The Repetitive DNA Elements Called CRISPRs and Their Associated Genes: Evidence of Horizontal Transfer Among Prokaryotes View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2006-04-11

AUTHORS

James S. Godde, Amanda Bickerton

ABSTRACT

We have found direct DNA repeats 21–47 bp in length interspersed with nonrepetitive sequences of similar length, or clustered regularly interspaced short palindromic repeats (CRISPRs) in a wide range of diverse prokaryotes, including many Archaeal and Eubacterial species. A number of cas, CRISPR-associated genes have also been characterized in many of the same organisms. Phylogenetic analysis of these cas genes suggests that the CRISPR loci have been propagated via HGT, horizontal gene transfer. We suggest a mechanism by which this HGT has occurred, namely, that the CRISPR loci can be carried between cells on megaplasmids ≥40 kb in length. More... »

PAGES

718-729

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00239-005-0223-z

DOI

http://dx.doi.org/10.1007/s00239-005-0223-z

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1033365389

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/16612537


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