Incidence of Respiratory Disease During the First Two Years of Life in Children with Hemodynamically Significant Congenital Heart Disease in ... View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2016-12

AUTHORS

Giacomo Pongiglione, Alessandro Possidoni, Umberto di Luzio Paparatti, Anna Maria Costanzo, Giuliana Gualberti, Marco Bonvicini, Alessandro Rimini, Gabriella Agnoletti, Maria Pia Calabrò, Marco Pozzi, Roberto Tumbarello, Patrizia Salice, Patrizio Fiorini, Maria Giovanna Russo, Ornella Milanesi

ABSTRACT

Children affected by hemodynamically significant congenital heart disease (HSCHD) experience severe respiratory complications that can increase the frequency of hospitalizations. The aim of the SINERGY study was to describe the incidence of respiratory diseases and to collect information on active and passive immunoprophylaxis in the first 2 years of life. In this retrospective, multicenter, and epidemiologic study, children with HSCHD were enrolled across 11 Italian sites. Children born between December 31, 2007, and December 31, 2012, were observed during their first 2 years of life. Data were collected through hospital database searches and parent interviews. Four hundred twenty children were enrolled: 51.7 % were female, 79.5 % were born full-term (≥37 weeks), and 77.6 % weighed >2500 g at birth. The most frequent heart defects were ventricular septal defect (23.1 %) and coarctation of the aorta (14.3 %). The incidence of respiratory diseases was 63.1 %. Frequent respiratory diseases not requiring hospitalization were upper respiratory tract infections (76.4 %), acute bronchitis (43.3 %), and influenza (22.1 %), while those requiring hospitalization were bronchitis and bronchiolitis (8.3 % each one). While active immunoprophylaxis was applied with wide compliance (diphtheria/pertussis/tetanus, 99.5 %; Haemophilus influenzae type b, 72.5 %; pneumococcus, 79.9 %; meningococcus, 77.4 %), only 54 % of children received respiratory syncytial virus (RSV) passive prophylaxis (palivizumab). Of the 35 hospitalizations due to bronchiolitis, 27 (77.1 %) did not receive prophylaxis against RSV, compared with 8 (22.9 %) who received prophylaxis (P < 0.0001). Children with HSCHD are at major risk of respiratory diseases. Passive immunoprophylaxis can help to prevent hospitalizations for bronchiolitis. More... »

