Microstructures of Randall’s plaques and their interfaces with calcium oxalate monohydrate kidney stones reflect underlying mineral precipitation mechanisms View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2017-06

AUTHORS

Ingo Sethmann, Gunnar Wendt-Nordahl, Thomas Knoll, Frieder Enzmann, Ludwig Simon, Hans-Joachim Kleebe

ABSTRACT

Randall's plaques (RP) are preferred sites for the formation of calcium oxalate monohydrate (COM) kidney stones. However, although processes of interstitial calcium phosphate (CaP) plaque formation are not well understood, the potential of plaque microstructures as indicators of CaP precipitation conditions received only limited attention. We investigated RP-associated COM stones for structural details of the calcified tissues and microstructural features of plaque-stone interfaces as indicators of the initial processes of stone formation. Significantly increased CaP supersaturation can be expected for interstitial fluid, if reabsorbed ions from the tubular system continuously diffuse into the collagenous connective tissue. Densely packed, fine-grained CaP particles were found in dense textures of basement membranes while larger, laminated particles were scattered in coarse-meshed interstitial tissue, which we propose to be due to differential spatial confinements and restrictions of ion diffusion. Particle morphologies suggest an initial precipitation as metastable amorphous calcium phosphate (ACP). Morphologies and arrangements of first COM crystals at the RP-stone interface ranged from stacked euhedral platelets to skeletal morphologies and even porous, dendritic structures, indicating, in this order, increasing levels of COM supersaturation. Furthermore, these first COM crystals were often coated with CaP. On this basis, we propose that ions from CaP-supersaturated interstitial fluid may diffuse through porous RP into the urine, where a resulting local increase in COM supersaturation could trigger crystal nucleation and, hence, initiate stone formation. Ion-depleted fluid in persistent pores of initial COM layers may get replenished from interstitial fluid, leading to CaP precipitation in porous COM. More... »

PAGES

235-248

References to SciGraph publications

  • 2009-08. Studies on the role of calcium phosphate in the process of calcium oxalate crystal formation in UROLITHIASIS
  • 2015-01. Unified theory on the pathogenesis of Randall’s plaques and plugs in UROLITHIASIS
  • 2015-01. Vascular theory of the formation of Randall plaques in UROLITHIASIS
  • 2009-02. Mechanism of formation of concentrically laminated spherules: implication to Randall’s plaque and stone formation in UROLITHIASIS
  • 1994-09. Calcium oxalate nephrolithiasis, a free or fixed particle disease in KIDNEY INTERNATIONAL
  • 2004-11. Relative effect of urinary calcium and oxalate on saturation of calcium oxalate Rapid Communication in KIDNEY INTERNATIONAL
  • 2010-06. Three pathways for human kidney stone formation in UROLITHIASIS
  • 2002-11. Phosphorus and uremic serum up-regulate osteopontin expression in vascular smooth muscle cells in KIDNEY INTERNATIONAL
  • 2008-05. Kalziumoxalatsteinbildung in DER UROLOGE
  • 2015-01. Biomimetic Randall’s plaque as an in vitro model system for studying the role of acidic biopolymers in idiopathic stone formation in UROLITHIASIS
  • 1983-08. Crystallization theory relating to urinary stone formation in WORLD JOURNAL OF UROLOGY
  • 1994. Role of Uropontin in Urinary Calcium Stone Formation in UROLITHIASIS 2
  • 2010-08. Mineralogical signatures of stone formation mechanisms in UROLITHIASIS
  • 1995-11. Sex- and age-related composition of 10 617 calculi analyzed by infrared spectroscopy in UROLITHIASIS
  • 1978-05. Physicochemical aspects of urolithiasis in KIDNEY INTERNATIONAL
  • 2011-08. A hypothesis of calcium stone formation: an interpretation of stone research during the past decades in UROLITHIASIS
  • 2013-10. Role of Osteopontin in Modulation of Hydroxyapatite Formation in CALCIFIED TISSUE INTERNATIONAL
  • 2005-07. Apatite plaque particles in inner medulla of kidneys of calcium oxalate stone formers: Osteopontin localization in KIDNEY INTERNATIONAL
  • 1998-12. Solubility of the Three Calcium Oxalate Hydrates in Sodium Chloride Solutionsand Urine-Like Liquors in MONATSHEFTE FÜR CHEMIE - CHEMICAL MONTHLY
  • 2006-04. Randall's plaque: Pathogenesis and role in calcium oxalate nephrolithiasis in KIDNEY INTERNATIONAL
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s00240-016-0925-2

