Myocardial Strain Using Cardiac MR Feature Tracking and Speckle Tracking Echocardiography in Duchenne Muscular Dystrophy Patients View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2018-03

AUTHORS

Bryan Siegel, Laura Olivieri, Heather Gordish-Dressman, Christopher F. Spurney

ABSTRACT

Duchenne muscular dystrophy (DMD) is an inherited X-linked disorder with an incidence of 1 in 3500 male births, and cardiomyopathy is becoming the leading cause of death. While Cardiac MRI (CMR) and late gadolinium enhancement (LGE) are important tools in recognizing myocardial involvement, myocardial strain imaging may demonstrate early changes and allow patients to avoid gadolinium contrast. We performed CMR feature tracking (FT) and echo-based speckle tracking (STE) strain measures on DMD patients and age/sex matched controls who had received a CMR with contrast and transthoracic echocardiogram. Data were collected for longitudinal strain in the apical four-chamber view and circumferential strain in the mid-papillary parasternal short axis. Segmental wall analysis was performed and compared with the presence of LGE. Data were analyzed using student's t tests or one-way ANOVA adjusting for multiple comparisons. We measured 24 subjects with DMD and 8 controls. Thirteen of 24 DMD subjects were LGE positive only in the lateral segments in short-axis views. Average circumferential strain (CS) measured by FT was significantly decreased in DMD compared to controls (- 18.8 ± 6.1 vs. - 25.5 ± 3.2; p < 0.001) and showed significant differences in the anterolateral, inferolateral, and inferior segments. Average CS by STE trended towards significance (p = 0.06) but showed significance in only the inferior segment. FT showed significant differences in the inferolateral segment between LGE positive (- 15.5 ± 9.0) and LGE negative (- 18.2 ± 8.3) in DMD subjects compared to controls (- 28.6 ± 7.3; p ≤ 0.04). FT also showed significant differences between anteroseptal and inferolateral segments within LGE-positive (p < 0.003) and LGE-negative (p < 0.03) DMD subjects while STE did not. There were no significant differences in longitudinal strain measures. CMR-FT-derived myocardial strain was able to demonstrate differences between subjects with DMD and controls not detected by STE. FT was also able to demonstrate differences in LGE-positive and LGE-negative segments within patients with DMD. FT may be able to predict LGE-positive segments in DMD without the use of gadolinium contrast. More... »

