Short Homologous Sequences Are Strongly Associated with the Generation of Chimeric RNAs in Eukaryotes View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2009-01

AUTHORS

Xin Li, Li Zhao, Huifeng Jiang, Wen Wang

ABSTRACT

Chimeric RNAs have been reported in varieties of organisms and are conventionally thought to be produced by trans-splicing of two or more distinct transcripts. Here, we conducted a large-scale search for chimeric RNAs in the budding yeast, fruit fly, mouse, and human. Thousands of chimeric transcripts were identified in these organisms except in yeast, in which five chimeric RNAs were observed. RT-PCR experiments for a sample of yeast and fly chimeric transcripts using specific primers show that about one-third of these chimeric RNAs can be reproduced. The results suggest that at least a considerable amount of chimeric RNAs is unlikely from aberrant transcription or splicing, and thus formation of chimeric RNAs is probably a widespread process and can greatly contribute to the complexity of the transcriptome and proteome of organisms. However, only a small fraction (<20%) of these chimeric RNAs has GU-AG at the junction sequences which fits the classical trans-splicing model. In contrast, we observed that about half of the chimeric RNAs have short homologous sequences (SHSs) at the junction sites of the source sequences. Our sequence mutation experiments in yeast showed that disruption of SHSs resulted in the disappearance of the corresponding chimeric RNAs, suggesting that SHSs are essential for generating this kind of chimeric RNA. In addition to the classical trans-splicing model, we propose a new model, the transcriptional slippage model, to explain the generation of those chimeric RNAs synthesized from templates with SHSs. More... »

PAGES

56-65

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00239-008-9187-0

DOI

http://dx.doi.org/10.1007/s00239-008-9187-0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1003901165

