The Restoration of the Vaginal Microbiota After Treatment for Bacterial Vaginosis with Metronidazole or Probiotics View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2012-12-19

AUTHORS

Zongxin Ling, Xia Liu, Weiguang Chen, Yueqiu Luo, Li Yuan, Yaxian Xia, Karen E Nelson, Shaolei Huang, Shaoen Zhang, Yuezhu Wang, Jieli Yuan, Lanjuan Li, Charlie Xiang

ABSTRACT

Whether or not treatment with antibiotics or probiotics for bacterial vaginosis (BV) is associated with a change in the diversity of vaginal microbiota in women was investigated. One hundred fifteen women, consisting of 30 healthy subjects, 30 BV-positive control subjects, 30 subjects with BV treated with a 7-day metronidazole regimen, and 25 subjects with BV treated with a 10-day probiotics regimen, were analyzed to determine the efficacy and disparity of diversity and richness of vaginal microbiota using 454 pyrosequencing. Follow-up visits at days 5 and 30 showed a greater BV cure rate in the probiotics-treated subjects (88.0 and 96 %, respectively) compared to the metronidazole-treated subjects (83.3 and 70 %, respectively [p = 0.625 at day 5 and p = 0.013 at day 30]). Treatment with metronidazole reduced the taxa diversity and eradicated most of the BV-associated phylotypes, while probiotics only suppressed the overgrowth and re-established vaginal homeostasis gradually and steadily. Despite significant interindividual variation, the microbiota of the actively treated groups or participants constituted a unique profile. Along with the decrease in pathogenic bacteria, such as Gardnerella, Atopobium, Prevotella, Megasphaera, Coriobacteriaceae, Lachnospiraceae, Mycoplasma, and Sneathia, a Lactobacillus-dominated vaginal microbiota was recovered. Acting as vaginal sentinels and biomarkers, the relative abundance of Lactobacillus and pathogenic bacteria determined the consistency of the BV clinical and microbiologic cure rates, as well as recurrent BV. Both 7-day intravaginal metronidazole and 10-day intravaginal probiotics have good efficacy against BV, while probiotics maintained normal vaginal microbiota longer due to effective and steady vaginal microbiota restoration, which provide new insights into BV treatment. More... »

