Error Minimization and Coding Triplet/Binding Site Associations Are Independent Features of the Canonical Genetic Code View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2005-10-06

AUTHORS

J. Gregory Caporaso, Michael Yarus, Rob Knight

ABSTRACT

The canonical genetic code has been reported both to be error minimizing and to show stereochemical associations between coding triplets and binding sites. In order to test whether these two properties are unexpectedly overlapping, we generated 200,000 randomized genetic codes using each of five randomization schemes, with and without randomization of stop codons. Comparison of the code error (difference in polar requirement for single-nucleotide codon interchanges) with the coding triplet concentrations in RNA binding sites for eight amino acids shows that these properties are independent and uncorrelated. Thus, one is not the result of the other, and error minimization and triplet associations probably arose independently during the history of the genetic code. We explicitly show that prior fixation of a stereochemical core is consistent with an effective later minimization of error. More... »

PAGES

597-607

References to SciGraph publications

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  • 2001-12. A Blind Empiricism Against the Coevolution Theory of the Origin of the Genetic Code in JOURNAL OF MOLECULAR EVOLUTION
  • 1996-02. Phylogenetic analysis using parsimony and likelihood methods in JOURNAL OF MOLECULAR EVOLUTION
  • 2000-03. The Robust Statistical Bases of the Coevolution Theory of Genetic Code Origin in JOURNAL OF MOLECULAR EVOLUTION
  • 2003-09. Codon Usage Decreases the Error Minimization Within the Genetic Code in JOURNAL OF MOLECULAR EVOLUTION
  • 1973-10. Evolution of the genetic code in THE SCIENCE OF NATURE
  • 1998-06. The Historical Factor: The Biosynthetic Relationships Between Amino Acids and Their Physicochemical Properties in the Origin of the Genetic Code in JOURNAL OF MOLECULAR EVOLUTION
  • 1998-09. The Genetic Code Is One in a Million in JOURNAL OF MOLECULAR EVOLUTION
  • 1998-07. Amino Acids as RNA Ligands: A Direct-RNA-Template Theory for the Code's Origin in JOURNAL OF MOLECULAR EVOLUTION
  • 1997-05. An Analysis of the Metabolic Theory of the Origin of the Genetic Code in JOURNAL OF MOLECULAR EVOLUTION
  • 1989-11-01. Genetic code origins in NATURE
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s00239-004-0314-2

    DOI

    http://dx.doi.org/10.1007/s00239-004-0314-2

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1045951767

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/16211428


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