sg:person.01306110472.61 schema:affiliation grid-institutes:grid.186775.a
    228 schema:familyName Tang
    229 schema:givenName Xianfa
    230 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01306110472.61
    231 rdf:type schema:Person
    232 sg:person.01335351245.33 schema:affiliation grid-institutes:grid.186775.a
    233 schema:familyName Fan
    234 schema:givenName Xing
    235 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01335351245.33
    236 rdf:type schema:Person
    237 sg:person.0676732772.96 schema:affiliation grid-institutes:grid.186775.a
    238 schema:familyName Zheng
    239 schema:givenName Xiaodong
    240 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0676732772.96
    241 rdf:type schema:Person
    242 sg:person.0741205072.53 schema:affiliation grid-institutes:grid.186775.a
    243 schema:familyName Yin
    244 schema:givenName Xianyong
    245 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0741205072.53
    246 rdf:type schema:Person
    247 sg:person.0745046172.70 schema:affiliation grid-institutes:grid.186775.a
    248 schema:familyName Yang
    249 schema:givenName Sen
    250 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0745046172.70
    251 rdf:type schema:Person
    252 sg:pub.10.1038/nature08494 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005147626
    253 https://doi.org/10.1038/nature08494
    254 rdf:type schema:CreativeWork
    255 sg:pub.10.1038/nature09534 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010608717
    256 https://doi.org/10.1038/nature09534
    257 rdf:type schema:CreativeWork
    258 sg:pub.10.1038/ng.2467 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030050039
    259 https://doi.org/10.1038/ng.2467
    260 rdf:type schema:CreativeWork
    261 sg:pub.10.1038/ng.2579 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020935195
    262 https://doi.org/10.1038/ng.2579
    263 rdf:type schema:CreativeWork
    264 sg:pub.10.1038/ng.311 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032264135
    265 https://doi.org/10.1038/ng.311
    266 rdf:type schema:CreativeWork
    267 sg:pub.10.1038/ng.689 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017620469
    268 https://doi.org/10.1038/ng.689
    269 rdf:type schema:CreativeWork
    270 sg:pub.10.1038/ng.690 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035342457
    271 https://doi.org/10.1038/ng.690
    272 rdf:type schema:CreativeWork
    273 sg:pub.10.1038/ng.694 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023718631
    274 https://doi.org/10.1038/ng.694
    275 rdf:type schema:CreativeWork
    276 grid-institutes:grid.186775.a schema:alternateName Collaborative Innovation Center for Complex and Severe Dermatosis, Anhui Medical University, 230032, Hefei, Anhui, China
    277 schema:name Collaborative Innovation Center for Complex and Severe Dermatosis, Anhui Medical University, 230032, Hefei, Anhui, China
    278 Institute of Dermatology, Department of Dermatology, The First Affiliated Hospital, Anhui Medical University, 230032, Hefei, Anhui, China
    279 Key Lab of Gene Resource Utilization for Complex Diseases, 230032, Hefei, Anhui, China
    280 Key Laboratory of Dermatology, Ministry of Education, Anhui Medical University and State Key Laboratory of Dermatology Incubation, 230032, Hefei, Anhui, China
    281 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...