PAGES

773-780

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00248-012-0154-3

DOI

http://dx.doi.org/10.1007/s00248-012-0154-3

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1029951712

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/23250116


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/05", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Environmental Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0503", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Soil Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0602", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Ecology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0605", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Microbiology", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Administration, Intravaginal", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Bacteria", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cohort Studies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Lactobacillus", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Metagenome", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Metronidazole", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Molecular Sequence Data", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Phylogeny", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Probiotics", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Treatment Outcome", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Vagina", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Vaginosis, Bacterial", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, the First Affiliated Hospital, College of Medicine, Zhejiang University, 310003, Hangzhou, Zhejiang, China", 
          "id": "http://www.grid.ac/institutes/grid.13402.34", 
          "name": [
            "State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, the First Affiliated Hospital, College of Medicine, Zhejiang University, 310003, Hangzhou, Zhejiang, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ling", 
        "givenName": "Zongxin", 
        "id": "sg:person.01026720607.54", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01026720607.54"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Intensive Care Unit, the First Affiliated Hospital, College of Medicine, Zhejiang University, 310003, Hangzhou, Zhejiang, China", 
          "id": "http://www.grid.ac/institutes/grid.13402.34", 
          "name": [
            "Department of Intensive Care Unit, the First Affiliated Hospital, College of Medicine, Zhejiang University, 310003, Hangzhou, Zhejiang, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Liu", 
        "givenName": "Xia", 
        "id": "sg:person.01301115024.52", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01301115024.52"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, the First Affiliated Hospital, College of Medicine, Zhejiang University, 310003, Hangzhou, Zhejiang, China", 
          "id": "http://www.grid.ac/institutes/grid.13402.34", 
          "name": [
            "State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, the First Affiliated Hospital, College of Medicine, Zhejiang University, 310003, Hangzhou, Zhejiang, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Chen", 
        "givenName": "Weiguang", 
        "id": "sg:person.01052050627.08", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01052050627.08"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, the First Affiliated Hospital, College of Medicine, Zhejiang University, 310003, Hangzhou, Zhejiang, China", 
          "id": "http://www.grid.ac/institutes/grid.13402.34", 
          "name": [
            "State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, the First Affiliated Hospital, College of Medicine, Zhejiang University, 310003, Hangzhou, Zhejiang, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Luo", 
        "givenName": "Yueqiu", 
        "id": "sg:person.01351102552.22", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01351102552.22"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, the First Affiliated Hospital, College of Medicine, Zhejiang University, 310003, Hangzhou, Zhejiang, China", 
          "id": "http://www.grid.ac/institutes/grid.13402.34", 
          "name": [
            "State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, the First Affiliated Hospital, College of Medicine, Zhejiang University, 310003, Hangzhou, Zhejiang, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Yuan", 
        "givenName": "Li", 
        "id": "sg:person.01241654520.67", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01241654520.67"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Obstetrics and Gynecology, the First Affiliated Hospital, College of Medicine, Zhejiang University, 310003, Hangzhou, Zhejiang, China", 
          "id": "http://www.grid.ac/institutes/grid.13402.34", 
