Cholesterol and Cardiolipin Importance in Local Anesthetics–Membrane Interactions: The Langmuir Monolayer Study View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2019-02

AUTHORS

Justyna Mildner, Anita Wnętrzak, Patrycja Dynarowicz-Latka

ABSTRACT

Local anesthetics (LAs) are known to act on membrane level; however, the molecular mechanism of their activity is still not fully understood. One hypothesis holds that these drugs can incorporate into lipid membrane of nerve cells and in this way change conformation of channel proteins responsible for transport of sodium ions. However, the action of anesthetics is not limited to nerve cells. These drugs also affect other types of cells and organelles, causing severe side effects. In this paper, we applied Langmuir monolayers-as model of cellular membranes-and investigated interactions between selected amide-type local anesthetics (lidocaine prilocaine, mepivacaine and ropivacaine, in the form of hydrochlorides) and lipid components of natural membranes: cholesterol, POPC and cardiolipin (CL) and their mixtures (POPC/cholesterol and POPC/CL/cholesterol), which can serve as simplified models of nerve cell membranes, erythrocytes, and mitochondria. The influence of the drug was monitored by registering the surface pressure (π) as a function of surface area per molecule (A) in a monolayer in the presence of the drug in the subphase. The structure of lipid monolayers on subphases containing and devoid of the studied drugs were visualized with Brewster angle microscopy (BAM). Langmuir monolayer studies complemented with surface visualization technique reveal the expansion and fluidization of lipid monolayers, with the most pronounced effect observed for cardiolipin. In mixed systems, the effect of LAs was found to depend on cholesterol proportion. The observed fluidization of membranes by local anesthetics may negatively affect cells functioning and therefore can explain side effects of these drugs both on the cardiovascular and nervous systems. More... »

