Synonymous nucleotide substitutions in the neonatal Fc receptor View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2002-05

AUTHORS

Carolyn A. Gunraj, Bernard J. Fernandes, Gregory A. Denomme

ABSTRACT

The neonatal Fc receptor (FcRn) is a key receptor involved in the transcytosis of IgG across the maternal-fetal barrier. The level of IgG varies considerably among newborn infants. Since other Fc gamma receptors show single nucleotide functional variants, we determined whether common variant alleles exist for the FcRn. Direct sequence analysis was performed on PCR-amplified complementary DNA (cDNA) isolated from ten placental mRNAs (20 alleles examined). Two synonymous nucleotide polymorphisms were detected from the same source. A G251T and C707T substitution, reflecting amino acid positions Pro19 and Arg171 of the mature polypeptide, did not alter the amino acid encoded. No other nucleotide substitutions or sequence variations were observed. Thus, the variation in IgG transport is not due to common variant alleles among the human population. Due to the limited number of samples tested (n=20), low-frequency alleles would go undetected by chance alone when q has a frequency < or = 0.14. It is unlikely that low-frequency variant alleles, if present, are responsible for the major variation seen in the transcytosis of IgG. More... »

PAGES

139-140

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00251-002-0449-5

DOI

http://dx.doi.org/10.1007/s00251-002-0449-5

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1032038828

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/12037606


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