          "name": [
            "Department of Obstetrics and Gynecology, the First Affiliated Hospital, College of Medicine, Zhejiang University, 310003, Hangzhou, Zhejiang, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Xia", 
        "givenName": "Yaxian", 
        "id": "sg:person.0740052524.64", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0740052524.64"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "J. Craig Venter Institute, 20850, Rockville, MD, USA", 
          "id": "http://www.grid.ac/institutes/grid.469946.0", 
          "name": [
            "J. Craig Venter Institute, 20850, Rockville, MD, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Nelson", 
        "givenName": "Karen E", 
        "id": "sg:person.01213406210.22", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01213406210.22"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Insititue of Microecology, Dalian Medical University, 116044, Dalian, Liaoning, China", 
          "id": "http://www.grid.ac/institutes/grid.411971.b", 
          "name": [
            "Insititue of Microecology, Dalian Medical University, 116044, Dalian, Liaoning, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Huang", 
        "givenName": "Shaolei", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Insititue of Microecology, Dalian Medical University, 116044, Dalian, Liaoning, China", 
          "id": "http://www.grid.ac/institutes/grid.411971.b", 
          "name": [
            "Insititue of Microecology, Dalian Medical University, 116044, Dalian, Liaoning, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Zhang", 
        "givenName": "Shaoen", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Chinese National Human Genome Center at Shanghai, 201203, Shanghai, China", 
          "id": "http://www.grid.ac/institutes/grid.464306.3", 
          "name": [
            "Chinese National Human Genome Center at Shanghai, 201203, Shanghai, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Wang", 
        "givenName": "Yuezhu", 
        "id": "sg:person.01170527524.65", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01170527524.65"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Insititue of Microecology, Dalian Medical University, 116044, Dalian, Liaoning, China", 
          "id": "http://www.grid.ac/institutes/grid.411971.b", 
          "name": [
            "Insititue of Microecology, Dalian Medical University, 116044, Dalian, Liaoning, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Yuan", 
        "givenName": "Jieli", 
        "id": "sg:person.01103002104.72", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01103002104.72"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, the First Affiliated Hospital, College of Medicine, Zhejiang University, 310003, Hangzhou, Zhejiang, China", 
          "id": "http://www.grid.ac/institutes/grid.13402.34", 
          "name": [
            "State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, the First Affiliated Hospital, College of Medicine, Zhejiang University, 310003, Hangzhou, Zhejiang, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Li", 
        "givenName": "Lanjuan", 
        "id": "sg:person.01362152061.09", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01362152061.09"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "J. Craig Venter Institute, 20850, Rockville, MD, USA", 
          "id": "http://www.grid.ac/institutes/grid.469946.0", 
          "name": [
            "State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, the First Affiliated Hospital, College of Medicine, Zhejiang University, 310003, Hangzhou, Zhejiang, China", 
            "J. Craig Venter Institute, 20850, Rockville, MD, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Xiang", 
        "givenName": "Charlie", 
        "id": "sg:person.01353071324.89", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01353071324.89"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1186/1471-2164-11-488", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051912306", 
          "https://doi.org/10.1186/1471-2164-11-488"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1471-2334-4-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017764187", 
          "https://doi.org/10.1186/1471-2334-4-5"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00248-011-9813-z", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032066401", 
          "https://doi.org/10.1007/s00248-011-9813-z"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00248-010-9712-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036312224", 
          "https://doi.org/10.1007/s00248-010-9712-8"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrmicro2473", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003384875", 
          "https://doi.org/10.1038/nrmicro2473"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2012-12-19", 