PAGES

1-9

Journal

TITLE

The Journal of Membrane Biology

ISSUE

N/A

VOLUME

N/A

Author Affiliations

From Grant

  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s00232-018-0055-6

    DOI

    http://dx.doi.org/10.1007/s00232-018-0055-6

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1110286097

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/30506104


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Biochemistry and Cell Biology", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Biological Sciences", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Jagiellonian University", 
              "id": "https://www.grid.ac/institutes/grid.5522.0", 
              "name": [
                "Department of General Chemistry, Faculty of Chemistry, Jagiellonian University, Gronostajowa 2, 30-387, Krak\u00f3w, Poland"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Mildner", 
            "givenName": "Justyna", 
            "id": "sg:person.0756013353.15", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0756013353.15"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Jagiellonian University", 
              "id": "https://www.grid.ac/institutes/grid.5522.0", 
              "name": [
                "Department of General Chemistry, Faculty of Chemistry, Jagiellonian University, Gronostajowa 2, 30-387, Krak\u00f3w, Poland"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Wn\u0119trzak", 
            "givenName": "Anita", 
            "id": "sg:person.01367772760.86", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01367772760.86"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Jagiellonian University", 
              "id": "https://www.grid.ac/institutes/grid.5522.0", 
              "name": [
                "Department of General Chemistry, Faculty of Chemistry, Jagiellonian University, Gronostajowa 2, 30-387, Krak\u00f3w, Poland"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Dynarowicz-Latka", 
            "givenName": "Patrycja", 
            "id": "sg:person.0733135451.72", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0733135451.72"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "https://doi.org/10.1111/j.1600-0773.1954.tb01349.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000412491"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1046/j.1472-8206.2002.00090.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002287316"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1006/bcmd.2002.0531", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004623783"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0927-7765(01)00209-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004981222"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00232-015-9814-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008423496", 
              "https://doi.org/10.1007/s00232-015-9814-9"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00232-015-9814-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008423496", 
              "https://doi.org/10.1007/s00232-015-9814-9"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/978-3-642-71110-7_2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010218234", 
              "https://doi.org/10.1007/978-3-642-71110-7_2"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cis.2014.02.013", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012770354"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cbpa.2007.09.020", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018540864"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.2147/lra.s3876", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018977800"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/00000542-199004000-00022", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022193946"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/00000542-199004000-00022", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022193946"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf00313273", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023587434", 
              "https://doi.org/10.1007/bf00313273"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf00313273", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023587434", 
              "https://doi.org/10.1007/bf00313273"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00540-010-0943-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027734638", 
              "https://doi.org/10.1007/s00540-010-0943-0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00540-010-0943-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027734638", 
              "https://doi.org/10.1007/s00540-010-0943-0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/mp9000662", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028566162"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/mp9000662", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028566162"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.bpj.2015.03.026", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033011573"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1749-6632.1991.tb33901.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039315998"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cbi.2007.06.002", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039340259"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0005-2736(87)90400-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046711293"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0005-2736(87)90400-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046711293"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.tsf.2015.09.047", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047226193"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0301-4622(02)00029-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049852306"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1600-0773.1954.tb01348.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052840647"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1053/rapm.2002.36458", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052915755"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1085/jgp.62.1.37", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053385164"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/jp401182c", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1056094009"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/la051216n", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1056148918"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/la051216n", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1056148918"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1074751786", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1075636664", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1124/mol.55.1.134", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1083372005"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2019-02", 
        "datePublishedReg": "2019-02-01", 
        "description": "Local anesthetics (LAs) are known to act on membrane level; however, the molecular mechanism of their activity is still not fully understood. One hypothesis holds that these drugs can incorporate into lipid membrane of nerve cells and in this way change conformation of channel proteins responsible for transport of sodium ions. However, the action of anesthetics is not limited to nerve cells. These drugs also affect other types of cells and organelles, causing severe side effects. In this paper, we applied Langmuir monolayers-as model of cellular membranes-and investigated interactions between selected amide-type local anesthetics (lidocaine prilocaine, mepivacaine and ropivacaine, in the form of hydrochlorides) and lipid components of natural membranes: cholesterol, POPC and cardiolipin (CL) and their mixtures (POPC/cholesterol and POPC/CL/cholesterol), which can serve as simplified models of nerve cell membranes, erythrocytes, and mitochondria. The influence of the drug was monitored by registering the surface pressure (\u03c0) as a function of surface area per molecule (A) in a monolayer in the presence of the drug in the subphase. The structure of lipid monolayers on subphases containing and devoid of the studied drugs were visualized with Brewster angle microscopy (BAM). Langmuir monolayer studies complemented with surface visualization technique reveal the expansion and fluidization of lipid monolayers, with the most pronounced effect observed for cardiolipin. In mixed systems, the effect of LAs was found to depend on cholesterol proportion. The observed fluidization of membranes by local anesthetics may negatively affect cells functioning and therefore can explain side effects of these drugs both on the cardiovascular and nervous systems.", 
        "genre": "research_article", 
        "id": "sg:pub.10.1007/s00232-018-0055-6", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": false, 
        "isFundedItemOf": [
          {
            "id": "sg:grant.4704017", 
            "type": "MonetaryGrant"
          }
        ], 
        "isPartOf": [
          {
            "id": "sg:journal.1012006", 
            "issn": [
              "0022-2631", 
              "1432-1424"
            ], 
            "name": "The Journal of Membrane Biology", 
            "type": "Periodical"
          }
        ], 
        "name": "Cholesterol and Cardiolipin Importance in Local Anesthetics\u2013Membrane Interactions: The Langmuir Monolayer Study", 
        "pagination": "1-9", 
        "productId": [
          {
            "name": "readcube_id", 
            "type": "PropertyValue", 
            "value": [
              "df1ee37811e46008d48fe78c3135e9109eed1762be718d668b02262a6fad590e"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "30506104"
            ]
          }, 
          {
            "name": "nlm_unique_id", 
            "type": "PropertyValue", 
            "value": [
              "0211301"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1007/s00232-018-0055-6"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1110286097"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1007/s00232-018-0055-6", 
          "https://app.dimensions.ai/details/publication/pub.1110286097"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2019-04-11T08:18", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000281_0000000281/records_9848_00000000.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://link.springer.com/10.1007%2Fs00232-018-0055-6"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s00232-018-0055-6'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s00232-018-0055-6'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s00232-018-0055-6'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s00232-018-0055-6'


     

    This table displays all metadata directly associated to this object as RDF triples.

