Toxicokinetics of Organic Contaminants in Hyalella azteca View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2003-05

AUTHORS

Susanna Nuutinen, Peter F. Landrum, Lance J. Schuler, Jussi V. K. Kukkonen, Michael J. Lydy

ABSTRACT

Uptake, biotransformation, and elimination rates were determined for pentachlorophenol (PCP), methyl parathion (MP), fluoranthene (FU), and 2,2',4,4',5,5'-hexachlorobiphenyl (HCBP) using juvenile Hyalella azteca under water-only exposures. A two-compartment model that included biotransformation described the kinetics for each chemical. The uptake clearance coefficients (k(u)) were 25.7 +/- 2.9, 11.5 +/- 1.1, 184.4 +/- 9.3, and 251.7 +/- 9.0 (ml g(-1) h(-1)) for PCP, MP, FU, and HCBP, respectively. The elimination rate constant of the parent compound (k(ep)) for MP was almost an order of magnitude faster (0.403 +/- 0.070 h(-1)) than for PCP and FU (0.061 +/- 0.034 and 0.040 +/- 0.008 h(-1)). The elimination rate constants for FU and PCP metabolites (k(em)) were similar to the parent compound elimination 0.040 +/- 0.005 h(-1) and 0.076 +/- 0.012 h(-1), respectively. For MP, the metabolites were excreted much more slowly than the parent compound (0.021 +/- 0.001 h(-1)). For PCP, FU, and MP whose metabolites were measured, the biological half-life (t(1/2p)) of the parent compound was shorter than the half-life for metabolites (t(1/2m)) because the rate is driven both by elimination and biotransformation processes. Thus, H. azteca is capable of metabolizing compounds with varying chemical structures and modes of toxic action, which may complicate interpretation of toxicity and bioaccumulation results. This finding improves our understanding of H. azteca as a test organism, because most biomonitoring activities do not account for biotransformation and some metabolites can contribute significantly to the noted toxicity. More... »