    "datePublishedReg": "2012-12-19", 
    "description": "Whether or not treatment with antibiotics or probiotics for bacterial vaginosis (BV) is associated with a change in the diversity of vaginal microbiota in women was investigated. One hundred fifteen women, consisting of 30 healthy subjects, 30 BV-positive control subjects, 30 subjects with BV treated with a 7-day metronidazole regimen, and 25 subjects with BV treated with a 10-day probiotics regimen, were analyzed to determine the efficacy and disparity of diversity and richness of vaginal microbiota using 454 pyrosequencing. Follow-up visits at days 5 and 30 showed a greater BV cure rate in the probiotics-treated subjects (88.0 and 96\u00a0%, respectively) compared to the metronidazole-treated subjects (83.3 and 70\u00a0%, respectively [p\u2009=\u20090.625 at day 5 and p\u2009=\u20090.013 at day 30]). Treatment with metronidazole reduced the taxa diversity and eradicated most of the BV-associated phylotypes, while probiotics only suppressed the overgrowth and re-established vaginal homeostasis gradually and steadily. Despite significant interindividual variation, the microbiota of the actively treated groups or participants constituted a unique profile. Along with the decrease in pathogenic bacteria, such as Gardnerella, Atopobium, Prevotella, Megasphaera, Coriobacteriaceae, Lachnospiraceae, Mycoplasma, and Sneathia, a Lactobacillus-dominated vaginal microbiota was recovered. Acting as vaginal sentinels and biomarkers, the relative abundance of Lactobacillus and pathogenic bacteria determined the consistency of the BV clinical and microbiologic cure rates, as well as recurrent BV. Both 7-day intravaginal metronidazole and 10-day intravaginal probiotics have good efficacy against BV, while probiotics maintained normal vaginal microbiota longer due to effective and steady vaginal microbiota restoration, which provide new insights into BV treatment.", 
    "genre": "article", 
    "id": "sg:pub.10.1007/s00248-012-0154-3", 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1081458", 
        "issn": [
          "0095-3628", 
          "1432-184X"
        ], 
        "name": "Microbial Ecology", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "3", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "65"
      }
    ], 
    "keywords": [
      "bacterial vaginosis", 
      "vaginal microbiota", 
      "cure rate", 
      "probiotics-treated subjects", 
      "microbiologic cure rates", 
      "recurrent bacterial vaginosis", 
      "normal vaginal microbiota", 
      "metronidazole regimen", 
      "probiotic regimen", 
      "significant interindividual variation", 
      "intravaginal metronidazole", 
      "microbiota restoration", 
      "control subjects", 
      "BV treatment", 
      "healthy subjects", 
      "pathogenic bacteria", 
      "better efficacy", 
      "day 5", 
      "vaginal homeostasis", 
      "interindividual variation", 
      "metronidazole", 
      "probiotics", 
      "microbiota", 
      "regimen", 
      "vaginosis", 
      "treatment", 
      "subjects", 
      "women", 
      "efficacy", 
      "unique profile", 
      "Lactobacillus", 
      "Sneathia", 
      "Gardnerella", 
      "visits", 
      "biomarkers", 
      "Atopobium", 
      "antibiotics", 
      "Prevotella", 
      "Lachnospiraceae", 
      "Coriobacteriaceae", 
      "restoration", 
      "homeostasis", 
      "rate", 
      "sentinels", 
      "participants", 
      "Megasphaera", 
      "overgrowth", 
      "group", 
      "bacteria", 
      "disparities", 
      "mycoplasmas", 
      "new insights", 
      "decrease", 
      "profile", 
      "changes", 
      "relative abundance", 
      "consistency", 
      "insights", 
      "variation", 
      "diversity", 
      "abundance", 
      "phylotypes", 
      "richness", 
      "taxon diversity"
    ], 
    "name": "The Restoration of the Vaginal Microbiota After Treatment for Bacterial Vaginosis with Metronidazole or Probiotics", 
    "pagination": "773-780", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1029951712"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s00248-012-0154-3"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "23250116"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s00248-012-0154-3", 
      "https://app.dimensions.ai/details/publication/pub.1029951712"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-08-04T16:59", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20220804/entities/gbq_results/article/article_559.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1007/s00248-012-0154-3"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s00248-012-0154-3'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s00248-012-0154-3'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s00248-012-0154-3'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s00248-012-0154-3'