PAGES

1581-1589

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00246-016-1473-9

DOI

http://dx.doi.org/10.1007/s00246-016-1473-9

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1033356987

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/27573216


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1117", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Public Health and Health Services", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Antibodies, Monoclonal", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Antibodies, Monoclonal, Humanized", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Antiviral Agents", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Child", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Heart Defects, Congenital", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Hospitalization", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Incidence", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Italy", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Respiratory Syncytial Virus Infections", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Retrospective Studies", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "name": [
            "Centro Cardiologico Paediatrico del Mediterraneo Taormina, Bambino Ges\u00f9 Roma, Rome, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Pongiglione", 
        "givenName": "Giacomo", 
        "id": "sg:person.01142632351.15", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01142632351.15"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "AbbVie SrL Italy, Campoverde, Via Pontina km 52, Campoverde di Aprilia (LT), Latina, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Possidoni", 
        "givenName": "Alessandro", 
        "id": "sg:person.013073173171.39", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013073173171.39"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "AbbVie SrL Italy, Campoverde, Via Pontina km 52, Campoverde di Aprilia (LT), Latina, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "di Luzio Paparatti", 
        "givenName": "Umberto", 
        "id": "sg:person.01256577311.65", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01256577311.65"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "AbbVie SrL Italy, Campoverde, Via Pontina km 52, Campoverde di Aprilia (LT), Latina, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Costanzo", 
        "givenName": "Anna Maria", 
        "id": "sg:person.01330204142.80", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01330204142.80"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "AbbVie SrL Italy, Campoverde, Via Pontina km 52, Campoverde di Aprilia (LT), Latina, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Gualberti", 
        "givenName": "Giuliana", 
        "id": "sg:person.01140013756.54", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01140013756.54"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Policlinico S.Orsola-Malpighi", 
          "id": "https://www.grid.ac/institutes/grid.412311.4", 
          "name": [
            "Azienda Ospedaliero Universitaria di Bologna, Policlinico Sant\u2019Orsola Malpighi, Bologna, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bonvicini", 
        "givenName": "Marco", 
        "id": "sg:person.01164464046.29", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01164464046.29"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Istituto Giannina Gaslini", 
          "id": "https://www.grid.ac/institutes/grid.419504.d", 
          "name": [
            "Istituto \u201cGiannina Gaslini\u201d Genova, Genoa, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Rimini", 
        "givenName": "Alessandro", 
        "id": "sg:person.01312440515.09", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01312440515.09"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "A.O. Citt\u00e0 della Salute e della Scienza di Torino, Ospedale Infantile Regina Margherita Torino, Turin, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Agnoletti", 
        "givenName": "Gabriella", 
        "id": "sg:person.01203017203.87", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01203017203.87"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Azienda Ospedaliera Universitaria Policlinico \"G. Martino\"", 
          "id": "https://www.grid.ac/institutes/grid.412507.5", 
          "name": [
            "Azienda Ospedaliera Universitaria Policlinico \u201cG. Martino\u201d di Messina, Messina, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Calabr\u00f2", 
        "givenName": "Maria Pia", 
        "id": "sg:person.0600063030.23", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0600063030.23"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Azienda Ospedaliera Universitaria Ospedali Riuniti di Ancona \u201cUmberto I, G.M. Lancisi, G. Salesi\u201d, Ancona, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Pozzi", 
        "givenName": "Marco", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Azienda Ospedaliera G. Brotzu", 
          "id": "https://www.grid.ac/institutes/grid.417308.9", 
          "name": [
            "Azienda Ospedaliera \u201cG.Brotzu\u201d Cagliari, Cagliari, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Tumbarello", 
        "givenName": "Roberto", 
        "id": "sg:person.01176747617.77", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01176747617.77"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "IRCCS C\u00e0 Granda Ospedale Maggiore Policlinico di Milano, Milan, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Salice", 
        "givenName": "Patrizia", 
        "id": "sg:person.01325426346.00", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01325426346.00"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Meyer Children's Hospital", 
          "id": "https://www.grid.ac/institutes/grid.413181.e", 
          "name": [
            "Azienda Ospedaliero-Universitaria Meyer Firenze, Florence, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Fiorini", 
        "givenName": "Patrizio", 
        "id": "sg:person.0621577042.67", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0621577042.67"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Ospedale Monaldi", 
          "id": "https://www.grid.ac/institutes/grid.416052.4", 
          "name": [
            "Ospedale Monaldi, Seconda Universit\u00e0 di Napoli, Naples, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Russo", 
        "givenName": "Maria Giovanna", 
        "id": "sg:person.01153450630.70", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01153450630.70"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Azienda Ospedaliera di Padova", 
          "id": "https://www.grid.ac/institutes/grid.411474.3", 
          "name": [
            "Azienda Ospedaliera di Padova, Padua, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Milanesi", 
        "givenName": "Ornella", 
        "id": "sg:person.0664251014.48", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0664251014.48"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1097/01.inf.0000108220.94201.1a", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000815994"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.inf.0000108220.94201.1a", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000815994"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10096-005-0082-y", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000856408", 
          "https://doi.org/10.1007/s10096-005-0082-y"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10096-005-0082-y", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000856408", 