PAGES

0467-0475

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00244-002-2127-x

DOI

http://dx.doi.org/10.1007/s00244-002-2127-x

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1005764943

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/12712277


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biochemistry and Cell Biology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Biotransformation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Crustacea", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Environmental Monitoring", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Fluorenes", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Methyl Parathion", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Models, Biological", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Pentachlorophenol", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Polychlorinated Biphenyls", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Water Pollutants, Chemical", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Wichita State University", 
          "id": "https://www.grid.ac/institutes/grid.268246.c", 
          "name": [
            "Department of Biological Sciences, Wichita State University, 1845 Fairmount, Wichita, Kansas 67260-0026, USA, US"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Nuutinen", 
        "givenName": "Susanna", 
        "id": "sg:person.01367315574.62", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01367315574.62"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Great Lakes Environmental Research Laboratory", 
          "id": "https://www.grid.ac/institutes/grid.474355.4", 
          "name": [
            "Great Lakes Environmental Research Laboratory, National Oceanic and Atmospheric Administration, 2205 Commonwealth Boulevard, Ann Arbor, Michigan 48105, USA, US"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Landrum", 
        "givenName": "Peter F.", 
        "id": "sg:person.0735743047.30", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0735743047.30"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Southern Illinois University System", 
          "id": "https://www.grid.ac/institutes/grid.411026.0", 
          "name": [
            "Fisheries and Illinois Aquaculture Center and Department of Zoology, Southern Illinois University, Carbondale, Illinois 62901-6501, USA, US"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Schuler", 
        "givenName": "Lance J.", 
        "id": "sg:person.0642212666.59", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0642212666.59"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Eastern Finland", 
          "id": "https://www.grid.ac/institutes/grid.9668.1", 
          "name": [
            "Laboratory of Aquatic Ecology and Ecotoxicology, Department of Biology, University of Joensuu, P.O. Box 111, FIN-80101, Joensuu, Finland, FI"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kukkonen", 
        "givenName": "Jussi V. K.", 
        "id": "sg:person.011650374117.31", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011650374117.31"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Wichita State University", 
          "id": "https://www.grid.ac/institutes/grid.268246.c", 
          "name": [
            "Department of Biological Sciences, Wichita State University, 1845 Fairmount, Wichita, Kansas 67260-0026, USA, US"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lydy", 
        "givenName": "Michael J.", 
        "id": "sg:person.01175461163.22", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01175461163.22"
        ], 
        "type": "Person"
      }
    ], 
    "datePublished": "2003-05", 
    "datePublishedReg": "2003-05-01", 
    "description": "Uptake, biotransformation, and elimination rates were determined for pentachlorophenol (PCP), methyl parathion (MP), fluoranthene (FU), and 2,2',4,4',5,5'-hexachlorobiphenyl (HCBP) using juvenile Hyalella azteca under water-only exposures. A two-compartment model that included biotransformation described the kinetics for each chemical. The uptake clearance coefficients (k(u)) were 25.7 +/- 2.9, 11.5 +/- 1.1, 184.4 +/- 9.3, and 251.7 +/- 9.0 (ml g(-1) h(-1)) for PCP, MP, FU, and HCBP, respectively. The elimination rate constant of the parent compound (k(ep)) for MP was almost an order of magnitude faster (0.403 +/- 0.070 h(-1)) than for PCP and FU (0.061 +/- 0.034 and 0.040 +/- 0.008 h(-1)). The elimination rate constants for FU and PCP metabolites (k(em)) were similar to the parent compound elimination 0.040 +/- 0.005 h(-1) and 0.076 +/- 0.012 h(-1), respectively. For MP, the metabolites were excreted much more slowly than the parent compound (0.021 +/- 0.001 h(-1)). For PCP, FU, and MP whose metabolites were measured, the biological half-life (t(1/2p)) of the parent compound was shorter than the half-life for metabolites (t(1/2m)) because the rate is driven both by elimination and biotransformation processes. Thus, H. azteca is capable of metabolizing compounds with varying chemical structures and modes of toxic action, which may complicate interpretation of toxicity and bioaccumulation results. This finding improves our understanding of H. azteca as a test organism, because most biomonitoring activities do not account for biotransformation and some metabolites can contribute significantly to the noted toxicity.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/s00244-002-2127-x", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1016396", 
        "issn": [
          "0090-4341", 
          "1432-0703"
        ], 
        "name": "Archives of Environmental Contamination and Toxicology", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "4", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "44"
      }
    ], 
    "name": "Toxicokinetics of Organic Contaminants in Hyalella azteca", 
    "pagination": "0467-0475", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "1b7763a0c2952d769e0a076e7f263081ee6a52df3d42cb35f1c346445397a553"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "12712277"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "0357245"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s00244-002-2127-x"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1005764943"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s00244-002-2127-x", 
      "https://app.dimensions.ai/details/publication/pub.1005764943"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T01:59", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8700_00000510.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1007%2Fs00244-002-2127-x"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s00244-002-2127-x'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s00244-002-2127-x'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s00244-002-2127-x'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s00244-002-2127-x'


 

This table displays all metadata directly associated to this object as RDF triples.

