Evolution of the porcine (Sus scrofa domestica) immunoglobulin kappa locus through germline gene conversion View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2012-04

AUTHORS

John C. Schwartz, Marie-Paule Lefranc, Michael P. Murtaugh

ABSTRACT

Immunoglobulin (IG) gene rearrangement and expression are central to disease resistance and health maintenance in animals. The IG kappa (IGK) locus in swine (Sus scrofa domestica) contributes to approximately half of all antibody molecules, in contrast to many other Cetartiodactyla, whose members provide the majority of human dietary protein and in which kappa locus utilization is limited. The porcine IGK variable locus is 27.9 kb upstream of five IG kappa J genes (IGKJ) which are separated from a single constant gene (IGKC) by 2.8 kb. Fourteen variable genes (IGKV) were identified, of which nine are functional and two are open reading frame (ORF). Of the three pseudogenes, IGKV3-1 contains a frameshift and multiple stop codons, IGKV7-2 contains multiple stop codons, and IGKV2-5 is missing exon 2. The nine functional IGKV genes are phylogenetically related to either the human IGKV1 or IGKV2 subgroups. IGKV2 subgroup genes were found to be dominantly expressed. Polymorphisms were identified on overlapping BACs derived from the same individual such that 11 genes contain amino acid differences. The most striking allelic differences are present in IGKV2 genes, which contain as many as 16 amino acid changes between alleles, the majority of which are in complementarity determining region (CDR) 1. In addition, many IGKV2 CDR1 are shared between genes but not between alleles, suggesting extensive diversification of this locus through gene conversion. More... »

