Ontology type: schema:ScholarlyArticle
2012-06-05
AUTHORSAnne Marie Valente, Kimberlee Gauvreau, Gabriele Egidy Assenza, Sonya V. Babu-Narayan, Sarah P. Evans, Michael Gatzoulis, Maarten Groenink, Ryo Inuzuka, Philip J. Kilner, Zeliha Koyak, Michael J. Landzberg, Barbara Mulder, Andrew J. Powell, Rachel Wald, Tal Geva
ABSTRACTAlthough early survival after tetralogy of Fallot (TOF) repair in the modern era is excellent, studies on late outcomes have shown increasing rates of mortality and morbidity. Despite multiple publications on factors associated with late complications, risk factors for major outcomes (death and sustained ventricular tachycardia [VT]) remain poorly defined. Consequently, the International Multicenter TOF Registry (INDICATOR) was established. This article describes the development, structure, and goals of this registry and characterizes the initial cohort derived from four large congenital heart centers in the United States, Canada, and Europe. A data coordinating center with a core cardiac magnetic resonance (CMR) laboratory and statistical core was established. Subjects with repaired TOF who had CMR imaging performed between 1997 and 2010 and ≥1 year follow-up were included. Clinical end points were death and sustained VT. Demographic, electrophysiologic, exercise, and outcome data were collected. A total of 873 subjects fulfilled inclusion criteria (median age at repair 2.9 years and at CMR imaging 22.8 years). Of these, 9 % had QRS duration >180 ms on electrocardiogram (ECG). On CMR imaging, 38 % had severe right-ventricular (RV) dilatation (≥160 mL/m2), and 6 % had severe RV dysfunction (ejection fraction < 35 %). Of the 551 subjects with exercise testing available, 28 % had severely decreased exercise capacity with <50 % predicted peak oxygen consumption. The INDICATOR cohort allows robust statistical analysis to evaluate major clinical outcomes in patients with repaired TOF. Continued follow-up and further expansion of the registry may provide new insights into innovative therapeutic strategies to improve late outcomes. More... »
PAGES95-104
http://scigraph.springernature.com/pub.10.1007/s00246-012-0394-5
DOIhttp://dx.doi.org/10.1007/s00246-012-0394-5
DIMENSIONShttps://app.dimensions.ai/details/publication/pub.1034096445
PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/22669402
JSON-LD is the canonical representation for SciGraph data.
TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT
[
{
"@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json",
"about": [
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Medical and Health Sciences",
"type": "DefinedTerm"
},
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1102",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Cardiorespiratory Medicine and Haematology",
"type": "DefinedTerm"
},
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Clinical Sciences",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Adolescent",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Adult",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Canada",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Child",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Child, Preschool",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Cohort Studies",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Electrocardiography",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Europe",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Exercise Test",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Female",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Humans",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Infant",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Infant, Newborn",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Magnetic Resonance Imaging",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Male",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Middle Aged",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Prognosis",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Registries",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Research Design",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Risk Factors",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Tetralogy of Fallot",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Treatment Outcome",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "United States",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Young Adult",
"type": "DefinedTerm"
}
],
"author": [
{
"affiliation": {
"alternateName": "Department of Cardiology, Boston Children\u2019s Hospital and Department of Pediatrics, Harvard Medical School, 02115, Boston, MA, USA",