          "https://doi.org/10.1007/s10096-005-0082-y"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/ppul.10047", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002402842"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/bmb/62.1.99", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007046738"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jpeds.2008.05.059", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007457365"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/archpedi.152.8.739", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008725332"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1080/13814780600757153", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008979533"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/apa.12658", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009445603"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0735-1097(02)01886-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010634253"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/eurheartj/ehq249", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013716686"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/eurheartj/ehq249", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013716686"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/jama.1980.03300390029017", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017113990"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1179/joc.2010.22.1.30", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025375482"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/jp.2008.28", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025398396", 
          "https://doi.org/10.1038/jp.2008.28"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(99)01241-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026767124"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2223/jped.2202", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027964002"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.vaccine.2005.02.004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031847607"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.inf.0000053884.21238.13", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034067855"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.inf.0000053884.21238.13", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034067855"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1651-2227.2007.00275.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034393319"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1046/j.1460-9592.2003.01192.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035549766"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0002-9343(01)01058-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035622054"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/bdra.23111", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036458394"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa0804877", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038522253"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/ppul.23102", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040483583"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00006454-200404000-00008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040487436"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00006454-200404000-00008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040487436"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1440-1754.2011.02219.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040813712"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/ppul.10288", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042855256"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.siny.2012.01.008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043609071"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0022-3476(86)81034-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044750459"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00431-011-1525-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044867848", 
          "https://doi.org/10.1007/s00431-011-1525-3"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jpeds.2009.11.062", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045412228"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pmed.0030076", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046917335"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pmed.0030076", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046917335"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s40121-014-0046-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049475122", 
          "https://doi.org/10.1007/s40121-014-0046-6"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/jama.243.13.1345", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1054138800"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/doi:http://dx.doi.org/10.2223/jped.2202", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1078581071"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2016-12", 
    "datePublishedReg": "2016-12-01", 
    "description": "Children affected by hemodynamically significant congenital heart disease (HSCHD) experience severe respiratory complications that can increase the frequency of hospitalizations. The aim of the SINERGY study was to describe the incidence of respiratory diseases and to collect information on active and passive immunoprophylaxis in the first 2\u00a0years of life. In this retrospective, multicenter, and epidemiologic study, children with HSCHD were enrolled across 11 Italian sites. Children born between December 31, 2007, and December 31, 2012, were observed during their first 2\u00a0years of life. Data were collected through hospital database searches and parent interviews. Four hundred twenty children were enrolled: 51.7\u00a0% were female, 79.5\u00a0% were born full-term (\u226537\u00a0weeks), and 77.6\u00a0% weighed >2500\u00a0g at birth. The most frequent heart defects were ventricular septal defect (23.1\u00a0%) and coarctation of the aorta (14.3\u00a0%). The incidence of respiratory diseases was 63.1\u00a0%. Frequent respiratory diseases not requiring hospitalization were upper respiratory tract infections (76.4\u00a0%), acute bronchitis (43.3\u00a0%), and influenza (22.1\u00a0%), while those requiring hospitalization were bronchitis and bronchiolitis (8.3\u00a0% each one). While active immunoprophylaxis was applied with wide compliance (diphtheria/pertussis/tetanus, 99.5\u00a0%; Haemophilus influenzae type b, 72.5\u00a0%; pneumococcus, 79.9\u00a0%; meningococcus, 77.4\u00a0%), only 54\u00a0% of children received respiratory syncytial virus (RSV) passive prophylaxis (palivizumab). Of the 35 hospitalizations due to bronchiolitis, 27 (77.1\u00a0%) did not receive prophylaxis against RSV, compared with 8 (22.9\u00a0%) who received prophylaxis (P\u00a0<\u00a00.0001). Children with HSCHD are at major risk of respiratory diseases. Passive immunoprophylaxis can help to prevent hospitalizations for bronchiolitis.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/s00246-016-1473-9", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1091102", 
        "issn": [
          "0172-0643", 
          "1432-1971"
        ], 
        "name": "Pediatric Cardiology", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "8", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "37"
      }
    ], 
    "name": "Incidence of Respiratory Disease During the First Two Years of Life in Children with Hemodynamically Significant Congenital Heart Disease in Italy: A Retrospective Study", 
    "pagination": "1581-1589", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "9ee832a66c9476c132dddc64dd61d6f25145e729cf246a33c63bea6b013929c0"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "27573216"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "8003849"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s00246-016-1473-9"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1033356987"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s00246-016-1473-9", 
      "https://app.dimensions.ai/details/publication/pub.1033356987"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T12:37", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000363_0000000363/records_70037_00000001.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://link.springer.com/10.1007%2Fs00246-016-1473-9"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s00246-016-1473-9'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s00246-016-1473-9'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s00246-016-1473-9'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s00246-016-1473-9'