PAGES

478-483

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00246-017-1777-4

DOI

http://dx.doi.org/10.1007/s00246-017-1777-4

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1093074744

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/29188318


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1109", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Neurosciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adolescent", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cardiomyopathies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Child", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cross-Sectional Studies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Echocardiography", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Gadolinium", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Magnetic Resonance Imaging, Cine", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Muscular Dystrophy, Duchenne", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Myocardium", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Retrospective Studies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Young Adult", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Children\u2019s National Health System", 
          "id": "https://www.grid.ac/institutes/grid.239560.b", 
          "name": [
            "Division of Cardiology, Children\u2019s National Health System, Washington DC, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Siegel", 
        "givenName": "Bryan", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Children\u2019s National Health System", 
          "id": "https://www.grid.ac/institutes/grid.239560.b", 
          "name": [
            "Division of Cardiology, Children\u2019s National Health System, Washington DC, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Olivieri", 
        "givenName": "Laura", 
        "id": "sg:person.01224064701.57", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01224064701.57"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Children\u2019s National Health System", 
          "id": "https://www.grid.ac/institutes/grid.239560.b", 
          "name": [
            "Center for Genetic Medicine Research, Children\u2019s National Health System, Washington DC, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Gordish-Dressman", 
        "givenName": "Heather", 
        "id": "sg:person.01250747034.44", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01250747034.44"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Children\u2019s National Health System", 
          "id": "https://www.grid.ac/institutes/grid.239560.b", 
          "name": [
            "Division of Cardiology, Children\u2019s National Health System, Washington DC, USA", 
            "Center for Genetic Medicine Research, Children\u2019s National Health System, Washington DC, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Spurney", 
        "givenName": "Christopher F.", 
        "id": "sg:person.011707332027.86", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011707332027.86"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1002/mus.24163", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001251644"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.echo.2015.03.003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002570610"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1532-429x-15-107", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003860108", 
          "https://doi.org/10.1186/1532-429x-15-107"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4103/0974-2069.197046", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006634606"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00246-014-0972-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007298503", 
          "https://doi.org/10.1007/s00246-014-0972-9"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1532-429x-13-20", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008841216", 
          "https://doi.org/10.1186/1532-429x-13-20"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0167-5273(90)90082-g", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010582937"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00246-016-1451-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013894148", 
          "https://doi.org/10.1007/s00246-016-1451-2"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00246-016-1451-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013894148", 
          "https://doi.org/10.1007/s00246-016-1451-2"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00246-012-0622-z", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014091615", 
          "https://doi.org/10.1007/s00246-012-0622-z"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.echo.2016.07.001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017264979"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s12968-016-0231-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020580973", 
          "https://doi.org/10.1186/s12968-016-0231-8"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00247-016-3553-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034578724", 
          "https://doi.org/10.1007/s00247-016-3553-7"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0960-8966(02)00140-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036107046"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0960-8966(02)00140-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036107046"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10554-016-0998-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036857293", 
          "https://doi.org/10.1007/s10554-016-0998-6"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10554-016-0998-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036857293", 
          "https://doi.org/10.1007/s10554-016-0998-6"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ejrad.2015.11.023", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039387727"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jacc.2016.02.081", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041969890"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jcmg.2009.11.006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046323379"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00246-016-1549-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047753375", 