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/19089307


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0604", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Genetics", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Drosophila", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Evolution, Molecular", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "RNA", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Reverse Transcriptase Polymerase Chain Reaction", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Saccharomyces cerevisiae", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Sequence Homology", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Trans-Splicing", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Chinese Academy of Sciences", 
          "id": "https://www.grid.ac/institutes/grid.9227.e", 
          "name": [
            "CAS-Max Planck Junior Research Group on Evolutionary Genomics, State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences (CAS), 650223, Kunming, China", 
            "Graduate School of Chinese Academy of Sciences, 100049, Beijing, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Li", 
        "givenName": "Xin", 
        "id": "sg:person.0666476155.36", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0666476155.36"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Chinese Academy of Sciences", 
          "id": "https://www.grid.ac/institutes/grid.9227.e", 
          "name": [
            "CAS-Max Planck Junior Research Group on Evolutionary Genomics, State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences (CAS), 650223, Kunming, China", 
            "Graduate School of Chinese Academy of Sciences, 100049, Beijing, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Zhao", 
        "givenName": "Li", 
        "id": "sg:person.01116511144.24", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01116511144.24"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Chinese Academy of Sciences", 
          "id": "https://www.grid.ac/institutes/grid.9227.e", 
          "name": [
            "CAS-Max Planck Junior Research Group on Evolutionary Genomics, State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences (CAS), 650223, Kunming, China", 
            "Graduate School of Chinese Academy of Sciences, 100049, Beijing, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Jiang", 
        "givenName": "Huifeng", 
        "id": "sg:person.01331102575.73", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01331102575.73"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Kunming Institute of Zoology", 
          "id": "https://www.grid.ac/institutes/grid.419010.d", 
          "name": [
            "CAS-Max Planck Junior Research Group on Evolutionary Genomics, State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences (CAS), 650223, Kunming, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Wang", 
        "givenName": "Wen", 
        "id": "sg:person.0770664455.32", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0770664455.32"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1046/j.1365-313x.1999.00493.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000840764"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1058040", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001517867"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0960-0760(91)90302-l", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002452325"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1534/genetics.103.020842", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002701994"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1534/genetics.103.020842", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002701994"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/271501a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003420417", 
          "https://doi.org/10.1038/271501a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/271501a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003420417", 
          "https://doi.org/10.1038/271501a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0000254", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004311984"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/gr.229202", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006260064"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0092-8674(87)90361-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006705725"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.151268698", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012067949"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng1423", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013569568", 
          "https://doi.org/10.1038/ng1423"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng1423", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013569568", 
          "https://doi.org/10.1038/ng1423"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.tig.2007.06.001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014038595"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.86.20.8020", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014379563"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/gr.6339607", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015155991"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1590/s0074-02762005000500010", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015681109"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/gad.1137303", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016495917"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m606010200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016516346"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m002010200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020355952"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1097-2765(02)00578-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021534495"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0378-1119(89)90358-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021797759"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0378-1119(89)90358-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021797759"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.274.16.11060", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021855830"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0092-8674(91)90464-a", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022237827"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1084/jem.173.6.1385", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023814443"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/gb-2005-6-11-237", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023990983", 