 

This table displays all metadata directly associated to this object as RDF triples.

358 TRIPLES      21 PREDICATES      76 URIs      34 LITERALS      22 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s00246-016-1473-9 schema:about N0fb3fd35105e48b48123a08d1dc9479a
2 N1091f13c35074fe486f6bf03444e0fea
3 N1f59f15d3c5249caa9fcab3aa2861ab4
4 N62dab8161a9943a89aa4c76ab2a23781
5 N6540a34e919742d9b6ec5881b28b3ad2
6 Nabb0189db2ee400eb689c1b3acff486b
7 Nbd7faca6b62549f499b38cae2467e6b6
8 Nc25dc6ec3bfc4578a61ca587a8d64184
9 Nce051567c2cd4e66a463bbf7b9d2786b
10 Ncf28900db3f64ccc816dfc1748fd2aaa
11 Nf41b547296784b76bb9d85b607903fe9
12 Nfa12f6ff5bb4498d99e6c03e0bbc180b
13 Nfa804db65dae478397389d05365f9c18
14 anzsrc-for:11
15 anzsrc-for:1117
16 schema:author N409e456324ba4e3697d8cfd0f458c292
17 schema:citation sg:pub.10.1007/s00431-011-1525-3
18 sg:pub.10.1007/s10096-005-0082-y
19 sg:pub.10.1007/s40121-014-0046-6
20 sg:pub.10.1038/jp.2008.28
21 https://doi.org/10.1001/archpedi.152.8.739
22 https://doi.org/10.1001/jama.1980.03300390029017
23 https://doi.org/10.1001/jama.243.13.1345
24 https://doi.org/10.1002/bdra.23111
25 https://doi.org/10.1002/ppul.10047
26 https://doi.org/10.1002/ppul.10288
27 https://doi.org/10.1002/ppul.23102
28 https://doi.org/10.1016/j.jpeds.2008.05.059
29 https://doi.org/10.1016/j.jpeds.2009.11.062
30 https://doi.org/10.1016/j.siny.2012.01.008
31 https://doi.org/10.1016/j.vaccine.2005.02.004
32 https://doi.org/10.1016/s0002-9343(01)01058-0
33 https://doi.org/10.1016/s0022-3476(86)81034-4
34 https://doi.org/10.1016/s0140-6736(99)01241-6
35 https://doi.org/10.1016/s0735-1097(02)01886-7
36 https://doi.org/10.1046/j.1460-9592.2003.01192.x
37 https://doi.org/10.1056/nejmoa0804877
38 https://doi.org/10.1080/13814780600757153
39 https://doi.org/10.1093/bmb/62.1.99
40 https://doi.org/10.1093/eurheartj/ehq249
41 https://doi.org/10.1097/00006454-200404000-00008
42 https://doi.org/10.1097/01.inf.0000053884.21238.13
43 https://doi.org/10.1097/01.inf.0000108220.94201.1a
44 https://doi.org/10.1111/apa.12658
45 https://doi.org/10.1111/j.1440-1754.2011.02219.x
46 https://doi.org/10.1111/j.1651-2227.2007.00275.x
47 https://doi.org/10.1179/joc.2010.22.1.30
48 https://doi.org/10.1371/journal.pmed.0030076
49 https://doi.org/10.2223/jped.2202
50 https://doi.org/doi:http:/dx.doi.org/10.2223/jped.2202
51 schema:datePublished 2016-12
52 schema:datePublishedReg 2016-12-01
53 schema:description Children affected by hemodynamically significant congenital heart disease (HSCHD) experience severe respiratory complications that can increase the frequency of hospitalizations. The aim of the SINERGY study was to describe the incidence of respiratory diseases and to collect information on active and passive immunoprophylaxis in the first 2 years of life. In this retrospective, multicenter, and epidemiologic study, children with HSCHD were enrolled across 11 Italian sites. Children born between December 31, 2007, and December 31, 2012, were observed during their first 2 years of life. Data were collected through hospital database searches and parent interviews. Four hundred twenty children were enrolled: 51.7 % were female, 79.5 % were born full-term (≥37 weeks), and 77.6 % weighed >2500 g at birth. The most frequent heart defects were ventricular septal defect (23.1 %) and coarctation of the aorta (14.3 %). The incidence of respiratory diseases was 63.1 %. Frequent respiratory diseases not requiring hospitalization were upper respiratory tract infections (76.4 %), acute bronchitis (43.3 %), and influenza (22.1 %), while those requiring hospitalization were bronchitis and bronchiolitis (8.3 % each one). While active immunoprophylaxis was applied with wide compliance (diphtheria/pertussis/tetanus, 99.5 %; Haemophilus influenzae type b, 72.5 %; pneumococcus, 79.9 %; meningococcus, 77.4 %), only 54 % of children received respiratory syncytial virus (RSV) passive prophylaxis (palivizumab). Of the 35 hospitalizations due to bronchiolitis, 27 (77.1 %) did not receive prophylaxis against RSV, compared with 8 (22.9 %) who received prophylaxis (P < 0.0001). Children with HSCHD are at major risk of respiratory diseases. Passive immunoprophylaxis can help to prevent hospitalizations for bronchiolitis.
54 schema:genre research_article
55 schema:inLanguage en
56 schema:isAccessibleForFree false
57 schema:isPartOf N6a1766eeb49341e9af3564be2e81b787
58 Nbdf337ca0d234e6a874592fc8789049f