          "https://doi.org/10.1007/s00246-016-1549-6"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00246-016-1549-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047753375", 
          "https://doi.org/10.1007/s00246-016-1549-6"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s12968-016-0269-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048555865", 
          "https://doi.org/10.1186/s12968-016-0269-7"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s12968-016-0269-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048555865", 
          "https://doi.org/10.1186/s12968-016-0269-7"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jacr.2015.11.009", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050247383"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jacr.2015.11.009", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050247383"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jacr.2015.11.009", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050247383"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jacr.2015.11.009", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050247383"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jacr.2015.11.009", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050247383"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/circulationaha.114.015151", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050708998"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/circulationaha.114.015151", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050708998"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00246-015-1329-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052062548", 
          "https://doi.org/10.1007/s00246-015-1329-8"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1081/jcmr-120003946", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1058431637"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/ehjci/jew042", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059501702"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2018-03", 
    "datePublishedReg": "2018-03-01", 
    "description": "Duchenne muscular dystrophy (DMD) is an inherited X-linked disorder with an incidence of 1 in 3500 male births, and cardiomyopathy is becoming the leading cause of death. While Cardiac MRI (CMR) and late gadolinium enhancement (LGE) are important tools in recognizing myocardial involvement, myocardial strain imaging may demonstrate early changes and allow patients to avoid gadolinium contrast. We performed CMR feature tracking (FT) and echo-based speckle tracking (STE) strain measures on DMD patients and age/sex matched controls who had received a CMR with contrast and transthoracic echocardiogram. Data were collected for longitudinal strain in the apical four-chamber view and circumferential strain in the mid-papillary parasternal short axis. Segmental wall analysis was performed and compared with the presence of LGE. Data were analyzed using student's t tests or one-way ANOVA adjusting for multiple comparisons. We measured 24 subjects with DMD and 8 controls. Thirteen of 24 DMD subjects were LGE positive only in the lateral segments in short-axis views. Average circumferential strain (CS) measured by FT was significantly decreased in DMD compared to controls (-\u200918.8\u2009\u00b1\u20096.1 vs. -\u200925.5\u2009\u00b1\u20093.2; p\u2009<\u20090.001) and showed significant differences in the anterolateral, inferolateral, and inferior segments. Average CS by STE trended towards significance (p\u2009=\u20090.06) but showed significance in only the inferior segment. FT showed significant differences in the inferolateral segment between LGE positive (-\u200915.5\u2009\u00b1\u20099.0) and LGE negative (-\u200918.2\u2009\u00b1\u20098.3) in DMD subjects compared to controls (-\u200928.6\u2009\u00b1\u20097.3; p\u2009\u2264\u20090.04). FT also showed significant differences between anteroseptal and inferolateral segments within LGE-positive (p\u2009<\u20090.003) and LGE-negative (p\u2009<\u20090.03) DMD subjects while STE did not. There were no significant differences in longitudinal strain measures. CMR-FT-derived myocardial strain was able to demonstrate differences between subjects with DMD and controls not detected by STE. FT was also able to demonstrate differences in LGE-positive and LGE-negative segments within patients with DMD. FT may be able to predict LGE-positive segments in DMD without the use of gadolinium contrast.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/s00246-017-1777-4", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1091102", 
        "issn": [
          "0172-0643", 
          "1432-1971"
        ], 
        "name": "Pediatric Cardiology", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "3", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "39"
      }
    ], 
    "name": "Myocardial Strain Using Cardiac MR Feature Tracking and Speckle Tracking Echocardiography in Duchenne Muscular Dystrophy Patients", 
    "pagination": "478-483", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "0bc02850a44a9cf6dcda49c0a825daecb3c608e99bcc455f3a14531a5d4220bc"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "29188318"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "8003849"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s00246-017-1777-4"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1093074744"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s00246-017-1777-4", 
      "https://app.dimensions.ai/details/publication/pub.1093074744"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T14:23", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8660_00000602.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1007/s00246-017-1777-4"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s00246-017-1777-4'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s00246-017-1777-4'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s00246-017-1777-4'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s00246-017-1777-4'


