Predictors of Rapid Aortic Root Dilation and Referral for Aortic Surgery in Marfan Syndrome View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2018-10

AUTHORS

Arvind Hoskoppal, Shaji Menon, Felicia Trachtenberg, Kristin M. Burns, Julie De Backer, Bruce D. Gelb, Marie Gleason, Jeanne James, Wyman W. Lai, Aimee Liou, Lynn Mahony, Aaron K. Olson, Reed E. Pyeritz, Angela M. Sharkey, Mario Stylianou, Stephanie Burns Wechsler, Luciana Young, Jami C. Levine, Elif Seda Selamet Tierney, Ronald V. Lacro, Timothy J. Bradley, Pediatric Heart Network Investigators

ABSTRACT

Few data exist regarding predictors of rapid aortic root dilation and referral for aortic surgery in Marfan syndrome (MFS). To identify independent predictors of the rate of aortic root (AoR) dilation and referral for aortic surgery, we investigated the data from the Pediatric Heart Network randomized trial of atenolol versus losartan in young patients with MFS. Data were analyzed from the echocardiograms at 0, 12, 24, and 36 months read in the core laboratory of 608 trial subjects, aged 6 months to 25 years, who met original Ghent criteria and had an AoR z-score (AoRz) > 3. Repeated measures linear and logistic regressions were used to determine multivariable predictors of AoR dilation. Receiver operator characteristic curves were used to determine cut-points in AoR dilation predicting referral for aortic surgery. Multivariable analysis showed rapid AoR dilation as defined by change in AoRz/year > 90th percentile was associated with older age, higher sinotubular junction z-score, and atenolol use (R2 = 0.01) or by change in AoR diameter (AoRd)/year > 90th percentile with higher sinotubular junction z-score and non-white race (R2 = 0.02). Referral for aortic root surgery was associated with higher AoRd, higher ascending aorta z-score, and higher sinotubular junction diameter:ascending aorta diameter ratio (R2 = 0.17). Change in AoRz of 0.72 SD units/year had 42% sensitivity and 92% specificity and change in AoRd of 0.34 cm/year had 38% sensitivity and 95% specificity for predicting referral for aortic surgery. In this cohort of young patients with MFS, no new robust predictors of rapid AoR dilation or referral for aortic root surgery were identified. Further investigation may determine whether generalized proximal aortic dilation and effacement of the sinotubular junction will allow for better risk stratification. Rate of AoR dilation cut-points had high specificity, but low sensitivity for predicting referral for aortic surgery, limiting their clinical use. Clinical Trial Number ClinicalTrials.gov number, NCT00429364. More... »