PAGES

303-311

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00251-011-0589-6

DOI

http://dx.doi.org/10.1007/s00251-011-0589-6

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1005405944

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/22109540


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0604", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Genetics", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Alleles", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Amino Acid Sequence", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Base Sequence", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Evolution, Molecular", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Gene Conversion", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Genetic Variation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Germ Cells", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Immunoglobulin kappa-Chains", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Molecular Sequence Data", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Open Reading Frames", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Phylogeny", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Polymorphism, Genetic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Pseudogenes", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Sequence Analysis, DNA", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Sequence Homology, Amino Acid", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Sequence Homology, Nucleic Acid", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Sus scrofa", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Transcription, Genetic", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "University of Minnesota", 
          "id": "https://www.grid.ac/institutes/grid.17635.36", 
          "name": [
            "Department of Veterinary and Biomedical Sciences, University of Minnesota, 1971 Commonwealth Avenue, 55108, St. Paul, MN, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Schwartz", 
        "givenName": "John C.", 
        "id": "sg:person.01341766273.44", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01341766273.44"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Montpellier", 
          "id": "https://www.grid.ac/institutes/grid.121334.6", 
          "name": [
            "IMGT\u00ae, the international ImMunoGeneTics information system\u00ae, Laboratoire d\u2019ImmunoG\u00e9n\u00e9tique Mol\u00e9culaire and Institut de G\u00e9n\u00e9tique Humaine, Universit\u00e9 Montpellier, 34396, Montpellier, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lefranc", 
        "givenName": "Marie-Paule", 
        "id": "sg:person.01303425741.42", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01303425741.42"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Minnesota", 
          "id": "https://www.grid.ac/institutes/grid.17635.36", 
          "name": [
            "Department of Veterinary and Biomedical Sciences, University of Minnesota, 1971 Commonwealth Avenue, 55108, St. Paul, MN, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Murtaugh", 
        "givenName": "Michael P.", 
        "id": "sg:person.012320047420.13", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012320047420.13"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1002/cfg.479", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005224607"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/cfg.479", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005224607"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0092-8674(95)90116-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007844187"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/nar/gki010", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008895081"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.78.11.7064", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010187418"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.molimm.2009.05.180", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010881530"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/gr.089532.108", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011404279"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0022-2836(05)80360-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013618994"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/bioinformatics/16.10.944", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014452632"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/gb-2007-8-4-r45", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016174151", 
          "https://doi.org/10.1186/gb-2007-8-4-r45"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0092-8674(80)90168-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016442666"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.dci.2005.06.025", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016837104"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.dci.2005.06.025", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016837104"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/nar/11.24.8877", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018325135"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.vetimm.2005.07.016", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019230326"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.vetimm.2005.07.016", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019230326"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/nar/22.10.1785", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021561060"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0145-305x(02)00039-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023004273"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/gb-2007-8-7-r139", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024205457", 
          "https://doi.org/10.1186/gb-2007-8-7-r139"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3390/genes2010048", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024448967"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0092-8674(84)90348-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027515082"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s003359900512", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028055123", 
          "https://doi.org/10.1007/s003359900512"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/nar/30.1.38", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030186249"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.dci.2004.07.003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033745882"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.dci.2007.09.008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034340934"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.vetimm.2009.12.012", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034785823"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1084/jem.132.2.211", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035555693"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/316260a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042306472", 
          "https://doi.org/10.1038/316260a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0092-8674(83)90508-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042476831"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00251-007-0260-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045218837", 
          "https://doi.org/10.1007/s00251-007-0260-4"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00251-007-0260-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045218837", 
          "https://doi.org/10.1007/s00251-007-0260-4"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf02421328", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045858622", 
          "https://doi.org/10.1007/bf02421328"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf02421328", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045858622", 
          "https://doi.org/10.1007/bf02421328"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0161-5890(91)90051-k", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047017513"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0161-5890(91)90051-k", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047017513"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/1521-4141(200104)31:4<1017::aid-immu1017>3.0.co;2-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047738611"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/1521-4141(200104)31:4<1017::aid-immu1017>3.0.co;2-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047738611"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/nar/gkn838", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049641848"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1471-2105-8-460", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050692349", 
          "https://doi.org/10.1186/1471-2105-8-460"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1471-2172-10-22", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051269520", 
          "https://doi.org/10.1186/1471-2172-10-22"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/gr.074492.107", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051720574"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0014-5793(86)80221-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052322104"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1471-2164-11-438", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052501364", 
          "https://doi.org/10.1186/1471-2164-11-438"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074698373", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4049/jimmunol.173.11.6794", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1076969450"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4049/jimmunol.177.8.5459", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1077303891"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4049/jimmunol.0903616", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1078057366"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/j.1460-2075.1983.tb01693.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1081732936"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2012-04", 
    "datePublishedReg": "2012-04-01", 
    "description": "Immunoglobulin (IG) gene rearrangement and expression are central to disease resistance and health maintenance in animals. The IG kappa (IGK) locus in swine (Sus scrofa domestica) contributes to approximately half of all antibody molecules, in contrast to many other Cetartiodactyla, whose members provide the majority of human dietary protein and in which kappa locus utilization is limited. The porcine IGK variable locus is 27.9 kb upstream of five IG kappa J genes (IGKJ) which are separated from a single constant gene (IGKC) by 2.8 kb. Fourteen variable genes (IGKV) were identified, of which nine are functional and two are open reading frame (ORF). Of the three pseudogenes, IGKV3-1 contains a frameshift and multiple stop codons, IGKV7-2 contains multiple stop codons, and IGKV2-5 is missing exon 2. The nine functional IGKV genes are phylogenetically related to either the human IGKV1 or IGKV2 subgroups. IGKV2 subgroup genes were found to be dominantly expressed. Polymorphisms were identified on overlapping BACs derived from the same individual such that 11 genes contain amino acid differences. The most striking allelic differences are present in IGKV2 genes, which contain as many as 16 amino acid changes between alleles, the majority of which are in complementarity determining region (CDR) 1. In addition, many IGKV2 CDR1 are shared between genes but not between alleles, suggesting extensive diversification of this locus through gene conversion.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/s00251-011-0589-6", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.2682056", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1019755", 
        "issn": [
          "0093-7711", 
          "1432-1211"
        ], 
        "name": "Immunogenetics", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "4", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "64"
      }
    ], 
    "name": "Evolution of the porcine (Sus scrofa domestica) immunoglobulin kappa locus through germline gene conversion", 
    "pagination": "303-311", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "19c19c25679005507c98e16e64323e4e16e1f36384d8ccab5e40835874b4fd02"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "22109540"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "0420404"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s00251-011-0589-6"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1005405944"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s00251-011-0589-6", 
      "https://app.dimensions.ai/details/publication/pub.1005405944"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T22:24", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8690_00000480.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1007/s00251-011-0589-6"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s00251-011-0589-6'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s00251-011-0589-6'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s00251-011-0589-6'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s00251-011-0589-6'