59 sg:journal.1091102
60 schema:name Incidence of Respiratory Disease During the First Two Years of Life in Children with Hemodynamically Significant Congenital Heart Disease in Italy: A Retrospective Study
61 schema:pagination 1581-1589
62 schema:productId N14ff8863cefe4b898dd088e0893242fe
63 N6d01741f2112454e84e9f93e66f4691a
64 N9d2d39d58efb462a9cbc34321db27f21
65 Nbec906874f5846cb800195fb6d6c6022
66 Ne660983dec034caf8cbe071a268c438b
67 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033356987
68 https://doi.org/10.1007/s00246-016-1473-9
69 schema:sdDatePublished 2019-04-11T12:37
70 schema:sdLicense https://scigraph.springernature.com/explorer/license/
71 schema:sdPublisher Nabc995aa9edd4ecbaabaf014f5f02591
72 schema:url https://link.springer.com/10.1007%2Fs00246-016-1473-9
73 sgo:license sg:explorer/license/
74 sgo:sdDataset articles
75 rdf:type schema:ScholarlyArticle
76 N0ae009a3810a44b19803b0c9c16bc87c rdf:first sg:person.01325426346.00
77 rdf:rest Ne717568ece164cedaea74ef210d3038e
78 N0fb3fd35105e48b48123a08d1dc9479a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
79 schema:name Female
80 rdf:type schema:DefinedTerm
81 N1091f13c35074fe486f6bf03444e0fea schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
82 schema:name Incidence
83 rdf:type schema:DefinedTerm
84 N14ff8863cefe4b898dd088e0893242fe schema:name pubmed_id
85 schema:value 27573216
86 rdf:type schema:PropertyValue
87 N1f1f0d13c7ea4b6ba282912939c8f3df rdf:first sg:person.013073173171.39
88 rdf:rest N7089b88f16b14f1099b9f0444992eb80
89 N1f59f15d3c5249caa9fcab3aa2861ab4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
90 schema:name Antibodies, Monoclonal
91 rdf:type schema:DefinedTerm
92 N23cd3dae6524418aaa8a632d8dbcac6f schema:name AbbVie SrL Italy, Campoverde, Via Pontina km 52, Campoverde di Aprilia (LT), Latina, Italy
93 rdf:type schema:Organization
94 N352465e1a2d54944bdcbeda25a90cadd rdf:first sg:person.0600063030.23
95 rdf:rest N954000d5cc3946078afa1a729901aa13
96 N3eb77734aa40483ea93249811caadb70 schema:name A.O. Città della Salute e della Scienza di Torino, Ospedale Infantile Regina Margherita Torino, Turin, Italy
97 rdf:type schema:Organization
98 N409e456324ba4e3697d8cfd0f458c292 rdf:first sg:person.01142632351.15
99 rdf:rest N1f1f0d13c7ea4b6ba282912939c8f3df
100 N4b21381dd1fc468291e9b65c468eab0c schema:name AbbVie SrL Italy, Campoverde, Via Pontina km 52, Campoverde di Aprilia (LT), Latina, Italy
101 rdf:type schema:Organization
102 N5036f01ea862449382813c6637014800 schema:name Centro Cardiologico Paediatrico del Mediterraneo Taormina, Bambino Gesù Roma, Rome, Italy
103 rdf:type schema:Organization
104 N62dab8161a9943a89aa4c76ab2a23781 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
105 schema:name Antiviral Agents
106 rdf:type schema:DefinedTerm
107 N6343050ed39a403698c75f80e80fe6f6 rdf:first sg:person.01140013756.54
108 rdf:rest N6bbb3530c7584f34b6bf741ca6fc7cc3
109 N6540a34e919742d9b6ec5881b28b3ad2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
110 schema:name Antibodies, Monoclonal, Humanized
111 rdf:type schema:DefinedTerm
112 N665eed5fbc8740589a7a2878350bc479 schema:name Azienda Ospedaliera Universitaria Ospedali Riuniti di Ancona “Umberto I, G.M. Lancisi, G. Salesi”, Ancona, Italy
113 rdf:type schema:Organization
114 N6a1766eeb49341e9af3564be2e81b787 schema:volumeNumber 37
115 rdf:type schema:PublicationVolume
116 N6bbb3530c7584f34b6bf741ca6fc7cc3 rdf:first sg:person.01164464046.29
117 rdf:rest N8e60ac6aba1f4ec39536278d90f3b4ed
118 N6d01741f2112454e84e9f93e66f4691a schema:name doi
119 schema:value 10.1007/s00246-016-1473-9
120 rdf:type schema:PropertyValue
121 N6d1de59a9fd048d1ad994f161dfec429 rdf:first sg:person.01176747617.77
122 rdf:rest N0ae009a3810a44b19803b0c9c16bc87c
123 N7089b88f16b14f1099b9f0444992eb80 rdf:first sg:person.01256577311.65
124 rdf:rest Nf2b06ce4d91c4bcaa65294e3493a6e23
125 N8e60ac6aba1f4ec39536278d90f3b4ed rdf:first sg:person.01312440515.09
126 rdf:rest Nf26f7272392246cc87779609c15131cf
127 N954000d5cc3946078afa1a729901aa13 rdf:first Na8fa610f42fc483992b68f9da1b49e2f
128 rdf:rest N6d1de59a9fd048d1ad994f161dfec429
129 N9d2d39d58efb462a9cbc34321db27f21 schema:name nlm_unique_id
130 schema:value 8003849
131 rdf:type schema:PropertyValue
132 Na6f152956f8746b0b3cb97b5c8fab8e3 rdf:first sg:person.0664251014.48
133 rdf:rest rdf:nil
134 Na8fa610f42fc483992b68f9da1b49e2f schema:affiliation N665eed5fbc8740589a7a2878350bc479