"id": "http://www.grid.ac/institutes/grid.38142.3c",
"name": [
"Department of Cardiology, Boston Children\u2019s Hospital and Department of Pediatrics, Harvard Medical School, 02115, Boston, MA, USA"
],
"type": "Organization"
},
"familyName": "Valente",
"givenName": "Anne Marie",
"id": "sg:person.01155701215.63",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01155701215.63"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Cardiology, Boston Children\u2019s Hospital and Department of Pediatrics, Harvard Medical School, 02115, Boston, MA, USA",
"id": "http://www.grid.ac/institutes/grid.38142.3c",
"name": [
"Department of Cardiology, Boston Children\u2019s Hospital and Department of Pediatrics, Harvard Medical School, 02115, Boston, MA, USA"
],
"type": "Organization"
},
"familyName": "Gauvreau",
"givenName": "Kimberlee",
"id": "sg:person.013716076657.80",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013716076657.80"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Cardiology, Boston Children\u2019s Hospital and Department of Pediatrics, Harvard Medical School, 02115, Boston, MA, USA",
"id": "http://www.grid.ac/institutes/grid.38142.3c",
"name": [
"Department of Cardiology, Boston Children\u2019s Hospital and Department of Pediatrics, Harvard Medical School, 02115, Boston, MA, USA"
],
"type": "Organization"
},
"familyName": "Assenza",
"givenName": "Gabriele Egidy",
"id": "sg:person.01301302450.47",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01301302450.47"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "NIHR Cardiovascular Biomedical Research Unit, Royal Brompton and Harefield NHS Foundation Trust, National Heart and Lung Institute, Imperial College, London, UK",
"id": "http://www.grid.ac/institutes/grid.7445.2",
"name": [
"NIHR Cardiovascular Biomedical Research Unit, Royal Brompton and Harefield NHS Foundation Trust, National Heart and Lung Institute, Imperial College, London, UK"
],
"type": "Organization"
},
"familyName": "Babu-Narayan",
"givenName": "Sonya V.",
"id": "sg:person.01057207260.72",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01057207260.72"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Cardiology, Boston Children\u2019s Hospital and Department of Pediatrics, Harvard Medical School, 02115, Boston, MA, USA",
"id": "http://www.grid.ac/institutes/grid.38142.3c",
"name": [
"Department of Cardiology, Boston Children\u2019s Hospital and Department of Pediatrics, Harvard Medical School, 02115, Boston, MA, USA"
],
"type": "Organization"
},
"familyName": "Evans",
"givenName": "Sarah P.",
"id": "sg:person.0624011550.14",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0624011550.14"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "NIHR Cardiovascular Biomedical Research Unit, Royal Brompton and Harefield NHS Foundation Trust, National Heart and Lung Institute, Imperial College, London, UK",
"id": "http://www.grid.ac/institutes/grid.7445.2",
"name": [
"NIHR Cardiovascular Biomedical Research Unit, Royal Brompton and Harefield NHS Foundation Trust, National Heart and Lung Institute, Imperial College, London, UK"
],
"type": "Organization"
},
"familyName": "Gatzoulis",
"givenName": "Michael",
"id": "sg:person.01343446131.14",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01343446131.14"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Cardiology, Academic Medical Centre, Amsterdam, The Netherlands",
"id": "http://www.grid.ac/institutes/grid.5650.6",
"name": [
"Department of Cardiology, Academic Medical Centre, Amsterdam, The Netherlands"
],
"type": "Organization"
},
"familyName": "Groenink",
"givenName": "Maarten",
"id": "sg:person.01166552765.02",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01166552765.02"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "NIHR Cardiovascular Biomedical Research Unit, Royal Brompton and Harefield NHS Foundation Trust, National Heart and Lung Institute, Imperial College, London, UK",
"id": "http://www.grid.ac/institutes/grid.7445.2",
"name": [
"NIHR Cardiovascular Biomedical Research Unit, Royal Brompton and Harefield NHS Foundation Trust, National Heart and Lung Institute, Imperial College, London, UK"
],
"type": "Organization"
},
"familyName": "Inuzuka",
"givenName": "Ryo",
"id": "sg:person.0754703647.73",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0754703647.73"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "NIHR Cardiovascular Biomedical Research Unit, Royal Brompton and Harefield NHS Foundation Trust, National Heart and Lung Institute, Imperial College, London, UK",
"id": "http://www.grid.ac/institutes/grid.7445.2",
"name": [
