Ontology type: schema:ScholarlyArticle
2003-05
AUTHORSSusanna Nuutinen, Peter F. Landrum, Lance J. Schuler, Jussi V. K. Kukkonen, Michael J. Lydy
ABSTRACTUptake, biotransformation, and elimination rates were determined for pentachlorophenol (PCP), methyl parathion (MP), fluoranthene (FU), and 2,2',4,4',5,5'-hexachlorobiphenyl (HCBP) using juvenile Hyalella azteca under water-only exposures. A two-compartment model that included biotransformation described the kinetics for each chemical. The uptake clearance coefficients (k(u)) were 25.7 +/- 2.9, 11.5 +/- 1.1, 184.4 +/- 9.3, and 251.7 +/- 9.0 (ml g(-1) h(-1)) for PCP, MP, FU, and HCBP, respectively. The elimination rate constant of the parent compound (k(ep)) for MP was almost an order of magnitude faster (0.403 +/- 0.070 h(-1)) than for PCP and FU (0.061 +/- 0.034 and 0.040 +/- 0.008 h(-1)). The elimination rate constants for FU and PCP metabolites (k(em)) were similar to the parent compound elimination 0.040 +/- 0.005 h(-1) and 0.076 +/- 0.012 h(-1), respectively. For MP, the metabolites were excreted much more slowly than the parent compound (0.021 +/- 0.001 h(-1)). For PCP, FU, and MP whose metabolites were measured, the biological half-life (t(1/2p)) of the parent compound was shorter than the half-life for metabolites (t(1/2m)) because the rate is driven both by elimination and biotransformation processes. Thus, H. azteca is capable of metabolizing compounds with varying chemical structures and modes of toxic action, which may complicate interpretation of toxicity and bioaccumulation results. This finding improves our understanding of H. azteca as a test organism, because most biomonitoring activities do not account for biotransformation and some metabolites can contribute significantly to the noted toxicity. More... »
PAGES0467-0475
http://scigraph.springernature.com/pub.10.1007/s00244-002-2127-x
DOIhttp://dx.doi.org/10.1007/s00244-002-2127-x
DIMENSIONShttps://app.dimensions.ai/details/publication/pub.1005764943
PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/12712277
JSON-LD is the canonical representation for SciGraph data.
TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT
[
{
"@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json",
"about": [
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Biochemistry and Cell Biology",
"type": "DefinedTerm"
},
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Biological Sciences",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Animals",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Biotransformation",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Crustacea",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Environmental Monitoring",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Fluorenes",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Methyl Parathion",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Models, Biological",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Pentachlorophenol",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Polychlorinated Biphenyls",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Water Pollutants, Chemical",
"type": "DefinedTerm"
}
],
"author": [
{
"affiliation": {
"alternateName": "Wichita State University",
"id": "https://www.grid.ac/institutes/grid.268246.c",
"name": [
"Department of Biological Sciences, Wichita State University, 1845 Fairmount, Wichita, Kansas 67260-0026, USA, US"
],
"type": "Organization"
},
"familyName": "Nuutinen",
"givenName": "Susanna",
"id": "sg:person.01367315574.62",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01367315574.62"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Great Lakes Environmental Research Laboratory",
"id": "https://www.grid.ac/institutes/grid.474355.4",
"name": [
"Great Lakes Environmental Research Laboratory, National Oceanic and Atmospheric Administration, 2205 Commonwealth Boulevard, Ann Arbor, Michigan 48105, USA, US"
],
"type": "Organization"
},
"familyName": "Landrum",
"givenName": "Peter F.",
"id": "sg:person.0735743047.30",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0735743047.30"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Southern Illinois University System",
"id": "https://www.grid.ac/institutes/grid.411026.0",
"name": [
"Fisheries and Illinois Aquaculture Center and Department of Zoology, Southern Illinois University, Carbondale, Illinois 62901-6501, USA, US"
],
"type": "Organization"
},
"familyName": "Schuler",
"givenName": "Lance J.",
"id": "sg:person.0642212666.59",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0642212666.59"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "University of Eastern Finland",
"id": "https://www.grid.ac/institutes/grid.9668.1",
"name": [