 

This table displays all metadata directly associated to this object as RDF triples.

299 TRIPLES      21 PREDICATES      90 URIs      41 LITERALS      29 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s00251-011-0589-6 schema:about N02490464a44a4d5283ca28a2071fbcb8
2 N1e96b002c8dd45a38e4ec27f259332ff
3 N3407ec74c31e43d2a59aec699af0bc08
4 N381138739eb14d00bf15d4627b4ee5c2
5 N3ce0bbab69ab420485cc6d32c32d0c81
6 N3fc6ef0c5e7c40c5b0673e20a774b1ea
7 N41d49b310e00410297d9ae2ca319ea00
8 N437238c4c4b349d7b1320a2861c62543
9 N45ffd7a0b6944de3bfddbd5d246ad357
10 N5502935d7c7048b6befbc022f915373d
11 N68ce4736550a4dc4a8a5be038040adab
12 N6bcbf033f2494a16b408eadb69f6bffc
13 N84ab117b0bb841a4b4188a885cd17a8f
14 N896866e747814b158fb56ace464a7601
15 N8c0010fc80a44bd8b03052f9301966d4
16 Nb5b092dae22f488b9e44b925893d408e
17 Nc24714bf03d24b0881aa7c68d1151763
18 Ned551cc39f9e4d9a87fcbe794c10d080
19 Nf93b8838a6cb44159f6ed6f463a4b47d
20 Nfa06653263f84cdca58f43952ff06aed
21 anzsrc-for:06
22 anzsrc-for:0604
23 schema:author N3f7982124958439a8044c083c386af31
24 schema:citation sg:pub.10.1007/bf02421328
25 sg:pub.10.1007/s00251-007-0260-4
26 sg:pub.10.1007/s003359900512
27 sg:pub.10.1038/316260a0
28 sg:pub.10.1186/1471-2105-8-460
29 sg:pub.10.1186/1471-2164-11-438
30 sg:pub.10.1186/1471-2172-10-22
31 sg:pub.10.1186/gb-2007-8-4-r45
32 sg:pub.10.1186/gb-2007-8-7-r139
33 https://app.dimensions.ai/details/publication/pub.1074698373
34 https://doi.org/10.1002/1521-4141(200104)31:4<1017::aid-immu1017>3.0.co;2-3
35 https://doi.org/10.1002/cfg.479
36 https://doi.org/10.1002/j.1460-2075.1983.tb01693.x
37 https://doi.org/10.1016/0014-5793(86)80221-6
38 https://doi.org/10.1016/0092-8674(80)90168-3
39 https://doi.org/10.1016/0092-8674(83)90508-1
40 https://doi.org/10.1016/0092-8674(84)90348-9
41 https://doi.org/10.1016/0092-8674(95)90116-7
42 https://doi.org/10.1016/0161-5890(91)90051-k
43 https://doi.org/10.1016/j.dci.2004.07.003
44 https://doi.org/10.1016/j.dci.2005.06.025
45 https://doi.org/10.1016/j.dci.2007.09.008
46 https://doi.org/10.1016/j.molimm.2009.05.180
47 https://doi.org/10.1016/j.vetimm.2005.07.016
48 https://doi.org/10.1016/j.vetimm.2009.12.012
49 https://doi.org/10.1016/s0022-2836(05)80360-2
50 https://doi.org/10.1016/s0145-305x(02)00039-3
51 https://doi.org/10.1073/pnas.78.11.7064
52 https://doi.org/10.1084/jem.132.2.211
53 https://doi.org/10.1093/bioinformatics/16.10.944
54 https://doi.org/10.1093/nar/11.24.8877
55 https://doi.org/10.1093/nar/22.10.1785
56 https://doi.org/10.1093/nar/30.1.38
57 https://doi.org/10.1093/nar/gki010
58 https://doi.org/10.1093/nar/gkn838
59 https://doi.org/10.1101/gr.074492.107
60 https://doi.org/10.1101/gr.089532.108
61 https://doi.org/10.3390/genes2010048
62 https://doi.org/10.4049/jimmunol.0903616
63 https://doi.org/10.4049/jimmunol.173.11.6794
64 https://doi.org/10.4049/jimmunol.177.8.5459
65 schema:datePublished 2012-04
66 schema:datePublishedReg 2012-04-01
67 schema:description Immunoglobulin (IG) gene rearrangement and expression are central to disease resistance and health maintenance in animals. The IG kappa (IGK) locus in swine (Sus scrofa domestica) contributes to approximately half of all antibody molecules, in contrast to many other Cetartiodactyla, whose members provide the majority of human dietary protein and in which kappa locus utilization is limited. The porcine IGK variable locus is 27.9 kb upstream of five IG kappa J genes (IGKJ) which are separated from a single constant gene (IGKC) by 2.8 kb. Fourteen variable genes (IGKV) were identified, of which nine are functional and