"NIHR Cardiovascular Biomedical Research Unit, Royal Brompton and Harefield NHS Foundation Trust, National Heart and Lung Institute, Imperial College, London, UK"
],
"type": "Organization"
},
"familyName": "Kilner",
"givenName": "Philip J.",
"id": "sg:person.0755074121.43",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0755074121.43"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Cardiology, Academic Medical Centre, Amsterdam, The Netherlands",
"id": "http://www.grid.ac/institutes/grid.5650.6",
"name": [
"Department of Cardiology, Academic Medical Centre, Amsterdam, The Netherlands"
],
"type": "Organization"
},
"familyName": "Koyak",
"givenName": "Zeliha",
"id": "sg:person.0640241571.70",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0640241571.70"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Cardiology, Boston Children\u2019s Hospital and Department of Pediatrics, Harvard Medical School, 02115, Boston, MA, USA",
"id": "http://www.grid.ac/institutes/grid.38142.3c",
"name": [
"Department of Cardiology, Boston Children\u2019s Hospital and Department of Pediatrics, Harvard Medical School, 02115, Boston, MA, USA"
],
"type": "Organization"
},
"familyName": "Landzberg",
"givenName": "Michael J.",
"id": "sg:person.0773337415.41",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0773337415.41"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Cardiology, Academic Medical Centre, Amsterdam, The Netherlands",
"id": "http://www.grid.ac/institutes/grid.5650.6",
"name": [
"Department of Cardiology, Academic Medical Centre, Amsterdam, The Netherlands"
],
"type": "Organization"
},
"familyName": "Mulder",
"givenName": "Barbara",
"id": "sg:person.012345747157.69",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012345747157.69"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Cardiology, Boston Children\u2019s Hospital and Department of Pediatrics, Harvard Medical School, 02115, Boston, MA, USA",
"id": "http://www.grid.ac/institutes/grid.38142.3c",
"name": [
"Department of Cardiology, Boston Children\u2019s Hospital and Department of Pediatrics, Harvard Medical School, 02115, Boston, MA, USA"
],
"type": "Organization"
},
"familyName": "Powell",
"givenName": "Andrew J.",
"id": "sg:person.01140320125.82",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01140320125.82"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Division of Cardiology, University of Toronto, Peter Munk Cardiac Centre, Toronto, ON, Canada",
"id": "http://www.grid.ac/institutes/grid.17063.33",
"name": [
"Division of Cardiology, University of Toronto, Peter Munk Cardiac Centre, Toronto, ON, Canada"
],
"type": "Organization"
},
"familyName": "Wald",
"givenName": "Rachel",
"id": "sg:person.01027410207.36",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01027410207.36"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Cardiology, Boston Children\u2019s Hospital and Department of Pediatrics, Harvard Medical School, 02115, Boston, MA, USA",
"id": "http://www.grid.ac/institutes/grid.38142.3c",
"name": [
"Department of Cardiology, Boston Children\u2019s Hospital and Department of Pediatrics, Harvard Medical School, 02115, Boston, MA, USA"
],
"type": "Organization"
},
"familyName": "Geva",
"givenName": "Tal",
"id": "sg:person.01272775674.98",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01272775674.98"
],
"type": "Person"
}
],
"citation": [
{
"id": "sg:pub.10.1186/1532-429x-13-9",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1023963221",
"https://doi.org/10.1186/1532-429x-13-9"
],
"type": "CreativeWork"
}
],
"datePublished": "2012-06-05",
"datePublishedReg": "2012-06-05",
"description": "Although early survival after tetralogy of Fallot (TOF) repair in the modern era is excellent, studies on late outcomes have shown increasing rates of mortality and morbidity. Despite multiple publications on factors associated with late complications, risk factors for major outcomes (death and sustained ventricular tachycardia [VT]) remain poorly defined. Consequently, the International Multicenter TOF Registry (INDICATOR) was established. This article describes the development, structure, and goals of this registry and characterizes the initial cohort derived from four large congenital heart centers in the United States, Canada, and Europe. A data coordinating center with a core cardiac magnetic resonance (CMR) laboratory and statistical core was established. Subjects with repaired TOF who had CMR imaging performed between 1997 and 2010 and \u22651\u00a0year follow-up were included. Clinical end points were death and sustained VT. Demographic, electrophysiologic, exercise, and outcome data were collected. A