146 TRIPLES      20 PREDICATES      39 URIs      31 LITERALS      19 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s00244-002-2127-x schema:about N0113949cd4f04a13933a57537fccb938
2 N238bf9974b57499486e21acc55381f8e
3 N443369a417024efaa01de784ef710c24
4 N6ae3fc1b1be14a56944e71ec7f36eaaf
5 N75daec1d2afd43898555ef4bf89a915e
6 N7e2d1ae7895d41b587384341cee0f6b0
7 N8fc1d66a7e2748f08cf9fdf1951f6b2d
8 N97749b12323b4a2f9981dddc3aa992d2
9 Na3ddcb7951b647738f6afde9b7203538
10 Ne74b598e51c8443394b3dc1acd159666
11 anzsrc-for:06
12 anzsrc-for:0601
13 schema:author N3da4f0937e25453986abc6e5f017ac4c
14 schema:datePublished 2003-05
15 schema:datePublishedReg 2003-05-01
16 schema:description Uptake, biotransformation, and elimination rates were determined for pentachlorophenol (PCP), methyl parathion (MP), fluoranthene (FU), and 2,2',4,4',5,5'-hexachlorobiphenyl (HCBP) using juvenile Hyalella azteca under water-only exposures. A two-compartment model that included biotransformation described the kinetics for each chemical. The uptake clearance coefficients (k(u)) were 25.7 +/- 2.9, 11.5 +/- 1.1, 184.4 +/- 9.3, and 251.7 +/- 9.0 (ml g(-1) h(-1)) for PCP, MP, FU, and HCBP, respectively. The elimination rate constant of the parent compound (k(ep)) for MP was almost an order of magnitude faster (0.403 +/- 0.070 h(-1)) than for PCP and FU (0.061 +/- 0.034 and 0.040 +/- 0.008 h(-1)). The elimination rate constants for FU and PCP metabolites (k(em)) were similar to the parent compound elimination 0.040 +/- 0.005 h(-1) and 0.076 +/- 0.012 h(-1), respectively. For MP, the metabolites were excreted much more slowly than the parent compound (0.021 +/- 0.001 h(-1)). For PCP, FU, and MP whose metabolites were measured, the biological half-life (t(1/2p)) of the parent compound was shorter than the half-life for metabolites (t(1/2m)) because the rate is driven both by elimination and biotransformation processes. Thus, H. azteca is capable of metabolizing compounds with varying chemical structures and modes of toxic action, which may complicate interpretation of toxicity and bioaccumulation results. This finding improves our understanding of H. azteca as a test organism, because most biomonitoring activities do not account for biotransformation and some metabolites can contribute significantly to the noted toxicity.
17 schema:genre research_article
18 schema:inLanguage en
19 schema:isAccessibleForFree false
20 schema:isPartOf N00bb4e4424ca44fb9d2777669e0b84d8
21 Na6dede0d28c84bccbb85e565035be030
22 sg:journal.1016396
23 schema:name Toxicokinetics of Organic Contaminants in Hyalella azteca
24 schema:pagination 0467-0475
25 schema:productId N3a5faa4b963f4341b1249ff343ec7708
26 N4ec17089f35543fa8693a9404651db21
27 N65adf2b7da99453db9d7c4fad0b785f1
28 Nbcae809ce05a4caeafeedfd85feece48
29 Nfe356f184e9b4f4e84dfa8786eba1bc4
30 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005764943
31 https://doi.org/10.1007/s00244-002-2127-x
32 schema:sdDatePublished 2019-04-11T01:59
33 schema:sdLicense https://scigraph.springernature.com/explorer/license/
34 schema:sdPublisher N8624808dd100488cbaf826ef2619e623
35 schema:url http://link.springer.com/10.1007%2Fs00244-002-2127-x
36 sgo:license sg:explorer/license/
37 sgo:sdDataset articles
38 rdf:type schema:ScholarlyArticle
39 N00bb4e4424ca44fb9d2777669e0b84d8 schema:issueNumber 4
40 rdf:type schema:PublicationIssue
41 N0113949cd4f04a13933a57537fccb938 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
42 schema:name Pentachlorophenol
43 rdf:type schema:DefinedTerm
44 N238bf9974b57499486e21acc55381f8e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
45 schema:name Environmental Monitoring
46 rdf:type schema:DefinedTerm
47 N35ff64968f1b475a8d87ca2b864f74e3 rdf:first sg:person.011650374117.31
48 rdf:rest N818f7bc310ca43f1848208f1eb9deba0
49 N3a5faa4b963f4341b1249ff343ec7708 schema:name nlm_unique_id
50 schema:value 0357245
51 rdf:type schema:PropertyValue
52 N3da4f0937e25453986abc6e5f017ac4c rdf:first sg:person.01367315574.62
53 rdf:rest Nc2bb93e546ae45e9a004762d9d1b2cd1
54 N443369a417024efaa01de784ef710c24 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
55 schema:name Water Pollutants, Chemical
56 rdf:type schema:DefinedTerm
57 N4ec17089f35543fa8693a9404651db21 schema:name pubmed_id
58 schema:value 12712277
59 rdf:type schema:PropertyValue
60 N645790924d9b450fabaabc3ac663eeb4 rdf:first sg:person.0642212666.59
61 rdf:rest N35ff64968f1b475a8d87ca2b864f74e3
62 N65adf2b7da99453db9d7c4fad0b785f1 schema:name dimensions_id
63 schema:value pub.1005764943
64 rdf:type schema:PropertyValue
