Slow relaxation during and after perturbation of bistable kinetics of gene expression View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2019-04

AUTHORS

Vladimir P. Zhdanov

ABSTRACT

After a short perturbation of a bistable genetic network, it returns to its initial steady state or transits to another steady state. The time scale characterizing such transient regimes can be appreciably longer compared to those of the degradation of the perturbed mRNAs and proteins. The author shows in detail the specifics of this slowdown of the transient kinetics using mean-field kinetic equations and Monte Carlo simulations. Attention is focused on nanocarrier-mediated delivery and release of short non-coding RNA (e.g., miRNA or siRNA) into cells with subsequent suppression of the populations of the targeted mRNA and corresponding protein. More... »

PAGES

1-6

References to SciGraph publications

Journal

TITLE

European Biophysics Journal

ISSUE

3

VOLUME

48

Author Affiliations

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00249-019-01358-3

DOI

http://dx.doi.org/10.1007/s00249-019-01358-3

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1112941949

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30903265


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