Recent divergence of the HLA-DRB1*04 allelic lineage from the DRB1*0701 lineage after the separation of the human and chimpanzee species View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2003-03-07

AUTHORS

Hirohiko Hohjoh, Jun Ohashi, Miwa Takasu, Tomoki Nishioka, Takafumi Ishida, Katsushi Tokunaga

ABSTRACT

Conventional phylogenetic trees for the human leukocyte antigen (HLA)-DRB1 alleles constructed by the neighbor-joining (Saitou and Nei 1987) and UPGMA (Sneath and Sokal 1973) methods using nucleotide sequences of the DRB1 alleles suggest that DRB1*0701 may have diverged from other DRB1 alleles before the separation of the human and chimpanzee species, because of a large number of nucleotide changes in DRB1*0701 compared with any of the other DRB1 alleles. Here we show new evidence that the haplotypes centering on DRB1*0701 and DRB1*04 alleles are the most homologous. This suggests that these haplotypes have derived from the common ancestral haplotype, and that they have likely retained complete linkage disequilibrium even after the divergence of the DRB1*0701 and DRB1*04 allelic lineages. Together with the corresponding haplotype carrying chimpanzee DRB1*0701, which has a high sequence homology to HLA-DRB1*0701, these haplotypes reveal that: (1) the DRB1*04 allelic lineage may have been generated from the DRB1*0701 lineage after the separation of the human and chimpanzee species; (2) the DRB1*04 allelic lineage possibly has a higher substitution rate of DRB1 compared with pseudogene and neutral region; (3) there could be a significant difference in the substitution rate of DRB1 between the DRB1*0701 and DRB1*04 allelic lineages. Based on the difference between the present and previous results, we would like to propose that phylogenetic studies using not only nucleotide sequences of the DRB1 alleles but also haplotypes centering on the alleles should be conducted for understanding detailed phylogenetic relationships of the DRB1 alleles. More... »

