Combined effect of five single nucleotide polymorphisms related to IL23/Th17 pathway in the risk of psoriasis View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2014-01-14

AUTHORS

Xianyong Yin, Hui Cheng, Ran Zhang, Xing Fan, Fusheng Zhou, Long Jiang, Xianfa Tang, Gang Chen, Xianbo Zuo, Xiaodong Zheng, Sen Yang, Xuejun Zhang

ABSTRACT

Psoriasis is a common immune-mediated inflammatory skin disease with strong genetic components, in which the IL23/Th17 pathway has been implicated. To explore the effective role in psoriasis, we genotyped five single nucleotide polymorphisms in genes related to IL23/Th17 pathway in 14,929 Han Chinese samples. A Bonferroni-corrected significant single-variant association was identified between rs1512970 within IL21 (odds ratio (OR) = 1.07, 95 % confidence interval (CI) = 1.02–1.13, P = 4.94 × 10−03). We failed to validate rs744166 (OR = 1.06, 95 % CI = 1.01–1.11, P = 1.52 × 10−02) and other three SNPs (P = 2.48 × 10−01 ∼ 1.27 × 10−02) to meet the single-variant association significance threshold. However, we found that their combined effect substantially contributed to the risk of psoriasis in our sample (P = 3.91 × 10−07) and the highest score group conferred the largest risk effect size (OR = 1.22, 95 % CI = 1.11–1.34, P = 1.85 × 10−05). Our results implicate the ethnic heterogeneity in the susceptibility of psoriasis and suggest common variants with weak effect in IL23/Th17 pathway, which do not show significance in conventional single-variant association study, may contribute to the risk of psoriasis. This study sheds light on the important role of IL23/Th17 pathway in the susceptibility of psoriasis. More... »

PAGES

215-218

Journal

TITLE

Immunogenetics

ISSUE

3

VOLUME

66

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s00251-013-0756-z

    DOI

    http://dx.doi.org/10.1007/s00251-013-0756-z

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1007431074

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/24419661


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        "description": "Psoriasis is a common immune-mediated inflammatory skin disease with strong genetic components, in which the IL23/Th17 pathway has been implicated. To explore the effective role in psoriasis, we genotyped five single nucleotide polymorphisms in genes related to IL23/Th17 pathway in 14,929 Han Chinese samples. A Bonferroni-corrected significant single-variant association was identified between rs1512970 within IL21 (odds ratio (OR)\u2009=\u20091.07, 95\u00a0% confidence interval (CI)\u2009=\u20091.02\u20131.13, P\u2009=\u20094.94\u2009\u00d7\u200910\u221203). We failed to validate rs744166 (OR\u2009=\u20091.06, 95\u00a0% CI\u2009=\u20091.01\u20131.11, P\u2009=\u20091.52\u2009\u00d7\u200910\u221202) and other three SNPs (P\u2009=\u20092.48\u2009\u00d7\u200910\u221201\u2009\u223c\u20091.27\u2009\u00d7\u200910\u221202) to meet the single-variant association significance threshold. However, we found that their combined effect substantially contributed to the risk of psoriasis in our sample (P\u2009=\u20093.91\u2009\u00d7\u200910\u221207) and the highest score group conferred the largest risk effect size (OR\u2009=\u20091.22, 95\u00a0% CI\u2009=\u20091.11\u20131.34, P\u2009=\u20091.85\u2009\u00d7\u200910\u221205). Our results implicate the ethnic heterogeneity in the susceptibility of psoriasis and suggest common variants with weak effect in IL23/Th17 pathway, which do not show significance in conventional single-variant association study, may contribute to the risk of psoriasis. This study sheds light on the important role of IL23/Th17 pathway in the susceptibility of psoriasis.", 
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