    DOI

    http://dx.doi.org/10.1007/s00240-016-0925-2

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1044374789

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/27695926


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0306", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Physical Chemistry (incl. Structural)", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/03", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Chemical Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Basement Membrane", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Calcium Oxalate", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Calcium Phosphates", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Extracellular Fluid", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Humans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Kidney Calculi", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Kidney Medulla", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Microscopy, Electron, Scanning", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Nephrolithotomy, Percutaneous", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Tomography, X-Ray Computed", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Technical University of Darmstadt", 
              "id": "https://www.grid.ac/institutes/grid.6546.1", 
              "name": [
                "Institut f\u00fcr Angewandte Geowissenschaften, Technische Universit\u00e4t Darmstadt, Schnittspahnstr. 9, 64287, Darmstadt, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Sethmann", 
            "givenName": "Ingo", 
            "id": "sg:person.01026057217.64", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01026057217.64"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Klinikum Sindelfingen-B\u00f6blingen", 
              "id": "https://www.grid.ac/institutes/grid.491906.3", 
              "name": [
                "Urologische Klinik Sindelfingen, Klinikum Sindelfingen-B\u00f6blingen, Arthur-Gruber-Str. 70, 71065, Sindelfingen, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Wendt-Nordahl", 
            "givenName": "Gunnar", 
            "id": "sg:person.01337164702.66", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01337164702.66"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Klinikum Sindelfingen-B\u00f6blingen", 
              "id": "https://www.grid.ac/institutes/grid.491906.3", 
              "name": [
                "Urologische Klinik Sindelfingen, Klinikum Sindelfingen-B\u00f6blingen, Arthur-Gruber-Str. 70, 71065, Sindelfingen, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Knoll", 
            "givenName": "Thomas", 
            "id": "sg:person.0775646451.31", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0775646451.31"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Johannes Gutenberg University of Mainz", 
              "id": "https://www.grid.ac/institutes/grid.5802.f", 
              "name": [
                "Institut f\u00fcr Geowissenschaften, Johannes Gutenberg-Universit\u00e4t Mainz, Johann-Joachim-Becher-Weg 21, 55128, Mainz, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Enzmann", 
            "givenName": "Frieder", 
            "id": "sg:person.01215775302.92", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01215775302.92"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Johannes Gutenberg University of Mainz", 
              "id": "https://www.grid.ac/institutes/grid.5802.f", 
              "name": [
                "Institut f\u00fcr Geowissenschaften, Johannes Gutenberg-Universit\u00e4t Mainz, Johann-Joachim-Becher-Weg 21, 55128, Mainz, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Simon", 
            "givenName": "Ludwig", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Technical University of Darmstadt", 
              "id": "https://www.grid.ac/institutes/grid.6546.1", 
              "name": [
                "Institut f\u00fcr Angewandte Geowissenschaften, Technische Universit\u00e4t Darmstadt, Schnittspahnstr. 9, 64287, Darmstadt, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Kleebe", 
            "givenName": "Hans-Joachim", 
            "id": "sg:person.01154067647.02", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01154067647.02"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "sg:pub.10.1007/s00223-013-9698-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002332741", 
              "https://doi.org/10.1007/s00223-013-9698-6"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00240-014-0705-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003053831", 
              "https://doi.org/10.1007/s00240-014-0705-9"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/ar.20580", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004047927"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00120-008-1707-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007926532", 
              "https://doi.org/10.1007/s00120-008-1707-4"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00120-008-1707-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007926532", 
              "https://doi.org/10.1007/s00120-008-1707-4"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.juro.2011.10.125", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007971874"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/jbm.a.20066", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009860732"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00240-009-0191-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010368567", 
              "https://doi.org/10.1007/s00240-009-0191-7"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00240-009-0191-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010368567", 
              "https://doi.org/10.1007/s00240-009-0191-7"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00240-009-0191-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010368567", 
              "https://doi.org/10.1007/s00240-009-0191-7"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1107/s0909049510003791", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010621124"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1107/s0909049510003791", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010621124"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf00300021", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012290479", 
              "https://doi.org/10.1007/bf00300021"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00240-010-0288-z", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012968693", 
              "https://doi.org/10.1007/s00240-010-0288-z"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00240-010-0288-z", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012968693", 
              "https://doi.org/10.1007/s00240-010-0288-z"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00240-010-0271-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013157190", 
              "https://doi.org/10.1007/s00240-010-0271-8"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00240-010-0271-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013157190", 
              "https://doi.org/10.1007/s00240-010-0271-8"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00240-014-0704-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013716261", 
              "https://doi.org/10.1007/s00240-014-0704-x"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ki.1978.53", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013982001", 
              "https://doi.org/10.1038/ki.1978.53"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ki.1994.341", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015378798", 
              "https://doi.org/10.1038/ki.1994.341"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00240-014-0718-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016020422", 
              "https://doi.org/10.1007/s00240-014-0718-4"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1111/j.1523-1755.2004.00975.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018737889", 
              "https://doi.org/10.1111/j.1523-1755.2004.00975.x"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1042/cs0490369", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020303448"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1042/cs0490369", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020303448"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0174-173x(86)80008-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023283944"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1111/j.1523-1755.2005.00388.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023323101", 
              "https://doi.org/10.1111/j.1523-1755.2005.00388.x"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1523-1755.2005.00388.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023323101"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/978-1-4615-2556-1_94", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025148213", 
              "https://doi.org/10.1007/978-1-4615-2556-1_94"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf00326900", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029001194", 