PAGES

856-861

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00251-003-0539-z

DOI

http://dx.doi.org/10.1007/s00251-003-0539-z

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1075262561

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/12671736


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1107", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Immunology", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Alleles", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Base Sequence", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "DNA", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Evolution, Molecular", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "HLA-DR Antigens", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "HLA-DRB1 Chains", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Haplotypes", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Models, Genetic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Pan troglodytes", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Phylogeny", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Pseudogenes", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Species Specificity", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "National Institute of Neuroscience, NCNP, 4-1-1 Ogawahigashi, 187-8502, Kodaira, Tokyo, Japan", 
          "id": "http://www.grid.ac/institutes/grid.419280.6", 
          "name": [
            "Department of Human Genetics, Graduate School of Medicine, University of Tokyo, Tokyo, Japan", 
            "National Institute of Neuroscience, NCNP, 4-1-1 Ogawahigashi, 187-8502, Kodaira, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hohjoh", 
        "givenName": "Hirohiko", 
        "id": "sg:person.0763012550.88", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0763012550.88"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Human Genetics, Graduate School of Medicine, University of Tokyo, Tokyo, Japan", 
          "id": "http://www.grid.ac/institutes/grid.26999.3d", 
          "name": [
            "Department of Human Genetics, Graduate School of Medicine, University of Tokyo, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ohashi", 
        "givenName": "Jun", 
        "id": "sg:person.0646643507.05", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0646643507.05"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Human Genetics, Graduate School of Medicine, University of Tokyo, Tokyo, Japan", 
          "id": "http://www.grid.ac/institutes/grid.26999.3d", 
          "name": [
            "Department of Human Genetics, Graduate School of Medicine, University of Tokyo, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Takasu", 
        "givenName": "Miwa", 
        "id": "sg:person.0604624433.65", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0604624433.65"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Biological Science, Graduate School of Science, University of Tokyo, Tokyo, Japan", 
          "id": "http://www.grid.ac/institutes/grid.26999.3d", 
          "name": [
            "Department of Biological Science, Graduate School of Science, University of Tokyo, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Nishioka", 
        "givenName": "Tomoki", 
        "id": "sg:person.01310354746.16", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01310354746.16"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Biological Science, Graduate School of Science, University of Tokyo, Tokyo, Japan", 
          "id": "http://www.grid.ac/institutes/grid.26999.3d", 
          "name": [
            "Department of Biological Science, Graduate School of Science, University of Tokyo, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ishida", 
        "givenName": "Takafumi", 
        "id": "sg:person.015576331772.42", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015576331772.42"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Human Genetics, Graduate School of Medicine, University of Tokyo, Tokyo, Japan", 
          "id": "http://www.grid.ac/institutes/grid.26999.3d", 
          "name": [
            "Department of Human Genetics, Graduate School of Medicine, University of Tokyo, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Tokunaga", 
        "givenName": "Katsushi", 
        "id": "sg:person.01215176214.31", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01215176214.31"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1007/s002510000270", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029910213", 
          "https://doi.org/10.1007/s002510000270"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/193855a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037468338", 
          "https://doi.org/10.1038/193855a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00223539", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047509703", 
          "https://doi.org/10.1007/bf00223539"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng0398-237", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020550146", 
          "https://doi.org/10.1038/ng0398-237"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2003-03-07", 
    "datePublishedReg": "2003-03-07", 
    "description": "Conventional phylogenetic trees for the human leukocyte antigen (HLA)-DRB1 alleles constructed by the neighbor-joining (Saitou and Nei 1987) and UPGMA (Sneath and Sokal 1973) methods using nucleotide sequences of the DRB1 alleles suggest that DRB1*0701 may have diverged from other DRB1 alleles before the separation of the human and chimpanzee species, because of a large number of nucleotide changes in DRB1*0701 compared with any of the other DRB1 alleles. Here we show new evidence that the haplotypes centering on DRB1*0701 and DRB1*04 alleles are the most homologous. This suggests that these haplotypes have derived from the common ancestral haplotype, and that they have likely retained complete linkage disequilibrium even after the divergence of the DRB1*0701 and DRB1*04 allelic lineages. Together with the corresponding haplotype carrying chimpanzee DRB1*0701, which has a high sequence homology to HLA-DRB1*0701, these haplotypes reveal that: (1) the DRB1*04 allelic lineage may have been generated from the DRB1*0701 lineage after the separation of the human and chimpanzee species; (2) the DRB1*04 allelic lineage possibly has a higher substitution rate of DRB1 compared with pseudogene and neutral region; (3) there could be a significant difference in the substitution rate of DRB1 between the DRB1*0701 and DRB1*04 allelic lineages. Based on the difference between the present and previous results, we would like to propose that phylogenetic studies using not only nucleotide sequences of the DRB1 alleles but also haplotypes centering on the alleles should be conducted for understanding detailed phylogenetic relationships of the DRB1 alleles.", 
    "genre": "article", 
    "id": "sg:pub.10.1007/s00251-003-0539-z", 
    "inLanguage": "en", 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1019755", 
        "issn": [
          "0093-7711", 
          "1432-1211"
        ], 
        "name": "Immunogenetics", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "12", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "54"
      }
    ], 
    "keywords": [
      "allelic lineages", 
      "chimpanzee species", 
      "nucleotide sequence", 
      "substitution rates", 
      "detailed phylogenetic relationships", 
      "high substitution rates", 
      "conventional phylogenetic trees", 
      "high sequence homology", 
      "recent divergence", 
      "phylogenetic tree", 
      "phylogenetic relationships", 
      "phylogenetic studies", 
      "common ancestral haplotype", 
      "sequence homology", 
      "lineages", 
      "UPGMA method", 
      "nucleotide changes", 
      "ancestral haplotype", 
      "complete linkage disequilibrium", 
      "linkage disequilibrium", 
      "species", 
      "alleles", 
      "haplotypes", 
      "divergence", 
      "sequence", 
      "pseudogenes", 
      "homology", 
      "humans", 
      "neutral region", 
      "trees", 
      "large number", 
      "disequilibrium", 
      "new evidence", 
      "DRB1 alleles", 
      "region", 
      "previous results", 
      "evidence", 
      "differences", 
      "changes", 
      "antigen", 
      "number", 
      "rate", 
      "study", 
      "relationship", 
      "separation", 
      "significant differences", 
      "results", 
      "human leukocyte antigen", 
      "leukocyte antigen", 
      "HLA-DRB1", 
      "DRB1", 
      "method", 
      "HLA"
    ], 
    "name": "Recent divergence of the HLA-DRB1*04 allelic lineage from the DRB1*0701 lineage after the separation of the human and chimpanzee species", 
    "pagination": "856-861", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1075262561"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s00251-003-0539-z"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "12671736"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s00251-003-0539-z", 
      "https://app.dimensions.ai/details/publication/pub.1075262561"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2021-11-01T18:06", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20211101/entities/gbq_results/article/article_376.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1007/s00251-003-0539-z"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s00251-003-0539-z'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s00251-003-0539-z'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s00251-003-0539-z'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s00251-003-0539-z'


 

This table displays all metadata directly associated to this object as RDF triples.