    162 TRIPLES      21 PREDICATES      54 URIs      19 LITERALS      7 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1007/s00232-018-0055-6 schema:about anzsrc-for:06
    2 anzsrc-for:0601
    3 schema:author Ndfc96b8fb719498db46501acf2bdae40
    4 schema:citation sg:pub.10.1007/978-3-642-71110-7_2
    5 sg:pub.10.1007/bf00313273
    6 sg:pub.10.1007/s00232-015-9814-9
    7 sg:pub.10.1007/s00540-010-0943-0
    8 https://app.dimensions.ai/details/publication/pub.1074751786
    9 https://app.dimensions.ai/details/publication/pub.1075636664
    10 https://doi.org/10.1006/bcmd.2002.0531
    11 https://doi.org/10.1016/0005-2736(87)90400-7
    12 https://doi.org/10.1016/j.bpj.2015.03.026
    13 https://doi.org/10.1016/j.cbi.2007.06.002
    14 https://doi.org/10.1016/j.cbpa.2007.09.020
    15 https://doi.org/10.1016/j.cis.2014.02.013
    16 https://doi.org/10.1016/j.tsf.2015.09.047
    17 https://doi.org/10.1016/s0301-4622(02)00029-7
    18 https://doi.org/10.1016/s0927-7765(01)00209-0
    19 https://doi.org/10.1021/jp401182c
    20 https://doi.org/10.1021/la051216n
    21 https://doi.org/10.1021/mp9000662
    22 https://doi.org/10.1046/j.1472-8206.2002.00090.x
    23 https://doi.org/10.1053/rapm.2002.36458
    24 https://doi.org/10.1085/jgp.62.1.37
    25 https://doi.org/10.1097/00000542-199004000-00022
    26 https://doi.org/10.1111/j.1600-0773.1954.tb01348.x
    27 https://doi.org/10.1111/j.1600-0773.1954.tb01349.x
    28 https://doi.org/10.1111/j.1749-6632.1991.tb33901.x
    29 https://doi.org/10.1124/mol.55.1.134
    30 https://doi.org/10.2147/lra.s3876
    31 schema:datePublished 2019-02
    32 schema:datePublishedReg 2019-02-01
    33 schema:description Local anesthetics (LAs) are known to act on membrane level; however, the molecular mechanism of their activity is still not fully understood. One hypothesis holds that these drugs can incorporate into lipid membrane of nerve cells and in this way change conformation of channel proteins responsible for transport of sodium ions. However, the action of anesthetics is not limited to nerve cells. These drugs also affect other types of cells and organelles, causing severe side effects. In this paper, we applied Langmuir monolayers-as model of cellular membranes-and investigated interactions between selected amide-type local anesthetics (lidocaine prilocaine, mepivacaine and ropivacaine, in the form of hydrochlorides) and lipid components of natural membranes: cholesterol, POPC and cardiolipin (CL) and their mixtures (POPC/cholesterol and POPC/CL/cholesterol), which can serve as simplified models of nerve cell membranes, erythrocytes, and mitochondria. The influence of the drug was monitored by registering the surface pressure (π) as a function of surface area per molecule (A) in a monolayer in the presence of the drug in the subphase. The structure of lipid monolayers on subphases containing and devoid of the studied drugs were visualized with Brewster angle microscopy (BAM). Langmuir monolayer studies complemented with surface visualization technique reveal the expansion and fluidization of lipid monolayers, with the most pronounced effect observed for cardiolipin. In mixed systems, the effect of LAs was found to depend on cholesterol proportion. The observed fluidization of membranes by local anesthetics may negatively affect cells functioning and therefore can explain side effects of these drugs both on the cardiovascular and nervous systems.
    34 schema:genre research_article
    35 schema:inLanguage en
    36 schema:isAccessibleForFree false
    37 schema:isPartOf sg:journal.1012006
    38 schema:name Cholesterol and Cardiolipin Importance in Local Anesthetics–Membrane Interactions: The Langmuir Monolayer Study
    39 schema:pagination 1-9
    40 schema:productId N0143c0eb95db4934a0260794d042dd02