              "https://doi.org/10.1007/bf00326900"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.ki.5000238", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029784490", 
              "https://doi.org/10.1038/sj.ki.5000238"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/01.ju.0000147270.68481.ce", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030516690"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/01.ju.0000147270.68481.ce", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030516690"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00240-010-0349-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031418484", 
              "https://doi.org/10.1007/s00240-010-0349-3"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1529/biophysj.106.101881", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032824371"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0302-2838(02)00316-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034945077"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1172/jci18016", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036233328"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0022-0248(90)90079-z", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037895394"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0022-0248(90)90079-z", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037895394"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1046/j.1523-1755.2002.00625.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038384660", 
              "https://doi.org/10.1046/j.1523-1755.2002.00625.x"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1046/j.1523-1755.2002.00625.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038384660"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.juro.2016.04.086", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042874523"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.140021997", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044189449"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1172/jci17038", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046751470"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0022-5347(01)65381-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047552946"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00240-008-0169-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048419715", 
              "https://doi.org/10.1007/s00240-008-0169-x"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00240-008-0169-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048419715", 
              "https://doi.org/10.1007/s00240-008-0169-x"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/00000658-193706000-00014", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049185567"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/00000658-193706000-00014", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049185567"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/pl00010134", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049614380", 
              "https://doi.org/10.1007/pl00010134"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.juro.2010.11.073", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052291748"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/cr0782574", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053941638"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/cr0782574", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053941638"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/cm501770r", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053950753"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1017/s0016756800011389", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1054026523"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1017/s0016756800011389", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1054026523"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/acs.cgd.5b00139", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1055083192"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/la00051a028", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1056139493"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.242.4885.1585-a", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062537101"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1180/minmag.2014.078.1.07", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1064121603"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1180/minmag.2014.078.6.11", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1064121692"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0022-5347(17)50211-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1081806078"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1082213329", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1082505580", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1082757933", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0022-5347(17)71305-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1090302053"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0022-5347(17)71305-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1090302053"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1017/cbo9780511525223", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1098665995"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2017-06", 
        "datePublishedReg": "2017-06-01", 
        "description": "Randall's plaques (RP) are preferred sites for the formation of calcium oxalate monohydrate (COM) kidney stones. However, although processes of interstitial calcium phosphate (CaP) plaque formation are not well understood, the potential of plaque microstructures as indicators of CaP precipitation conditions received only limited attention. We investigated RP-associated COM stones for structural details of the calcified tissues and microstructural features of plaque-stone interfaces as indicators of the initial processes of stone formation. Significantly increased CaP supersaturation can be expected for interstitial fluid, if reabsorbed ions from the tubular system continuously diffuse into the collagenous connective tissue. Densely packed, fine-grained CaP particles were found in dense textures of basement membranes while larger, laminated particles were scattered in coarse-meshed interstitial tissue, which we propose to be due to differential spatial confinements and restrictions of ion diffusion. Particle morphologies suggest an initial precipitation as metastable amorphous calcium phosphate (ACP). Morphologies and arrangements of first COM crystals at the RP-stone interface ranged from stacked euhedral platelets to skeletal morphologies and even porous, dendritic structures, indicating, in this order, increasing levels of COM supersaturation. Furthermore, these first COM crystals were often coated with CaP. On this basis, we propose that ions from CaP-supersaturated interstitial fluid may diffuse through porous RP into the urine, where a resulting local increase in COM supersaturation could trigger crystal nucleation and, hence, initiate stone formation. Ion-depleted fluid in persistent pores of initial COM layers may get replenished from interstitial fluid, leading to CaP precipitation in porous COM.", 
        "genre": "research_article", 
        "id": "sg:pub.10.1007/s00240-016-0925-2", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": false, 
        "isPartOf": [
          {
            "id": "sg:journal.1016657", 
            "issn": [
              "2194-7228", 
              "2194-7236"
            ], 
            "name": "Urolithiasis", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "3", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "45"
          }
        ], 
        "name": "Microstructures of Randall\u2019s plaques and their interfaces with calcium oxalate monohydrate kidney stones reflect underlying mineral precipitation mechanisms", 
        "pagination": "235-248", 
        "productId": [
          {
            "name": "readcube_id", 
            "type": "PropertyValue", 
            "value": [
              "d35f79b726eaa0107cf2a88312e1922a83bfc5ddd62e141230265ff538f62439"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "27695926"
            ]
          }, 
          {
            "name": "nlm_unique_id", 
            "type": "PropertyValue", 
            "value": [
              "101602699"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1007/s00240-016-0925-2"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1044374789"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1007/s00240-016-0925-2", 
          "https://app.dimensions.ai/details/publication/pub.1044374789"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2019-04-11T12:43", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000363_0000000363/records_70061_00000002.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://link.springer.com/10.1007%2Fs00240-016-0925-2"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s00240-016-0925-2'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s00240-016-0925-2'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s00240-016-0925-2'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s00240-016-0925-2'