PAGES

1453-1461

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00246-018-1916-6

DOI

http://dx.doi.org/10.1007/s00246-018-1916-6

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1104528265

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/29948025


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "University of Utah", 
          "id": "https://www.grid.ac/institutes/grid.223827.e", 
          "name": [
            "University of Utah, Salt Lake City, UT, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hoskoppal", 
        "givenName": "Arvind", 
        "id": "sg:person.01306151031.14", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01306151031.14"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Utah", 
          "id": "https://www.grid.ac/institutes/grid.223827.e", 
          "name": [
            "University of Utah, Salt Lake City, UT, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Menon", 
        "givenName": "Shaji", 
        "id": "sg:person.0760604337.14", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0760604337.14"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "New England Research Institutes", 
          "id": "https://www.grid.ac/institutes/grid.280460.8", 
          "name": [
            "New England Research Institutes Inc., Watertown, MA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Trachtenberg", 
        "givenName": "Felicia", 
        "id": "sg:person.01321305021.43", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01321305021.43"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "National Heart Lung and Blood Institute", 
          "id": "https://www.grid.ac/institutes/grid.279885.9", 
          "name": [
            "National Heart, Lung, and Blood Institute, Bethesda, MD, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Burns", 
        "givenName": "Kristin M.", 
        "id": "sg:person.0622223754.59", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0622223754.59"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Ghent University Hospital", 
          "id": "https://www.grid.ac/institutes/grid.410566.0", 
          "name": [
            "Ghent University Hospital, Ghent, Belgium"
          ], 
          "type": "Organization"
        }, 
        "familyName": "De Backer", 
        "givenName": "Julie", 
        "id": "sg:person.0661555136.00", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0661555136.00"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Icahn School of Medicine at Mount Sinai", 
          "id": "https://www.grid.ac/institutes/grid.59734.3c", 
          "name": [
            "Icahn School of Medicine at Mount Sinai, New York, NY, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Gelb", 
        "givenName": "Bruce D.", 
        "id": "sg:person.01072606053.28", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01072606053.28"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Children\u2019s Hospital of Philadelphia, University of Pennsylvania, Philadelphia, PA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Gleason", 
        "givenName": "Marie", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Cincinnati Children\u2019s Hospital Medical Center, University of Cincinnati, Cincinnati, OH, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "James", 
        "givenName": "Jeanne", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Columbia University", 
          "id": "https://www.grid.ac/institutes/grid.21729.3f", 
          "name": [
            "Columbia University, New York, NY, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lai", 
        "givenName": "Wyman W.", 
        "id": "sg:person.01171147060.32", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01171147060.32"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Baylor College of Medicine", 
          "id": "https://www.grid.ac/institutes/grid.39382.33", 
          "name": [
            "Texas Children\u2019s Hospital, Baylor College of Medicine, Houston, TX, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Liou", 
        "givenName": "Aimee", 
        "id": "sg:person.01163503345.82", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01163503345.82"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Southwestern Medical Center", 
          "id": "https://www.grid.ac/institutes/grid.416214.4", 
          "name": [
            "Southwestern Medical Center, University of Texas, Dallas, TX, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Mahony", 
        "givenName": "Lynn", 
        "id": "sg:person.01336516634.01", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01336516634.01"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Washington", 
          "id": "https://www.grid.ac/institutes/grid.34477.33", 
          "name": [
            "University of Washington, Seattle, WA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Olson", 
        "givenName": "Aaron K.", 
        "id": "sg:person.0613254763.33", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0613254763.33"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Pennsylvania", 
          "id": "https://www.grid.ac/institutes/grid.25879.31", 
          "name": [
            "The Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Pyeritz", 
        "givenName": "Reed E.", 
        "id": "sg:person.0744465762.69", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0744465762.69"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Washington University in St. Louis", 
          "id": "https://www.grid.ac/institutes/grid.4367.6", 
          "name": [
            "Washington University, St. Louis, MO, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sharkey", 
        "givenName": "Angela M.", 
        "id": "sg:person.01103352442.30", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01103352442.30"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "National Heart Lung and Blood Institute", 
          "id": "https://www.grid.ac/institutes/grid.279885.9", 
          "name": [
            "National Heart, Lung, and Blood Institute, Bethesda, MD, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Stylianou", 
        "givenName": "Mario", 
        "id": "sg:person.0633160367.30", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0633160367.30"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Duke University", 
          "id": "https://www.grid.ac/institutes/grid.26009.3d", 
          "name": [
            "Duke University Medical Center, Duke University, Durham, NC, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Wechsler", 
        "givenName": "Stephanie Burns", 
        "id": "sg:person.01217601042.92", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01217601042.92"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Lurie Children's Hospital", 
          "id": "https://www.grid.ac/institutes/grid.413808.6", 
          "name": [
            "Ann and Robert H. Lurie Children\u2019s Hospital of Chicago, Chicago, IL, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Young", 
        "givenName": "Luciana", 
        "id": "sg:person.07611354716.48", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07611354716.48"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Boston Children\u2019s Hospital, Harvard Medical School, Boston, MA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Levine", 
        "givenName": "Jami C.", 
        "id": "sg:person.0710707751.24", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0710707751.24"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Boston Children\u2019s Hospital, Harvard Medical School, Boston, MA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Tierney", 
        "givenName": "Elif Seda Selamet", 
        "id": "sg:person.01355311023.18", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01355311023.18"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Boston Children\u2019s Hospital, Harvard Medical School, Boston, MA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lacro", 