 

This table displays all metadata directly associated to this object as RDF triples.

229 TRIPLES      21 PREDICATES      67 URIs      35 LITERALS      23 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s00246-017-1777-4 schema:about N06e8048c7fec4940923f830a16d5e752
2 N1947f29d821c4011bd7fe875e37d3b4e
3 N35637b869f4145ceb02cd9e9caf643d3
4 N4e8ef07217134c12926da3b5b824a39d
5 N54b2aecf8cd84e528db527195837e7d5
6 N5eff3f70f7ef4c3091392bd1b5b3be59
7 N73d5548954c94e7ca957b270347f79c4
8 N770da8658fff498181ca1efff1cf26aa
9 N82a0c18e7b44432aab5b122156a392b6
10 Nb90af9cb32cc4af39b600a36f91498dc
11 Nbff0f523541649b9ad7d99a4c6281a3e
12 Nc179170c074b4bf1953cbad24255947f
13 Nc4ec40d98c904db1b4bd88fe457f10ff
14 Ne169a690042846358cc2283d06683c66
15 anzsrc-for:11
16 anzsrc-for:1109
17 schema:author N7bfa33251d7d497a91a36e4f370ad7e0
18 schema:citation sg:pub.10.1007/s00246-012-0622-z
19 sg:pub.10.1007/s00246-014-0972-9
20 sg:pub.10.1007/s00246-015-1329-8
21 sg:pub.10.1007/s00246-016-1451-2
22 sg:pub.10.1007/s00246-016-1549-6
23 sg:pub.10.1007/s00247-016-3553-7
24 sg:pub.10.1007/s10554-016-0998-6
25 sg:pub.10.1186/1532-429x-13-20
26 sg:pub.10.1186/1532-429x-15-107
27 sg:pub.10.1186/s12968-016-0231-8
28 sg:pub.10.1186/s12968-016-0269-7
29 https://doi.org/10.1002/mus.24163
30 https://doi.org/10.1016/0167-5273(90)90082-g
31 https://doi.org/10.1016/j.echo.2015.03.003
32 https://doi.org/10.1016/j.echo.2016.07.001
33 https://doi.org/10.1016/j.ejrad.2015.11.023
34 https://doi.org/10.1016/j.jacc.2016.02.081
35 https://doi.org/10.1016/j.jacr.2015.11.009
36 https://doi.org/10.1016/j.jcmg.2009.11.006
37 https://doi.org/10.1016/s0960-8966(02)00140-2
38 https://doi.org/10.1081/jcmr-120003946
39 https://doi.org/10.1093/ehjci/jew042
40 https://doi.org/10.1161/circulationaha.114.015151
41 https://doi.org/10.4103/0974-2069.197046
42 schema:datePublished 2018-03
43 schema:datePublishedReg 2018-03-01
44 schema:description Duchenne muscular dystrophy (DMD) is an inherited X-linked disorder with an incidence of 1 in 3500 male births, and cardiomyopathy is becoming the leading cause of death. While Cardiac MRI (CMR) and late gadolinium enhancement (LGE) are important tools in recognizing myocardial involvement, myocardial strain imaging may demonstrate early changes and allow patients to avoid gadolinium contrast. We performed CMR feature tracking (FT) and echo-based speckle tracking (STE) strain measures on DMD patients and age/sex matched controls who had received a CMR with contrast and transthoracic echocardiogram. Data were collected for longitudinal strain in the apical four-chamber view and circumferential strain in the mid-papillary parasternal short axis. Segmental wall analysis was performed and compared with the presence of LGE. Data were analyzed using student's t tests or one-way ANOVA adjusting for multiple comparisons. We measured 24 subjects with DMD and 8 controls. Thirteen of 24 DMD subjects were LGE positive only in the lateral segments in short-axis views. Average circumferential strain (CS) measured by FT was significantly decreased in DMD compared to controls (- 18.8 ± 6.1 vs. - 25.5 ± 3.2; p < 0.001) and showed significant differences in the anterolateral, inferolateral, and inferior segments. Average CS by STE trended towards significance (p = 0.06) but showed significance in only the inferior segment. FT showed significant differences in the inferolateral segment between LGE positive (- 15.5 ± 9.0) and LGE negative (- 18.2 ± 8.3) in DMD subjects compared to controls (- 28.6 ± 7.3; p ≤ 0.04). FT also showed significant differences between anteroseptal and inferolateral segments within LGE-positive (p < 0.003) and LGE-negative (p < 0.03) DMD subjects while STE did not. There were no significant differences in longitudinal strain measures. CMR-FT-derived myocardial strain was able to demonstrate differences between subjects with DMD and controls not detected by STE. FT was also able to demonstrate differences in LGE-positive and LGE-negative segments within patients with DMD. FT may be able to predict LGE-positive segments in DMD without the use of gadolinium contrast.
45 schema:genre research_article
46 schema:inLanguage en
47 schema:isAccessibleForFree false
48 schema:isPartOf N0d168bd24352490d83bedf6943b92293
49 N80f25e32feef44bb86b0500bf4467e8b
50 sg:journal.1091102
51 schema:name Myocardial Strain Using Cardiac MR Feature Tracking and Speckle Tracking Echocardiography in Duchenne Muscular Dystrophy Patients
52 schema:pagination 478-483
53 schema:productId N6a492b6496e14140a2251f8341afbc64
54 N901fe4c89d5a4b248820adf81f3d89c5
55 Na61dbdd9550748aa87684082296c81c4
56 Na92812619514415dbb41c2f4fe77e5d8
57 Nf4eb845f7cc143bb97e8d8b4ab400285
58 schema:sameAs https://app.dimensions.ai/details/publication/pub.1093074744