     

    This table displays all metadata directly associated to this object as RDF triples.

    325 TRIPLES      21 PREDICATES      92 URIs      31 LITERALS      19 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1007/s00240-016-0925-2 schema:about N0892500431ce49bd9eb9fc11f8eb73ee
    2 N22e131782580439cad6add416a814347
    3 N2df6947753c24d2db1f5ddfbd74c5b8a
    4 N39805875ca6149f9b489e5ecbb4dc9ff
    5 N506babe3834c4e3a9d624216337628ad
    6 N77e6595e275d4f968c975308b6ad1d79
    7 Nc325e96eb35544d3badbafa0826f442e
    8 Nc7edfc56b00a4dce98cf98a5d3d94c08
    9 Ncee7665b93ff461aa00168c6e7c3a39d
    10 Nd5676163ac18458fae51494d793918ca
    11 anzsrc-for:03
    12 anzsrc-for:0306
    13 schema:author N24ece039e4e0444d943c002baa56ec7b
    14 schema:citation sg:pub.10.1007/978-1-4615-2556-1_94
    15 sg:pub.10.1007/bf00300021
    16 sg:pub.10.1007/bf00326900
    17 sg:pub.10.1007/pl00010134
    18 sg:pub.10.1007/s00120-008-1707-4
    19 sg:pub.10.1007/s00223-013-9698-6
    20 sg:pub.10.1007/s00240-008-0169-x
    21 sg:pub.10.1007/s00240-009-0191-7
    22 sg:pub.10.1007/s00240-010-0271-8
    23 sg:pub.10.1007/s00240-010-0288-z
    24 sg:pub.10.1007/s00240-010-0349-3
    25 sg:pub.10.1007/s00240-014-0704-x
    26 sg:pub.10.1007/s00240-014-0705-9
    27 sg:pub.10.1007/s00240-014-0718-4
    28 sg:pub.10.1038/ki.1978.53
    29 sg:pub.10.1038/ki.1994.341
    30 sg:pub.10.1038/sj.ki.5000238
    31 sg:pub.10.1046/j.1523-1755.2002.00625.x
    32 sg:pub.10.1111/j.1523-1755.2004.00975.x
    33 sg:pub.10.1111/j.1523-1755.2005.00388.x
    34 https://app.dimensions.ai/details/publication/pub.1082213329
    35 https://app.dimensions.ai/details/publication/pub.1082505580
    36 https://app.dimensions.ai/details/publication/pub.1082757933
    37 https://doi.org/10.1002/ar.20580
    38 https://doi.org/10.1002/jbm.a.20066
    39 https://doi.org/10.1016/0022-0248(90)90079-z
    40 https://doi.org/10.1016/j.juro.2010.11.073
    41 https://doi.org/10.1016/j.juro.2011.10.125
    42 https://doi.org/10.1016/j.juro.2016.04.086
    43 https://doi.org/10.1016/s0022-5347(01)65381-3
    44 https://doi.org/10.1016/s0022-5347(17)50211-6
    45 https://doi.org/10.1016/s0022-5347(17)71305-5
    46 https://doi.org/10.1016/s0174-173x(86)80008-5
    47 https://doi.org/10.1016/s0302-2838(02)00316-0
    48 https://doi.org/10.1017/cbo9780511525223
    49 https://doi.org/10.1017/s0016756800011389
    50 https://doi.org/10.1021/acs.cgd.5b00139
    51 https://doi.org/10.1021/cm501770r
    52 https://doi.org/10.1021/cr0782574
    53 https://doi.org/10.1021/la00051a028
    54 https://doi.org/10.1042/cs0490369
    55 https://doi.org/10.1046/j.1523-1755.2002.00625.x
    56 https://doi.org/10.1073/pnas.140021997
    57 https://doi.org/10.1097/00000658-193706000-00014
    58 https://doi.org/10.1097/01.ju.0000147270.68481.ce
    59 https://doi.org/10.1107/s0909049510003791
    60 https://doi.org/10.1111/j.1523-1755.2005.00388.x
    61 https://doi.org/10.1126/science.242.4885.1585-a
    62 https://doi.org/10.1172/jci17038
    63 https://doi.org/10.1172/jci18016
    64 https://doi.org/10.1180/minmag.2014.078.1.07
    65 https://doi.org/10.1180/minmag.2014.078.6.11
    66 https://doi.org/10.1529/biophysj.106.101881
    67 schema:datePublished 2017-06
    68 schema:datePublishedReg 2017-06-01
    69 schema:description Randall's plaques (RP) are preferred sites for the formation of calcium oxalate monohydrate (COM) kidney stones. However, although processes of interstitial calcium phosphate (CaP) plaque formation are not well understood, the potential of plaque microstructures as indicators of CaP precipitation conditions received only limited attention. We investigated RP-associated COM stones for structural details of the calcified tissues and microstructural features of plaque-stone interfaces as indicators of the initial processes of stone formation. Significantly increased CaP supersaturation can be expected for interstitial fluid, if reabsorbed ions from the tubular system continuously diffuse into the collagenous connective tissue. Densely packed, fine-grained CaP particles were found in dense textures of basement membranes while larger, laminated particles were scattered in coarse-meshed interstitial tissue, which we propose