        "givenName": "Ronald V.", 
        "id": "sg:person.0725263765.04", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0725263765.04"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Toronto", 
          "id": "https://www.grid.ac/institutes/grid.17063.33", 
          "name": [
            "The Hospital for Sick Children, University of Toronto, Toronto, ON, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bradley", 
        "givenName": "Timothy J.", 
        "id": "sg:person.011744702077.29", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011744702077.29"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Pediatric Heart Network Investigators", 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1016/s0003-4975(01)03236-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000754161"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/hrt.79.1.69", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003771208"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0002-9149(99)80659-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004304199"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa1404731", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017332267"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/jama.1943.82840370001006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018066309"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.athoracsur.2005.06.026", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021841006"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ahj.2007.06.024", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023746002"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/hrt.80.2.163", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025098102"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf01959393", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034330298", 
          "https://doi.org/10.1007/bf01959393"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf01959393", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034330298", 
          "https://doi.org/10.1007/bf01959393"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0735-1097(93)90559-j", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034338776"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ijcard.2005.01.040", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035931718"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0002-9149(89)90430-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045109798"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.amjcard.2009.11.040", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045267334"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.echo.2013.02.018", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045433339"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/hrt.75.4.389", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051910472"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(05)67789-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051956451"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/(sici)1096-8628(19960424)62:4<417::aid-ajmg15>3.0.co;2-r", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053284167"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ehj.2004.04.033", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1054732521"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2018-10", 
    "datePublishedReg": "2018-10-01", 
    "description": "Few data exist regarding predictors of rapid aortic root dilation and referral for aortic surgery in Marfan syndrome (MFS). To identify independent predictors of the rate of aortic root (AoR) dilation and referral for aortic surgery, we investigated the data from the Pediatric Heart Network randomized trial of atenolol versus losartan in young patients with MFS. Data were analyzed from the echocardiograms at 0, 12, 24, and 36\u00a0months read in the core laboratory of 608 trial subjects, aged 6\u00a0months to 25 years, who met original Ghent criteria and had an AoR z-score (AoRz)\u2009>\u20093. Repeated measures linear and logistic regressions were used to determine multivariable predictors of AoR dilation. Receiver operator characteristic curves were used to determine cut-points in AoR dilation predicting referral for aortic surgery. Multivariable analysis showed rapid AoR dilation as defined by change in AoRz/year\u2009>\u200990th percentile was associated with older age, higher sinotubular junction z-score, and atenolol use (R2\u2009=\u20090.01) or by change in AoR diameter (AoRd)/year\u2009>\u200990th percentile with higher sinotubular junction z-score and non-white race (R2\u2009=\u20090.02). Referral for aortic root surgery was associated with higher AoRd, higher ascending aorta z-score, and higher sinotubular junction diameter:ascending aorta diameter ratio (R2\u2009=\u20090.17). Change in AoRz of 0.72 SD units/year had 42% sensitivity and 92% specificity and change in AoRd of 0.34\u00a0cm/year had 38% sensitivity and 95% specificity for predicting referral for aortic surgery. In this cohort of young patients with MFS, no new robust predictors of rapid AoR dilation or referral for aortic root surgery were identified. Further investigation may determine whether generalized proximal aortic dilation and effacement of the sinotubular junction will allow for better risk stratification. Rate of AoR dilation cut-points had high specificity, but low sensitivity for predicting referral for aortic surgery, limiting their clinical use. Clinical Trial Number ClinicalTrials.gov number, NCT00429364.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/s00246-018-1916-6", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.2691884", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2691706", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2691709", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2691711", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2691704", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2694372", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2691705", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2694460", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.6541420", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2691710", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2691708", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2691707", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1091102", 
        "issn": [
          "0172-0643", 
          "1432-1971"
        ], 
        "name": "Pediatric Cardiology", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "7", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "39"
      }
    ], 
    "name": "Predictors of Rapid Aortic Root Dilation and Referral for Aortic Surgery in Marfan Syndrome", 
    "pagination": "1453-1461", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "cbf9f79c60d55cc79a8fff6e982d734d345c9a1d8758c524a0accc8994b52dc0"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "29948025"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "8003849"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s00246-018-1916-6"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1104528265"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s00246-018-1916-6", 
      "https://app.dimensions.ai/details/publication/pub.1104528265"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T20:06", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8681_00000570.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1007%2Fs00246-018-1916-6"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s00246-018-1916-6'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s00246-018-1916-6'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s00246-018-1916-6'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s00246-018-1916-6'