two are open reading frame (ORF). Of the three pseudogenes, IGKV3-1 contains a frameshift and multiple stop codons, IGKV7-2 contains multiple stop codons, and IGKV2-5 is missing exon 2. The nine functional IGKV genes are phylogenetically related to either the human IGKV1 or IGKV2 subgroups. IGKV2 subgroup genes were found to be dominantly expressed. Polymorphisms were identified on overlapping BACs derived from the same individual such that 11 genes contain amino acid differences. The most striking allelic differences are present in IGKV2 genes, which contain as many as 16 amino acid changes between alleles, the majority of which are in complementarity determining region (CDR) 1. In addition, many IGKV2 CDR1 are shared between genes but not between alleles, suggesting extensive diversification of this locus through gene conversion.
68 schema:genre research_article
69 schema:inLanguage en
70 schema:isAccessibleForFree true
71 schema:isPartOf N16e862504b2d4beabc48ee8b7673124a
72 Nd224807233d44f2bac5e8e8df0136fe6
73 sg:journal.1019755
74 schema:name Evolution of the porcine (Sus scrofa domestica) immunoglobulin kappa locus through germline gene conversion
75 schema:pagination 303-311
76 schema:productId N090affa3754741a688791199b8534639
77 N26a462c4df434f22bddb9cf7ea5b3700
78 N3774555b8d0a4c23a9699293f379f8e8
79 Nab152842de5c43d181f5a70a2c51ef90
80 Nefd91ec7cfe04547bfc851a704a0f907
81 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005405944
82 https://doi.org/10.1007/s00251-011-0589-6
83 schema:sdDatePublished 2019-04-10T22:24
84 schema:sdLicense https://scigraph.springernature.com/explorer/license/
85 schema:sdPublisher N7d3e186ceef4462aa1c9b0209fb47ce9
86 schema:url http://link.springer.com/10.1007/s00251-011-0589-6
87 sgo:license sg:explorer/license/
88 sgo:sdDataset articles
89 rdf:type schema:ScholarlyArticle
90 N02490464a44a4d5283ca28a2071fbcb8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
91 schema:name Gene Conversion
92 rdf:type schema:DefinedTerm
93 N090affa3754741a688791199b8534639 schema:name dimensions_id
94 schema:value pub.1005405944
95 rdf:type schema:PropertyValue
96 N16e862504b2d4beabc48ee8b7673124a schema:issueNumber 4
97 rdf:type schema:PublicationIssue
98 N1e96b002c8dd45a38e4ec27f259332ff schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
99 schema:name Genetic Variation
100 rdf:type schema:DefinedTerm
101 N26a462c4df434f22bddb9cf7ea5b3700 schema:name doi
102 schema:value 10.1007/s00251-011-0589-6
103 rdf:type schema:PropertyValue
104 N3407ec74c31e43d2a59aec699af0bc08 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
105 schema:name Base Sequence
106 rdf:type schema:DefinedTerm
107 N3774555b8d0a4c23a9699293f379f8e8 schema:name pubmed_id
108 schema:value 22109540
109 rdf:type schema:PropertyValue
110 N381138739eb14d00bf15d4627b4ee5c2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
111 schema:name Pseudogenes
112 rdf:type schema:DefinedTerm
113 N3ce0bbab69ab420485cc6d32c32d0c81 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
114 schema:name Transcription, Genetic
115 rdf:type schema:DefinedTerm
116 N3f7982124958439a8044c083c386af31 rdf:first sg:person.01341766273.44
117 rdf:rest N430d891d3f37415784d9484d2c60ed61
118 N3fc6ef0c5e7c40c5b0673e20a774b1ea schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
119 schema:name Animals
120 rdf:type schema:DefinedTerm
121 N41d49b310e00410297d9ae2ca319ea00 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
122 schema:name Open Reading Frames
123 rdf:type schema:DefinedTerm
124 N430d891d3f37415784d9484d2c60ed61 rdf:first sg:person.01303425741.42