to be due to differential spatial confinements and restrictions of ion diffusion. Particle morphologies suggest an initial precipitation as metastable amorphous calcium phosphate (ACP). Morphologies and arrangements of first COM crystals at the RP-stone interface ranged from stacked euhedral platelets to skeletal morphologies and even porous, dendritic structures, indicating, in this order, increasing levels of COM supersaturation. Furthermore, these first COM crystals were often coated with CaP. On this basis, we propose that ions from CaP-supersaturated interstitial fluid may diffuse through porous RP into the urine, where a resulting local increase in COM supersaturation could trigger crystal nucleation and, hence, initiate stone formation. Ion-depleted fluid in persistent pores of initial COM layers may get replenished from interstitial fluid, leading to CaP precipitation in porous COM.
    70 schema:genre research_article
    71 schema:inLanguage en
    72 schema:isAccessibleForFree false
    73 schema:isPartOf N3622555d276b4ba4b8603bfd9cb350e0
    74 Ncfa74772e7854c178460cb4dfad0cd4b
    75 sg:journal.1016657
    76 schema:name Microstructures of Randall’s plaques and their interfaces with calcium oxalate monohydrate kidney stones reflect underlying mineral precipitation mechanisms
    77 schema:pagination 235-248
    78 schema:productId N2e16d5418af249b086d15b40a807ba05
    79 N319f77abe7224988ab88deb2ea7b4aee
    80 N6716f475931842b1bbed0eda7a797fbd
    81 Nc5dab7cc4e5f4c469e16db9cb31997f1
    82 Ne2f292a411f1456aaa9cb8c72f1bc92c
    83 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044374789
    84 https://doi.org/10.1007/s00240-016-0925-2
    85 schema:sdDatePublished 2019-04-11T12:43
    86 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    87 schema:sdPublisher N57a1bbe8501a4b9a9cd1bc3420fef75e
    88 schema:url https://link.springer.com/10.1007%2Fs00240-016-0925-2
    89 sgo:license sg:explorer/license/
    90 sgo:sdDataset articles
    91 rdf:type schema:ScholarlyArticle
    92 N0892500431ce49bd9eb9fc11f8eb73ee schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    93 schema:name Calcium Phosphates
    94 rdf:type schema:DefinedTerm
    95 N22e131782580439cad6add416a814347 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    96 schema:name Extracellular Fluid
    97 rdf:type schema:DefinedTerm
    98 N24ece039e4e0444d943c002baa56ec7b rdf:first sg:person.01026057217.64
    99 rdf:rest Na3087b7091ed4807bfda4350a6891fd4
    100 N2df6947753c24d2db1f5ddfbd74c5b8a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    101 schema:name Kidney Medulla
    102 rdf:type schema:DefinedTerm
    103 N2e16d5418af249b086d15b40a807ba05 schema:name nlm_unique_id
    104 schema:value 101602699
    105 rdf:type schema:PropertyValue
    106 N319f77abe7224988ab88deb2ea7b4aee schema:name readcube_id
    107 schema:value d35f79b726eaa0107cf2a88312e1922a83bfc5ddd62e141230265ff538f62439
    108 rdf:type schema:PropertyValue
    109 N33399a2bf38f4c128c6a8486095dfdf3 rdf:first sg:person.0775646451.31
    110 rdf:rest N41b675c0ad254a9c8d009784588b95e0
    111 N3622555d276b4ba4b8603bfd9cb350e0 schema:volumeNumber 45
    112 rdf:type schema:PublicationVolume
    113 N39805875ca6149f9b489e5ecbb4dc9ff schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    114 schema:name Tomography, X-Ray Computed
    115 rdf:type schema:DefinedTerm
    116 N41b675c0ad254a9c8d009784588b95e0 rdf:first sg:person.01215775302.92
    117 rdf:rest N526579c4d40343ce9d0b17ca5b304961
    118 N4b8fe8834f9842e8ad12981a400f6bd6 rdf:first sg:person.01154067647.02
    119 rdf:rest rdf:nil
    120 N506babe3834c4e3a9d624216337628ad schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    121 schema:name Microscopy, Electron, Scanning
    122 rdf:type schema:DefinedTerm
    123 N526579c4d40343ce9d0b17ca5b304961 rdf:first N6fc0674027b740b4831dc60cc69d66eb
    124 rdf:rest N4b8fe8834f9842e8ad12981a400f6bd6
    125 N57a1bbe8501a4b9a9cd1bc3420fef75e schema:name Springer Nature - SN SciGraph project
    126 rdf:type schema:Organization
    127 N6716f475931842b1bbed0eda7a797fbd schema:name doi
    128 schema:value 10.1007/s00240-016-0925-2
    129 rdf:type schema:PropertyValue