228 TRIPLES      22 PREDICATES      97 URIs      85 LITERALS      21 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s00251-003-0539-z schema:about N08ab77fe01df49d4879d441836be5c97
2 N10429d91de8343b5b9cbd3da57c3a285
3 N33d0455514734642a0c1a0eadee179f1
4 N7225c9222bc1426881c67cd6b0af2586
5 N850d7b7ea7d04ab39ec6acec04fa8c96
6 N85ca53a87ce8488ebe89e9b4445db3be
7 N8bc187704da64cb09137c3d7ebe6637b
8 Na1da81d4afda49f9bb92db4df47c39f1
9 Nb07c6b27368641ed9cf16792b57e596c
10 Nb84d5eb194ab411f8a614e48c3ffa74a
11 Ncf4997b3a4b844f6b3979bfbf3f171c5
12 Ne06e4138f2424d12b8df37a9f1061478
13 Ne597e153c465474abd33c4b7e06d16bd
14 Nf86702ad30e34e5caeb9164d7da93f8e
15 anzsrc-for:11
16 anzsrc-for:1107
17 schema:author Nf9147b00d0a247339cf42939d8a85bb3
18 schema:citation sg:pub.10.1007/bf00223539
19 sg:pub.10.1007/s002510000270
20 sg:pub.10.1038/193855a0
21 sg:pub.10.1038/ng0398-237
22 schema:datePublished 2003-03-07
23 schema:datePublishedReg 2003-03-07
24 schema:description Conventional phylogenetic trees for the human leukocyte antigen (HLA)-DRB1 alleles constructed by the neighbor-joining (Saitou and Nei 1987) and UPGMA (Sneath and Sokal 1973) methods using nucleotide sequences of the DRB1 alleles suggest that DRB1*0701 may have diverged from other DRB1 alleles before the separation of the human and chimpanzee species, because of a large number of nucleotide changes in DRB1*0701 compared with any of the other DRB1 alleles. Here we show new evidence that the haplotypes centering on DRB1*0701 and DRB1*04 alleles are the most homologous. This suggests that these haplotypes have derived from the common ancestral haplotype, and that they have likely retained complete linkage disequilibrium even after the divergence of the DRB1*0701 and DRB1*04 allelic lineages. Together with the corresponding haplotype carrying chimpanzee DRB1*0701, which has a high sequence homology to HLA-DRB1*0701, these haplotypes reveal that: (1) the DRB1*04 allelic lineage may have been generated from the DRB1*0701 lineage after the separation of the human and chimpanzee species; (2) the DRB1*04 allelic lineage possibly has a higher substitution rate of DRB1 compared with pseudogene and neutral region; (3) there could be a significant difference in the substitution rate of DRB1 between the DRB1*0701 and DRB1*04 allelic lineages. Based on the difference between the present and previous results, we would like to propose that phylogenetic studies using not only nucleotide sequences of the DRB1 alleles but also haplotypes centering on the alleles should be conducted for understanding detailed phylogenetic relationships of the DRB1 alleles.
25 schema:genre article
26 schema:inLanguage en
27 schema:isAccessibleForFree false
28 schema:isPartOf N01db7208e016408484bf6f62b2a6d4de
29 N2086e91849aa4be686f3d4405687b4e0
30 sg:journal.1019755
31 schema:keywords DRB1
32 DRB1 alleles
33 HLA
34 HLA-DRB1
35 UPGMA method
36 alleles
37 allelic lineages
38 ancestral haplotype
39 antigen
40 changes
41 chimpanzee species
42 common ancestral haplotype
43 complete linkage disequilibrium
44 conventional phylogenetic trees
45 detailed phylogenetic relationships
46 differences
47 disequilibrium
48 divergence
49 evidence
50 haplotypes
51 high sequence homology
52 high substitution rates
53 homology
54 human leukocyte antigen
55 humans
56 large number
57 leukocyte antigen
58 lineages
59 linkage disequilibrium
60 method
61 neutral region
62 new evidence
63 nucleotide changes
64 nucleotide sequence
65 number
66 phylogenetic relationships
67 phylogenetic studies
68 phylogenetic tree
69 previous results
70 pseudogenes
71 rate
72 recent divergence
73 region
74 relationship
75 results
76 separation
77 sequence
78 sequence homology
79 significant differences
80 species
81 study
82 substitution rates
83 trees