total of 873 subjects fulfilled inclusion criteria (median age at repair 2.9\u00a0years and at CMR imaging 22.8\u00a0years). Of these, 9\u00a0% had QRS duration >180\u00a0ms on electrocardiogram (ECG). On CMR imaging, 38\u00a0% had severe right-ventricular (RV) dilatation (\u2265160\u00a0mL/m2), and 6\u00a0% had severe RV dysfunction (ejection fraction\u00a0<\u00a035\u00a0%). Of the 551 subjects with exercise testing available, 28\u00a0% had severely decreased exercise capacity with <50\u00a0% predicted peak oxygen consumption. The INDICATOR cohort allows robust statistical analysis to evaluate major clinical outcomes in patients with repaired TOF. Continued follow-up and further expansion of the registry may provide new insights into innovative therapeutic strategies to improve late outcomes.",
"genre": "article",
"id": "sg:pub.10.1007/s00246-012-0394-5",
"inLanguage": "en",
"isAccessibleForFree": false,
"isFundedItemOf": [
{
"id": "sg:grant.2541610",
"type": "MonetaryGrant"
},
{
"id": "sg:grant.5140541",
"type": "MonetaryGrant"
}
],
"isPartOf": [
{
"id": "sg:journal.1091102",
"issn": [
"0172-0643",
"1432-1971"
],
"name": "Pediatric Cardiology",
"publisher": "Springer Nature",
"type": "Periodical"
},
{
"issueNumber": "1",
"type": "PublicationIssue"
},
{
"type": "PublicationVolume",
"volumeNumber": "34"
}
],
"keywords": [
"risk factors",
"late outcomes",
"large congenital heart centres",
"severe right ventricular dilatation",
"international multicenter registry",
"right ventricular dilatation",
"major clinical outcomes",
"clinical end points",
"severe RV dysfunction",
"late adverse outcomes",
"peak oxygen consumption",
"congenital heart centers",
"innovative therapeutic strategies",
"rate of mortality",
"RV dysfunction",
"multicenter registry",
"late complications",
"exercise testing",
"exercise capacity",
"Fallot repair",
"Heart Center",
"clinical outcomes",
"repaired tetralogy",
"adverse outcomes",
"QRS duration",
"inclusion criteria",
"initial cohort",
"outcome data",
"CMR imaging",
"therapeutic strategies",
"registry",
"end point",
"cohort",
"outcomes",
"patients",
"early survival",
"tetralogy",
"oxygen consumption",
"multiple publications",
"electrocardiogram",
"subjects",
"major outcomes",
"morbidity",
"complications",
"electrophysiologic",
"Fallot",
"statistical analysis",
"dysfunction",
"dilatation",
"mortality",
"factors",
"death",
"survival",
"United States",
"CMR",
"total",
"exercise",
"center",
"repair",
"duration",
"statistical core",
"VT",
"imaging",
"modern era",
"years",
"new insights",
"rationale",
"data",
"testing",
"criteria",
"study",
"robust statistical analysis",
"TOF",
"ms",
"rate",
"further expansion",
"laboratory",
"publications",
"development",
"strategies",
"consumption",
"Canada",
"analysis",
"capacity",
"goal",
"era",
"insights",
"point",
"article",
"Europe",
"expansion",
"state",
"design",
"structure",
"core"
],
"name": "Rationale and Design of an International Multicenter Registry of Patients With Repaired Tetralogy of Fallot to Define Risk Factors for Late Adverse Outcomes: The INDICATOR Cohort",
"pagination": "95-104",
"productId": [
{
"name": "dimensions_id",
"type": "PropertyValue",
"value": [
"pub.1034096445"
]
},
{
"name": "doi",
"type": "PropertyValue",
"value": [
"10.1007/s00246-012-0394-5"
]
},
{
"name": "pubmed_id",
"type": "PropertyValue",
"value": [
"22669402"
]
}
],
"sameAs": [
"https://doi.org/10.1007/s00246-012-0394-5",
"https://app.dimensions.ai/details/publication/pub.1034096445"
],
"sdDataset": "articles",
"sdDatePublished": "2022-05-20T07:27",
"sdLicense": "https://scigraph.springernature.com/explorer/license/",
"sdPublisher": {
"name": "Springer Nature - SN SciGraph project",
"type": "Organization"
},
"sdSource": "s3://com-springernature-scigraph/baseset/20220519/entities/gbq_results/article/article_553.jsonl",
"type": "ScholarlyArticle",
"url": "https://doi.org/10.1007/s00246-012-0394-5"
}
]
Download the RDF metadata as: json-ld nt turtle xml License info
JSON-LD is a popular format for linked data which is fully compatible with JSON.
curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s00246-012-0394-5'
N-Triples is a line-based linked data format ideal for batch operations.
curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s00246-012-0394-5'
Turtle is a human-readable linked data format.
curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s00246-012-0394-5'
RDF/XML is a standard XML format for linked data.
curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s00246-012-0394-5'
This table displays all metadata directly associated to this object as RDF triples.
372 TRIPLES
22 PREDICATES
146 URIs
136 LITERALS
31 BLANK NODES