125 rdf:rest N471e2b8c9d1d4aa08400f2bd0b2db41a
126 N437238c4c4b349d7b1320a2861c62543 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
127 schema:name Sequence Homology, Amino Acid
128 rdf:type schema:DefinedTerm
129 N45ffd7a0b6944de3bfddbd5d246ad357 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
130 schema:name Immunoglobulin kappa-Chains
131 rdf:type schema:DefinedTerm
132 N471e2b8c9d1d4aa08400f2bd0b2db41a rdf:first sg:person.012320047420.13
133 rdf:rest rdf:nil
134 N5502935d7c7048b6befbc022f915373d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
135 schema:name Amino Acid Sequence
136 rdf:type schema:DefinedTerm
137 N68ce4736550a4dc4a8a5be038040adab schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
138 schema:name Evolution, Molecular
139 rdf:type schema:DefinedTerm
140 N6bcbf033f2494a16b408eadb69f6bffc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
141 schema:name Sequence Analysis, DNA
142 rdf:type schema:DefinedTerm
143 N7d3e186ceef4462aa1c9b0209fb47ce9 schema:name Springer Nature - SN SciGraph project
144 rdf:type schema:Organization
145 N84ab117b0bb841a4b4188a885cd17a8f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
146 schema:name Molecular Sequence Data
147 rdf:type schema:DefinedTerm
148 N896866e747814b158fb56ace464a7601 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
149 schema:name Germ Cells
150 rdf:type schema:DefinedTerm
151 N8c0010fc80a44bd8b03052f9301966d4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
152 schema:name Polymorphism, Genetic
153 rdf:type schema:DefinedTerm
154 Nab152842de5c43d181f5a70a2c51ef90 schema:name readcube_id
155 schema:value 19c19c25679005507c98e16e64323e4e16e1f36384d8ccab5e40835874b4fd02
156 rdf:type schema:PropertyValue
157 Nb5b092dae22f488b9e44b925893d408e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
158 schema:name Phylogeny
159 rdf:type schema:DefinedTerm
160 Nc24714bf03d24b0881aa7c68d1151763 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
161 schema:name Sus scrofa
162 rdf:type schema:DefinedTerm
163 Nd224807233d44f2bac5e8e8df0136fe6 schema:volumeNumber 64
164 rdf:type schema:PublicationVolume
165 Ned551cc39f9e4d9a87fcbe794c10d080 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
166 schema:name Humans
167 rdf:type schema:DefinedTerm
168 Nefd91ec7cfe04547bfc851a704a0f907 schema:name nlm_unique_id
169 schema:value 0420404
170 rdf:type schema:PropertyValue
171 Nf93b8838a6cb44159f6ed6f463a4b47d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
172 schema:name Alleles
173 rdf:type schema:DefinedTerm
174 Nfa06653263f84cdca58f43952ff06aed schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
175 schema:name Sequence Homology, Nucleic Acid
176 rdf:type schema:DefinedTerm
177 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
178 schema:name Biological Sciences
179 rdf:type schema:DefinedTerm
180 anzsrc-for:0604 schema:inDefinedTermSet anzsrc-for:
181 schema:name Genetics
182 rdf:type schema:DefinedTerm
183 sg:grant.2682056 http://pending.schema.org/fundedItem sg:pub.10.1007/s00251-011-0589-6
184 rdf:type schema:MonetaryGrant
185 sg:journal.1019755 schema:issn 0093-7711
186 1432-1211
187 schema:name Immunogenetics
188 rdf:type schema:Periodical
189 sg:person.012320047420.13 schema:affiliation https://www.grid.ac/institutes/grid.17635.36
190 schema:familyName Murtaugh
191 schema:givenName Michael P.
192 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012320047420.13
193 rdf:type schema:Person
194 sg:person.01303425741.42 schema:affiliation https://www.grid.ac/institutes/grid.121334.6