    41 N06ad4a6ec37a454daef6dd7569975cce
    42 N0a3c1cd96b8e4cefa4e1dc19fbe041d5
    43 N5df07229974e4ad98d0fde29cf0c363a
    44 Nb6118c06d47a42ac9021b5c7aee677e7
    45 schema:sameAs https://app.dimensions.ai/details/publication/pub.1110286097
    46 https://doi.org/10.1007/s00232-018-0055-6
    47 schema:sdDatePublished 2019-04-11T08:18
    48 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    49 schema:sdPublisher N1c072a5ca46c48cd889e121ed4721d81
    50 schema:url https://link.springer.com/10.1007%2Fs00232-018-0055-6
    51 sgo:license sg:explorer/license/
    52 sgo:sdDataset articles
    53 rdf:type schema:ScholarlyArticle
    54 N0143c0eb95db4934a0260794d042dd02 schema:name readcube_id
    55 schema:value df1ee37811e46008d48fe78c3135e9109eed1762be718d668b02262a6fad590e
    56 rdf:type schema:PropertyValue
    57 N06ad4a6ec37a454daef6dd7569975cce schema:name pubmed_id
    58 schema:value 30506104
    59 rdf:type schema:PropertyValue
    60 N0a038281b26e4213bb698324cb5ede3a rdf:first sg:person.0733135451.72
    61 rdf:rest rdf:nil
    62 N0a3c1cd96b8e4cefa4e1dc19fbe041d5 schema:name dimensions_id
    63 schema:value pub.1110286097
    64 rdf:type schema:PropertyValue
    65 N1c072a5ca46c48cd889e121ed4721d81 schema:name Springer Nature - SN SciGraph project
    66 rdf:type schema:Organization
    67 N5df07229974e4ad98d0fde29cf0c363a schema:name nlm_unique_id
    68 schema:value 0211301
    69 rdf:type schema:PropertyValue
    70 Naf2669d85e99420ea9520ce9f51fb5e0 rdf:first sg:person.01367772760.86
    71 rdf:rest N0a038281b26e4213bb698324cb5ede3a
    72 Nb6118c06d47a42ac9021b5c7aee677e7 schema:name doi
    73 schema:value 10.1007/s00232-018-0055-6
    74 rdf:type schema:PropertyValue
    75 Ndfc96b8fb719498db46501acf2bdae40 rdf:first sg:person.0756013353.15
    76 rdf:rest Naf2669d85e99420ea9520ce9f51fb5e0
    77 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
    78 schema:name Biological Sciences
    79 rdf:type schema:DefinedTerm
    80 anzsrc-for:0601 schema:inDefinedTermSet anzsrc-for:
    81 schema:name Biochemistry and Cell Biology
    82 rdf:type schema:DefinedTerm
    83 sg:grant.4704017 http://pending.schema.org/fundedItem sg:pub.10.1007/s00232-018-0055-6
    84 rdf:type schema:MonetaryGrant
    85 sg:journal.1012006 schema:issn 0022-2631
    86 1432-1424
    87 schema:name The Journal of Membrane Biology
    88 rdf:type schema:Periodical
    89 sg:person.01367772760.86 schema:affiliation https://www.grid.ac/institutes/grid.5522.0
    90 schema:familyName Wnętrzak
    91 schema:givenName Anita
    92 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01367772760.86
    93 rdf:type schema:Person
    94 sg:person.0733135451.72 schema:affiliation https://www.grid.ac/institutes/grid.5522.0
    95 schema:familyName Dynarowicz-Latka
    96 schema:givenName Patrycja
    97 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0733135451.72
    98 rdf:type schema:Person
    99 sg:person.0756013353.15 schema:affiliation https://www.grid.ac/institutes/grid.5522.0
    100 schema:familyName Mildner
    101 schema:givenName Justyna
    102 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0756013353.15
    103 rdf:type schema:Person
    104 sg:pub.10.1007/978-3-642-71110-7_2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010218234
    105 https://doi.org/10.1007/978-3-642-71110-7_2
    106 rdf:type schema:CreativeWork
    107 sg:pub.10.1007/bf00313273 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023587434
    108 https://doi.org/10.1007/bf00313273
    109 rdf:type schema:CreativeWork
    110 sg:pub.10.1007/s00232-015-9814-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008423496
    111 https://doi.org/10.1007/s00232-015-9814-9
    112 rdf:type schema:CreativeWork
