Metabolic Alterations and Neurodevelopmental Outcome of Infants with Transposition of the Great Arteries View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2006-10

AUTHORS

I. Sook Park, S. Young Yoon, J. Yeon Min, Y. Hwue Kim, J. Kok Ko, K. Soo Kim, D. Man Seo, J. Hee Lee

ABSTRACT

Abnormal neurodevelopment has been reported for infants who were born with transposition of the great arteries (TGA) and underwent arterial switch operation (ASO). This study evaluates the cerebral metabolism of TGA infants at birth and before ASO and neurodevelopment 1 year after ASO. Proton magnetic resonance spectroscopy (1H-MRS) was performed on 16 full-term TGA brains before ASO within 3-6 days after birth. The brain metabolite ratios of [NAA/Cr], [Cho/Cr], and [mI/Cr] evaluated measured. Ten infants were evaluated at 1 year using the Bayley Scales of Infants Development II (BSED II). Cerebral metabolism of infants with TGA was altered in parietal white matter (PWM) and occipital gray matter (OGM) at birth before ASO. One year after ASO, [Cho/Cr] in PWM remained altered, but all metabolic ratios in OGM were normal. The results of BSID II at 1 year showed delayed mental and psychomotor development. This delayed neurodevelopmental outcome may reflect consequences of the altered cerebral metabolism in PWM measured by 1H-MRS. It is speculated that the abnormal hemodynamics due to TGA in utero may be responsible for the impaired cerebral metabolism and the subsequent neurodevelopmental deficit. More... »

PAGES

569-576

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00246-004-0730-5

DOI

http://dx.doi.org/10.1007/s00246-004-0730-5

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1033396094

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/16897317


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Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s00246-004-0730-5'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s00246-004-0730-5'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s00246-004-0730-5'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s00246-004-0730-5'


 

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303 rdf:type schema:Organization
304 https://www.grid.ac/institutes/grid.414964.a schema:alternateName Samsung Medical Center
305 schema:name Department of Radiology, Samsung Medical Center, SungKyunKwan University School of Medicine, Seoul, Korea
306 NMR Laboratory, Asan Medical Center, Asan Institute for Life Sciences, University of Ulsan College of Medicine, Seoul, Korea
307 rdf:type schema:Organization
 




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