135 schema:familyName Pozzi
136 schema:givenName Marco
137 rdf:type schema:Person
138 Nabb0189db2ee400eb689c1b3acff486b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
139 schema:name Child
140 rdf:type schema:DefinedTerm
141 Nabc995aa9edd4ecbaabaf014f5f02591 schema:name Springer Nature - SN SciGraph project
142 rdf:type schema:Organization
143 Nb2e6923526da4a76afd55ac7e93f014d schema:name IRCCS Cà Granda Ospedale Maggiore Policlinico di Milano, Milan, Italy
144 rdf:type schema:Organization
145 Nbd7faca6b62549f499b38cae2467e6b6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
146 schema:name Humans
147 rdf:type schema:DefinedTerm
148 Nbdf337ca0d234e6a874592fc8789049f schema:issueNumber 8
149 rdf:type schema:PublicationIssue
150 Nbec906874f5846cb800195fb6d6c6022 schema:name dimensions_id
151 schema:value pub.1033356987
152 rdf:type schema:PropertyValue
153 Nc25dc6ec3bfc4578a61ca587a8d64184 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
154 schema:name Hospitalization
155 rdf:type schema:DefinedTerm
156 Nce051567c2cd4e66a463bbf7b9d2786b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
157 schema:name Heart Defects, Congenital
158 rdf:type schema:DefinedTerm
159 Ncf28900db3f64ccc816dfc1748fd2aaa schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
160 schema:name Italy
161 rdf:type schema:DefinedTerm
162 Nd0a6f8ce1a1349ecae6715a709be3b7a schema:name AbbVie SrL Italy, Campoverde, Via Pontina km 52, Campoverde di Aprilia (LT), Latina, Italy
163 rdf:type schema:Organization
164 Nd41e9711231a4806a730135c3b9bb314 rdf:first sg:person.01153450630.70
165 rdf:rest Na6f152956f8746b0b3cb97b5c8fab8e3
166 Ne660983dec034caf8cbe071a268c438b schema:name readcube_id
167 schema:value 9ee832a66c9476c132dddc64dd61d6f25145e729cf246a33c63bea6b013929c0
168 rdf:type schema:PropertyValue
169 Ne6974d88b65f407abd7d5295ed663150 schema:name AbbVie SrL Italy, Campoverde, Via Pontina km 52, Campoverde di Aprilia (LT), Latina, Italy
170 rdf:type schema:Organization
171 Ne717568ece164cedaea74ef210d3038e rdf:first sg:person.0621577042.67
172 rdf:rest Nd41e9711231a4806a730135c3b9bb314
173 Nf26f7272392246cc87779609c15131cf rdf:first sg:person.01203017203.87
174 rdf:rest N352465e1a2d54944bdcbeda25a90cadd
175 Nf2b06ce4d91c4bcaa65294e3493a6e23 rdf:first sg:person.01330204142.80
176 rdf:rest N6343050ed39a403698c75f80e80fe6f6
177 Nf41b547296784b76bb9d85b607903fe9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
178 schema:name Male
179 rdf:type schema:DefinedTerm
180 Nfa12f6ff5bb4498d99e6c03e0bbc180b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
181 schema:name Respiratory Syncytial Virus Infections
182 rdf:type schema:DefinedTerm
183 Nfa804db65dae478397389d05365f9c18 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
184 schema:name Retrospective Studies
185 rdf:type schema:DefinedTerm
186 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
187 schema:name Medical and Health Sciences
188 rdf:type schema:DefinedTerm
189 anzsrc-for:1117 schema:inDefinedTermSet anzsrc-for:
190 schema:name Public Health and Health Services
191 rdf:type schema:DefinedTerm
192 sg:journal.1091102 schema:issn 0172-0643
193 1432-1971
194 schema:name Pediatric Cardiology
195 rdf:type schema:Periodical
196 sg:person.01140013756.54 schema:affiliation Ne6974d88b65f407abd7d5295ed663150
197 schema:familyName Gualberti
198 schema:givenName Giuliana
199 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01140013756.54
200 rdf:type schema:Person
201 sg:person.01142632351.15 schema:affiliation N5036f01ea862449382813c6637014800
202 schema:familyName Pongiglione
203 schema:givenName Giacomo
204 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01142632351.15
205 rdf:type schema:Person
206 sg:person.01153450630.70 schema:affiliation https://www.grid.ac/institutes/grid.416052.4
207 schema:familyName Russo
208 schema:givenName Maria Giovanna
209 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01153450630.70
210 rdf:type schema:Person
211 sg:person.01164464046.29 schema:affiliation https://www.grid.ac/institutes/grid.412311.4
212 schema:familyName Bonvicini
213 schema:givenName Marco
214 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01164464046.29
215 rdf:type schema:Person
216 sg:person.01176747617.77 schema:affiliation https://www.grid.ac/institutes/grid.417308.9
217 schema:familyName Tumbarello
218 schema:givenName Roberto