 

This table displays all metadata directly associated to this object as RDF triples.

339 TRIPLES      21 PREDICATES      47 URIs      21 LITERALS      9 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s00246-018-1916-6 schema:about anzsrc-for:11
2 anzsrc-for:1103
3 schema:author Nd2d592aad2ed408c9bbbed357050c84b
4 schema:citation sg:pub.10.1007/bf01959393
5 https://doi.org/10.1001/jama.1943.82840370001006
6 https://doi.org/10.1002/(sici)1096-8628(19960424)62:4<417::aid-ajmg15>3.0.co;2-r
7 https://doi.org/10.1016/0002-9149(89)90430-x
8 https://doi.org/10.1016/0735-1097(93)90559-j
9 https://doi.org/10.1016/j.ahj.2007.06.024
10 https://doi.org/10.1016/j.amjcard.2009.11.040
11 https://doi.org/10.1016/j.athoracsur.2005.06.026
12 https://doi.org/10.1016/j.echo.2013.02.018
13 https://doi.org/10.1016/j.ehj.2004.04.033
14 https://doi.org/10.1016/j.ijcard.2005.01.040
15 https://doi.org/10.1016/s0002-9149(99)80659-6
16 https://doi.org/10.1016/s0003-4975(01)03236-2
17 https://doi.org/10.1016/s0140-6736(05)67789-6
18 https://doi.org/10.1056/nejmoa1404731
19 https://doi.org/10.1136/hrt.75.4.389
20 https://doi.org/10.1136/hrt.79.1.69
21 https://doi.org/10.1136/hrt.80.2.163
22 schema:datePublished 2018-10
23 schema:datePublishedReg 2018-10-01
24 schema:description Few data exist regarding predictors of rapid aortic root dilation and referral for aortic surgery in Marfan syndrome (MFS). To identify independent predictors of the rate of aortic root (AoR) dilation and referral for aortic surgery, we investigated the data from the Pediatric Heart Network randomized trial of atenolol versus losartan in young patients with MFS. Data were analyzed from the echocardiograms at 0, 12, 24, and 36 months read in the core laboratory of 608 trial subjects, aged 6 months to 25 years, who met original Ghent criteria and had an AoR z-score (AoRz) &gt; 3. Repeated measures linear and logistic regressions were used to determine multivariable predictors of AoR dilation. Receiver operator characteristic curves were used to determine cut-points in AoR dilation predicting referral for aortic surgery. Multivariable analysis showed rapid AoR dilation as defined by change in AoRz/year &gt; 90th percentile was associated with older age, higher sinotubular junction z-score, and atenolol use (R<sup>2</sup> = 0.01) or by change in AoR diameter (AoRd)/year &gt; 90th percentile with higher sinotubular junction z-score and non-white race (R<sup>2</sup> = 0.02). Referral for aortic root surgery was associated with higher AoRd, higher ascending aorta z-score, and higher sinotubular junction diameter:ascending aorta diameter ratio (R<sup>2</sup> = 0.17). Change in AoRz of 0.72 SD units/year had 42% sensitivity and 92% specificity and change in AoRd of 0.34 cm/year had 38% sensitivity and 95% specificity for predicting referral for aortic surgery. In this cohort of young patients with MFS, no new robust predictors of rapid AoR dilation or referral for aortic root surgery were identified. Further investigation may determine whether generalized proximal aortic dilation and effacement of the sinotubular junction will allow for better risk stratification. Rate of AoR dilation cut-points had high specificity, but low sensitivity for predicting referral for aortic surgery, limiting their clinical use. Clinical Trial Number ClinicalTrials.gov number, NCT00429364.
25 schema:genre research_article
26 schema:inLanguage en
27 schema:isAccessibleForFree true
28 schema:isPartOf N0a45ce8c5214474daabdbe982508c28d
29 Nac97ccf5c497459dad653cf2969e777d
30 sg:journal.1091102
31 schema:name Predictors of Rapid Aortic Root Dilation and Referral for Aortic Surgery in Marfan Syndrome
32 schema:pagination 1453-1461
33 schema:productId N3619d1c6c04143659d1cd89485cda9e1
34 N5e453fe403674b8698bba3e5fea392bf
35 N65d64f9913984d43a0b3cd3172e7370e
36 N68819905deba4b6cbe4ccbdb13b47f5c
37 Nf0af201ed24e42a49c870915cfd8566b
38 schema:sameAs https://app.dimensions.ai/details/publication/pub.1104528265
39 https://doi.org/10.1007/s00246-018-1916-6
40 schema:sdDatePublished 2019-04-10T20:06
41 schema:sdLicense https://scigraph.springernature.com/explorer/license/
42 schema:sdPublisher N1ee1745370904ea6986f697beb4d9866
43 schema:url http://link.springer.com/10.1007%2Fs00246-018-1916-6