 

This table displays all metadata directly associated to this object as RDF triples.

309 TRIPLES      21 PREDICATES      111 URIs      95 LITERALS      21 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s00248-012-0154-3 schema:about N0559bbf2b3b9480f8ee65068fd09bcf8
2 N05bb7ce34b244235ab559e5f7284fa44
3 N09b3ff439c1c4edb970e476e25744d5b
4 N10c6fa38911b4f63b4ad7d2a7dc0b5d5
5 N13c139255f5444c6a3b076b1f20870f6
6 N1b9964d837c146eb8a107192285964a1
7 N31784124f34d4ec4bfab174b414b8fe3
8 N72e7e225c79a493b8c8e3092762e931f
9 N81a32c6a7d8040d08caad7b4d18eedbc
10 N99967d17f7a8429cb4f0eb4bbea16fdb
11 Nb62e840da9c1472eb848fa1c22288bf9
12 Ncab2c1d37f8248b296ffd3707d97c5f5
13 Nf503cdc1daf84d9ead1eafb6a8ca20d8
14 Nf6d95f29b0a743d88843d14fd1773201
15 anzsrc-for:05
16 anzsrc-for:0503
17 anzsrc-for:06
18 anzsrc-for:0602
19 anzsrc-for:0605
20 schema:author N4e1fd3c2bbba4121a263b41a41a6d61c
21 schema:citation sg:pub.10.1007/s00248-010-9712-8
22 sg:pub.10.1007/s00248-011-9813-z
23 sg:pub.10.1038/nrmicro2473
24 sg:pub.10.1186/1471-2164-11-488
25 sg:pub.10.1186/1471-2334-4-5
26 schema:datePublished 2012-12-19
27 schema:datePublishedReg 2012-12-19
28 schema:description Whether or not treatment with antibiotics or probiotics for bacterial vaginosis (BV) is associated with a change in the diversity of vaginal microbiota in women was investigated. One hundred fifteen women, consisting of 30 healthy subjects, 30 BV-positive control subjects, 30 subjects with BV treated with a 7-day metronidazole regimen, and 25 subjects with BV treated with a 10-day probiotics regimen, were analyzed to determine the efficacy and disparity of diversity and richness of vaginal microbiota using 454 pyrosequencing. Follow-up visits at days 5 and 30 showed a greater BV cure rate in the probiotics-treated subjects (88.0 and 96 %, respectively) compared to the metronidazole-treated subjects (83.3 and 70 %, respectively [p = 0.625 at day 5 and p = 0.013 at day 30]). Treatment with metronidazole reduced the taxa diversity and eradicated most of the BV-associated phylotypes, while probiotics only suppressed the overgrowth and re-established vaginal homeostasis gradually and steadily. Despite significant interindividual variation, the microbiota of the actively treated groups or participants constituted a unique profile. Along with the decrease in pathogenic bacteria, such as Gardnerella, Atopobium, Prevotella, Megasphaera, Coriobacteriaceae, Lachnospiraceae, Mycoplasma, and Sneathia, a Lactobacillus-dominated vaginal microbiota was recovered. Acting as vaginal sentinels and biomarkers, the relative abundance of Lactobacillus and pathogenic bacteria determined the consistency of the BV clinical and microbiologic cure rates, as well as recurrent BV. Both 7-day intravaginal metronidazole and 10-day intravaginal probiotics have good efficacy against BV, while probiotics maintained normal vaginal microbiota longer due to effective and steady vaginal microbiota restoration, which provide new insights into BV treatment.
29 schema:genre article
30 schema:isAccessibleForFree false
31 schema:isPartOf N30e4f374032646ecafb02c28028e0567
32 Nbf46849ed2034d2da6c0e69456a597f5
33 sg:journal.1081458
34 schema:keywords Atopobium
35 BV treatment
36 Coriobacteriaceae
37 Gardnerella
38 Lachnospiraceae
39 Lactobacillus
40 Megasphaera
41 Prevotella
42 Sneathia
43 abundance
44 antibiotics
45 bacteria
46 bacterial vaginosis
47 better efficacy
48 biomarkers
49 changes
50 consistency
51 control subjects
52 cure rate
53 day 5
54 decrease
55 disparities
56 diversity
57 efficacy
58 group
59 healthy subjects
60 homeostasis
61 insights
62 interindividual variation
63 intravaginal metronidazole
64 metronidazole
65 metronidazole regimen
66 microbiologic cure rates
67 microbiota
68 microbiota restoration
69 mycoplasmas
70 new insights
71 normal vaginal microbiota
72 overgrowth
73 participants
74 pathogenic bacteria
75 phylotypes
76 probiotic regimen
77 probiotics
78 probiotics-treated subjects