219 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01176747617.77
220 rdf:type schema:Person
221 sg:person.01203017203.87 schema:affiliation N3eb77734aa40483ea93249811caadb70
222 schema:familyName Agnoletti
223 schema:givenName Gabriella
224 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01203017203.87
225 rdf:type schema:Person
226 sg:person.01256577311.65 schema:affiliation N23cd3dae6524418aaa8a632d8dbcac6f
227 schema:familyName di Luzio Paparatti
228 schema:givenName Umberto
229 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01256577311.65
230 rdf:type schema:Person
231 sg:person.013073173171.39 schema:affiliation Nd0a6f8ce1a1349ecae6715a709be3b7a
232 schema:familyName Possidoni
233 schema:givenName Alessandro
234 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013073173171.39
235 rdf:type schema:Person
236 sg:person.01312440515.09 schema:affiliation https://www.grid.ac/institutes/grid.419504.d
237 schema:familyName Rimini
238 schema:givenName Alessandro
239 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01312440515.09
240 rdf:type schema:Person
241 sg:person.01325426346.00 schema:affiliation Nb2e6923526da4a76afd55ac7e93f014d
242 schema:familyName Salice
243 schema:givenName Patrizia
244 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01325426346.00
245 rdf:type schema:Person
246 sg:person.01330204142.80 schema:affiliation N4b21381dd1fc468291e9b65c468eab0c
247 schema:familyName Costanzo
248 schema:givenName Anna Maria
249 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01330204142.80
250 rdf:type schema:Person
251 sg:person.0600063030.23 schema:affiliation https://www.grid.ac/institutes/grid.412507.5
252 schema:familyName Calabrò
253 schema:givenName Maria Pia
254 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0600063030.23
255 rdf:type schema:Person
256 sg:person.0621577042.67 schema:affiliation https://www.grid.ac/institutes/grid.413181.e
257 schema:familyName Fiorini
258 schema:givenName Patrizio
259 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0621577042.67
260 rdf:type schema:Person
261 sg:person.0664251014.48 schema:affiliation https://www.grid.ac/institutes/grid.411474.3
262 schema:familyName Milanesi
263 schema:givenName Ornella
264 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0664251014.48
265 rdf:type schema:Person
266 sg:pub.10.1007/s00431-011-1525-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044867848
267 https://doi.org/10.1007/s00431-011-1525-3
268 rdf:type schema:CreativeWork
269 sg:pub.10.1007/s10096-005-0082-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1000856408
270 https://doi.org/10.1007/s10096-005-0082-y
271 rdf:type schema:CreativeWork
272 sg:pub.10.1007/s40121-014-0046-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049475122
273 https://doi.org/10.1007/s40121-014-0046-6
274 rdf:type schema:CreativeWork
275 sg:pub.10.1038/jp.2008.28 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025398396
276 https://doi.org/10.1038/jp.2008.28
277 rdf:type schema:CreativeWork
278 https://doi.org/10.1001/archpedi.152.8.739 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008725332
279 rdf:type schema:CreativeWork
280 https://doi.org/10.1001/jama.1980.03300390029017 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017113990
281 rdf:type schema:CreativeWork
282 https://doi.org/10.1001/jama.243.13.1345 schema:sameAs https://app.dimensions.ai/details/publication/pub.1054138800
283 rdf:type schema:CreativeWork
284 https://doi.org/10.1002/bdra.23111 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036458394
285 rdf:type schema:CreativeWork
286 https://doi.org/10.1002/ppul.10047 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002402842
287 rdf:type schema:CreativeWork
288 https://doi.org/10.1002/ppul.10288 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042855256
289 rdf:type schema:CreativeWork
290 https://doi.org/10.1002/ppul.23102 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040483583
291 rdf:type schema:CreativeWork
292 https://doi.org/10.1016/j.jpeds.2008.05.059 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007457365
293 rdf:type schema:CreativeWork
294 https://doi.org/10.1016/j.jpeds.2009.11.062 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045412228
295 rdf:type schema:CreativeWork
296 https://doi.org/10.1016/j.siny.2012.01.008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043609071
297 rdf:type schema:CreativeWork