59 https://doi.org/10.1007/s00246-017-1777-4
60 schema:sdDatePublished 2019-04-10T14:23
61 schema:sdLicense https://scigraph.springernature.com/explorer/license/
62 schema:sdPublisher N47e6948c68794e3483cfd34a21b548e4
63 schema:url http://link.springer.com/10.1007/s00246-017-1777-4
64 sgo:license sg:explorer/license/
65 sgo:sdDataset articles
66 rdf:type schema:ScholarlyArticle
67 N06e8048c7fec4940923f830a16d5e752 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
68 schema:name Muscular Dystrophy, Duchenne
69 rdf:type schema:DefinedTerm
70 N0d168bd24352490d83bedf6943b92293 schema:volumeNumber 39
71 rdf:type schema:PublicationVolume
72 N1947f29d821c4011bd7fe875e37d3b4e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
73 schema:name Echocardiography
74 rdf:type schema:DefinedTerm
75 N35637b869f4145ceb02cd9e9caf643d3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
76 schema:name Humans
77 rdf:type schema:DefinedTerm
78 N47e6948c68794e3483cfd34a21b548e4 schema:name Springer Nature - SN SciGraph project
79 rdf:type schema:Organization
80 N4e8ef07217134c12926da3b5b824a39d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
81 schema:name Retrospective Studies
82 rdf:type schema:DefinedTerm
83 N54b2aecf8cd84e528db527195837e7d5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
84 schema:name Female
85 rdf:type schema:DefinedTerm
86 N5eff3f70f7ef4c3091392bd1b5b3be59 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
87 schema:name Magnetic Resonance Imaging, Cine
88 rdf:type schema:DefinedTerm
89 N6a492b6496e14140a2251f8341afbc64 schema:name nlm_unique_id
90 schema:value 8003849
91 rdf:type schema:PropertyValue
92 N73d5548954c94e7ca957b270347f79c4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
93 schema:name Gadolinium
94 rdf:type schema:DefinedTerm
95 N770b90f25d12421792f88bd2f62ac3a6 rdf:first sg:person.011707332027.86
96 rdf:rest rdf:nil
97 N770da8658fff498181ca1efff1cf26aa schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
98 schema:name Child
99 rdf:type schema:DefinedTerm
100 N7bfa33251d7d497a91a36e4f370ad7e0 rdf:first Na941a2822821491281e10f22275e124d
101 rdf:rest Nf66e90e13cf24dda835addd1f487fa42
102 N80f25e32feef44bb86b0500bf4467e8b schema:issueNumber 3
103 rdf:type schema:PublicationIssue
104 N82a0c18e7b44432aab5b122156a392b6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
105 schema:name Adolescent
106 rdf:type schema:DefinedTerm
107 N901fe4c89d5a4b248820adf81f3d89c5 schema:name readcube_id
108 schema:value 0bc02850a44a9cf6dcda49c0a825daecb3c608e99bcc455f3a14531a5d4220bc
109 rdf:type schema:PropertyValue
110 Na61dbdd9550748aa87684082296c81c4 schema:name pubmed_id
111 schema:value 29188318
112 rdf:type schema:PropertyValue
113 Na92812619514415dbb41c2f4fe77e5d8 schema:name doi
114 schema:value 10.1007/s00246-017-1777-4
115 rdf:type schema:PropertyValue
116 Na941a2822821491281e10f22275e124d schema:affiliation https://www.grid.ac/institutes/grid.239560.b
117 schema:familyName Siegel
118 schema:givenName Bryan
119 rdf:type schema:Person
120 Nb90af9cb32cc4af39b600a36f91498dc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
121 schema:name Cross-Sectional Studies
122 rdf:type schema:DefinedTerm
123 Nbff0f523541649b9ad7d99a4c6281a3e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
124 schema:name Male
125 rdf:type schema:DefinedTerm
126 Nc179170c074b4bf1953cbad24255947f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
127 schema:name Myocardium
128 rdf:type schema:DefinedTerm
129 Nc4ec40d98c904db1b4bd88fe457f10ff schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
130 schema:name Young Adult
131 rdf:type schema:DefinedTerm
132 Nd695dbba548d464f9ade843248c21391 rdf:first sg:person.01250747034.44
133 rdf:rest N770b90f25d12421792f88bd2f62ac3a6
134 Ne169a690042846358cc2283d06683c66 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
135 schema:name Cardiomyopathies
136 rdf:type schema:DefinedTerm
137 Nf4eb845f7cc143bb97e8d8b4ab400285 schema:name dimensions_id
138 schema:value pub.1093074744
139 rdf:type schema:PropertyValue
140 Nf66e90e13cf24dda835addd1f487fa42 rdf:first sg:person.01224064701.57
141 rdf:rest Nd695dbba548d464f9ade843248c21391
142 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
143 schema:name Medical and Health Sciences
144 rdf:type schema:DefinedTerm
145 anzsrc-for:1109 schema:inDefinedTermSet anzsrc-for:
146 schema:name Neurosciences
147 rdf:type schema:DefinedTerm
148 sg:journal.1091102 schema:issn 0172-0643
149 1432-1971
150 schema:name Pediatric Cardiology
151 rdf:type schema:Periodical
152 sg:person.011707332027.86 schema:affiliation https://www.grid.ac/institutes/grid.239560.b
153 schema:familyName Spurney
154 schema:givenName Christopher F.