44 sgo:license sg:explorer/license/
45 sgo:sdDataset articles
46 rdf:type schema:ScholarlyArticle
47 N0a45ce8c5214474daabdbe982508c28d schema:issueNumber 7
48 rdf:type schema:PublicationIssue
49 N12bf645bda6f4e6b83b4310125ca023c rdf:first sg:person.0744465762.69
50 rdf:rest N1fe50289112c4d74834308e6c6be21a7
51 N13783cf0bd0f41e8b27b78132030d595 schema:name Children’s Hospital of Philadelphia, University of Pennsylvania, Philadelphia, PA, USA
52 rdf:type schema:Organization
53 N1bcb50f36d1b4859b03bf464b638d4a0 rdf:first sg:person.0760604337.14
54 rdf:rest N66b980b4bafb468db8f48147dbd928eb
55 N1ee1745370904ea6986f697beb4d9866 schema:name Springer Nature - SN SciGraph project
56 rdf:type schema:Organization
57 N1fe50289112c4d74834308e6c6be21a7 rdf:first sg:person.01103352442.30
58 rdf:rest N85039d53a3514a45bb621603a33b5864
59 N2927ea074ea845c8ba1d6f2c2382416b schema:name Boston Children’s Hospital, Harvard Medical School, Boston, MA, USA
60 rdf:type schema:Organization
61 N33b8e0fe201e4f22a9f58c79f8e5af25 rdf:first Ne307922e5cb24cd0af035852e2d47326
62 rdf:rest N51aece00d2804200bea233dd9f0376d0
63 N3619d1c6c04143659d1cd89485cda9e1 schema:name doi
64 schema:value 10.1007/s00246-018-1916-6
65 rdf:type schema:PropertyValue
66 N462bfafe48b24f7bb025a7c095121f65 rdf:first sg:person.01217601042.92
67 rdf:rest Na3db5de6fbc9460185348b25f18c13f0
68 N4702ddd0da89476dacd6c650f76c0ac8 rdf:first N90ccfd0608714a6ab873de6127860481
69 rdf:rest N33b8e0fe201e4f22a9f58c79f8e5af25
70 N51aece00d2804200bea233dd9f0376d0 rdf:first sg:person.01171147060.32
71 rdf:rest N6b82d23021d4429c897c636c76d726a2
72 N5e453fe403674b8698bba3e5fea392bf schema:name pubmed_id
73 schema:value 29948025
74 rdf:type schema:PropertyValue
75 N65d64f9913984d43a0b3cd3172e7370e schema:name readcube_id
76 schema:value cbf9f79c60d55cc79a8fff6e982d734d345c9a1d8758c524a0accc8994b52dc0
77 rdf:type schema:PropertyValue
78 N66b980b4bafb468db8f48147dbd928eb rdf:first sg:person.01321305021.43
79 rdf:rest N689e39ebaba3446b9b495684243f2d84
80 N68819905deba4b6cbe4ccbdb13b47f5c schema:name nlm_unique_id
81 schema:value 8003849
82 rdf:type schema:PropertyValue
83 N689e39ebaba3446b9b495684243f2d84 rdf:first sg:person.0622223754.59
84 rdf:rest Ncb73133cade84921ab0bb66bad944640
85 N6b82d23021d4429c897c636c76d726a2 rdf:first sg:person.01163503345.82
86 rdf:rest Na8fbc02467ff474d8bd3d8ab72fdcc3c
87 N78f120958729478e8706e8627757232a rdf:first sg:person.01072606053.28
88 rdf:rest N4702ddd0da89476dacd6c650f76c0ac8
89 N85039d53a3514a45bb621603a33b5864 rdf:first sg:person.0633160367.30
90 rdf:rest N462bfafe48b24f7bb025a7c095121f65
91 N90ccfd0608714a6ab873de6127860481 schema:affiliation N13783cf0bd0f41e8b27b78132030d595
92 schema:familyName Gleason
93 schema:givenName Marie
94 rdf:type schema:Person
95 N9200eee246d4486f829cc9504d612b31 schema:name Cincinnati Children’s Hospital Medical Center, University of Cincinnati, Cincinnati, OH, USA
96 rdf:type schema:Organization
97 N95c0c0a62d64422881eb353fd689d7ae rdf:first Ndcdaf53bed284e9388a329b30f0e23b6
98 rdf:rest rdf:nil
99 Na3db5de6fbc9460185348b25f18c13f0 rdf:first sg:person.07611354716.48
100 rdf:rest Nc044835cc3ba4d13bf9d0359a9f9420e
101 Na8fbc02467ff474d8bd3d8ab72fdcc3c rdf:first sg:person.01336516634.01
102 rdf:rest Nee9d9394ea2b46b9a024086472b32741
103 Nac97ccf5c497459dad653cf2969e777d schema:volumeNumber 39
104 rdf:type schema:PublicationVolume
105 Nc044835cc3ba4d13bf9d0359a9f9420e rdf:first sg:person.0710707751.24
106 rdf:rest Ne8d6c78fce3b48a784772a2527b6b9da
107 Nc618ccaeacd442559b5d9073784112c7 rdf:first sg:person.011744702077.29
108 rdf:rest N95c0c0a62d64422881eb353fd689d7ae
109 Nc838d08a549243798fd99f398535769e schema:name Boston Children’s Hospital, Harvard Medical School, Boston, MA, USA
110 rdf:type schema:Organization
111 Ncb73133cade84921ab0bb66bad944640 rdf:first sg:person.0661555136.00
112 rdf:rest N78f120958729478e8706e8627757232a
113 Nd2d592aad2ed408c9bbbed357050c84b rdf:first sg:person.01306151031.14
114 rdf:rest N1bcb50f36d1b4859b03bf464b638d4a0
115 Ndcdaf53bed284e9388a329b30f0e23b6 schema:familyName Pediatric Heart Network Investigators
116 rdf:type schema:Person
117 Ne307922e5cb24cd0af035852e2d47326 schema:affiliation N9200eee246d4486f829cc9504d612b31
118 schema:familyName James
119 schema:givenName Jeanne