65 N6ae3fc1b1be14a56944e71ec7f36eaaf schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
66 schema:name Biotransformation
67 rdf:type schema:DefinedTerm
68 N75daec1d2afd43898555ef4bf89a915e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
69 schema:name Models, Biological
70 rdf:type schema:DefinedTerm
71 N7e2d1ae7895d41b587384341cee0f6b0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
72 schema:name Fluorenes
73 rdf:type schema:DefinedTerm
74 N818f7bc310ca43f1848208f1eb9deba0 rdf:first sg:person.01175461163.22
75 rdf:rest rdf:nil
76 N8624808dd100488cbaf826ef2619e623 schema:name Springer Nature - SN SciGraph project
77 rdf:type schema:Organization
78 N8fc1d66a7e2748f08cf9fdf1951f6b2d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
79 schema:name Crustacea
80 rdf:type schema:DefinedTerm
81 N97749b12323b4a2f9981dddc3aa992d2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
82 schema:name Animals
83 rdf:type schema:DefinedTerm
84 Na3ddcb7951b647738f6afde9b7203538 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
85 schema:name Methyl Parathion
86 rdf:type schema:DefinedTerm
87 Na6dede0d28c84bccbb85e565035be030 schema:volumeNumber 44
88 rdf:type schema:PublicationVolume
89 Nbcae809ce05a4caeafeedfd85feece48 schema:name doi
90 schema:value 10.1007/s00244-002-2127-x
91 rdf:type schema:PropertyValue
92 Nc2bb93e546ae45e9a004762d9d1b2cd1 rdf:first sg:person.0735743047.30
93 rdf:rest N645790924d9b450fabaabc3ac663eeb4
94 Ne74b598e51c8443394b3dc1acd159666 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
95 schema:name Polychlorinated Biphenyls
96 rdf:type schema:DefinedTerm
97 Nfe356f184e9b4f4e84dfa8786eba1bc4 schema:name readcube_id
98 schema:value 1b7763a0c2952d769e0a076e7f263081ee6a52df3d42cb35f1c346445397a553
99 rdf:type schema:PropertyValue
100 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
101 schema:name Biological Sciences
102 rdf:type schema:DefinedTerm
103 anzsrc-for:0601 schema:inDefinedTermSet anzsrc-for:
104 schema:name Biochemistry and Cell Biology
105 rdf:type schema:DefinedTerm
106 sg:journal.1016396 schema:issn 0090-4341
107 1432-0703
108 schema:name Archives of Environmental Contamination and Toxicology
109 rdf:type schema:Periodical
110 sg:person.011650374117.31 schema:affiliation https://www.grid.ac/institutes/grid.9668.1
111 schema:familyName Kukkonen
112 schema:givenName Jussi V. K.
113 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011650374117.31
114 rdf:type schema:Person
115 sg:person.01175461163.22 schema:affiliation https://www.grid.ac/institutes/grid.268246.c
116 schema:familyName Lydy
117 schema:givenName Michael J.
118 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01175461163.22
119 rdf:type schema:Person
120 sg:person.01367315574.62 schema:affiliation https://www.grid.ac/institutes/grid.268246.c
121 schema:familyName Nuutinen
122 schema:givenName Susanna
123 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01367315574.62
124 rdf:type schema:Person
125 sg:person.0642212666.59 schema:affiliation https://www.grid.ac/institutes/grid.411026.0
126 schema:familyName Schuler
127 schema:givenName Lance J.
128 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0642212666.59
129 rdf:type schema:Person
130 sg:person.0735743047.30 schema:affiliation https://www.grid.ac/institutes/grid.474355.4
131 schema:familyName Landrum
132 schema:givenName Peter F.
133 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0735743047.30
134 rdf:type schema:Person
135 https://www.grid.ac/institutes/grid.268246.c schema:alternateName Wichita State University
136 schema:name Department of Biological Sciences, Wichita State University, 1845 Fairmount, Wichita, Kansas 67260-0026, USA, US
137 rdf:type schema:Organization
138 https://www.grid.ac/institutes/grid.411026.0 schema:alternateName Southern Illinois University System
139 schema:name Fisheries and Illinois Aquaculture Center and Department of Zoology, Southern Illinois University, Carbondale, Illinois 62901-6501, USA, US
140 rdf:type schema:Organization
141 https://www.grid.ac/institutes/grid.474355.4 schema:alternateName Great Lakes Environmental Research Laboratory
142 schema:name Great Lakes Environmental Research Laboratory, National Oceanic and Atmospheric Administration, 2205 Commonwealth Boulevard, Ann Arbor, Michigan 48105, USA, US
143 rdf:type schema:Organization
144 https://www.grid.ac/institutes/grid.9668.1 schema:alternateName University of Eastern Finland
145 schema:name Laboratory of Aquatic Ecology and Ecotoxicology, Department of Biology, University of Joensuu, P.O. Box 111, FIN-80101, Joensuu, Finland, FI
146 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...