          "https://doi.org/10.1186/gb-2005-6-11-237"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/nar/gkf483", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025400190"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1123191", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026843212"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1006/geno.1999.6063", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028853298"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1534/genetics.107.070938", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029006217"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1534/genetics.107.070938", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029006217"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.96.10.5400", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031332428"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0168-9525(01)02499-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031784017"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.95.21.12185", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032720345"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0014-5793(97)00555-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033446683"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m109175200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033599089"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nmeth0706-541", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033837237", 
          "https://doi.org/10.1038/nmeth0706-541"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nmeth0706-541", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033837237", 
          "https://doi.org/10.1038/nmeth0706-541"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/gb-2005-6-3-r25", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034482573", 
          "https://doi.org/10.1186/gb-2005-6-3-r25"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.gene.2004.08.016", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034977438"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/nar/27.13.2585", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037244962"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0092-8674(85)80112-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037486309"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0168-9525(00)02176-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037623303"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/gr.3929705", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037712226"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/bies.10371", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038119563"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/418236a", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039558582", 
          "https://doi.org/10.1038/418236a"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/418236a", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039558582", 
          "https://doi.org/10.1038/418236a"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/418236a", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039558582", 
          "https://doi.org/10.1038/418236a"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.89.7.2511", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041460541"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0092-8674(85)80111-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043312402"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m011040200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044896064"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1091/mbc.9.6.1523", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046086846"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.279.5348.242", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047406917"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/nar/18.12.3529", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052098682"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1042/bc20050002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052897261"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/bioinformatics/btl575", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053331021"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1089/104454903322216653", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059203819"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1075039907", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/j.1460-2075.1987.tb02489.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1077183939"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1077305998", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2009-01", 
    "datePublishedReg": "2009-01-01", 
    "description": "Chimeric RNAs have been reported in varieties of organisms and are conventionally thought to be produced by trans-splicing of two or more distinct transcripts. Here, we conducted a large-scale search for chimeric RNAs in the budding yeast, fruit fly, mouse, and human. Thousands of chimeric transcripts were identified in these organisms except in yeast, in which five chimeric RNAs were observed. RT-PCR experiments for a sample of yeast and fly chimeric transcripts using specific primers show that about one-third of these chimeric RNAs can be reproduced. The results suggest that at least a considerable amount of chimeric RNAs is unlikely from aberrant transcription or splicing, and thus formation of chimeric RNAs is probably a widespread process and can greatly contribute to the complexity of the transcriptome and proteome of organisms. However, only a small fraction (<20%) of these chimeric RNAs has GU-AG at the junction sequences which fits the classical trans-splicing model. In contrast, we observed that about half of the chimeric RNAs have short homologous sequences (SHSs) at the junction sites of the source sequences. Our sequence mutation experiments in yeast showed that disruption of SHSs resulted in the disappearance of the corresponding chimeric RNAs, suggesting that SHSs are essential for generating this kind of chimeric RNA. In addition to the classical trans-splicing model, we propose a new model, the transcriptional slippage model, to explain the generation of those chimeric RNAs synthesized from templates with SHSs.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/s00239-008-9187-0", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.4939149", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1016442", 
        "issn": [
          "0022-2844", 
          "1432-1432"
        ], 
        "name": "Journal of Molecular Evolution", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "68"
      }
    ], 
    "name": "Short Homologous Sequences Are Strongly Associated with the Generation of Chimeric RNAs in Eukaryotes", 
    "pagination": "56-65", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "12960636641d6dbc62768f2891f5122310038f1a5cedbc466ae1a1ffeace8930"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "19089307"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "0360051"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s00239-008-9187-0"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1003901165"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s00239-008-9187-0", 
      "https://app.dimensions.ai/details/publication/pub.1003901165"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T14:34", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000373_0000000373/records_13109_00000000.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1007%2Fs00239-008-9187-0"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s00239-008-9187-0'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s00239-008-9187-0'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s00239-008-9187-0'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s00239-008-9187-0'


