The Restoration of the Vaginal Microbiota After Treatment for Bacterial Vaginosis with Metronidazole or Probiotics View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2012-12-19

AUTHORS

Zongxin Ling, Xia Liu, Weiguang Chen, Yueqiu Luo, Li Yuan, Yaxian Xia, Karen E Nelson, Shaolei Huang, Shaoen Zhang, Yuezhu Wang, Jieli Yuan, Lanjuan Li, Charlie Xiang

ABSTRACT

Whether or not treatment with antibiotics or probiotics for bacterial vaginosis (BV) is associated with a change in the diversity of vaginal microbiota in women was investigated. One hundred fifteen women, consisting of 30 healthy subjects, 30 BV-positive control subjects, 30 subjects with BV treated with a 7-day metronidazole regimen, and 25 subjects with BV treated with a 10-day probiotics regimen, were analyzed to determine the efficacy and disparity of diversity and richness of vaginal microbiota using 454 pyrosequencing. Follow-up visits at days 5 and 30 showed a greater BV cure rate in the probiotics-treated subjects (88.0 and 96 %, respectively) compared to the metronidazole-treated subjects (83.3 and 70 %, respectively [p = 0.625 at day 5 and p = 0.013 at day 30]). Treatment with metronidazole reduced the taxa diversity and eradicated most of the BV-associated phylotypes, while probiotics only suppressed the overgrowth and re-established vaginal homeostasis gradually and steadily. Despite significant interindividual variation, the microbiota of the actively treated groups or participants constituted a unique profile. Along with the decrease in pathogenic bacteria, such as Gardnerella, Atopobium, Prevotella, Megasphaera, Coriobacteriaceae, Lachnospiraceae, Mycoplasma, and Sneathia, a Lactobacillus-dominated vaginal microbiota was recovered. Acting as vaginal sentinels and biomarkers, the relative abundance of Lactobacillus and pathogenic bacteria determined the consistency of the BV clinical and microbiologic cure rates, as well as recurrent BV. Both 7-day intravaginal metronidazole and 10-day intravaginal probiotics have good efficacy against BV, while probiotics maintained normal vaginal microbiota longer due to effective and steady vaginal microbiota restoration, which provide new insights into BV treatment. More... »

PAGES

773-780

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00248-012-0154-3

DOI

http://dx.doi.org/10.1007/s00248-012-0154-3

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1029951712

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/23250116


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28 schema:description Whether or not treatment with antibiotics or probiotics for bacterial vaginosis (BV) is associated with a change in the diversity of vaginal microbiota in women was investigated. One hundred fifteen women, consisting of 30 healthy subjects, 30 BV-positive control subjects, 30 subjects with BV treated with a 7-day metronidazole regimen, and 25 subjects with BV treated with a 10-day probiotics regimen, were analyzed to determine the efficacy and disparity of diversity and richness of vaginal microbiota using 454 pyrosequencing. Follow-up visits at days 5 and 30 showed a greater BV cure rate in the probiotics-treated subjects (88.0 and 96 %, respectively) compared to the metronidazole-treated subjects (83.3 and 70 %, respectively [p = 0.625 at day 5 and p = 0.013 at day 30]). Treatment with metronidazole reduced the taxa diversity and eradicated most of the BV-associated phylotypes, while probiotics only suppressed the overgrowth and re-established vaginal homeostasis gradually and steadily. Despite significant interindividual variation, the microbiota of the actively treated groups or participants constituted a unique profile. Along with the decrease in pathogenic bacteria, such as Gardnerella, Atopobium, Prevotella, Megasphaera, Coriobacteriaceae, Lachnospiraceae, Mycoplasma, and Sneathia, a Lactobacillus-dominated vaginal microbiota was recovered. Acting as vaginal sentinels and biomarkers, the relative abundance of Lactobacillus and pathogenic bacteria determined the consistency of the BV clinical and microbiologic cure rates, as well as recurrent BV. Both 7-day intravaginal metronidazole and 10-day intravaginal probiotics have good efficacy against BV, while probiotics maintained normal vaginal microbiota longer due to effective and steady vaginal microbiota restoration, which provide new insights into BV treatment.
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34 schema:keywords Atopobium
35 BV treatment
36 Coriobacteriaceae
37 Gardnerella
38 Lachnospiraceae
39 Lactobacillus
40 Megasphaera
41 Prevotella
42 Sneathia
43 abundance
44 antibiotics
45 bacteria
46 bacterial vaginosis
47 better efficacy
48 biomarkers
49 changes
50 consistency
51 control subjects
52 cure rate
53 day 5
54 decrease
55 disparities
56 diversity
57 efficacy
58 group
59 healthy subjects
60 homeostasis
61 insights
62 interindividual variation
63 intravaginal metronidazole
64 metronidazole
65 metronidazole regimen
66 microbiologic cure rates
67 microbiota
68 microbiota restoration
69 mycoplasmas
70 new insights
71 normal vaginal microbiota
72 overgrowth
73 participants
74 pathogenic bacteria
75 phylotypes
76 probiotic regimen
77 probiotics
78 probiotics-treated subjects
79 profile
80 rate
81 recurrent bacterial vaginosis
82 regimen
83 relative abundance
84 restoration
85 richness
86 sentinels
87 significant interindividual variation
88 subjects
89 taxon diversity
90 treatment
91 unique profile
92 vaginal homeostasis
93 vaginal microbiota
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