Importance of whole-body imaging with complete coverage of hands and feet in alveolar rhabdomyosarcoma staging View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2018-05

AUTHORS

Monika Scheer, Tobias Dantonello, Peter Brossart, Dagmar Dilloo, Lothar Schweigerer, Simone Feuchtgruber, Monika Sparber-Sauer, Christian Vokuhl, Stefan S. Bielack, Thomas Klingebiel, Ewa Koscielniak, Thekla von Kalle, on behalf of the Cooperative Weichteilsarkom Studiengruppe (CWS)

ABSTRACT

BACKGROUND: Alveolar rhabdomyosarcoma commonly arises in the extremities and is characterized by aggressive biology and high frequency of metastases. Whole-body imaging is increasingly employed in pediatric oncology but not recommended as standard in the staging of soft-tissue sarcomas. OBJECTIVE: After observing patients with a large symptomatic alveolar rhabdomyosarcoma lesion and a smaller silent lesion in the more distal part of an extremity we sought to estimate the frequency of this constellation. MATERIALS AND METHODS: We retrospectively evaluated the data of prospectively registered paediatric patients (age <21 years) with alveolar rhabdomyosarcoma in the SoTiSaR (Soft Tissue Sarcoma Registry) of the Cooperative Weichteilsarkom Studiengruppe (CWS) 09/2011-04/2015 with regard to whole-body imaging. RESULTS: Seventy-five patients were eligible. Images of 57 patients had been submitted for reference consultation, including 80 whole-body examinations in 36 patients. Among them were 5 patients (14%, 95% confidence interval 3-25%) who had been diagnosed because of a symptomatic lesion while an additional silent lesion in the distal part of an extremity had remained unnoticed and had only been detected by later whole-body imaging. It is noteworthy that in 42 (53%) of all 80 whole-body examinations, the hands and feet had been only partially covered or completely excluded. CONCLUSION: In alveolar rhabdomyosarcoma silent lesions can be overlooked when the distal parts of the limbs are not thoroughly examined and not completely covered by imaging. Missing them influences treatment decisions and prognosis. Our results should be considered when evaluating the potential role of whole-body imaging in rhabdomyosarcoma. More... »

PAGES

648-657

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00247-017-4066-8

DOI

http://dx.doi.org/10.1007/s00247-017-4066-8

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1100622812

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/29368010


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Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

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Turtle is a human-readable linked data format.

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RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s00247-017-4066-8'


 

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