195 schema:familyName Lefranc
196 schema:givenName Marie-Paule
197 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01303425741.42
198 rdf:type schema:Person
199 sg:person.01341766273.44 schema:affiliation https://www.grid.ac/institutes/grid.17635.36
200 schema:familyName Schwartz
201 schema:givenName John C.
202 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01341766273.44
203 rdf:type schema:Person
204 sg:pub.10.1007/bf02421328 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045858622
205 https://doi.org/10.1007/bf02421328
206 rdf:type schema:CreativeWork
207 sg:pub.10.1007/s00251-007-0260-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045218837
208 https://doi.org/10.1007/s00251-007-0260-4
209 rdf:type schema:CreativeWork
210 sg:pub.10.1007/s003359900512 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028055123
211 https://doi.org/10.1007/s003359900512
212 rdf:type schema:CreativeWork
213 sg:pub.10.1038/316260a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042306472
214 https://doi.org/10.1038/316260a0
215 rdf:type schema:CreativeWork
216 sg:pub.10.1186/1471-2105-8-460 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050692349
217 https://doi.org/10.1186/1471-2105-8-460
218 rdf:type schema:CreativeWork
219 sg:pub.10.1186/1471-2164-11-438 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052501364
220 https://doi.org/10.1186/1471-2164-11-438
221 rdf:type schema:CreativeWork
222 sg:pub.10.1186/1471-2172-10-22 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051269520
223 https://doi.org/10.1186/1471-2172-10-22
224 rdf:type schema:CreativeWork
225 sg:pub.10.1186/gb-2007-8-4-r45 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016174151
226 https://doi.org/10.1186/gb-2007-8-4-r45
227 rdf:type schema:CreativeWork
228 sg:pub.10.1186/gb-2007-8-7-r139 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024205457
229 https://doi.org/10.1186/gb-2007-8-7-r139
230 rdf:type schema:CreativeWork
231 https://app.dimensions.ai/details/publication/pub.1074698373 schema:CreativeWork
232 https://doi.org/10.1002/1521-4141(200104)31:4<1017::aid-immu1017>3.0.co;2-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047738611
233 rdf:type schema:CreativeWork
234 https://doi.org/10.1002/cfg.479 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005224607
235 rdf:type schema:CreativeWork
236 https://doi.org/10.1002/j.1460-2075.1983.tb01693.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1081732936
237 rdf:type schema:CreativeWork
238 https://doi.org/10.1016/0014-5793(86)80221-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052322104
239 rdf:type schema:CreativeWork
240 https://doi.org/10.1016/0092-8674(80)90168-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016442666
241 rdf:type schema:CreativeWork
242 https://doi.org/10.1016/0092-8674(83)90508-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042476831
243 rdf:type schema:CreativeWork
244 https://doi.org/10.1016/0092-8674(84)90348-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027515082
245 rdf:type schema:CreativeWork
246 https://doi.org/10.1016/0092-8674(95)90116-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007844187
247 rdf:type schema:CreativeWork
248 https://doi.org/10.1016/0161-5890(91)90051-k schema:sameAs https://app.dimensions.ai/details/publication/pub.1047017513
249 rdf:type schema:CreativeWork
250 https://doi.org/10.1016/j.dci.2004.07.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033745882
251 rdf:type schema:CreativeWork
