Molecular characterization of major histocompatibility complex class 1 (MHC-I) from squirrel monkeys (Saimiri sciureus) View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2003-12

AUTHORS

Hervé Pascalis, Jean-Michel Heraud, Rolf Fendel, Anne Lavergne, Mirdad Kazanji

ABSTRACT

Little is known about the major histocompatibility complex (MHC) class 1 in squirrel monkeys ( Saimiri sciureus). We cloned, sequenced and characterized two alleles and the cDNA of the coding region of MHC class 1 in these New World monkeys. Phylogenetic analyses showed that these sequences are related to HLA class 1 genes ( HLA-A and HLA-G). The structure and organization of one of the two identified clones was similar to that of a class 1 MHC gene ( HLA-A2). All the exon/intron splice acceptor/donor sites are conserved and their locations correspond to the HLA-A2 gene. The sequences of the newly described cDNAs reveal that they code for the characteristic class 1 MHC proteins, with all the features thought necessary for cell surface expression. Typical sequences for the leader peptide, alpha(1), alpha(2), alpha(3), transmembrane and cytoplasmic domains were found. More... »

PAGES

633-639

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00251-003-0607-4

DOI

http://dx.doi.org/10.1007/s00251-003-0607-4

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1024752884

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/14574519


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