Successful Treatment with Bosentan for Pulmonary Hypertension and Reduced Peripheral Circulation in Juvenile Systemic Sclerosis View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2011-10

AUTHORS

Masaki Shimizu, Yoko Hashida, Kazuyuki Ueno, Tadafumi Yokoyama, Yuko Nakayama, Takekatsu Saito, Kunio Ohta, Kazuhiko Takehara, Akihiro Yachie

ABSTRACT

Pulmonary arterial hypertension (PAH) when associated with systemic sclerosis (SSc) (SSc-PAH) is one of the leading causes of mortality and is found in 10-15% of adult patients with SSc. The ET receptor antagonist bosentan has been shown to be effective in the treatment of adult patients with SSc-PAH. Furthermore, it has been shown that bosentan ameliorates decreased skin perfusion and digital ulceration secondary to SSc. However, the effectiveness and safety of bosentan for treatment of juvenile SSc still remains unclear. We describe a case of juvenile SSc-PAH successfully treated with bosentan. The present case shows that bosentan ameliorated PAH and peripheral circulation as evaluated by cold stress thermography. No bosentan-related adverse events such as liver dysfunction were observed. Prospective randomized trials are required to validate the effectiveness of bosentan for patients with juvenile SSc; however, bosentan might be useful for the management of patients with juvenile SSc. More... »

PAGES

1040

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00246-011-0056-z

DOI

http://dx.doi.org/10.1007/s00246-011-0056-z

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1023701977

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/21789477


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