    130 N6fc0674027b740b4831dc60cc69d66eb schema:affiliation https://www.grid.ac/institutes/grid.5802.f
    131 schema:familyName Simon
    132 schema:givenName Ludwig
    133 rdf:type schema:Person
    134 N77e6595e275d4f968c975308b6ad1d79 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    135 schema:name Humans
    136 rdf:type schema:DefinedTerm
    137 Na3087b7091ed4807bfda4350a6891fd4 rdf:first sg:person.01337164702.66
    138 rdf:rest N33399a2bf38f4c128c6a8486095dfdf3
    139 Nc325e96eb35544d3badbafa0826f442e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    140 schema:name Nephrolithotomy, Percutaneous
    141 rdf:type schema:DefinedTerm
    142 Nc5dab7cc4e5f4c469e16db9cb31997f1 schema:name dimensions_id
    143 schema:value pub.1044374789
    144 rdf:type schema:PropertyValue
    145 Nc7edfc56b00a4dce98cf98a5d3d94c08 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    146 schema:name Calcium Oxalate
    147 rdf:type schema:DefinedTerm
    148 Ncee7665b93ff461aa00168c6e7c3a39d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    149 schema:name Kidney Calculi
    150 rdf:type schema:DefinedTerm
    151 Ncfa74772e7854c178460cb4dfad0cd4b schema:issueNumber 3
    152 rdf:type schema:PublicationIssue
    153 Nd5676163ac18458fae51494d793918ca schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    154 schema:name Basement Membrane
    155 rdf:type schema:DefinedTerm
    156 Ne2f292a411f1456aaa9cb8c72f1bc92c schema:name pubmed_id
    157 schema:value 27695926
    158 rdf:type schema:PropertyValue
    159 anzsrc-for:03 schema:inDefinedTermSet anzsrc-for:
    160 schema:name Chemical Sciences
    161 rdf:type schema:DefinedTerm
    162 anzsrc-for:0306 schema:inDefinedTermSet anzsrc-for:
    163 schema:name Physical Chemistry (incl. Structural)
    164 rdf:type schema:DefinedTerm
    165 sg:journal.1016657 schema:issn 2194-7228
    166 2194-7236
    167 schema:name Urolithiasis
    168 rdf:type schema:Periodical
    169 sg:person.01026057217.64 schema:affiliation https://www.grid.ac/institutes/grid.6546.1
    170 schema:familyName Sethmann
    171 schema:givenName Ingo
    172 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01026057217.64
    173 rdf:type schema:Person
    174 sg:person.01154067647.02 schema:affiliation https://www.grid.ac/institutes/grid.6546.1
    175 schema:familyName Kleebe
    176 schema:givenName Hans-Joachim
    177 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01154067647.02
    178 rdf:type schema:Person
    179 sg:person.01215775302.92 schema:affiliation https://www.grid.ac/institutes/grid.5802.f
    180 schema:familyName Enzmann
    181 schema:givenName Frieder
    182 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01215775302.92
    183 rdf:type schema:Person
    184 sg:person.01337164702.66 schema:affiliation https://www.grid.ac/institutes/grid.491906.3
    185 schema:familyName Wendt-Nordahl
    186 schema:givenName Gunnar
    187 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01337164702.66
    188 rdf:type schema:Person
    189 sg:person.0775646451.31 schema:affiliation https://www.grid.ac/institutes/grid.491906.3
    190 schema:familyName Knoll
    191 schema:givenName Thomas
    192 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0775646451.31
    193 rdf:type schema:Person
    194 sg:pub.10.1007/978-1-4615-2556-1_94 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025148213
    195 https://doi.org/10.1007/978-1-4615-2556-1_94
    196 rdf:type schema:CreativeWork
    197 sg:pub.10.1007/bf00300021 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012290479
    198 https://doi.org/10.1007/bf00300021
    199 rdf:type schema:CreativeWork
    200 sg:pub.10.1007/bf00326900 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029001194
    201 https://doi.org/10.1007/bf00326900
    202 rdf:type schema:CreativeWork
    203 sg:pub.10.1007/pl00010134 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049614380
    204 https://doi.org/10.1007/pl00010134
    205 rdf:type schema:CreativeWork
    206 sg:pub.10.1007/s00120-008-1707-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007926532
    207 https://doi.org/10.1007/s00120-008-1707-4
    208 rdf:type schema:CreativeWork
    209 sg:pub.10.1007/s00223-013-9698-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002332741