120 rdf:type schema:Person
121 Ne6e8c0ff3f674a24bb41423b46682ffd rdf:first sg:person.0725263765.04
122 rdf:rest Nc618ccaeacd442559b5d9073784112c7
123 Ne8d6c78fce3b48a784772a2527b6b9da rdf:first sg:person.01355311023.18
124 rdf:rest Ne6e8c0ff3f674a24bb41423b46682ffd
125 Nebf7135c337149dd9c639c644f9f9441 schema:name Boston Children’s Hospital, Harvard Medical School, Boston, MA, USA
126 rdf:type schema:Organization
127 Nee9d9394ea2b46b9a024086472b32741 rdf:first sg:person.0613254763.33
128 rdf:rest N12bf645bda6f4e6b83b4310125ca023c
129 Nf0af201ed24e42a49c870915cfd8566b schema:name dimensions_id
130 schema:value pub.1104528265
131 rdf:type schema:PropertyValue
132 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
133 schema:name Medical and Health Sciences
134 rdf:type schema:DefinedTerm
135 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
136 schema:name Clinical Sciences
137 rdf:type schema:DefinedTerm
138 sg:grant.2691704 http://pending.schema.org/fundedItem sg:pub.10.1007/s00246-018-1916-6
139 rdf:type schema:MonetaryGrant
140 sg:grant.2691705 http://pending.schema.org/fundedItem sg:pub.10.1007/s00246-018-1916-6
141 rdf:type schema:MonetaryGrant
142 sg:grant.2691706 http://pending.schema.org/fundedItem sg:pub.10.1007/s00246-018-1916-6
143 rdf:type schema:MonetaryGrant
144 sg:grant.2691707 http://pending.schema.org/fundedItem sg:pub.10.1007/s00246-018-1916-6
145 rdf:type schema:MonetaryGrant
146 sg:grant.2691708 http://pending.schema.org/fundedItem sg:pub.10.1007/s00246-018-1916-6
147 rdf:type schema:MonetaryGrant
148 sg:grant.2691709 http://pending.schema.org/fundedItem sg:pub.10.1007/s00246-018-1916-6
149 rdf:type schema:MonetaryGrant
150 sg:grant.2691710 http://pending.schema.org/fundedItem sg:pub.10.1007/s00246-018-1916-6
151 rdf:type schema:MonetaryGrant
152 sg:grant.2691711 http://pending.schema.org/fundedItem sg:pub.10.1007/s00246-018-1916-6
153 rdf:type schema:MonetaryGrant
154 sg:grant.2691884 http://pending.schema.org/fundedItem sg:pub.10.1007/s00246-018-1916-6
155 rdf:type schema:MonetaryGrant
156 sg:grant.2694372 http://pending.schema.org/fundedItem sg:pub.10.1007/s00246-018-1916-6
157 rdf:type schema:MonetaryGrant
158 sg:grant.2694460 http://pending.schema.org/fundedItem sg:pub.10.1007/s00246-018-1916-6
159 rdf:type schema:MonetaryGrant
160 sg:grant.6541420 http://pending.schema.org/fundedItem sg:pub.10.1007/s00246-018-1916-6
161 rdf:type schema:MonetaryGrant
162 sg:journal.1091102 schema:issn 0172-0643
163 1432-1971
164 schema:name Pediatric Cardiology
165 rdf:type schema:Periodical
166 sg:person.01072606053.28 schema:affiliation https://www.grid.ac/institutes/grid.59734.3c
167 schema:familyName Gelb
168 schema:givenName Bruce D.
169 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01072606053.28
170 rdf:type schema:Person
171 sg:person.01103352442.30 schema:affiliation https://www.grid.ac/institutes/grid.4367.6
172 schema:familyName Sharkey
173 schema:givenName Angela M.
174 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01103352442.30
175 rdf:type schema:Person
176 sg:person.01163503345.82 schema:affiliation https://www.grid.ac/institutes/grid.39382.33
177 schema:familyName Liou
178 schema:givenName Aimee
179 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01163503345.82
180 rdf:type schema:Person
181 sg:person.01171147060.32 schema:affiliation https://www.grid.ac/institutes/grid.21729.3f
182 schema:familyName Lai
183 schema:givenName Wyman W.
184 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01171147060.32
185 rdf:type schema:Person
186 sg:person.011744702077.29 schema:affiliation https://www.grid.ac/institutes/grid.17063.33
187 schema:familyName Bradley
188 schema:givenName Timothy J.
189 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011744702077.29
190 rdf:type schema:Person
191 sg:person.01217601042.92 schema:affiliation https://www.grid.ac/institutes/grid.26009.3d
192 schema:familyName Wechsler
193 schema:givenName Stephanie Burns
194 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01217601042.92
195 rdf:type schema:Person
196 sg:person.01306151031.14 schema:affiliation https://www.grid.ac/institutes/grid.223827.e
197 schema:familyName Hoskoppal
198 schema:givenName Arvind
199 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01306151031.14