 

This table displays all metadata directly associated to this object as RDF triples.

299 TRIPLES      21 PREDICATES      92 URIs      31 LITERALS      19 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s00239-008-9187-0 schema:about N17eb03afb3644086ac89d5631dc49156
2 N1e64d4732cab4209ae6c8678ab82b8ec
3 N2161492260fd4c1ba70f058e8fbbc27b
4 N2dcc44c4d13641789fce614c2cd9bcc1
5 N32dbd86508424e9981b02d8784ef19bb
6 N768eac490d544e8a9f28d87c88716c65
7 N7783d74d2f834872bdbfaae2c31294c8
8 Nae7a6b09f0334336873aae6642bfddca
9 Naf0360facc644d849e2f7f7fa98865b6
10 Nf03be69223e449b592a70c2ba234f7b7
11 anzsrc-for:06
12 anzsrc-for:0604
13 schema:author N96e69144668942679013a29e4973afcf
14 schema:citation sg:pub.10.1038/271501a0
15 sg:pub.10.1038/418236a
16 sg:pub.10.1038/ng1423
17 sg:pub.10.1038/nmeth0706-541
18 sg:pub.10.1186/gb-2005-6-11-237
19 sg:pub.10.1186/gb-2005-6-3-r25
20 https://app.dimensions.ai/details/publication/pub.1075039907
21 https://app.dimensions.ai/details/publication/pub.1077305998
22 https://doi.org/10.1002/bies.10371
23 https://doi.org/10.1002/j.1460-2075.1987.tb02489.x
24 https://doi.org/10.1006/geno.1999.6063
25 https://doi.org/10.1016/0092-8674(87)90361-8
26 https://doi.org/10.1016/0092-8674(91)90464-a
27 https://doi.org/10.1016/0378-1119(89)90358-2
28 https://doi.org/10.1016/0960-0760(91)90302-l
29 https://doi.org/10.1016/j.gene.2004.08.016
30 https://doi.org/10.1016/j.tig.2007.06.001
31 https://doi.org/10.1016/s0014-5793(97)00555-3
32 https://doi.org/10.1016/s0092-8674(85)80111-2
33 https://doi.org/10.1016/s0092-8674(85)80112-4
34 https://doi.org/10.1016/s0168-9525(00)02176-4
35 https://doi.org/10.1016/s0168-9525(01)02499-4
36 https://doi.org/10.1016/s1097-2765(02)00578-6
37 https://doi.org/10.1042/bc20050002
38 https://doi.org/10.1046/j.1365-313x.1999.00493.x
39 https://doi.org/10.1073/pnas.151268698
40 https://doi.org/10.1073/pnas.86.20.8020
41 https://doi.org/10.1073/pnas.89.7.2511
42 https://doi.org/10.1073/pnas.95.21.12185
43 https://doi.org/10.1073/pnas.96.10.5400
44 https://doi.org/10.1074/jbc.274.16.11060
45 https://doi.org/10.1074/jbc.m002010200
46 https://doi.org/10.1074/jbc.m011040200
47 https://doi.org/10.1074/jbc.m109175200
48 https://doi.org/10.1074/jbc.m606010200
49 https://doi.org/10.1084/jem.173.6.1385
50 https://doi.org/10.1089/104454903322216653
51 https://doi.org/10.1091/mbc.9.6.1523
52 https://doi.org/10.1093/bioinformatics/btl575
53 https://doi.org/10.1093/nar/18.12.3529
54 https://doi.org/10.1093/nar/27.13.2585
55 https://doi.org/10.1093/nar/gkf483
56 https://doi.org/10.1101/gad.1137303
57 https://doi.org/10.1101/gr.229202
58 https://doi.org/10.1101/gr.3929705
59 https://doi.org/10.1101/gr.6339607
60 https://doi.org/10.1126/science.1058040
61 https://doi.org/10.1126/science.1123191
62 https://doi.org/10.1126/science.279.5348.242
63 https://doi.org/10.1371/journal.pone.0000254
64 https://doi.org/10.1534/genetics.103.020842
65 https://doi.org/10.1534/genetics.107.070938
66 https://doi.org/10.1590/s0074-02762005000500010
67 schema:datePublished 2009-01
68 schema:datePublishedReg 2009-01-01
69 schema:description Chimeric RNAs have been reported in varieties of organisms and are conventionally thought to be produced by trans-splicing of two or more distinct transcripts. Here, we conducted a large-scale search for chimeric RNAs in the budding yeast, fruit fly, mouse, and human. Thousands of chimeric transcripts were identified in these organisms except in yeast, in which five chimeric RNAs were observed. RT-PCR experiments for a sample of yeast and fly chimeric transcripts using specific primers show that about one-third of these chimeric RNAs can be reproduced. The results suggest that at least a considerable amount of chimeric RNAs is unlikely from aberrant transcription or splicing, and thus formation of chimeric RNAs is probably a widespread process and can greatly contribute to the complexity of the transcriptome and proteome of organisms. However, only a small fraction (<20%) of these chimeric RNAs has GU-AG at the junction sequences which fits the classical trans-splicing model. In contrast, we observed that about half of the chimeric RNAs have short homologous sequences (SHSs) at the junction sites of the source sequences. Our sequence mutation experiments in yeast showed that disruption of SHSs resulted in the disappearance of the corresponding chimeric RNAs, suggesting that SHSs are essential for generating this kind of chimeric RNA. In addition to the classical trans-splicing model, we propose a new model, the transcriptional slippage model, to explain the generation of those chimeric RNAs synthesized from templates with SHSs.