"Laboratory of Aquatic Ecology and Ecotoxicology, Department of Biology, University of Joensuu, P.O. Box 111, FIN-80101, Joensuu, Finland, FI"
],
"type": "Organization"
},
"familyName": "Kukkonen",
"givenName": "Jussi V. K.",
"id": "sg:person.011650374117.31",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011650374117.31"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Wichita State University",
"id": "https://www.grid.ac/institutes/grid.268246.c",
"name": [
"Department of Biological Sciences, Wichita State University, 1845 Fairmount, Wichita, Kansas 67260-0026, USA, US"
],
"type": "Organization"
},
"familyName": "Lydy",
"givenName": "Michael J.",
"id": "sg:person.01175461163.22",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01175461163.22"
],
"type": "Person"
}
],
"datePublished": "2003-05",
"datePublishedReg": "2003-05-01",
"description": "Uptake, biotransformation, and elimination rates were determined for pentachlorophenol (PCP), methyl parathion (MP), fluoranthene (FU), and 2,2',4,4',5,5'-hexachlorobiphenyl (HCBP) using juvenile Hyalella azteca under water-only exposures. A two-compartment model that included biotransformation described the kinetics for each chemical. The uptake clearance coefficients (k(u)) were 25.7 +/- 2.9, 11.5 +/- 1.1, 184.4 +/- 9.3, and 251.7 +/- 9.0 (ml g(-1) h(-1)) for PCP, MP, FU, and HCBP, respectively. The elimination rate constant of the parent compound (k(ep)) for MP was almost an order of magnitude faster (0.403 +/- 0.070 h(-1)) than for PCP and FU (0.061 +/- 0.034 and 0.040 +/- 0.008 h(-1)). The elimination rate constants for FU and PCP metabolites (k(em)) were similar to the parent compound elimination 0.040 +/- 0.005 h(-1) and 0.076 +/- 0.012 h(-1), respectively. For MP, the metabolites were excreted much more slowly than the parent compound (0.021 +/- 0.001 h(-1)). For PCP, FU, and MP whose metabolites were measured, the biological half-life (t(1/2p)) of the parent compound was shorter than the half-life for metabolites (t(1/2m)) because the rate is driven both by elimination and biotransformation processes. Thus, H. azteca is capable of metabolizing compounds with varying chemical structures and modes of toxic action, which may complicate interpretation of toxicity and bioaccumulation results. This finding improves our understanding of H. azteca as a test organism, because most biomonitoring activities do not account for biotransformation and some metabolites can contribute significantly to the noted toxicity.",
"genre": "research_article",
"id": "sg:pub.10.1007/s00244-002-2127-x",
"inLanguage": [
"en"
],
"isAccessibleForFree": false,
"isPartOf": [
{
"id": "sg:journal.1016396",
"issn": [
"0090-4341",
"1432-0703"
],
"name": "Archives of Environmental Contamination and Toxicology",
"type": "Periodical"
},
{
"issueNumber": "4",
"type": "PublicationIssue"
},
{
"type": "PublicationVolume",
"volumeNumber": "44"
}
],
"name": "Toxicokinetics of Organic Contaminants in Hyalella azteca",
"pagination": "0467-0475",
"productId": [
{
"name": "readcube_id",
"type": "PropertyValue",
"value": [
"1b7763a0c2952d769e0a076e7f263081ee6a52df3d42cb35f1c346445397a553"
]
},
{
"name": "pubmed_id",
"type": "PropertyValue",
"value": [
"12712277"
]
},
{
"name": "nlm_unique_id",
"type": "PropertyValue",
"value": [
"0357245"
]
},
{
"name": "doi",
"type": "PropertyValue",
"value": [
"10.1007/s00244-002-2127-x"
]
},
{
"name": "dimensions_id",
"type": "PropertyValue",
"value": [
"pub.1005764943"
]
}
],
"sameAs": [
"https://doi.org/10.1007/s00244-002-2127-x",
"https://app.dimensions.ai/details/publication/pub.1005764943"
],
"sdDataset": "articles",
"sdDatePublished": "2019-04-11T01:59",
"sdLicense": "https://scigraph.springernature.com/explorer/license/",
"sdPublisher": {
"name": "Springer Nature - SN SciGraph project",
"type": "Organization"
},
"sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8700_00000510.jsonl",
"type": "ScholarlyArticle",
"url": "http://link.springer.com/10.1007%2Fs00244-002-2127-x"
}
]Download the RDF metadata as: json-ld nt turtle xml License info
JSON-LD is a popular format for linked data which is fully compatible with JSON.
curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s00244-002-2127-x'
N-Triples is a line-based linked data format ideal for batch operations.
curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s00244-002-2127-x'
Turtle is a human-readable linked data format.
curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s00244-002-2127-x'
RDF/XML is a standard XML format for linked data.
curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s00244-002-2127-x'
This table displays all metadata directly associated to this object as RDF triples.
146 TRIPLES
20 PREDICATES
39 URIs
31 LITERALS
19 BLANK NODES