Evolving Management of Pediatric Pulmonary Arterial Hypertension: Impact of Phosphodiesterase Inhibitors View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2013-02

AUTHORS

Andrew James Wardle, Robert M. R. Tulloh

ABSTRACT

The treatment of pulmonary arterial hypertension (PAH) has undergone significant change in recent years, improving both quality of life and survival for patients. One of the principal new agents is sildenafil, a phosphodiesterase-V inhibitor with great PAH efficacy. Its success has led to consideration of other phosphodiesterase inhibitors not yet licensed for pediatric PAH including tadalafil and vardenafil, among others. This article summarizes the evidence base for phosphodiesterase inhibitors used to ameliorate pediatric PAH pathology and associated symptoms. It also analyzes their suitability for contemporary practice with the aim of clarifying and helping to direct regimens that produce improved patient outcomes. More... »

PAGES

213-219

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00246-012-0598-8

DOI

http://dx.doi.org/10.1007/s00246-012-0598-8

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1026109233

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/23250648


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