    210 https://doi.org/10.1007/s00223-013-9698-6
    211 rdf:type schema:CreativeWork
    212 sg:pub.10.1007/s00240-008-0169-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1048419715
    213 https://doi.org/10.1007/s00240-008-0169-x
    214 rdf:type schema:CreativeWork
    215 sg:pub.10.1007/s00240-009-0191-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010368567
    216 https://doi.org/10.1007/s00240-009-0191-7
    217 rdf:type schema:CreativeWork
    218 sg:pub.10.1007/s00240-010-0271-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013157190
    219 https://doi.org/10.1007/s00240-010-0271-8
    220 rdf:type schema:CreativeWork
    221 sg:pub.10.1007/s00240-010-0288-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1012968693
    222 https://doi.org/10.1007/s00240-010-0288-z
    223 rdf:type schema:CreativeWork
    224 sg:pub.10.1007/s00240-010-0349-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031418484
    225 https://doi.org/10.1007/s00240-010-0349-3
    226 rdf:type schema:CreativeWork
    227 sg:pub.10.1007/s00240-014-0704-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1013716261
    228 https://doi.org/10.1007/s00240-014-0704-x
    229 rdf:type schema:CreativeWork
    230 sg:pub.10.1007/s00240-014-0705-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003053831
    231 https://doi.org/10.1007/s00240-014-0705-9
    232 rdf:type schema:CreativeWork
    233 sg:pub.10.1007/s00240-014-0718-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016020422
    234 https://doi.org/10.1007/s00240-014-0718-4
    235 rdf:type schema:CreativeWork
    236 sg:pub.10.1038/ki.1978.53 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013982001
    237 https://doi.org/10.1038/ki.1978.53
    238 rdf:type schema:CreativeWork
    239 sg:pub.10.1038/ki.1994.341 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015378798
    240 https://doi.org/10.1038/ki.1994.341
    241 rdf:type schema:CreativeWork
    242 sg:pub.10.1038/sj.ki.5000238 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029784490
    243 https://doi.org/10.1038/sj.ki.5000238
    244 rdf:type schema:CreativeWork
    245 sg:pub.10.1046/j.1523-1755.2002.00625.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1038384660
    246 https://doi.org/10.1046/j.1523-1755.2002.00625.x
    247 rdf:type schema:CreativeWork
    248 sg:pub.10.1111/j.1523-1755.2004.00975.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1018737889
    249 https://doi.org/10.1111/j.1523-1755.2004.00975.x
    250 rdf:type schema:CreativeWork
    251 sg:pub.10.1111/j.1523-1755.2005.00388.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1023323101
    252 https://doi.org/10.1111/j.1523-1755.2005.00388.x
    253 rdf:type schema:CreativeWork
    254 https://app.dimensions.ai/details/publication/pub.1082213329 schema:CreativeWork
    255 https://app.dimensions.ai/details/publication/pub.1082505580 schema:CreativeWork
    256 https://app.dimensions.ai/details/publication/pub.1082757933 schema:CreativeWork
    257 https://doi.org/10.1002/ar.20580 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004047927
    258 rdf:type schema:CreativeWork
    259 https://doi.org/10.1002/jbm.a.20066 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009860732
    260 rdf:type schema:CreativeWork
    261 https://doi.org/10.1016/0022-0248(90)90079-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1037895394
    262 rdf:type schema:CreativeWork
    263 https://doi.org/10.1016/j.juro.2010.11.073 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052291748
    264 rdf:type schema:CreativeWork
    265 https://doi.org/10.1016/j.juro.2011.10.125 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007971874
    266 rdf:type schema:CreativeWork
    267 https://doi.org/10.1016/j.juro.2016.04.086 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042874523
    268 rdf:type schema:CreativeWork
    269 https://doi.org/10.1016/s0022-5347(01)65381-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047552946
    270 rdf:type schema:CreativeWork
    271 https://doi.org/10.1016/s0022-5347(17)50211-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1081806078
    272 rdf:type schema:CreativeWork