70 schema:genre research_article
71 schema:inLanguage en
72 schema:isAccessibleForFree false
73 schema:isPartOf N25f01bbfaf7b4d0ea15077ec4dac525d
74 Nd108125dd9cc4d6dac80b4e9e89c0dff
75 sg:journal.1016442
76 schema:name Short Homologous Sequences Are Strongly Associated with the Generation of Chimeric RNAs in Eukaryotes
77 schema:pagination 56-65
78 schema:productId N09d89112fd764a7cb7dbf7ab07ec6866
79 N197190bbf7d9491daa81088fa6d3c689
80 N595e4f0619f1471b83e44ddad2267ce5
81 N5e5f37fa215e4007b9bb6ad2c20dbfaf
82 N740233a0c88d431d92753c21676720b1
83 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003901165
84 https://doi.org/10.1007/s00239-008-9187-0
85 schema:sdDatePublished 2019-04-11T14:34
86 schema:sdLicense https://scigraph.springernature.com/explorer/license/
87 schema:sdPublisher N77c79feff21b4baf9cac0f48817981c5
88 schema:url http://link.springer.com/10.1007%2Fs00239-008-9187-0
89 sgo:license sg:explorer/license/
90 sgo:sdDataset articles
91 rdf:type schema:ScholarlyArticle
92 N09d89112fd764a7cb7dbf7ab07ec6866 schema:name pubmed_id
93 schema:value 19089307
94 rdf:type schema:PropertyValue
95 N17eb03afb3644086ac89d5631dc49156 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
96 schema:name Trans-Splicing
97 rdf:type schema:DefinedTerm
98 N197190bbf7d9491daa81088fa6d3c689 schema:name doi
99 schema:value 10.1007/s00239-008-9187-0
100 rdf:type schema:PropertyValue
101 N1e64d4732cab4209ae6c8678ab82b8ec schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
102 schema:name Reverse Transcriptase Polymerase Chain Reaction
103 rdf:type schema:DefinedTerm
104 N2161492260fd4c1ba70f058e8fbbc27b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
105 schema:name Drosophila
106 rdf:type schema:DefinedTerm
107 N25f01bbfaf7b4d0ea15077ec4dac525d schema:volumeNumber 68
108 rdf:type schema:PublicationVolume
109 N2dcc44c4d13641789fce614c2cd9bcc1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
110 schema:name Sequence Homology
111 rdf:type schema:DefinedTerm
112 N300d5e5da3644817b03a14a3e3d2cc21 rdf:first sg:person.01331102575.73
113 rdf:rest Nb181df60674a468084eef248d885937b
114 N32dbd86508424e9981b02d8784ef19bb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
115 schema:name Evolution, Molecular
116 rdf:type schema:DefinedTerm
117 N595e4f0619f1471b83e44ddad2267ce5 schema:name readcube_id
118 schema:value 12960636641d6dbc62768f2891f5122310038f1a5cedbc466ae1a1ffeace8930
119 rdf:type schema:PropertyValue
120 N5e5f37fa215e4007b9bb6ad2c20dbfaf schema:name nlm_unique_id
121 schema:value 0360051
122 rdf:type schema:PropertyValue
123 N740233a0c88d431d92753c21676720b1 schema:name dimensions_id
124 schema:value pub.1003901165
125 rdf:type schema:PropertyValue
126 N768eac490d544e8a9f28d87c88716c65 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
127 schema:name Saccharomyces cerevisiae
128 rdf:type schema:DefinedTerm
129 N7783d74d2f834872bdbfaae2c31294c8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
130 schema:name Mice
131 rdf:type schema:DefinedTerm
132 N77c79feff21b4baf9cac0f48817981c5 schema:name Springer Nature - SN SciGraph project
133 rdf:type schema:Organization
134 N96e69144668942679013a29e4973afcf rdf:first sg:person.0666476155.36
135 rdf:rest Nf782b7cf2eeb436b8ed241cbfa6f1037
136 Nae7a6b09f0334336873aae6642bfddca schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
137 schema:name RNA
138 rdf:type schema:DefinedTerm
139 Naf0360facc644d849e2f7f7fa98865b6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
140 schema:name Humans
141 rdf:type schema:DefinedTerm
142 Nb181df60674a468084eef248d885937b rdf:first sg:person.0770664455.32
143 rdf:rest rdf:nil
144 Nd108125dd9cc4d6dac80b4e9e89c0dff schema:issueNumber 1
145 rdf:type schema:PublicationIssue
146 Nf03be69223e449b592a70c2ba234f7b7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
147 schema:name Animals
148 rdf:type schema:DefinedTerm
149 Nf782b7cf2eeb436b8ed241cbfa6f1037 rdf:first sg:person.01116511144.24
150 rdf:rest N300d5e5da3644817b03a14a3e3d2cc21
151 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
152 schema:name Biological Sciences
153 rdf:type schema:DefinedTerm
154 anzsrc-for:0604 schema:inDefinedTermSet anzsrc-for:
155 schema:name Genetics
156 rdf:type schema:DefinedTerm
157 sg:grant.4939149 http://pending.schema.org/fundedItem sg:pub.10.1007/s00239-008-9187-0
158 rdf:type schema:MonetaryGrant
159 sg:journal.1016442 schema:issn 0022-2844
160 1432-1432
161 schema:name Journal of Molecular Evolution
162 rdf:type schema:Periodical