252 https://doi.org/10.1016/j.dci.2005.06.025 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016837104
253 rdf:type schema:CreativeWork
254 https://doi.org/10.1016/j.dci.2007.09.008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034340934
255 rdf:type schema:CreativeWork
256 https://doi.org/10.1016/j.molimm.2009.05.180 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010881530
257 rdf:type schema:CreativeWork
258 https://doi.org/10.1016/j.vetimm.2005.07.016 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019230326
259 rdf:type schema:CreativeWork
260 https://doi.org/10.1016/j.vetimm.2009.12.012 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034785823
261 rdf:type schema:CreativeWork
262 https://doi.org/10.1016/s0022-2836(05)80360-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013618994
263 rdf:type schema:CreativeWork
264 https://doi.org/10.1016/s0145-305x(02)00039-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023004273
265 rdf:type schema:CreativeWork
266 https://doi.org/10.1073/pnas.78.11.7064 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010187418
267 rdf:type schema:CreativeWork
268 https://doi.org/10.1084/jem.132.2.211 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035555693
269 rdf:type schema:CreativeWork
270 https://doi.org/10.1093/bioinformatics/16.10.944 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014452632
271 rdf:type schema:CreativeWork
272 https://doi.org/10.1093/nar/11.24.8877 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018325135
273 rdf:type schema:CreativeWork
274 https://doi.org/10.1093/nar/22.10.1785 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021561060
275 rdf:type schema:CreativeWork
276 https://doi.org/10.1093/nar/30.1.38 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030186249
277 rdf:type schema:CreativeWork
278 https://doi.org/10.1093/nar/gki010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008895081
279 rdf:type schema:CreativeWork
280 https://doi.org/10.1093/nar/gkn838 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049641848
281 rdf:type schema:CreativeWork
282 https://doi.org/10.1101/gr.074492.107 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051720574
283 rdf:type schema:CreativeWork
284 https://doi.org/10.1101/gr.089532.108 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011404279
285 rdf:type schema:CreativeWork
286 https://doi.org/10.3390/genes2010048 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024448967
287 rdf:type schema:CreativeWork
288 https://doi.org/10.4049/jimmunol.0903616 schema:sameAs https://app.dimensions.ai/details/publication/pub.1078057366
289 rdf:type schema:CreativeWork
290 https://doi.org/10.4049/jimmunol.173.11.6794 schema:sameAs https://app.dimensions.ai/details/publication/pub.1076969450
291 rdf:type schema:CreativeWork
292 https://doi.org/10.4049/jimmunol.177.8.5459 schema:sameAs https://app.dimensions.ai/details/publication/pub.1077303891
293 rdf:type schema:CreativeWork
294 https://www.grid.ac/institutes/grid.121334.6 schema:alternateName University of Montpellier
295 schema:name IMGT®, the international ImMunoGeneTics information system®, Laboratoire d’ImmunoGénétique Moléculaire and Institut de Génétique Humaine, Université Montpellier, 34396, Montpellier, France
296 rdf:type schema:Organization
297 https://www.grid.ac/institutes/grid.17635.36 schema:alternateName University of Minnesota
298 schema:name Department of Veterinary and Biomedical Sciences, University of Minnesota, 1971 Commonwealth Avenue, 55108, St. Paul, MN, USA
299 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...