    273 https://doi.org/10.1016/s0022-5347(17)71305-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1090302053
    274 rdf:type schema:CreativeWork
    275 https://doi.org/10.1016/s0174-173x(86)80008-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023283944
    276 rdf:type schema:CreativeWork
    277 https://doi.org/10.1016/s0302-2838(02)00316-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034945077
    278 rdf:type schema:CreativeWork
    279 https://doi.org/10.1017/cbo9780511525223 schema:sameAs https://app.dimensions.ai/details/publication/pub.1098665995
    280 rdf:type schema:CreativeWork
    281 https://doi.org/10.1017/s0016756800011389 schema:sameAs https://app.dimensions.ai/details/publication/pub.1054026523
    282 rdf:type schema:CreativeWork
    283 https://doi.org/10.1021/acs.cgd.5b00139 schema:sameAs https://app.dimensions.ai/details/publication/pub.1055083192
    284 rdf:type schema:CreativeWork
    285 https://doi.org/10.1021/cm501770r schema:sameAs https://app.dimensions.ai/details/publication/pub.1053950753
    286 rdf:type schema:CreativeWork
    287 https://doi.org/10.1021/cr0782574 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053941638
    288 rdf:type schema:CreativeWork
    289 https://doi.org/10.1021/la00051a028 schema:sameAs https://app.dimensions.ai/details/publication/pub.1056139493
    290 rdf:type schema:CreativeWork
    291 https://doi.org/10.1042/cs0490369 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020303448
    292 rdf:type schema:CreativeWork
    293 https://doi.org/10.1046/j.1523-1755.2002.00625.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1038384660
    294 rdf:type schema:CreativeWork
    295 https://doi.org/10.1073/pnas.140021997 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044189449
    296 rdf:type schema:CreativeWork
    297 https://doi.org/10.1097/00000658-193706000-00014 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049185567
    298 rdf:type schema:CreativeWork
    299 https://doi.org/10.1097/01.ju.0000147270.68481.ce schema:sameAs https://app.dimensions.ai/details/publication/pub.1030516690
    300 rdf:type schema:CreativeWork
    301 https://doi.org/10.1107/s0909049510003791 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010621124
    302 rdf:type schema:CreativeWork
    303 https://doi.org/10.1111/j.1523-1755.2005.00388.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1023323101
    304 rdf:type schema:CreativeWork
    305 https://doi.org/10.1126/science.242.4885.1585-a schema:sameAs https://app.dimensions.ai/details/publication/pub.1062537101
    306 rdf:type schema:CreativeWork
    307 https://doi.org/10.1172/jci17038 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046751470
    308 rdf:type schema:CreativeWork
    309 https://doi.org/10.1172/jci18016 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036233328
    310 rdf:type schema:CreativeWork
    311 https://doi.org/10.1180/minmag.2014.078.1.07 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064121603
    312 rdf:type schema:CreativeWork
    313 https://doi.org/10.1180/minmag.2014.078.6.11 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064121692
    314 rdf:type schema:CreativeWork
    315 https://doi.org/10.1529/biophysj.106.101881 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032824371
    316 rdf:type schema:CreativeWork
    317 https://www.grid.ac/institutes/grid.491906.3 schema:alternateName Klinikum Sindelfingen-Böblingen
    318 schema:name Urologische Klinik Sindelfingen, Klinikum Sindelfingen-Böblingen, Arthur-Gruber-Str. 70, 71065, Sindelfingen, Germany
    319 rdf:type schema:Organization
    320 https://www.grid.ac/institutes/grid.5802.f schema:alternateName Johannes Gutenberg University of Mainz
    321 schema:name Institut für Geowissenschaften, Johannes Gutenberg-Universität Mainz, Johann-Joachim-Becher-Weg 21, 55128, Mainz, Germany
    322 rdf:type schema:Organization
    323 https://www.grid.ac/institutes/grid.6546.1 schema:alternateName Technical University of Darmstadt
    324 schema:name Institut für Angewandte Geowissenschaften, Technische Universität Darmstadt, Schnittspahnstr. 9, 64287, Darmstadt, Germany
    325 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...