Cave Microbes as a Potential Source of Drugs Development in the Modern Era View Full Text


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Article Info

DATE

2021-10-25

AUTHORS

Sahib Zada, Wasim Sajjad, Muhammad Rafiq, Sardar Ali, Zhong Hu, Hui Wang, Runlin Cai

ABSTRACT

The world is constantly facing threats, including the emergence of new pathogens and antibiotic resistance among extant pathogens, which is a matter of concern. Therefore, the need for natural and effective sources of drugs is inevitable. The ancient and pristine ecosystems of caves contain a unique microbial world and could provide a possible source of antimicrobial metabolites. The association between humans and caves is as old as human history itself. Historically, cave environments have been used to treat patients with respiratory tract infections, which is referred to as speleotherapy. Today, the pristine environment of caves that comprise a poorly explored microbial world is a potential source of antimicrobial and anticancer drugs. Oligotrophic conditions in caves enhance the competition among microbial communities, and unique antimicrobial agents may be used in this competition. This review suggests that the world needs a novel and effective source of drug discovery. Therefore, being the emerging spot of modern human civilization, caves could play a crucial role in the current medical crisis, and cave microorganisms may have the potential to produce novel antimicrobial and anticancer drugs. More... »

PAGES

1-12

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    30 schema:description The world is constantly facing threats, including the emergence of new pathogens and antibiotic resistance among extant pathogens, which is a matter of concern. Therefore, the need for natural and effective sources of drugs is inevitable. The ancient and pristine ecosystems of caves contain a unique microbial world and could provide a possible source of antimicrobial metabolites. The association between humans and caves is as old as human history itself. Historically, cave environments have been used to treat patients with respiratory tract infections, which is referred to as speleotherapy. Today, the pristine environment of caves that comprise a poorly explored microbial world is a potential source of antimicrobial and anticancer drugs. Oligotrophic conditions in caves enhance the competition among microbial communities, and unique antimicrobial agents may be used in this competition. This review suggests that the world needs a novel and effective source of drug discovery. Therefore, being the emerging spot of modern human civilization, caves could play a crucial role in the current medical crisis, and cave microorganisms may have the potential to produce novel antimicrobial and anticancer drugs.
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    39 antimicrobial metabolites
    40 antimicrobials
    41 association
    42 caves
    43 civilization
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    45 competition
    46 concern
    47 conditions
    48 crisis
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    50 current medical crisis
    51 development
    52 discovery
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    55 drugs
    56 ecosystems
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    58 emergence
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    60 era
    61 history
    62 human civilization
    63 human history
    64 humans
    65 infection
    66 matter
    67 matter of concern
    68 medical crisis
    69 metabolites
    70 microbes
    71 microbial communities
    72 microbial world
    73 microorganisms
    74 modern era
    75 modern human civilization
    76 need
    77 new pathogens
    78 novel antimicrobials
    79 oligotrophic conditions
    80 pathogens
    81 patients
    82 possible sources
    83 potential
    84 potential source
    85 pristine ecosystems
    86 pristine environment
    87 resistance
    88 respiratory tract infections
    89 review
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    92 speleotherapy
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