    113 sg:pub.10.1007/s00540-010-0943-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027734638
    114 https://doi.org/10.1007/s00540-010-0943-0
    115 rdf:type schema:CreativeWork
    116 https://app.dimensions.ai/details/publication/pub.1074751786 schema:CreativeWork
    117 https://app.dimensions.ai/details/publication/pub.1075636664 schema:CreativeWork
    118 https://doi.org/10.1006/bcmd.2002.0531 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004623783
    119 rdf:type schema:CreativeWork
    120 https://doi.org/10.1016/0005-2736(87)90400-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046711293
    121 rdf:type schema:CreativeWork
    122 https://doi.org/10.1016/j.bpj.2015.03.026 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033011573
    123 rdf:type schema:CreativeWork
    124 https://doi.org/10.1016/j.cbi.2007.06.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039340259
    125 rdf:type schema:CreativeWork
    126 https://doi.org/10.1016/j.cbpa.2007.09.020 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018540864
    127 rdf:type schema:CreativeWork
    128 https://doi.org/10.1016/j.cis.2014.02.013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012770354
    129 rdf:type schema:CreativeWork
    130 https://doi.org/10.1016/j.tsf.2015.09.047 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047226193
    131 rdf:type schema:CreativeWork
    132 https://doi.org/10.1016/s0301-4622(02)00029-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049852306
    133 rdf:type schema:CreativeWork
    134 https://doi.org/10.1016/s0927-7765(01)00209-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004981222
    135 rdf:type schema:CreativeWork
    136 https://doi.org/10.1021/jp401182c schema:sameAs https://app.dimensions.ai/details/publication/pub.1056094009
    137 rdf:type schema:CreativeWork
    138 https://doi.org/10.1021/la051216n schema:sameAs https://app.dimensions.ai/details/publication/pub.1056148918
    139 rdf:type schema:CreativeWork
    140 https://doi.org/10.1021/mp9000662 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028566162
    141 rdf:type schema:CreativeWork
    142 https://doi.org/10.1046/j.1472-8206.2002.00090.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1002287316
    143 rdf:type schema:CreativeWork
    144 https://doi.org/10.1053/rapm.2002.36458 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052915755
    145 rdf:type schema:CreativeWork
    146 https://doi.org/10.1085/jgp.62.1.37 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053385164
    147 rdf:type schema:CreativeWork
    148 https://doi.org/10.1097/00000542-199004000-00022 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022193946
    149 rdf:type schema:CreativeWork
    150 https://doi.org/10.1111/j.1600-0773.1954.tb01348.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1052840647
    151 rdf:type schema:CreativeWork
    152 https://doi.org/10.1111/j.1600-0773.1954.tb01349.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1000412491
    153 rdf:type schema:CreativeWork
    154 https://doi.org/10.1111/j.1749-6632.1991.tb33901.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1039315998
    155 rdf:type schema:CreativeWork
    156 https://doi.org/10.1124/mol.55.1.134 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083372005
    157 rdf:type schema:CreativeWork
    158 https://doi.org/10.2147/lra.s3876 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018977800
    159 rdf:type schema:CreativeWork
    160 https://www.grid.ac/institutes/grid.5522.0 schema:alternateName Jagiellonian University
    161 schema:name Department of General Chemistry, Faculty of Chemistry, Jagiellonian University, Gronostajowa 2, 30-387, Kraków, Poland
    162 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...