298 https://doi.org/10.1016/j.vaccine.2005.02.004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031847607
299 rdf:type schema:CreativeWork
300 https://doi.org/10.1016/s0002-9343(01)01058-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035622054
301 rdf:type schema:CreativeWork
302 https://doi.org/10.1016/s0022-3476(86)81034-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044750459
303 rdf:type schema:CreativeWork
304 https://doi.org/10.1016/s0140-6736(99)01241-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026767124
305 rdf:type schema:CreativeWork
306 https://doi.org/10.1016/s0735-1097(02)01886-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010634253
307 rdf:type schema:CreativeWork
308 https://doi.org/10.1046/j.1460-9592.2003.01192.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1035549766
309 rdf:type schema:CreativeWork
310 https://doi.org/10.1056/nejmoa0804877 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038522253
311 rdf:type schema:CreativeWork
312 https://doi.org/10.1080/13814780600757153 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008979533
313 rdf:type schema:CreativeWork
314 https://doi.org/10.1093/bmb/62.1.99 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007046738
315 rdf:type schema:CreativeWork
316 https://doi.org/10.1093/eurheartj/ehq249 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013716686
317 rdf:type schema:CreativeWork
318 https://doi.org/10.1097/00006454-200404000-00008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040487436
319 rdf:type schema:CreativeWork
320 https://doi.org/10.1097/01.inf.0000053884.21238.13 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034067855
321 rdf:type schema:CreativeWork
322 https://doi.org/10.1097/01.inf.0000108220.94201.1a schema:sameAs https://app.dimensions.ai/details/publication/pub.1000815994
323 rdf:type schema:CreativeWork
324 https://doi.org/10.1111/apa.12658 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009445603
325 rdf:type schema:CreativeWork
326 https://doi.org/10.1111/j.1440-1754.2011.02219.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1040813712
327 rdf:type schema:CreativeWork
328 https://doi.org/10.1111/j.1651-2227.2007.00275.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1034393319
329 rdf:type schema:CreativeWork
330 https://doi.org/10.1179/joc.2010.22.1.30 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025375482
331 rdf:type schema:CreativeWork
332 https://doi.org/10.1371/journal.pmed.0030076 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046917335
333 rdf:type schema:CreativeWork
334 https://doi.org/10.2223/jped.2202 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027964002
335 rdf:type schema:CreativeWork
336 https://doi.org/doi:http:/dx.doi.org/10.2223/jped.2202 schema:sameAs https://app.dimensions.ai/details/publication/pub.1078581071
337 rdf:type schema:CreativeWork
338 https://www.grid.ac/institutes/grid.411474.3 schema:alternateName Azienda Ospedaliera di Padova
339 schema:name Azienda Ospedaliera di Padova, Padua, Italy
340 rdf:type schema:Organization
341 https://www.grid.ac/institutes/grid.412311.4 schema:alternateName Policlinico S.Orsola-Malpighi
342 schema:name Azienda Ospedaliero Universitaria di Bologna, Policlinico Sant’Orsola Malpighi, Bologna, Italy
343 rdf:type schema:Organization
344 https://www.grid.ac/institutes/grid.412507.5 schema:alternateName Azienda Ospedaliera Universitaria Policlinico "G. Martino"
345 schema:name Azienda Ospedaliera Universitaria Policlinico “G. Martino” di Messina, Messina, Italy
346 rdf:type schema:Organization
347 https://www.grid.ac/institutes/grid.413181.e schema:alternateName Meyer Children's Hospital
348 schema:name Azienda Ospedaliero-Universitaria Meyer Firenze, Florence, Italy
349 rdf:type schema:Organization
350 https://www.grid.ac/institutes/grid.416052.4 schema:alternateName Ospedale Monaldi
351 schema:name Ospedale Monaldi, Seconda Università di Napoli, Naples, Italy
352 rdf:type schema:Organization
353 https://www.grid.ac/institutes/grid.417308.9 schema:alternateName Azienda Ospedaliera G. Brotzu
354 schema:name Azienda Ospedaliera “G.Brotzu” Cagliari, Cagliari, Italy
355 rdf:type schema:Organization
356 https://www.grid.ac/institutes/grid.419504.d schema:alternateName Istituto Giannina Gaslini
357 schema:name Istituto “Giannina Gaslini” Genova, Genoa, Italy
358 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...