155 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011707332027.86
156 rdf:type schema:Person
157 sg:person.01224064701.57 schema:affiliation https://www.grid.ac/institutes/grid.239560.b
158 schema:familyName Olivieri
159 schema:givenName Laura
160 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01224064701.57
161 rdf:type schema:Person
162 sg:person.01250747034.44 schema:affiliation https://www.grid.ac/institutes/grid.239560.b
163 schema:familyName Gordish-Dressman
164 schema:givenName Heather
165 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01250747034.44
166 rdf:type schema:Person
167 sg:pub.10.1007/s00246-012-0622-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1014091615
168 https://doi.org/10.1007/s00246-012-0622-z
169 rdf:type schema:CreativeWork
170 sg:pub.10.1007/s00246-014-0972-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007298503
171 https://doi.org/10.1007/s00246-014-0972-9
172 rdf:type schema:CreativeWork
173 sg:pub.10.1007/s00246-015-1329-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052062548
174 https://doi.org/10.1007/s00246-015-1329-8
175 rdf:type schema:CreativeWork
176 sg:pub.10.1007/s00246-016-1451-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013894148
177 https://doi.org/10.1007/s00246-016-1451-2
178 rdf:type schema:CreativeWork
179 sg:pub.10.1007/s00246-016-1549-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047753375
180 https://doi.org/10.1007/s00246-016-1549-6
181 rdf:type schema:CreativeWork
182 sg:pub.10.1007/s00247-016-3553-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034578724
183 https://doi.org/10.1007/s00247-016-3553-7
184 rdf:type schema:CreativeWork
185 sg:pub.10.1007/s10554-016-0998-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036857293
186 https://doi.org/10.1007/s10554-016-0998-6
187 rdf:type schema:CreativeWork
188 sg:pub.10.1186/1532-429x-13-20 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008841216
189 https://doi.org/10.1186/1532-429x-13-20
190 rdf:type schema:CreativeWork
191 sg:pub.10.1186/1532-429x-15-107 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003860108
192 https://doi.org/10.1186/1532-429x-15-107
193 rdf:type schema:CreativeWork
194 sg:pub.10.1186/s12968-016-0231-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020580973
195 https://doi.org/10.1186/s12968-016-0231-8
196 rdf:type schema:CreativeWork
197 sg:pub.10.1186/s12968-016-0269-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048555865
198 https://doi.org/10.1186/s12968-016-0269-7
199 rdf:type schema:CreativeWork
200 https://doi.org/10.1002/mus.24163 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001251644
201 rdf:type schema:CreativeWork
202 https://doi.org/10.1016/0167-5273(90)90082-g schema:sameAs https://app.dimensions.ai/details/publication/pub.1010582937
203 rdf:type schema:CreativeWork
204 https://doi.org/10.1016/j.echo.2015.03.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002570610
205 rdf:type schema:CreativeWork
206 https://doi.org/10.1016/j.echo.2016.07.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017264979
207 rdf:type schema:CreativeWork
208 https://doi.org/10.1016/j.ejrad.2015.11.023 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039387727
209 rdf:type schema:CreativeWork
210 https://doi.org/10.1016/j.jacc.2016.02.081 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041969890
211 rdf:type schema:CreativeWork
212 https://doi.org/10.1016/j.jacr.2015.11.009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050247383
213 rdf:type schema:CreativeWork
214 https://doi.org/10.1016/j.jcmg.2009.11.006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046323379
215 rdf:type schema:CreativeWork
216 https://doi.org/10.1016/s0960-8966(02)00140-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036107046
217 rdf:type schema:CreativeWork
218 https://doi.org/10.1081/jcmr-120003946 schema:sameAs https://app.dimensions.ai/details/publication/pub.1058431637
219 rdf:type schema:CreativeWork
220 https://doi.org/10.1093/ehjci/jew042 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059501702
221 rdf:type schema:CreativeWork
222 https://doi.org/10.1161/circulationaha.114.015151 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050708998
223 rdf:type schema:CreativeWork
224 https://doi.org/10.4103/0974-2069.197046 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006634606
225 rdf:type schema:CreativeWork
226 https://www.grid.ac/institutes/grid.239560.b schema:alternateName Children’s National Health System
227 schema:name Center for Genetic Medicine Research, Children’s National Health System, Washington DC, USA
228 Division of Cardiology, Children’s National Health System, Washington DC, USA
229 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...