163 sg:person.01116511144.24 schema:affiliation https://www.grid.ac/institutes/grid.9227.e
164 schema:familyName Zhao
165 schema:givenName Li
166 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01116511144.24
167 rdf:type schema:Person
168 sg:person.01331102575.73 schema:affiliation https://www.grid.ac/institutes/grid.9227.e
169 schema:familyName Jiang
170 schema:givenName Huifeng
171 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01331102575.73
172 rdf:type schema:Person
173 sg:person.0666476155.36 schema:affiliation https://www.grid.ac/institutes/grid.9227.e
174 schema:familyName Li
175 schema:givenName Xin
176 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0666476155.36
177 rdf:type schema:Person
178 sg:person.0770664455.32 schema:affiliation https://www.grid.ac/institutes/grid.419010.d
179 schema:familyName Wang
180 schema:givenName Wen
181 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0770664455.32
182 rdf:type schema:Person
183 sg:pub.10.1038/271501a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003420417
184 https://doi.org/10.1038/271501a0
185 rdf:type schema:CreativeWork
186 sg:pub.10.1038/418236a schema:sameAs https://app.dimensions.ai/details/publication/pub.1039558582
187 https://doi.org/10.1038/418236a
188 rdf:type schema:CreativeWork
189 sg:pub.10.1038/ng1423 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013569568
190 https://doi.org/10.1038/ng1423
191 rdf:type schema:CreativeWork
192 sg:pub.10.1038/nmeth0706-541 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033837237
193 https://doi.org/10.1038/nmeth0706-541
194 rdf:type schema:CreativeWork
195 sg:pub.10.1186/gb-2005-6-11-237 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023990983
196 https://doi.org/10.1186/gb-2005-6-11-237
197 rdf:type schema:CreativeWork
198 sg:pub.10.1186/gb-2005-6-3-r25 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034482573
199 https://doi.org/10.1186/gb-2005-6-3-r25
200 rdf:type schema:CreativeWork
201 https://app.dimensions.ai/details/publication/pub.1075039907 schema:CreativeWork
202 https://app.dimensions.ai/details/publication/pub.1077305998 schema:CreativeWork
203 https://doi.org/10.1002/bies.10371 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038119563
204 rdf:type schema:CreativeWork
205 https://doi.org/10.1002/j.1460-2075.1987.tb02489.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1077183939
206 rdf:type schema:CreativeWork
207 https://doi.org/10.1006/geno.1999.6063 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028853298
208 rdf:type schema:CreativeWork
209 https://doi.org/10.1016/0092-8674(87)90361-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006705725
210 rdf:type schema:CreativeWork
211 https://doi.org/10.1016/0092-8674(91)90464-a schema:sameAs https://app.dimensions.ai/details/publication/pub.1022237827
212 rdf:type schema:CreativeWork
213 https://doi.org/10.1016/0378-1119(89)90358-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021797759
214 rdf:type schema:CreativeWork
215 https://doi.org/10.1016/0960-0760(91)90302-l schema:sameAs https://app.dimensions.ai/details/publication/pub.1002452325
216 rdf:type schema:CreativeWork
217 https://doi.org/10.1016/j.gene.2004.08.016 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034977438
218 rdf:type schema:CreativeWork
219 https://doi.org/10.1016/j.tig.2007.06.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014038595
220 rdf:type schema:CreativeWork
221 https://doi.org/10.1016/s0014-5793(97)00555-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033446683
222 rdf:type schema:CreativeWork
223 https://doi.org/10.1016/s0092-8674(85)80111-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043312402
224 rdf:type schema:CreativeWork
225 https://doi.org/10.1016/s0092-8674(85)80112-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037486309
226 rdf:type schema:CreativeWork
227 https://doi.org/10.1016/s0168-9525(00)02176-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037623303
228 rdf:type schema:CreativeWork
229 https://doi.org/10.1016/s0168-9525(01)02499-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031784017
230 rdf:type schema:CreativeWork
231 https://doi.org/10.1016/s1097-2765(02)00578-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021534495
232 rdf:type schema:CreativeWork
233 https://doi.org/10.1042/bc20050002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052897261
234 rdf:type schema:CreativeWork
235 https://doi.org/10.1046/j.1365-313x.1999.00493.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1000840764
236 rdf:type schema:CreativeWork
