Compensatory Mutations Occur Within the Electrostatic Interaction Range of Deleterious Mutations in Protein Structure View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2015-01

AUTHORS

Amrita Bhattacherjee, Saurav Mallik, Sudip Kundu

ABSTRACT

A compensatory mutation (CM) counter balances lethal effects of a deleterious mutation (DM), ensuring the persistence of both through natural selection. However, little is known about the biological aspects of CMs those restore the structural alterations of proteins caused by slightly DMs. Here, by analyzing the evolution of the UDP-glycosyltransferase 73B4 protein among monocot-dicot plants, we investigate the occurrence of CMs around slightly DMs in 3D space. Our results illustrate that CMs exhibit significantly higher tendency to occur within the range of electrostatic interaction around the slightly DMs, compared to occurring randomly in the protein. More... »

PAGES

10-12

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00239-014-9654-8

DOI

http://dx.doi.org/10.1007/s00239-014-9654-8

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1032326909

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/25399321


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