84 schema:name Recent divergence of the HLA-DRB1*04 allelic lineage from the DRB1*0701 lineage after the separation of the human and chimpanzee species
85 schema:pagination 856-861
86 schema:productId N35ea480519bc485ea9271bb5b269fb80
87 N9c3d1653571b465188030e2e83a47bae
88 Nf187f5379a2f4c74b5d728f9d14a9fac
89 schema:sameAs https://app.dimensions.ai/details/publication/pub.1075262561
90 https://doi.org/10.1007/s00251-003-0539-z
91 schema:sdDatePublished 2021-11-01T18:06
92 schema:sdLicense https://scigraph.springernature.com/explorer/license/
93 schema:sdPublisher Nf225079b2f604eea9fea3283117f3313
94 schema:url https://doi.org/10.1007/s00251-003-0539-z
95 sgo:license sg:explorer/license/
96 sgo:sdDataset articles
97 rdf:type schema:ScholarlyArticle
98 N01db7208e016408484bf6f62b2a6d4de schema:issueNumber 12
99 rdf:type schema:PublicationIssue
100 N08ab77fe01df49d4879d441836be5c97 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
101 schema:name Base Sequence
102 rdf:type schema:DefinedTerm
103 N10429d91de8343b5b9cbd3da57c3a285 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
104 schema:name Species Specificity
105 rdf:type schema:DefinedTerm
106 N2086e91849aa4be686f3d4405687b4e0 schema:volumeNumber 54
107 rdf:type schema:PublicationVolume
108 N33d0455514734642a0c1a0eadee179f1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
109 schema:name HLA-DR Antigens
110 rdf:type schema:DefinedTerm
111 N35ea480519bc485ea9271bb5b269fb80 schema:name dimensions_id
112 schema:value pub.1075262561
113 rdf:type schema:PropertyValue
114 N52a29489046d479e869d8d594fdc9e28 rdf:first sg:person.01310354746.16
115 rdf:rest N67fa42e5e3494b84a00c7b03bbae09e9
116 N67fa42e5e3494b84a00c7b03bbae09e9 rdf:first sg:person.015576331772.42
117 rdf:rest N6c33267983d349c6a62af42c0dd33a45
118 N6c33267983d349c6a62af42c0dd33a45 rdf:first sg:person.01215176214.31
119 rdf:rest rdf:nil
120 N7225c9222bc1426881c67cd6b0af2586 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
121 schema:name Models, Genetic
122 rdf:type schema:DefinedTerm
123 N850d7b7ea7d04ab39ec6acec04fa8c96 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
124 schema:name HLA-DRB1 Chains
125 rdf:type schema:DefinedTerm
126 N85ca53a87ce8488ebe89e9b4445db3be schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
127 schema:name Evolution, Molecular
128 rdf:type schema:DefinedTerm
129 N8bc187704da64cb09137c3d7ebe6637b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
130 schema:name Haplotypes
131 rdf:type schema:DefinedTerm
132 N9c3d1653571b465188030e2e83a47bae schema:name doi
133 schema:value 10.1007/s00251-003-0539-z
134 rdf:type schema:PropertyValue
135 N9d6733d7856f4277b2c453053b35f7d3 rdf:first sg:person.0646643507.05
136 rdf:rest Ncf1526559a424045a85d3de5558f225e
137 Na1da81d4afda49f9bb92db4df47c39f1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
138 schema:name DNA
139 rdf:type schema:DefinedTerm
140 Nb07c6b27368641ed9cf16792b57e596c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
141 schema:name Pseudogenes
142 rdf:type schema:DefinedTerm
143 Nb84d5eb194ab411f8a614e48c3ffa74a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
144 schema:name Phylogeny
145 rdf:type schema:DefinedTerm
146 Ncf1526559a424045a85d3de5558f225e rdf:first sg:person.0604624433.65
147 rdf:rest N52a29489046d479e869d8d594fdc9e28
148 Ncf4997b3a4b844f6b3979bfbf3f171c5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
149 schema:name Humans
150 rdf:type schema:DefinedTerm
151 Ne06e4138f2424d12b8df37a9f1061478 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
152 schema:name Pan troglodytes
153 rdf:type schema:DefinedTerm
154 Ne597e153c465474abd33c4b7e06d16bd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
155 schema:name Alleles
156 rdf:type schema:DefinedTerm
157 Nf187f5379a2f4c74b5d728f9d14a9fac schema:name pubmed_id