79 profile
80 rate
81 recurrent bacterial vaginosis
82 regimen
83 relative abundance
84 restoration
85 richness
86 sentinels
87 significant interindividual variation
88 subjects
89 taxon diversity
90 treatment
91 unique profile
92 vaginal homeostasis
93 vaginal microbiota
94 vaginosis
95 variation
96 visits
97 women
98 schema:name The Restoration of the Vaginal Microbiota After Treatment for Bacterial Vaginosis with Metronidazole or Probiotics
99 schema:pagination 773-780
100 schema:productId N10ab2eb12e8a4025a56171f4d1abf573
101 N3e39543c31204dd39fe9f809eecd0aa1
102 N7b0056f9ac824dec90fc7ade09f4305f
103 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029951712
104 https://doi.org/10.1007/s00248-012-0154-3
105 schema:sdDatePublished 2022-08-04T16:59
106 schema:sdLicense https://scigraph.springernature.com/explorer/license/
107 schema:sdPublisher Nca956273ef604bf2bfd52e50f70afa0e
108 schema:url https://doi.org/10.1007/s00248-012-0154-3
109 sgo:license sg:explorer/license/
110 sgo:sdDataset articles
111 rdf:type schema:ScholarlyArticle
112 N0089c606e1f24e1b8d249a0655e670f3 rdf:first sg:person.01362152061.09
113 rdf:rest Ne7f408d5f530440da6508f1832a2939e
114 N0559bbf2b3b9480f8ee65068fd09bcf8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
115 schema:name Humans
116 rdf:type schema:DefinedTerm
117 N05bb7ce34b244235ab559e5f7284fa44 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
118 schema:name Cohort Studies
119 rdf:type schema:DefinedTerm
120 N09b3ff439c1c4edb970e476e25744d5b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
121 schema:name Phylogeny
122 rdf:type schema:DefinedTerm
123 N10ab2eb12e8a4025a56171f4d1abf573 schema:name pubmed_id
124 schema:value 23250116
125 rdf:type schema:PropertyValue
126 N10c6fa38911b4f63b4ad7d2a7dc0b5d5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
127 schema:name Metronidazole
128 rdf:type schema:DefinedTerm
129 N13c139255f5444c6a3b076b1f20870f6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
130 schema:name Administration, Intravaginal
131 rdf:type schema:DefinedTerm
132 N1b9964d837c146eb8a107192285964a1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
133 schema:name Lactobacillus
134 rdf:type schema:DefinedTerm
135 N1e993867fbac4195a038e5020a4c5fec rdf:first sg:person.01351102552.22
136 rdf:rest N22f1ccdec0cb4f88b02b72eca915b69c
137 N22f1ccdec0cb4f88b02b72eca915b69c rdf:first sg:person.01241654520.67
138 rdf:rest N511dbc7bf5ee453c9ad258a637acde9f
139 N2a61f935e1084598b76ba6a2915c4290 schema:affiliation grid-institutes:grid.411971.b
140 schema:familyName Huang
141 schema:givenName Shaolei
142 rdf:type schema:Person
143 N30e4f374032646ecafb02c28028e0567 schema:issueNumber 3
144 rdf:type schema:PublicationIssue
145 N31784124f34d4ec4bfab174b414b8fe3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
146 schema:name Molecular Sequence Data
147 rdf:type schema:DefinedTerm
148 N3e39543c31204dd39fe9f809eecd0aa1 schema:name dimensions_id
149 schema:value pub.1029951712
150 rdf:type schema:PropertyValue
151 N4e1fd3c2bbba4121a263b41a41a6d61c rdf:first sg:person.01026720607.54
152 rdf:rest Nf1bb9a9bc29d4ecc9fd67bb4a7712764
153 N511dbc7bf5ee453c9ad258a637acde9f rdf:first sg:person.0740052524.64
154 rdf:rest N683add449abf4679927f7abb37e1576d
155 N56616fb8bcba4a8aba123e3b8964a67f schema:affiliation grid-institutes:grid.411971.b
156 schema:familyName Zhang
157 schema:givenName Shaoen
158 rdf:type schema:Person
159 N619a9ff5be324003a99b32a77f34ed88 rdf:first sg:person.01170527524.65
160 rdf:rest Nab2176c5a711417091f1a216b03a5518
161 N67adc0105d524479b64583b55d2c6342 rdf:first N56616fb8bcba4a8aba123e3b8964a67f
162 rdf:rest N619a9ff5be324003a99b32a77f34ed88
163 N683add449abf4679927f7abb37e1576d rdf:first sg:person.01213406210.22
164 rdf:rest N94eae5f309dc4e08897c0872f3710e6f
165 N72e7e225c79a493b8c8e3092762e931f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
166 schema:name Vaginosis, Bacterial
167 rdf:type schema:DefinedTerm