200 rdf:type schema:Person
201 sg:person.01321305021.43 schema:affiliation https://www.grid.ac/institutes/grid.280460.8
202 schema:familyName Trachtenberg
203 schema:givenName Felicia
204 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01321305021.43
205 rdf:type schema:Person
206 sg:person.01336516634.01 schema:affiliation https://www.grid.ac/institutes/grid.416214.4
207 schema:familyName Mahony
208 schema:givenName Lynn
209 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01336516634.01
210 rdf:type schema:Person
211 sg:person.01355311023.18 schema:affiliation Nc838d08a549243798fd99f398535769e
212 schema:familyName Tierney
213 schema:givenName Elif Seda Selamet
214 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01355311023.18
215 rdf:type schema:Person
216 sg:person.0613254763.33 schema:affiliation https://www.grid.ac/institutes/grid.34477.33
217 schema:familyName Olson
218 schema:givenName Aaron K.
219 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0613254763.33
220 rdf:type schema:Person
221 sg:person.0622223754.59 schema:affiliation https://www.grid.ac/institutes/grid.279885.9
222 schema:familyName Burns
223 schema:givenName Kristin M.
224 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0622223754.59
225 rdf:type schema:Person
226 sg:person.0633160367.30 schema:affiliation https://www.grid.ac/institutes/grid.279885.9
227 schema:familyName Stylianou
228 schema:givenName Mario
229 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0633160367.30
230 rdf:type schema:Person
231 sg:person.0661555136.00 schema:affiliation https://www.grid.ac/institutes/grid.410566.0
232 schema:familyName De Backer
233 schema:givenName Julie
234 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0661555136.00
235 rdf:type schema:Person
236 sg:person.0710707751.24 schema:affiliation Nebf7135c337149dd9c639c644f9f9441
237 schema:familyName Levine
238 schema:givenName Jami C.
239 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0710707751.24
240 rdf:type schema:Person
241 sg:person.0725263765.04 schema:affiliation N2927ea074ea845c8ba1d6f2c2382416b
242 schema:familyName Lacro
243 schema:givenName Ronald V.
244 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0725263765.04
245 rdf:type schema:Person
246 sg:person.0744465762.69 schema:affiliation https://www.grid.ac/institutes/grid.25879.31
247 schema:familyName Pyeritz
248 schema:givenName Reed E.
249 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0744465762.69
250 rdf:type schema:Person
251 sg:person.0760604337.14 schema:affiliation https://www.grid.ac/institutes/grid.223827.e
252 schema:familyName Menon
253 schema:givenName Shaji
254 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0760604337.14
255 rdf:type schema:Person
256 sg:person.07611354716.48 schema:affiliation https://www.grid.ac/institutes/grid.413808.6
257 schema:familyName Young
258 schema:givenName Luciana
259 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07611354716.48
260 rdf:type schema:Person
261 sg:pub.10.1007/bf01959393 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034330298
262 https://doi.org/10.1007/bf01959393
263 rdf:type schema:CreativeWork
264 https://doi.org/10.1001/jama.1943.82840370001006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018066309
265 rdf:type schema:CreativeWork
266 https://doi.org/10.1002/(sici)1096-8628(19960424)62:4<417::aid-ajmg15>3.0.co;2-r schema:sameAs https://app.dimensions.ai/details/publication/pub.1053284167
267 rdf:type schema:CreativeWork
268 https://doi.org/10.1016/0002-9149(89)90430-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1045109798
269 rdf:type schema:CreativeWork
270 https://doi.org/10.1016/0735-1097(93)90559-j schema:sameAs https://app.dimensions.ai/details/publication/pub.1034338776
271 rdf:type schema:CreativeWork
272 https://doi.org/10.1016/j.ahj.2007.06.024 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023746002
273 rdf:type schema:CreativeWork
274 https://doi.org/10.1016/j.amjcard.2009.11.040 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045267334
275 rdf:type schema:CreativeWork
276 https://doi.org/10.1016/j.athoracsur.2005.06.026 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021841006
277 rdf:type schema:CreativeWork