158 schema:value 12671736
159 rdf:type schema:PropertyValue
160 Nf225079b2f604eea9fea3283117f3313 schema:name Springer Nature - SN SciGraph project
161 rdf:type schema:Organization
162 Nf86702ad30e34e5caeb9164d7da93f8e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
163 schema:name Animals
164 rdf:type schema:DefinedTerm
165 Nf9147b00d0a247339cf42939d8a85bb3 rdf:first sg:person.0763012550.88
166 rdf:rest N9d6733d7856f4277b2c453053b35f7d3
167 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
168 schema:name Medical and Health Sciences
169 rdf:type schema:DefinedTerm
170 anzsrc-for:1107 schema:inDefinedTermSet anzsrc-for:
171 schema:name Immunology
172 rdf:type schema:DefinedTerm
173 sg:journal.1019755 schema:issn 0093-7711
174 1432-1211
175 schema:name Immunogenetics
176 schema:publisher Springer Nature
177 rdf:type schema:Periodical
178 sg:person.01215176214.31 schema:affiliation grid-institutes:grid.26999.3d
179 schema:familyName Tokunaga
180 schema:givenName Katsushi
181 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01215176214.31
182 rdf:type schema:Person
183 sg:person.01310354746.16 schema:affiliation grid-institutes:grid.26999.3d
184 schema:familyName Nishioka
185 schema:givenName Tomoki
186 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01310354746.16
187 rdf:type schema:Person
188 sg:person.015576331772.42 schema:affiliation grid-institutes:grid.26999.3d
189 schema:familyName Ishida
190 schema:givenName Takafumi
191 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015576331772.42
192 rdf:type schema:Person
193 sg:person.0604624433.65 schema:affiliation grid-institutes:grid.26999.3d
194 schema:familyName Takasu
195 schema:givenName Miwa
196 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0604624433.65
197 rdf:type schema:Person
198 sg:person.0646643507.05 schema:affiliation grid-institutes:grid.26999.3d
199 schema:familyName Ohashi
200 schema:givenName Jun
201 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0646643507.05
202 rdf:type schema:Person
203 sg:person.0763012550.88 schema:affiliation grid-institutes:grid.419280.6
204 schema:familyName Hohjoh
205 schema:givenName Hirohiko
206 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0763012550.88
207 rdf:type schema:Person
208 sg:pub.10.1007/bf00223539 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047509703
209 https://doi.org/10.1007/bf00223539
210 rdf:type schema:CreativeWork
211 sg:pub.10.1007/s002510000270 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029910213
212 https://doi.org/10.1007/s002510000270
213 rdf:type schema:CreativeWork
214 sg:pub.10.1038/193855a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037468338
215 https://doi.org/10.1038/193855a0
216 rdf:type schema:CreativeWork
217 sg:pub.10.1038/ng0398-237 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020550146
218 https://doi.org/10.1038/ng0398-237
219 rdf:type schema:CreativeWork
220 grid-institutes:grid.26999.3d schema:alternateName Department of Biological Science, Graduate School of Science, University of Tokyo, Tokyo, Japan
221 Department of Human Genetics, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
222 schema:name Department of Biological Science, Graduate School of Science, University of Tokyo, Tokyo, Japan
223 Department of Human Genetics, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
224 rdf:type schema:Organization
225 grid-institutes:grid.419280.6 schema:alternateName National Institute of Neuroscience, NCNP, 4-1-1 Ogawahigashi, 187-8502, Kodaira, Tokyo, Japan
226 schema:name Department of Human Genetics, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
227 National Institute of Neuroscience, NCNP, 4-1-1 Ogawahigashi, 187-8502, Kodaira, Tokyo, Japan
228 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...