168 N7b0056f9ac824dec90fc7ade09f4305f schema:name doi
169 schema:value 10.1007/s00248-012-0154-3
170 rdf:type schema:PropertyValue
171 N81a32c6a7d8040d08caad7b4d18eedbc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
172 schema:name Metagenome
173 rdf:type schema:DefinedTerm
174 N94eae5f309dc4e08897c0872f3710e6f rdf:first N2a61f935e1084598b76ba6a2915c4290
175 rdf:rest N67adc0105d524479b64583b55d2c6342
176 N99967d17f7a8429cb4f0eb4bbea16fdb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
177 schema:name Vagina
178 rdf:type schema:DefinedTerm
179 Nab2176c5a711417091f1a216b03a5518 rdf:first sg:person.01103002104.72
180 rdf:rest N0089c606e1f24e1b8d249a0655e670f3
181 Nb62e840da9c1472eb848fa1c22288bf9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
182 schema:name Probiotics
183 rdf:type schema:DefinedTerm
184 Nbc17e2f89cb3494c8ceaa2573f60d41b rdf:first sg:person.01052050627.08
185 rdf:rest N1e993867fbac4195a038e5020a4c5fec
186 Nbf46849ed2034d2da6c0e69456a597f5 schema:volumeNumber 65
187 rdf:type schema:PublicationVolume
188 Nca956273ef604bf2bfd52e50f70afa0e schema:name Springer Nature - SN SciGraph project
189 rdf:type schema:Organization
190 Ncab2c1d37f8248b296ffd3707d97c5f5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
191 schema:name Female
192 rdf:type schema:DefinedTerm
193 Ne7f408d5f530440da6508f1832a2939e rdf:first sg:person.01353071324.89
194 rdf:rest rdf:nil
195 Nf1bb9a9bc29d4ecc9fd67bb4a7712764 rdf:first sg:person.01301115024.52
196 rdf:rest Nbc17e2f89cb3494c8ceaa2573f60d41b
197 Nf503cdc1daf84d9ead1eafb6a8ca20d8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
198 schema:name Bacteria
199 rdf:type schema:DefinedTerm
200 Nf6d95f29b0a743d88843d14fd1773201 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
201 schema:name Treatment Outcome
202 rdf:type schema:DefinedTerm
203 anzsrc-for:05 schema:inDefinedTermSet anzsrc-for:
204 schema:name Environmental Sciences
205 rdf:type schema:DefinedTerm
206 anzsrc-for:0503 schema:inDefinedTermSet anzsrc-for:
207 schema:name Soil Sciences
208 rdf:type schema:DefinedTerm
209 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
210 schema:name Biological Sciences
211 rdf:type schema:DefinedTerm
212 anzsrc-for:0602 schema:inDefinedTermSet anzsrc-for:
213 schema:name Ecology
214 rdf:type schema:DefinedTerm
215 anzsrc-for:0605 schema:inDefinedTermSet anzsrc-for:
216 schema:name Microbiology
217 rdf:type schema:DefinedTerm
218 sg:journal.1081458 schema:issn 0095-3628
219 1432-184X
220 schema:name Microbial Ecology
221 schema:publisher Springer Nature
222 rdf:type schema:Periodical
223 sg:person.01026720607.54 schema:affiliation grid-institutes:grid.13402.34
224 schema:familyName Ling
225 schema:givenName Zongxin
226 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01026720607.54
227 rdf:type schema:Person
228 sg:person.01052050627.08 schema:affiliation grid-institutes:grid.13402.34
229 schema:familyName Chen
230 schema:givenName Weiguang
231 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01052050627.08
232 rdf:type schema:Person
233 sg:person.01103002104.72 schema:affiliation grid-institutes:grid.411971.b
234 schema:familyName Yuan
235 schema:givenName Jieli
236 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01103002104.72
237 rdf:type schema:Person
238 sg:person.01170527524.65 schema:affiliation grid-institutes:grid.464306.3
239 schema:familyName Wang
240 schema:givenName Yuezhu
241 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01170527524.65
242 rdf:type schema:Person
243 sg:person.01213406210.22 schema:affiliation grid-institutes:grid.469946.0
244 schema:familyName Nelson
245 schema:givenName Karen E
246 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01213406210.22
247 rdf:type schema:Person
248 sg:person.01241654520.67 schema:affiliation grid-institutes:grid.13402.34
249 schema:familyName Yuan
250 schema:givenName Li
251 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01241654520.67
252 rdf:type schema:Person