278 https://doi.org/10.1016/j.echo.2013.02.018 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045433339
279 rdf:type schema:CreativeWork
280 https://doi.org/10.1016/j.ehj.2004.04.033 schema:sameAs https://app.dimensions.ai/details/publication/pub.1054732521
281 rdf:type schema:CreativeWork
282 https://doi.org/10.1016/j.ijcard.2005.01.040 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035931718
283 rdf:type schema:CreativeWork
284 https://doi.org/10.1016/s0002-9149(99)80659-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004304199
285 rdf:type schema:CreativeWork
286 https://doi.org/10.1016/s0003-4975(01)03236-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000754161
287 rdf:type schema:CreativeWork
288 https://doi.org/10.1016/s0140-6736(05)67789-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051956451
289 rdf:type schema:CreativeWork
290 https://doi.org/10.1056/nejmoa1404731 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017332267
291 rdf:type schema:CreativeWork
292 https://doi.org/10.1136/hrt.75.4.389 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051910472
293 rdf:type schema:CreativeWork
294 https://doi.org/10.1136/hrt.79.1.69 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003771208
295 rdf:type schema:CreativeWork
296 https://doi.org/10.1136/hrt.80.2.163 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025098102
297 rdf:type schema:CreativeWork
298 https://www.grid.ac/institutes/grid.17063.33 schema:alternateName University of Toronto
299 schema:name The Hospital for Sick Children, University of Toronto, Toronto, ON, Canada
300 rdf:type schema:Organization
301 https://www.grid.ac/institutes/grid.21729.3f schema:alternateName Columbia University
302 schema:name Columbia University, New York, NY, USA
303 rdf:type schema:Organization
304 https://www.grid.ac/institutes/grid.223827.e schema:alternateName University of Utah
305 schema:name University of Utah, Salt Lake City, UT, USA
306 rdf:type schema:Organization
307 https://www.grid.ac/institutes/grid.25879.31 schema:alternateName University of Pennsylvania
308 schema:name The Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA
309 rdf:type schema:Organization
310 https://www.grid.ac/institutes/grid.26009.3d schema:alternateName Duke University
311 schema:name Duke University Medical Center, Duke University, Durham, NC, USA
312 rdf:type schema:Organization
313 https://www.grid.ac/institutes/grid.279885.9 schema:alternateName National Heart Lung and Blood Institute
314 schema:name National Heart, Lung, and Blood Institute, Bethesda, MD, USA
315 rdf:type schema:Organization
316 https://www.grid.ac/institutes/grid.280460.8 schema:alternateName New England Research Institutes
317 schema:name New England Research Institutes Inc., Watertown, MA, USA
318 rdf:type schema:Organization
319 https://www.grid.ac/institutes/grid.34477.33 schema:alternateName University of Washington
320 schema:name University of Washington, Seattle, WA, USA
321 rdf:type schema:Organization
322 https://www.grid.ac/institutes/grid.39382.33 schema:alternateName Baylor College of Medicine
323 schema:name Texas Children’s Hospital, Baylor College of Medicine, Houston, TX, USA
324 rdf:type schema:Organization
325 https://www.grid.ac/institutes/grid.410566.0 schema:alternateName Ghent University Hospital
326 schema:name Ghent University Hospital, Ghent, Belgium
327 rdf:type schema:Organization
328 https://www.grid.ac/institutes/grid.413808.6 schema:alternateName Lurie Children's Hospital
329 schema:name Ann and Robert H. Lurie Children’s Hospital of Chicago, Chicago, IL, USA
330 rdf:type schema:Organization
331 https://www.grid.ac/institutes/grid.416214.4 schema:alternateName Southwestern Medical Center
332 schema:name Southwestern Medical Center, University of Texas, Dallas, TX, USA
333 rdf:type schema:Organization
334 https://www.grid.ac/institutes/grid.4367.6 schema:alternateName Washington University in St. Louis
335 schema:name Washington University, St. Louis, MO, USA
336 rdf:type schema:Organization
337 https://www.grid.ac/institutes/grid.59734.3c schema:alternateName Icahn School of Medicine at Mount Sinai
338 schema:name Icahn School of Medicine at Mount Sinai, New York, NY, USA
339 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...