237 https://doi.org/10.1073/pnas.151268698 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012067949
238 rdf:type schema:CreativeWork
239 https://doi.org/10.1073/pnas.86.20.8020 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014379563
240 rdf:type schema:CreativeWork
241 https://doi.org/10.1073/pnas.89.7.2511 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041460541
242 rdf:type schema:CreativeWork
243 https://doi.org/10.1073/pnas.95.21.12185 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032720345
244 rdf:type schema:CreativeWork
245 https://doi.org/10.1073/pnas.96.10.5400 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031332428
246 rdf:type schema:CreativeWork
247 https://doi.org/10.1074/jbc.274.16.11060 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021855830
248 rdf:type schema:CreativeWork
249 https://doi.org/10.1074/jbc.m002010200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020355952
250 rdf:type schema:CreativeWork
251 https://doi.org/10.1074/jbc.m011040200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044896064
252 rdf:type schema:CreativeWork
253 https://doi.org/10.1074/jbc.m109175200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033599089
254 rdf:type schema:CreativeWork
255 https://doi.org/10.1074/jbc.m606010200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016516346
256 rdf:type schema:CreativeWork
257 https://doi.org/10.1084/jem.173.6.1385 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023814443
258 rdf:type schema:CreativeWork
259 https://doi.org/10.1089/104454903322216653 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059203819
260 rdf:type schema:CreativeWork
261 https://doi.org/10.1091/mbc.9.6.1523 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046086846
262 rdf:type schema:CreativeWork
263 https://doi.org/10.1093/bioinformatics/btl575 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053331021
264 rdf:type schema:CreativeWork
265 https://doi.org/10.1093/nar/18.12.3529 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052098682
266 rdf:type schema:CreativeWork
267 https://doi.org/10.1093/nar/27.13.2585 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037244962
268 rdf:type schema:CreativeWork
269 https://doi.org/10.1093/nar/gkf483 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025400190
270 rdf:type schema:CreativeWork
271 https://doi.org/10.1101/gad.1137303 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016495917
272 rdf:type schema:CreativeWork
273 https://doi.org/10.1101/gr.229202 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006260064
274 rdf:type schema:CreativeWork
275 https://doi.org/10.1101/gr.3929705 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037712226
276 rdf:type schema:CreativeWork
277 https://doi.org/10.1101/gr.6339607 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015155991
278 rdf:type schema:CreativeWork
279 https://doi.org/10.1126/science.1058040 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001517867
280 rdf:type schema:CreativeWork
281 https://doi.org/10.1126/science.1123191 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026843212
282 rdf:type schema:CreativeWork
283 https://doi.org/10.1126/science.279.5348.242 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047406917
284 rdf:type schema:CreativeWork
285 https://doi.org/10.1371/journal.pone.0000254 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004311984
286 rdf:type schema:CreativeWork
287 https://doi.org/10.1534/genetics.103.020842 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002701994
288 rdf:type schema:CreativeWork
289 https://doi.org/10.1534/genetics.107.070938 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029006217
290 rdf:type schema:CreativeWork
291 https://doi.org/10.1590/s0074-02762005000500010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015681109
292 rdf:type schema:CreativeWork
293 https://www.grid.ac/institutes/grid.419010.d schema:alternateName Kunming Institute of Zoology
294 schema:name CAS-Max Planck Junior Research Group on Evolutionary Genomics, State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences (CAS), 650223, Kunming, China
295 rdf:type schema:Organization
296 https://www.grid.ac/institutes/grid.9227.e schema:alternateName Chinese Academy of Sciences
297 schema:name CAS-Max Planck Junior Research Group on Evolutionary Genomics, State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences (CAS), 650223, Kunming, China
298 Graduate School of Chinese Academy of Sciences, 100049, Beijing, China
299 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...