253 sg:person.01301115024.52 schema:affiliation grid-institutes:grid.13402.34
254 schema:familyName Liu
255 schema:givenName Xia
256 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01301115024.52
257 rdf:type schema:Person
258 sg:person.01351102552.22 schema:affiliation grid-institutes:grid.13402.34
259 schema:familyName Luo
260 schema:givenName Yueqiu
261 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01351102552.22
262 rdf:type schema:Person
263 sg:person.01353071324.89 schema:affiliation grid-institutes:grid.469946.0
264 schema:familyName Xiang
265 schema:givenName Charlie
266 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01353071324.89
267 rdf:type schema:Person
268 sg:person.01362152061.09 schema:affiliation grid-institutes:grid.13402.34
269 schema:familyName Li
270 schema:givenName Lanjuan
271 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01362152061.09
272 rdf:type schema:Person
273 sg:person.0740052524.64 schema:affiliation grid-institutes:grid.13402.34
274 schema:familyName Xia
275 schema:givenName Yaxian
276 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0740052524.64
277 rdf:type schema:Person
278 sg:pub.10.1007/s00248-010-9712-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036312224
279 https://doi.org/10.1007/s00248-010-9712-8
280 rdf:type schema:CreativeWork
281 sg:pub.10.1007/s00248-011-9813-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1032066401
282 https://doi.org/10.1007/s00248-011-9813-z
283 rdf:type schema:CreativeWork
284 sg:pub.10.1038/nrmicro2473 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003384875
285 https://doi.org/10.1038/nrmicro2473
286 rdf:type schema:CreativeWork
287 sg:pub.10.1186/1471-2164-11-488 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051912306
288 https://doi.org/10.1186/1471-2164-11-488
289 rdf:type schema:CreativeWork
290 sg:pub.10.1186/1471-2334-4-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017764187
291 https://doi.org/10.1186/1471-2334-4-5
292 rdf:type schema:CreativeWork
293 grid-institutes:grid.13402.34 schema:alternateName Department of Intensive Care Unit, the First Affiliated Hospital, College of Medicine, Zhejiang University, 310003, Hangzhou, Zhejiang, China
294 Department of Obstetrics and Gynecology, the First Affiliated Hospital, College of Medicine, Zhejiang University, 310003, Hangzhou, Zhejiang, China
295 State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, the First Affiliated Hospital, College of Medicine, Zhejiang University, 310003, Hangzhou, Zhejiang, China
296 schema:name Department of Intensive Care Unit, the First Affiliated Hospital, College of Medicine, Zhejiang University, 310003, Hangzhou, Zhejiang, China
297 Department of Obstetrics and Gynecology, the First Affiliated Hospital, College of Medicine, Zhejiang University, 310003, Hangzhou, Zhejiang, China
298 State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, the First Affiliated Hospital, College of Medicine, Zhejiang University, 310003, Hangzhou, Zhejiang, China
299 rdf:type schema:Organization
300 grid-institutes:grid.411971.b schema:alternateName Insititue of Microecology, Dalian Medical University, 116044, Dalian, Liaoning, China
301 schema:name Insititue of Microecology, Dalian Medical University, 116044, Dalian, Liaoning, China
302 rdf:type schema:Organization
303 grid-institutes:grid.464306.3 schema:alternateName Chinese National Human Genome Center at Shanghai, 201203, Shanghai, China
304 schema:name Chinese National Human Genome Center at Shanghai, 201203, Shanghai, China
305 rdf:type schema:Organization
306 grid-institutes:grid.469946.0 schema:alternateName J. Craig Venter Institute, 20850, Rockville, MD, USA
307 schema:name J. Craig Venter Institute, 20850, Rockville, MD, USA
308 State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, the First Affiliated Hospital, College of Medicine, Zhejiang University, 310003, Hangzhou, Zhejiang, China
309 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...